Result of FASTA (omim) for
pF1KB3493
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3493, 630 aa
1>>>pF1KB3493 630 - 630 aa - 630 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1340+/-0.000399; mu= 8.5315+/- 0.025
mean_var=226.2065+/-47.007, 0's: 0 Z-trim(120.2): 236 B-trim: 1892 in 1/57
Lambda= 0.085275
statistics sampled from 34884 (35161) to 34884 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.412), width: 16
Scan time: 11.480
The best scores are: opt bits E(85289)
NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 4285 540.4 7.3e-153
NP_036233 (OMIM: 610658) tripartite motif-containi ( 588) 424 65.3 6.8e-10
XP_011541034 (OMIM: 610658) PREDICTED: tripartite ( 621) 424 65.4 7e-10
XP_011541031 (OMIM: 610658) PREDICTED: tripartite ( 622) 424 65.4 7e-10
NP_006461 (OMIM: 609505) tripartite motif-containi ( 564) 394 61.6 8.5e-09
XP_006717401 (OMIM: 606556) PREDICTED: tripartite ( 392) 321 52.5 3.3e-06
XP_011517546 (OMIM: 606556) PREDICTED: tripartite ( 285) 315 51.6 4.4e-06
XP_016870841 (OMIM: 606556) PREDICTED: tripartite ( 442) 317 52.1 5.1e-06
NP_150088 (OMIM: 606556) tripartite motif-containi ( 442) 317 52.1 5.1e-06
XP_016870842 (OMIM: 606556) PREDICTED: tripartite ( 442) 317 52.1 5.1e-06
NP_055603 (OMIM: 606556) tripartite motif-containi ( 442) 317 52.1 5.1e-06
XP_005252377 (OMIM: 606556) PREDICTED: tripartite ( 442) 317 52.1 5.1e-06
XP_005258100 (OMIM: 611358,614192) PREDICTED: E3 u ( 251) 305 50.3 9.6e-06
XP_016880712 (OMIM: 611358,614192) PREDICTED: E3 u ( 251) 305 50.3 9.6e-06
NP_001332879 (OMIM: 606125) probable E3 ubiquitin- ( 519) 309 51.1 1.1e-05
NP_258411 (OMIM: 611041) tripartite motif-containi ( 638) 309 51.2 1.3e-05
NP_115698 (OMIM: 611358,614192) E3 ubiquitin-prote ( 432) 305 50.6 1.4e-05
NP_112174 (OMIM: 606125) probable E3 ubiquitin-pro ( 551) 306 50.8 1.5e-05
XP_011517383 (OMIM: 609829) PREDICTED: FSD1-like p ( 311) 287 48.2 5.1e-05
XP_011517382 (OMIM: 609829) PREDICTED: FSD1-like p ( 322) 287 48.2 5.3e-05
XP_016870675 (OMIM: 609829) PREDICTED: FSD1-like p ( 322) 287 48.2 5.3e-05
NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497) 290 48.8 5.5e-05
XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529) 290 48.8 5.8e-05
XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542) 290 48.8 5.9e-05
XP_005252317 (OMIM: 609829) PREDICTED: FSD1-like p ( 384) 287 48.3 6e-05
XP_016870673 (OMIM: 609829) PREDICTED: FSD1-like p ( 384) 287 48.3 6e-05
XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498) 287 48.4 7.1e-05
NP_001274120 (OMIM: 609829) FSD1-like protein isof ( 508) 287 48.4 7.2e-05
NP_001317668 (OMIM: 609829) FSD1-like protein isof ( 509) 287 48.4 7.2e-05
NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530) 287 48.4 7.4e-05
XP_005252311 (OMIM: 609829) PREDICTED: FSD1-like p ( 541) 287 48.5 7.6e-05
XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543) 287 48.5 7.6e-05
XP_011517379 (OMIM: 609829) PREDICTED: FSD1-like p ( 547) 287 48.5 7.6e-05
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 285 48.2 8.3e-05
XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313) 278 47.1 0.00011
NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313) 278 47.1 0.00011
NP_976039 (OMIM: 609315) tripartite motif-containi ( 303) 276 46.8 0.00013
NP_976040 (OMIM: 609315) tripartite motif-containi ( 303) 276 46.8 0.00013
XP_016865392 (OMIM: 609315) PREDICTED: tripartite ( 303) 276 46.8 0.00013
NP_976041 (OMIM: 609315) tripartite motif-containi ( 303) 276 46.8 0.00013
XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407) 278 47.2 0.00013
XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407) 278 47.2 0.00013
NP_853509 (OMIM: 613591) butyrophilin subfamily 2 ( 407) 278 47.2 0.00013
NP_976042 (OMIM: 609315) tripartite motif-containi ( 329) 276 46.9 0.00014
XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461) 278 47.3 0.00015
XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461) 278 47.3 0.00015
XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 278 47.3 0.00016
XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 278 47.3 0.00016
NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 278 47.3 0.00016
XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 278 47.3 0.00016
>>NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase TRI (630 aa)
initn: 4285 init1: 4285 opt: 4285 Z-score: 2865.4 bits: 540.4 E(85289): 7.3e-153
Smith-Waterman score: 4285; 99.5% identity (99.7% similar) in 630 aa overlap (1-630:1-630)
10 20 30 40 50 60
pF1KB3 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PQLHKNTVLCNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCLKEAAVKTCL
