FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3508, 328 aa 1>>>pF1KB3508 328 - 328 aa - 328 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4685+/-0.000443; mu= 14.7843+/- 0.028 mean_var=66.3142+/-13.209, 0's: 0 Z-trim(110.7): 73 B-trim: 111 in 1/49 Lambda= 0.157496 statistics sampled from 19046 (19120) to 19046 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.224), width: 16 Scan time: 6.370 The best scores are: opt bits E(85289) NP_064563 (OMIM: 604642) carbonic anhydrase-relate ( 328) 2216 512.7 4.3e-145 NP_001076003 (OMIM: 604642) carbonic anhydrase-rel ( 328) 2216 512.7 4.3e-145 NP_001076002 (OMIM: 604642) carbonic anhydrase-rel ( 328) 2216 512.7 4.3e-145 XP_016880367 (OMIM: 604642) PREDICTED: carbonic an ( 231) 1539 358.8 6.5e-99 NP_001208 (OMIM: 604644) carbonic anhydrase-relate ( 328) 1223 287.0 3.6e-77 NP_005173 (OMIM: 114770) carbonic anhydrase 7 isof ( 264) 523 127.9 2.3e-29 NP_000058 (OMIM: 259730,611492) carbonic anhydrase ( 260) 498 122.3 1.1e-27 NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Ho ( 262) 494 121.3 2.2e-27 XP_016884736 (OMIM: 300230) PREDICTED: carbonic an ( 278) 489 120.2 5e-27 NP_001730 (OMIM: 114761,615751) carbonic anhydrase ( 305) 484 119.1 1.2e-26 XP_005274499 (OMIM: 300230) PREDICTED: carbonic an ( 317) 484 119.1 1.2e-26 NP_009151 (OMIM: 300230) carbonic anhydrase 5B, mi ( 317) 484 119.1 1.2e-26 NP_005172 (OMIM: 114750) carbonic anhydrase 3 [Hom ( 260) 469 115.7 1.1e-25 NP_001308766 (OMIM: 114815,613227) carbonic anhydr ( 290) 468 115.5 1.4e-25 NP_004047 (OMIM: 114815,613227) carbonic anhydrase ( 290) 468 115.5 1.4e-25 NP_001122302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 464 114.5 2.4e-25 NP_001158302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 464 114.5 2.4e-25 NP_001122303 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 464 114.5 2.4e-25 NP_001729 (OMIM: 114800) carbonic anhydrase 1 isof ( 261) 464 114.5 2.4e-25 NP_001122301 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 464 114.5 2.4e-25 NP_001014435 (OMIM: 114770) carbonic anhydrase 7 i ( 208) 450 111.3 1.8e-24 XP_011521614 (OMIM: 114770) PREDICTED: carbonic an ( 208) 450 111.3 1.8e-24 XP_005256193 (OMIM: 114770) PREDICTED: carbonic an ( 208) 450 111.3 1.8e-24 XP_011521613 (OMIM: 114770) PREDICTED: carbonic an ( 242) 445 110.2 4.5e-24 NP_996808 (OMIM: 143860,603263) carbonic anhydrase ( 343) 437 108.5 2.2e-23 NP_001209 (OMIM: 143860,603263) carbonic anhydrase ( 354) 436 108.2 2.6e-23 XP_016879135 (OMIM: 114761,615751) PREDICTED: carb ( 314) 420 104.6 2.9e-22 XP_016884737 (OMIM: 300230) PREDICTED: carbonic an ( 248) 417 103.8 3.8e-22 NP_001308767 (OMIM: 114815,613227) carbonic anhydr ( 263) 411 102.5 1e-21 XP_006711322 (OMIM: 604832) PREDICTED: carbonic an ( 318) 411 102.5 1.2e-21 XP_016869307 (OMIM: 114815,613227) PREDICTED: carb ( 206) 407 101.5 1.6e-21 XP_005245117 (OMIM: 604832) PREDICTED: carbonic an ( 319) 409 102.1 1.7e-21 XP_005245116 (OMIM: 604832) PREDICTED: carbonic an ( 336) 409 102.1 1.7e-21 NP_036245 (OMIM: 604832) carbonic anhydrase 14 pre ( 337) 409 102.1 1.8e-21 NP_001278896 (OMIM: 114800) carbonic anhydrase 1 i ( 195) 402 100.4 3.3e-21 NP_001257429 (OMIM: 114780) carbonic anhydrase 6 i ( 313) 399 99.8 7.9e-21 XP_011540385 (OMIM: 114780) PREDICTED: carbonic an ( 294) 379 95.2 1.8e-19 NP_001206 (OMIM: 114780) carbonic anhydrase 6 isof ( 308) 379 95.3 1.8e-19 XP_011540386 (OMIM: 114780) PREDICTED: carbonic an ( 324) 379 95.3 1.9e-19 NP_001280571 (OMIM: 143860,603263) carbonic anhydr ( 283) 378 95.0 2e-19 NP_001207 (OMIM: 603179) carbonic anhydrase 9 prec ( 459) 372 93.7 7.8e-19 XP_016856382 (OMIM: 604832) PREDICTED: