FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3502, 243 aa 1>>>pF1KB3502 243 - 243 aa - 243 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8839+/-0.000374; mu= 13.4005+/- 0.023 mean_var=99.0987+/-19.738, 0's: 0 Z-trim(114.8): 9 B-trim: 1261 in 1/50 Lambda= 0.128837 statistics sampled from 24883 (24889) to 24883 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.292), width: 16 Scan time: 5.900 The best scores are: opt bits E(85289) NP_004729 (OMIM: 182980,605704,608627) vesicle-ass ( 243) 1570 301.8 7.2e-82 NP_919415 (OMIM: 605703) vesicle-associated membra ( 249) 1014 198.4 9.4e-51 XP_016881568 (OMIM: 605703) PREDICTED: vesicle-ass ( 236) 934 183.6 2.7e-46 NP_003565 (OMIM: 605703) vesicle-associated membra ( 294) 761 151.5 1.5e-36 XP_011524071 (OMIM: 605703) PREDICTED: vesicle-ass ( 281) 681 136.6 4.4e-32 NP_001182606 (OMIM: 182980,605704,608627) vesicle- ( 99) 467 96.4 1.9e-20 >>NP_004729 (OMIM: 182980,605704,608627) vesicle-associa (243 aa) initn: 1570 init1: 1570 opt: 1570 Z-score: 1590.8 bits: 301.8 E(85289): 7.2e-82 Smith-Waterman score: 1570; 100.0% identity (100.0% similar) in 243 aa overlap (1-243:1-243) 10 20 30 40 50 60 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 QRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGK 190 200 210 220 230 240 pF1KB3 IAL ::: NP_004 IAL >>NP_919415 (OMIM: 605703) vesicle-associated membrane p (249 aa) initn: 990 init1: 800 opt: 1014 Z-score: 1032.1 bits: 198.4 E(85289): 9.4e-51 Smith-Waterman score: 1014; 62.9% identity (85.3% similar) in 245 aa overlap (1-243:8-249) 10 20 30 40 50 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYC ::: ::.: :.: .:::.::::::::::::: ::.::.:::::::::::::: NP_919 MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPED ::::::::: :....:::::::::::::::::::::::..::: .:::::::::::::.. NP_919 VRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 LMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEEC :::::::::::.: :::: .:.: .: . .::: . :. : : ::.:::..:.:::: NP_919 LMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPM-PKPHSVSLNDTETRKLMEEC 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 KRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLST--RLLALVVLF ::::::...: :::.....: :::.::...:..: :. . . ... : ::.... . NP_919 KRLQGEMMKLSEENRHLRDE-GLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAI 180 190 200 210 220 230 240 pF1KB3 FIVGVIIGKIAL :: : ..::. : NP_919 FI-GFFLGKFIL 240 >>XP_016881568 (OMIM: 605703) PREDICTED: vesicle-associa (236 aa) initn: 910 init1: 720 opt: 934 Z-score: 952.1 bits: 183.6 E(85289): 2.7e-46 Smith-Waterman score: 934; 63.1% identity (85.8% similar) in 225 aa overlap (21-243:15-236) 10 20 30 40 50 60 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI :::::::::::: ::.::.::::::::::::::::::::: XP_016 MLQSKYSKMFIVECPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGI 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 IDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLR :: :....:::::::::::::::::::::::..::: .:::::::::::::..::::::: XP_016 IDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 CVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEV ::::.: :::: .:.: .: . .::: . :. : : ::.:::..:.::::::::::. XP_016 CVFEMPNENDKLNDMEPSKAVPLNASKQDGPM-PKPHSVSLNDTETRKLMEECKRLQGEM 120 130 140 150 160 170 190 200 210 220 230 pF1KB3 QRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLST--RLLALVVLFFIVGVII ..: :::.....: :::.::...:..: :. . . ... : ::.... .:: : .. XP_016 MKLSEENRHLRDE-GLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFI-GFFL 180 190 200 210 220 230 240 pF1KB3 GKIAL ::. : XP_016 GKFIL >>NP_003565 (OMIM: 605703) vesicle-associated membrane p (294 aa) initn: 982 init1: 756 opt: 761 Z-score: 777.0 bits: 151.5 E(85289): 1.5e-36 Smith-Waterman score: 897; 54.2% identity (73.5% similar) in 275 aa overlap (1-230:8-279) 10 20 30 40 50 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYC ::: ::.: :.: .:::.::::::::::::: ::.::.:::::::::::::: NP_003 MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPED ::::::::: :....:::::::::::::::::::::::..::: .:::::::::::::.. NP_003 VRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDE 70 80 90 100 110 120 120 130 pF1KB3 LMDSKLRCVFELPAENDK----P------------------------------------- :::::::::::.: :::: : NP_003 LMDSKLRCVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQ 130 140 150 160 170 180 140 150 160 170 180 pF1KB3 ----HDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENK .:.: .: . .::: . :. : : ::.:::..:.::::::::::...: :::. NP_003 EKQKNDMEPSKAVPLNASKQDGPM-PKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENR 190 200 210 220 230 190 200 210 220 230 240 pF1KB3 QFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL ....: :::.::...:..: :. . . ... ... : .:.:. NP_003 HLRDE-GLRLRKVAHSDKPGSTSTASFRDN-VTSPLPSLLVVIAAIFIGFFLGKFIL 240 250 260 270 280 290 >>XP_011524071 (OMIM: 605703) PREDICTED: vesicle-associa (281 aa) initn: 902 init1: 676 opt: 681 Z-score: 696.9 bits: 136.6 E(85289): 4.4e-32 Smith-Waterman score: 817; 53.7% identity (72.9% similar) in 255 aa overlap (21-230:15-266) 10 20 30 40 50 60 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI :::::::::::: ::.::.::::::::::::::::::::: XP_011 MLQSKYSKMFIVECPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGI 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 IDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLR :: :....:::::::::::::::::::::::..::: .:::::::::::::..::::::: XP_011 IDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLR 60 70 80 90 100 110 130 pF1KB3 CVFELPAENDK----P-----------------------------------------HDV ::::.: :::: : .:. XP_011 CVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDM 120 130 140 150 160 170 140 150 160 170 180 190 pF1KB3 EINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDG : .: . .::: . :. : : ::.:::..:.::::::::::...: :::.....: : XP_011 EPSKAVPLNASKQDGPM-PKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDE-G 180 190 200 210 220 230 200 210 220 230 240 pF1KB3 LRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL ::.::...:..: :. . . ... ... : .:.:. XP_011 LRLRKVAHSDKPGSTSTASFRDN-VTSPLPSLLVVIAAIFIGFFLGKFIL 240 250 260 270 280 >>NP_001182606 (OMIM: 182980,605704,608627) vesicle-asso (99 aa) initn: 463 init1: 463 opt: 467 Z-score: 488.1 bits: 96.4 E(85289): 1.9e-20 Smith-Waterman score: 467; 80.0% identity (87.8% similar) in 90 aa overlap (1-90:1-90) 10 20 30 40 50 60 pF1KB3 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLR :::::::::: : . . ... .: . NP_001 IDAGASINVSGRRWTADEEDSAEQQPHFSISPNWEGRRP 70 80 90 243 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:11:58 2016 done: Sat Nov 5 05:11:59 2016 Total Scan time: 5.900 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]