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_005 PQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 VCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 VEHKACSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQ
::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 KRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_005 KRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 VAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 RLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLM
550 560 570 580 590 600
610 620 630
pF1KB3 YKFRVDFTEALYPAFWVFSAGATLSICSPK
::::::::::::::::::::::::::::::
NP_005 YKFRVDFTEALYPAFWVFSAGATLSICSPK
610 620 630
>>NP_036233 (OMIM: 610658) tripartite motif-containing p (588 aa)
initn: 296 init1: 296 opt: 424 Z-score: 298.7 bits: 65.3 E(85289): 6.8e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)
70 80 90 100 110 120
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
: . .: :: :. :. :::.::::.::::
NP_036 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
140 150 160 170 180 190
130 140 150 160 170 180
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
. ::.::... ::.:: : :.::. ::: :.. :.:: . :::..:. :::
NP_036 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
200 210 220 230 240 250
190 200 210 220 230 240
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
: ... .:.:. :. : ...: . .:. .. . ..: .. .:.:.:. :.:
NP_036 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
260 270 280 290 300 310
250 260 270 280 290 300
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
.. .. :. .. ....:. . .. .:.. : .. . .. :. :: . :
NP_036 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
320 330 340 350 360 370
310 320 330 340 350 360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
::.. . : . . : : . : :..: . :: ..:..: . :. .....
NP_036 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
380 390 400 410 420
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
NP_036 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
430 440 450 460 470 480
>>XP_011541034 (OMIM: 610658) PREDICTED: tripartite moti (621 aa)
initn: 296 init1: 296 opt: 424 Z-score: 298.4 bits: 65.4 E(85289): 7e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)
70 80 90 100 110 120
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
: . .: :: :. :. :::.::::.::::
XP_011 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
140 150 160 170 180 190
130 140 150 160 170 180
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
. ::.::... ::.:: : :.::. ::: :.. :.:: . :::..:. :::
XP_011 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
200 210 220 230 240 250
190 200 210 220 230 240
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
: ... .:.:. :. : ...: . .:. .. . ..: .. .:.:.:. :.:
XP_011 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
260 270 280 290 300 310
250 260 270 280 290 300
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
.. .. :. .. ....:. . .. .:.. : .. . .. :. :: . :
XP_011 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
320 330 340 350 360 370
310 320 330 340 350 360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
::.. . : . . : : . : :..: . :: ..:..: . :. .....
XP_011 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
380 390 400 410 420
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
XP_011 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
430 440 450 460 470 480
>>XP_011541031 (OMIM: 610658) PREDICTED: tripartite moti (622 aa)
initn: 296 init1: 296 opt: 424 Z-score: 298.4 bits: 65.4 E(85289): 7e-10
Smith-Waterman score: 424; 28.7% identity (62.7% similar) in 268 aa overlap (100-358:166-427)
70 80 90 100 110 120
pF1KB3 CNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHCL--KEAAVKTCLVCMASFC
: . .: :: :. :. :::.::::.::::
XP_011 RKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFC
140 150 160 170 180 190
130 140 150 160 170 180
pF1KB3 QEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICLV-EHKAC
. ::.::... ::.:: : :.::. ::: :.. :.:: . :::..:. :::
XP_011 ELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNH
200 210 220 230 240 250
190 200 210 220 230 240
pF1KB3 SPASLSQASADLEATL---RHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQ
: ... .:.:. :. : ...: . .:. .. . ..: .. .:.:.:. :.:
XP_011 STVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKS--FTTNEKA-ILEQ
260 270 280 290 300 310
250 260 270 280 290 300
pF1KB3 EYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRD
.. .. :. .. ....:. . .. .:.. : .. . .. :. :: . :
XP_011 NFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISD
320 330 340 350 360 370
310 320 330 340 350 360
pF1KB3 EFEFLEKASKLRGISTKPVYIPEVELNHKLIKG--IHQSTIDLKNELKQ-CIGRLQELTP
::.. . : . . : : . : :..: . :: ..:..: . :. .....
