FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3492, 397 aa 1>>>pF1KB3492 397 - 397 aa - 397 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4675+/-0.000952; mu= 15.7847+/- 0.057 mean_var=61.6654+/-12.344, 0's: 0 Z-trim(103.4): 29 B-trim: 0 in 0/50 Lambda= 0.163325 statistics sampled from 7373 (7388) to 7373 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.227), width: 16 Scan time: 2.500 The best scores are: opt bits E(32554) CCDS5268.1 ACAT2 gene_id:39|Hs108|chr6 ( 397) 2583 617.4 7e-177 CCDS8339.1 ACAT1 gene_id:38|Hs108|chr11 ( 427) 1030 251.5 1.1e-66 CCDS11939.1 ACAA2 gene_id:10449|Hs108|chr18 ( 397) 1001 244.7 1.1e-64 CCDS2673.1 ACAA1 gene_id:30|Hs108|chr3 ( 424) 841 207.0 2.7e-53 CCDS46794.1 ACAA1 gene_id:30|Hs108|chr3 ( 331) 350 91.3 1.5e-18 >>CCDS5268.1 ACAT2 gene_id:39|Hs108|chr6 (397 aa) initn: 2583 init1: 2583 opt: 2583 Z-score: 3289.1 bits: 617.4 E(32554): 7e-177 Smith-Waterman score: 2583; 99.7% identity (100.0% similar) in 397 aa overlap (1-397:1-397) 10 20 30 40 50 60 pF1KB3 MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 LAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 NMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 NMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VAVLSQNRTENAQKAGHFDKEIVPVLVSTRRGLIEVKTDEFPRHGSNIEAMSKLKPYFLT ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: CCDS52 VAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPYFLT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 DGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 DGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 IKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 IKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGC 310 320 330 340 350 360 370 380 390 pF1KB3 RILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE ::::::::::::::::::::::::::::::::::::: CCDS52 RILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE 370 380 390 >>CCDS8339.1 ACAT1 gene_id:38|Hs108|chr11 (427 aa) initn: 993 init1: 395 opt: 1030 Z-score: 1310.9 bits: 251.5 E(32554): 1.1e-66 Smith-Waterman score: 1030; 43.8% identity (74.4% similar) in 390 aa overlap (8-396:42-426) 10 20 30 pF1KB3 MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTV ::::::.:: :::: :.:. .:. ::: . CCDS83 ARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSIA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB3 IKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLK :. ....: . :.:.:. .:.:: .: :: :.::: .:::.: :.: . . .:.::.: CCDS83 IQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB3 AVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHN :. .: ::. : ....::::::.::..:.. : .. : . : : :. :::::.... CCDS83 AIMMASQSLMCGHQDVMVAGGMESMSNVPYVMN-RGSTPYGGVKLEDLIVKDGLTDVYNK 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB3 CHMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTR-RGLIEV ::: :::.::: ...:..:: :. : .:.. : .::.: .:..:: :... . . : CCDS83 IHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVV 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB3 KTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTP : :: .. .. . ::: : .. :::: :::: .::::::.::: . : . ..:: CCDS83 KEDEEYKR-VDFSKVPKLKTVFQKEN-GTVTAANASTLNDGAAALVLMTADAAKRLNVTP 260 270 280 290 300 280 290 300 310 320 330 pF1KB3 LARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELG :::::......::: . :.:. : .... .: . ::. ..:.::::. : : .: : CCDS83 LARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB3 LNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQR ..:.::::.:::..::::.: :: ::. : :.: ..:. :.:..: ::: . :: .:. CCDS83 IDPQKVNINGGAVSLGHPIGMSGARIVGHLTHAL-KQGE-YGLASICNGGGGASAMLIQK 370 380 390 400 410 420 pF1KB3 E CCDS83 L >>CCDS11939.1 ACAA2 gene_id:10449|Hs108|chr18 (397 aa) initn: 1023 init1: 534 opt: 1001 Z-score: 1274.5 bits: 244.7 E(32554): 1.1e-64 Smith-Waterman score: 1001; 42.7% identity (72.1% similar) in 391 aa overlap (8-395:7-394) 10 20 30 40 50 60 pF1KB3 MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHV : .:.: :: .:...: : . ::. . : .:. . :.:: :. ::.:.: CCDS11 MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNV 10 20 30 40 50 70 80 90 100 110 pF1KB3 LAAGCGQNPV-RQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGM : .. . :.... .::: .:: . . .::::.... . : : . .. .:. :: CCDS11 LQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 ENMSKAPHLAY-LRTGVKIG-EMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSRED :.::.::. . .: :.:.: .. : ::. . ::: . :..::::.: : ..:::. CCDS11 ESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVS-LTDQHVQLPMAMTAENLAVKHKISREE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 QDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTRRGLIEVKTDEFPRHGSNIEAMSKLKPY :: :. ::.: . :. ::.:. :..:. :.:..: ...:: : ...: ..:: : CCDS11 CDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 FLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGP : ::: :: .::::. :::.::.. ... . :...:::::::.. : .:::::::: CCDS11 FKKDGT--VTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 IPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGA .:::. :. ::: ::.:.:. :.::::: :. . : :. :.:..:::::::::::. CCDS11 VPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGG 300 310 320 330 340 350 360 370 380 390 pF1KB3 SGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE :: :: . :.: :.: : . .:.. :::::.:::. .: CCDS11 SGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA 360 370 380 390 >>CCDS2673.1 ACAA1 gene_id:30|Hs108|chr3 (424 aa) initn: 817 init1: 414 opt: 841 Z-score: 1070.3 bits: 207.0 E(32554): 2.7e-53 Smith-Waterman score: 841; 41.6% identity (66.4% similar) in 399 aa overlap (3-391:33-416) 10 20 30 pF1KB3 MNAGSDPVVIVSAARTIIGSFN-GALAAVPVQ :.. ::.: . :: : . :.. . . CCDS26 RLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB3 DLGSTVIKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMI .: :.:. ::: ... ::..... :.:: : : .: :. . :: .:: . . CCDS26 ELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQ 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB3 CGSGLKAVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGL :.:::.:: . .: :. .: .: :.:.:: : . :. : : . CCDS26 CSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADR----------GNPGNITSRLME-- 130 140 150 160 170 160 170 180 190 200 pF1KB3 TDAFHNC--HMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVS- . ..: ::::.::::... .::: :: :. ::... ::. : :. ::::: .. CCDS26 KEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTV 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB3 -----TRRGLIEVKTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVL :.:. : : :: : ....:...:::: : :: ..: .:.: ..:::::..: CCDS26 HDDKGTKRS-ITVTQDEGIRPSTTMEGLAKLKPAFKKDG--STTAGNSSQVSDGAAAILL 240 250 260 270 280 270 280 290 300 310 320 pF1KB3 MKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEA ..:.:.. :: :. . :.. ::: :.:::::: :: :. ::: .. :::::::::: CCDS26 ARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEA 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB3 FAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMG-RSRGVAAL ::. .: :..: : ::::: :::.::::::: .: : ..:::. :.: : :. ::... CCDS26 FASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSM 350 360 370 380 390 400 390 pF1KB3 CIGGGMGIAMCVQRE ::: ::: : CCDS26 CIGTGMGAAAVFEYPGN 410 420 >>CCDS46794.1 ACAA1 gene_id:30|Hs108|chr3 (331 aa) initn: 636 init1: 259 opt: 350 Z-score: 446.8 bits: 91.3 E(32554): 1.5e-18 Smith-Waterman score: 489; 33.5% identity (51.4% similar) in 397 aa overlap (3-391:33-323) 10 20 30 pF1KB3 MNAGSDPVVIVSAARTIIGSFN-GALAAVPVQ :.. ::.: . :: : . :.. . . CCDS46 RLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB3 DLGSTVIKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMI .: :.:. ::: ... ::..... :.:: : : .: :. . :: .:: . . CCDS46 ELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQ 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB3 CGSGLKAVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGL :.:::.:: .:: :::..: : CCDS46 CSSGLQAV-----------ASI--AGGIRN----------------------------GS 130 140 160 170 180 190 200 pF1KB3 TDAFHNCHMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVS--- : : :::.::::... .::: :: :. ::... ::. : :. ::::: .. CCDS46 YDIGMAC--GITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHD 150 160 170 180 190 210 220 230 240 250 260 pF1KB3 ---TRRGLIEVKTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVLMK :.:. : : :: : ....:...:::: : ::. CCDS46 DKGTKRS-ITVTQDEGIRPSTTMEGLAKLKPAFKKDGS---------------------- 200 210 220 230 270 280 290 300 310 320 pF1KB3 KSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEAFA : :: .. :::::::::::: CCDS46 ----------------------------------------TTAGLTVSDVDIFEINEAFA 240 250 330 340 350 360 370 380 pF1KB3 AVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMG-RSRGVAALCI . .: :..: : ::::: :::.::::::: .: : ..:::. :.: : :. ::...:: CCDS46 SQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCI 260 270 280 290 300 310 390 pF1KB3 GGGMGIAMCVQRE : ::: : CCDS46 GTGMGAAAVFEYPGN 320 330 397 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:25:01 2016 done: Thu Nov 3 13:25:02 2016 Total Scan time: 2.500 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]