carbonic an ( 263) 361 91.1 2.7e-18 XP_006711324 (OMIM: 604832) PREDICTED: carbonic an ( 281) 361 91.1 2.9e-18 XP_011507681 (OMIM: 604832) PREDICTED: carbonic an ( 323) 360 90.9 3.8e-18 XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 355 90.1 3e-17 NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 355 90.1 3e-17 NP_000708 (OMIM: 114760,600852) carbonic anhydrase ( 312) 346 87.8 3.3e-17 XP_016862453 (OMIM: 176886) PREDICTED: receptor-ty (1329) 329 84.2 1.7e-15 XP_011521611 (OMIM: 114761,615751) PREDICTED: carb ( 376) 321 82.1 2e-15 XP_011521612 (OMIM: 114761,615751) PREDICTED: carb ( 222) 311 79.7 6.2e-15 >>NP_064563 (OMIM: 604642) carbonic anhydrase-related pr (328 aa) initn: 2216 init1: 2216 opt: 2216 Z-score: 2725.8 bits: 512.7 E(85289): 4.3e-145 Smith-Waterman score: 2216; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB3 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN 250 260 270 280 290 300 310 320 pF1KB3 INFSLQGKDCPNNRAQKLQYRVNEWLLK :::::::::::::::::::::::::::: NP_064 INFSLQGKDCPNNRAQKLQYRVNEWLLK 310 320 >>NP_001076003 (OMIM: 604642) carbonic anhydrase-related (328 aa) initn: 2216 init1: 2216 opt: 2216 Z-score: 2725.8 bits: 512.7 E(85289): 4.3e-145 Smith-Waterman score: 2216; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB3 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN 250 260 270 280 290 300 310 320 pF1KB3 INFSLQGKDCPNNRAQKLQYRVNEWLLK :::::::::::::::::::::::::::: NP_001 INFSLQGKDCPNNRAQKLQYRVNEWLLK 310 320 >>NP_001076002 (OMIM: 604642) carbonic anhydrase-related (328 aa) initn: 2216 init1: 2216 opt: 2216 Z-score: 2725.8 bits: 512.7 E(85289): 4.3e-145 Smith-Waterman score: 2216; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB3 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN 250 260 270 280 290 300 310 320 pF1KB3 INFSLQGKDCPNNRAQKLQYRVNEWLLK :::::::::::::::::::::::::::: NP_001 INFSLQGKDCPNNRAQKLQYRVNEWLLK 310 320 >>XP_016880367 (OMIM: 604642) PREDICTED: carbonic anhydr (231 aa) initn: 1539 init1: 1539 opt: 1539 Z-score: 1896.8 bits: 358.8 E(85289): 6.5e-99 Smith-Waterman score: 1539; 100.0% identity (100.0% similar) in 231 aa overlap (98-328:1-231) 70 80 90 100 110 120 pF1KB3 PVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGGPMTYSHR :::::::::::::::::::::::::::::: XP_016 MYNTGRHVSLRLDKEHLVNISGGPMTYSHR 10 20 30 130 140 150 160 170 180 pF1KB3 LEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIK 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB3 VSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYET 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB3 ASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQG 160 170 180 190 200 210 310 320 pF1KB3 KDCPNNRAQKLQYRVNEWLLK ::::::::::::::::::::: XP_016 KDCPNNRAQKLQYRVNEWLLK 220 230 >>NP_001208 (OMIM: 604644) carbonic anhydrase-related pr (328 aa) initn: 1210 init1: 1210 opt: 1223 Z-score: 1506.4 bits: 287.0 E(85289): 3.6e-77 Smith-Waterman score: 1223; 58.9% identity (84.0% similar) in 287 aa overlap (30-314:32-318) 10 20 30 40 50 pF1KB3 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNL : ::.::. .::.::: : ::::::.::.: NP_001 GAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 CSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISG :.::::::::..: .....:::: :::..:::.:. ::.::::::::. . .::.:: NP_001 CAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 GPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGL ::. ::::: :.:: ::..:. :::: .: :.::.::::::.:.::: : . :...:::: NP_001 GPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSM ...:.:..:...:::::.:.:::::::::.::::::.:: :..: :.::. .::::.::. NP_001 AILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 TIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRT . ::: ::..::.... . :: .::::::::::: ::::: :.: : ::.::: .: .: NP_001 STPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRG 250 260 270 280 290 300 300 310 320 pF1KB3 NINFSLQGKDC--PNNRAQKLQYRVNEWLLK : . . : :: : NP_001 NRDPRHPERRCRGPNYRLHVDGVPHGR 310 320 >>NP_005173 (OMIM: 114770) carbonic anhydrase 7 isoform (264 aa) initn: 470 init1: 284 opt: 523 Z-score: 648.3 bits: 127.9 E(85289): 2.3e-29 Smith-Waterman score: 526; 31.1% identity (68.9% similar) in 273 aa overlap (29-300:4-261) 10 20 30 40 50 60 pF1KB3 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLC :.:: .. .: :: : .. . . NP_005 MTGHHGWGYGQD--DG-----PSHW---HKLYPIA 10 20 70 80 90 100 110 pF1KB3 SVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRL-DKEHLVNISG . : ::::.:: .:. ...: : ::... . .: .. :.:. :.. . :.. . ..: NP_005 Q-GDRQSPINIISSQAVYSPSLQPLELSYEA-CMSLSITNNGHSVQVDFNDSDDRTVVTG 30 40 50 60 70 80 120 130 140 150 160 170 pF1KB3 GPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGL ::. .::.....:.:.. . :::: ..:..: .:..:.:.: . :.. :::..:.:: NP_005 GPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB3 VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSM .::..:....: .: .::. :.. . .:. .. .: . : : . . :: ::. NP_005 AVVGVFLETGDE-HPSMNRLT--DALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSL 150 160 170 180 190 200 240 250 260 270 280 290 pF1KB3 TIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRT : :: :...::.. .:. :.. :: ..: : .. .. . : .:::: :::..: ... NP_005 TTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKA 210 220 230 240 250 260 300 310 320 pF1KB3 NINFSLQGKDCPNNRAQKLQYRVNEWLLK . NP_005 SFRA >>NP_000058 (OMIM: 259730,611492) carbonic anhydrase 2 i (260 aa) initn: 423 init1: 204 opt: 498 Z-score: 617.7 bits: 122.3 E(85289): 1.1e-27 Smith-Waterman score: 498; 33.5% identity (71.5% similar) in 239 aa overlap (63-300:25-258) 40 50 60 70 80 90 pF1KB3 WAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGR :.:::::.:.: .:: : :: .. . NP_000 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYD-Q 10 20 30 40 50 100 110 120 130 140 150 pF1KB3 KVSGTMYNTGRHVSLRLD-KEHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQA .: . :.:. ....: .. . ..:::. ..:: ....:.:: :.::::: .. . NP_000 ATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKK 60 70 80 90 100 110 160 170 180 190 200 210 pF1KB3 FSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYK ...:..:.:.: . : . .:...:.::.:..::.::. :..: :.... :.. : : NP_000 YAAELHLVHWNTK-YGDFGKAVQQPDGLAVLGIFLKVG-SAKPGLQKVV--DVLDSIKTK 120 130 140 150 160 220 230 240 250 260 270 pF1KB3 NDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLS . . . ... . : ::. .. :: ::.: :: : ..::....:. .. :. ..: :. NP_000 GKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLN 170 180 190 200 210 220 280 290 300 310 320 pF1KB3 QNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK : .. : ::.::.:::.:: :... NP_000 FNGEGEPEELMVDNWRPAQPLKNRQIKASFK 230 240 250 260 >>NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Homo s (262 aa) initn: 450 init1: 290 opt: 494 Z-score: 612.7 bits: 121.3 E(85289): 2.2e-27 Smith-Waterman score: 494; 31.1% identity (70.5% similar) in 241 aa overlap (63-302:26-262) 40 50 60 70 80 90 pF1KB3 WAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGR : .:::..:.:... .: : :: :. NP_940 MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPS 10 20 30 40 50 100 110 120 130 140 150 pF1KB3 KVSGTMYNTGRHVSLRLDK-EHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQA ... . :.:. .. .: :. . :::.: :.::....::.:: :..::::...: . NP_940 SAK-IISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVS 60 70 80 90 100 110 160 170 180 190 200 210 pF1KB3 FSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYK ...:....:.: . : . .:::. :.::.:...:..... : :... ::. : : NP_940 YAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEP-NSQLQKIT--DTLDSIKEK 120 130 140 150 160 170 220 230 240 250 260 270 pF1KB3 NDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLS . . .... : : . .. :: ::.:.:: :...::....:. :. .:. ..: : NP_940 GKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLL 180 190 200 210 220 230 280 290 300 310 320 pF1KB3 QNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK . .. . .: :: :::..: .:.... NP_940 CTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 240 250 260 >>XP_016884736 (OMIM: 300230) PREDICTED: carbonic anhydr (278 aa) initn: 446 init1: 265 opt: 489 Z-score: 606.2 bits: 120.2 E(85289): 5e-27 Smith-Waterman score: 489; 31.8% identity (63.9% similar) in 277 aa overlap (40-311:4-271) 10 20 30 40 50 60 pF1KB3 LLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPV ::. : : .: :. : : ::::. XP_016 MLYQGQ-VGVHPLWESVD----LVPGGDRQSPI 10 20 70 80 90 100 110 120 pF1KB3 NIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRL-DKEHLVNISGGPMTYSHRL ::. ..:: : :: :. . ..:.: ... :. :.:::. ...:: XP_016 NIRWRDSVYDPGLKPLTISYDP-ATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRL 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB3 EEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKV .....:.:. :. :::: .... : .:..:.:.: . : .:: :::.:...:.:. XP_016 KQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKL 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB3 SDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETA . . . :.... ::. : .:. . ... :.: .. ::.::.: :: :.. XP_016 G-KHHKELQKLV--DTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB3 SWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNIN----FS .::: ..:: . . :....: : .. .. : :::::.::: :: .:... .. XP_016 TWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLN 210 220 230 240 250 260 310 320 pF1KB3 LQGKDCPNNRAQKLQYRVNEWLLK .:.: : XP_016 VQAKPKPATSQATP 270 >>NP_001730 (OMIM: 114761,615751) carbonic anhydrase 5A, (305 aa) initn: 440 init1: 268 opt: 484 Z-score: 599.4 bits: 119.1 E(85289): 1.2e-26 Smith-Waterman score: 484; 32.3% identity (66.5% similar) in 248 aa overlap (63-307:61-302) 40 50 60 70 80 90 pF1KB3 WAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGR : ::::.::. ..:: : :::.. NP_001 GRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVS---Y 40 50 60 70 80 100 110 120 130 140 pF1KB3 KVSGTMY--NTGRHVSLRLDKEHLVN-ISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNG .... .: ::: ....: .. :::::. .::.....:.:. . :::: ..: NP_001 EAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDG 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB3 QAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRIT .:. .:..:.:.: : : ::. . :::.:...:.:.. . . :.:.. : . .: NP_001 HAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLG-AHHQTLQRLV--DILPEIK 150 160 170 180 190 200 210 220 230 240 250 260 pF1KB3 YKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL .:. .. .. : : .. :: ::.: :: :...:::...:: .. :. ..: NP_001 HKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRT 210 220 230 240 250 260 270 280 290 300 310 320 pF1KB3 LSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK : . .. : .:.::.::: :: . .... . .: NP_001 LLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS 270 280 290 300 328 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:10:59 2016 done: Sat Nov 5 12:11:00 2016 Total Scan time: 6.370 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]