XP_011 SVLFLQEFGALMSNYSLP---PPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCK
380 390 400 410 420
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
XP_011 ADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSS
430 440 450 460 470 480
>>NP_006461 (OMIM: 609505) tripartite motif-containing p (564 aa)
initn: 558 init1: 326 opt: 394 Z-score: 278.9 bits: 61.6 E(85289): 8.5e-09
Smith-Waterman score: 559; 25.4% identity (54.9% similar) in 548 aa overlap (81-617:51-536)
60 70 80 90 100 110
pF1KB3 PQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADGWTPPARASAPSPNAQVACDHC
:.:: . ... . . .: :: :
NP_006 APLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFC
30 40 50 60 70 80
120 130 140 150 160
pF1KB3 LKEA----AVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKC-SQHNRLRE
: .. :::.::.::...:.:::::: . .:.: : ::.: : : ..:. :
NP_006 LDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSA
90 100 110 120 130 140
170 180 190 200 210 220
pF1KB3 FFCPEHSECICHICLVEHKACSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRN
: ::.. .:::. : ::.. . .::. : : :: :. . ... :.. ..
NP_006 FCCPDQ-QCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQA
150 160 170 180 190
230 240 250 260 270 280
pF1KB3 RQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKK
:..: ..... .... :. : . .... ..:.:. . :. . : : ..
NP_006 NQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRS
200 210 220 230 240 250
290 300 310 320 330 340
pF1KB3 SEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLK
.:.. :.:.:. . . .:::. :.. .:. . .: : . ::
NP_006 AEMEKSKQELERMAAISNTVQFLEEYCKFK--NTEDITFPSVY-------------VGLK
260 270 280 290 300
350 360 370 380 390 400
pF1KB3 NELKQCIGRLQELTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPT
..:. : . .: :. :. .. :. .:: :
NP_006 DKLS---GIRKVITEST-----------------VHLIQLLENYKKK----------LQE
310 320 330
410 420 430 440 450 460
pF1KB3 FGAPEQLVDLK-QAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYN
:. :. :.. :.. . : .:.:. .. : ..:.: . .: .
NP_006 FSKEEEY-DIRTQVSAVVQRKYWTSKPEPST-------------REQFLQYAYDITFDPD
340 350 360 370 380
470 480 490 500 510 520
pF1KB3 TAHNKVALSE-CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVEL-QKNN
:::. . :.: :.... . : :.:: . :::. . .:.:::. ..
NP_006 TAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGT
390 400 410 420 430 440
530 540 550 560 570 580
pF1KB3 FCGVGICYGSMNRQGPE--SRLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVL
. :. : : ..:.: : : .. :. :: ..: . ...::....: : . :.::
NP_006 YVGL-TCKG-IDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVY
450 460 470 480 490
590 600 610 620 630
pF1KB3 LNCDHGFVIFFAVA-DKVHLMYKFRVDFTEALYPAFWVFSAGATLSICSPK
.. :.. :..: : . :..:: :.: .: :::.
NP_006 IDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPS
500 510 520 530 540 550
NP_006 LVGTAP
560
>>XP_006717401 (OMIM: 606556) PREDICTED: tripartite moti (392 aa)
initn: 247 init1: 107 opt: 321 Z-score: 232.4 bits: 52.5 E(85289): 3.3e-06
Smith-Waterman score: 344; 26.1% identity (53.8% similar) in 398 aa overlap (236-616:16-382)
210 220 230 240 250 260
pF1KB3 LTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKE
.....:.:: .. :. .. . .:..
XP_006 MTLGKLPHLQMPPLEKNTRKLSQECLKQLAIKKQQHIDNITQIED
10 20 30 40
270 280 290 300 310 320
pF1KB3 EEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIP
...... .. : : .:.. : .: :..:.:. :..: ..: : ::
XP_006 ATEKLKANAESSKTWLKGKFTELRLLLDE-EEALAKK----FIDKNTQL----TLQVYRE
50 60 70 80 90
330 340 350 360 370 380
pF1KB3 EVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTPSSGDPGEHDPASTHKSTRPVKKVSK
... .. .:. :.:.. . ... : :: .. : : . ...:
XP_006 QADSCRE--------QLDIMNDLSNRVWSISQ-EP---DPVQRLQAYTATEQEMQQQMSL
100 110 120 130 140
390 400 410 420 430 440
pF1KB3 EEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATS----SHPNSTSLKAKVL
: .: :. : : : : . . :. :. : . : :.::. . .:
XP_006 GELC--HPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTK-PGTLL
150 160 170 180 190 200
450 460 470 480 490
pF1KB3 ETFLAKSRPELLEYYIKVILDYNTAHNKVALS------ECYTVASVAEMPQNYRPHPQRF
.: . : ::.: :: .: : .. :: .: ..:.. .: ::
XP_006 KTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPV------LRF
210 220 230 240 250
500 510 520 530 540 550
pF1KB3 TYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGSMNRQGPES--RLGRNSASWCV
:::. :. : :::::..:. . : :: :.:. :.: . ::: : :::.
XP_006 DALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYASLRRRGASAAARLGCNRQSWCL
260 270 280 290 300 310
560 570 580 590 600 610
pF1KB3 EWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEA
. .. . :.:.. .. : : :.::.:. . : . :. :. . .. ::. : :
XP_006 KRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEP
320 330 340 350 360 370
620 630
pF1KB3 LYPAF--WVFSAGATLSICSPK
::::. :
XP_006 LYPALRLWEGAISIPRLP
380 390
>>XP_011517546 (OMIM: 606556) PREDICTED: tripartite moti (285 aa)
initn: 247 init1: 107 opt: 315 Z-score: 230.1 bits: 51.6 E(85289): 4.4e-06
Smith-Waterman score: 315; 29.3% identity (54.4% similar) in 270 aa overlap (367-616:14-275)
340 350 360 370 380 390
pF1KB3 IHQSTIDLKNELKQCIGRLQELTPSSGDPGEHDPASTHKS-TRPVKKVSKEEKKSKKPPP
: ::.. .. : ...... . .. :
XP_011 MNDLSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHP
10 20 30 40
400 410 420 430 440
pF1KB3 VPALPSKLPTF--GAPEQLVDLKQAGLEAAAKATS----SHPNSTSLKAKVLETFLAKSR
:: . .: : : . . :. :. : . : :.::. . .:.: . :
XP_011 VPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTK-PGTLLKTSPSPER
50 60 70 80 90 100
450 460 470 480 490 500
pF1KB3 PELLEYYIKVILDYNTAHNKVALS------ECYTVASVAEMPQNYRPHPQRFTYCSQVLG
::.: :: .: : .. :: .: ..:.. .: :: :::.
XP_011 SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVP------VLRFDALWQVLA
110 120 130 140 150
510 520 530 540 550
pF1KB3 LHCYKKGIHYWEVELQKNNFCG--VGICYGSMNRQGPES--RLGRNSASWCVEWFNTKIS
:. : :::::..:. . : :: :.:. :.: . ::: : :::.. .. .
XP_011 RDCFATGRHYWEVDVQEAG-AGWWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYW
160 170 180 190 200 210
560 570 580 590 600 610
pF1KB3 AWHNNVEKTL-PSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAF--W
:.:.. .. : : :.::.:. . : . :. :. . .. ::. : : ::::. :
XP_011 AFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLW
220 230 240 250 260 270
620 630
pF1KB3 VFSAGATLSICSPK
XP_011 EGAISIPRLP
280
>>XP_016870841 (OMIM: 606556) PREDICTED: tripartite moti (442 aa)
initn: 275 init1: 107 opt: 317 Z-score: 229.1 bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)
130 140 150 160 170 180
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
.: .: .:. :.:: . .:.: .: :
XP_016 MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
10 20 30 40 50
190 200 210 220 230 240
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
:.. :..:. .:.. .. .. : . . . . .... . .. .:. . :
XP_016 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
60 70 80 90 100 110
250 260 270 280 290 300
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
. ..::.. ::: ::. . .:: . :.... ::. ::. .
XP_016 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
120 130 140 150
310 320 330 340 350 360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
:....... : .. .:: .: . .. :. ..:..: .. : ::
XP_016 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
160 170 180 190
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
: :. : .:::. : : :. : : : : .:.. :
XP_016 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
200 210 220 230
430 440 450 460 470
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
. . . : :.::. . .:.: . : ::.: :: .: : .. :: .
XP_016 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
240 250 260 270 280 290
480 490 500 510 520 530
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
: ..:.. .: :: :::. :. : :::::..:. . : :: :.:
XP_016 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
300 310 320 330 340
540 550 560 570 580
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
. :.: . ::: : :::.. .. . :.:.. .. : : :.::.:. . : .
XP_016 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
350 360 370 380 390 400
590 600 610 620 630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
:. :. . .. ::. : : ::::. :
XP_016 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP
410 420 430 440
>>NP_150088 (OMIM: 606556) tripartite motif-containing p (442 aa)
initn: 275 init1: 107 opt: 317 Z-score: 229.1 bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)
130 140 150 160 170 180
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
.: .: .:. :.:: . .:.: .: :
NP_150 MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
10 20 30 40 50
190 200 210 220 230 240
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
:.. :..:. .:.. .. .. : . . . . .... . .. .:. . :
NP_150 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
60 70 80 90 100 110
250 260 270 280 290 300
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
. ..::.. ::: ::. . .:: . :.... ::. ::. .
NP_150 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
120 130 140 150
310 320 330 340 350 360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
:....... : .. .:: .: . .. :. ..:..: .. : ::
NP_150 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
160 170 180 190
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
: :. : .:::. : : :. : : : : .:.. :
NP_150 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
200 210 220 230
430 440 450 460 470
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
. . . : :.::. . .:.: . : ::.: :: .: : .. :: .
NP_150 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
240 250 260 270 280 290
480 490 500 510 520 530
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
: ..:.. .: :: :::. :. : :::::..:. . : :: :.:
NP_150 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
300 310 320 330 340
540 550 560 570 580
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
. :.: . ::: : :::.. .. . :.:.. .. : : :.::.:. . : .
NP_150 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
350 360 370 380 390 400
590 600 610 620 630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
:. :. . .. ::. : : ::::. :
NP_150 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP
410 420 430 440
>>XP_016870842 (OMIM: 606556) PREDICTED: tripartite moti (442 aa)
initn: 275 init1: 107 opt: 317 Z-score: 229.1 bits: 52.1 E(85289): 5.1e-06
Smith-Waterman score: 377; 25.7% identity (52.8% similar) in 479 aa overlap (156-616:23-432)
130 140 150 160 170 180
pF1KB3 FCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH-NRLREFFCPEHSECICHICLV--E
.: .: .:. :.:: . .:.: .: :
XP_016 MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGA
10 20 30 40 50
190 200 210 220 230 240
pF1KB3 HKACSPASLS-QASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQL
:.. :..:. .:.. .. .. : . . . . .... . .. .:. . :
XP_016 HRG-HPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWL
60 70 80 90 100 110
250 260 270 280 290 300
pF1KB3 QQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTK
. ..::.. ::: ::. . .:: . :.... ::. ::. .
XP_016 KGKFTELRLLLD------------EEEALAKKF-------IDKNTQL-TLQVYREQADSC
120 130 140 150
310 320 330 340 350 360
pF1KB3 RDEFEFLEKAS-KLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQELTP
:....... : .. .:: .: . .. :. ..:..: .. : ::
XP_016 REQLDIMNDLSNRVWSISQEPDPVQRL-----------QAYTATEQEMQQQMS-LGELC-
160 170 180 190
370 380 390 400 410 420
pF1KB3 SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
: :. : .:::. : : :. : : : : .:.. :
XP_016 -------H-PVPL--SFEPVKSFFKGL--------VEAVESTLQT---P---LDIR---L
200 210 220 230
430 440 450 460 470
pF1KB3 EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALS------E
. . . : :.::. . .:.: . : ::.: :: .: : .. :: .
XP_016 KESINCQLSDPSSTK-PGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVR
240 250 260 270 280 290
480 490 500 510 520 530
pF1KB3 CYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCG--VGICYGS
: ..:.. .: :: :::. :. : :::::..:. . : :: :.:
XP_016 CGLLGSLGPVPV------LRFDALWQVLARDCFATGRHYWEVDVQEAG-AGWWVGAAYAS
300 310 320 330 340
540 550 560 570 580
pF1KB3 MNRQGPES--RLGRNSASWCVEWFNTKISAWHNNVEKTL-PSTKATRVGVLLNCDHGFVI
. :.: . ::: : :::.. .. . :.:.. .. : : :.::.:. . : .
XP_016 LRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLA
350 360 370 380 390 400
590 600 610 620 630
pF1KB3 FFAVADKVHLMYKFRVDFTEALYPAF--WVFSAGATLSICSPK
:. :. . .. ::. : : ::::. :
XP_016 FYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP
410 420 430 440
630 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:25:36 2016 done: Thu Nov 3 13:25:37 2016
Total Scan time: 11.480 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]