FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3552, 373 aa 1>>>pF1KB3552 373 - 373 aa - 373 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6680+/-0.000323; mu= -0.1712+/- 0.020 mean_var=262.7583+/-55.130, 0's: 0 Z-trim(125.3): 17 B-trim: 2771 in 2/57 Lambda= 0.079122 statistics sampled from 48587 (48604) to 48587 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.841), E-opt: 0.2 (0.57), width: 16 Scan time: 10.520 The best scores are: opt bits E(85289) NP_003466 (OMIM: 143023) ras association domain-co ( 373) 2513 299.1 1.1e-80 XP_016873850 (OMIM: 143023) PREDICTED: ras associa ( 373) 2513 299.1 1.1e-80 XP_016873849 (OMIM: 143023) PREDICTED: ras associa ( 421) 2513 299.1 1.2e-80 XP_006718401 (OMIM: 143023) PREDICTED: ras associa ( 374) 2319 276.9 5.2e-74 XP_005253207 (OMIM: 143023) PREDICTED: ras associa ( 374) 2319 276.9 5.2e-74 XP_011518691 (OMIM: 143023) PREDICTED: ras associa ( 374) 2319 276.9 5.2e-74 XP_016873851 (OMIM: 143023) PREDICTED: ras associa ( 320) 2121 254.3 2.9e-67 NP_001137466 (OMIM: 143023) ras association domain ( 320) 2121 254.3 2.9e-67 XP_005253206 (OMIM: 143023) PREDICTED: ras associa ( 368) 2121 254.3 3.2e-67 NP_001137465 (OMIM: 143023) ras association domain ( 337) 2114 253.5 5.3e-67 NP_009142 (OMIM: 608231) ras association domain-co ( 392) 483 67.4 6.6e-11 NP_001158218 (OMIM: 608231) ras association domain ( 419) 483 67.4 6.9e-11 XP_016874235 (OMIM: 608231) PREDICTED: ras associa ( 419) 483 67.4 6.9e-11 NP_001158219 (OMIM: 608231) ras association domain ( 419) 483 67.4 6.9e-11 NP_001158220 (OMIM: 608231) ras association domain ( 419) 483 67.4 6.9e-11 XP_006719091 (OMIM: 608231) PREDICTED: ras associa ( 419) 483 67.4 6.9e-11 XP_006719090 (OMIM: 608231) PREDICTED: ras associa ( 419) 483 67.4 6.9e-11 >>NP_003466 (OMIM: 143023) ras association domain-contai (373 aa) initn: 2513 init1: 2513 opt: 2513 Z-score: 1569.5 bits: 299.1 E(85289): 1.1e-80 Smith-Waterman score: 2513; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA 310 320 330 340 350 360 370 pF1KB3 PEWCPLAAQPQAL ::::::::::::: NP_003 PEWCPLAAQPQAL 370 >>XP_016873850 (OMIM: 143023) PREDICTED: ras association (373 aa) initn: 2513 init1: 2513 opt: 2513 Z-score: 1569.5 bits: 299.1 E(85289): 1.1e-80 Smith-Waterman score: 2513; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA 310 320 330 340 350 360 370 pF1KB3 PEWCPLAAQPQAL ::::::::::::: XP_016 PEWCPLAAQPQAL 370 >>XP_016873849 (OMIM: 143023) PREDICTED: ras association (421 aa) initn: 2513 init1: 2513 opt: 2513 Z-score: 1568.7 bits: 299.1 E(85289): 1.2e-80 Smith-Waterman score: 2513; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:49-421) 10 20 30 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTC :::::::::::::::::::::::::::::: XP_016 LRRAPPPSPGLVTLRPRDPCASRLLQLRTGMLLGLAAMELKVWVDGIQRVVCGVSEQTTC 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB3 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPS 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB3 LAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPG 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB3 CCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB3 DAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB3 RALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLG 320 330 340 350 360 370 340 350 360 370 pF1KB3 APSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL ::::::::::::::::::::::::::::::::::::::::::: XP_016 APSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL 380 390 400 410 420 >>XP_006718401 (OMIM: 143023) PREDICTED: ras association (374 aa) initn: 2312 init1: 2312 opt: 2319 Z-score: 1449.8 bits: 276.9 E(85289): 5.2e-74 Smith-Waterman score: 2327; 94.7% identity (95.2% similar) in 374 aa overlap (1-365:1-374) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRG-----GPHDAELLEV ::::::::::::::::::::::::::::::::::::::::::::: : : : XP_006 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGYVCAPPPPGAPGPPV 310 320 330 340 350 360 360 370 pF1KB3 AAAPA----PEWCPLAAQPQAL ::: . :.: : XP_006 AAATSACVLPQWPP 370 >>XP_005253207 (OMIM: 143023) PREDICTED: ras association (374 aa) initn: 2312 init1: 2312 opt: 2319 Z-score: 1449.8 bits: 276.9 E(85289): 5.2e-74 Smith-Waterman score: 2327; 94.7% identity (95.2% similar) in 374 aa overlap (1-365:1-374) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRG-----GPHDAELLEV ::::::::::::::::::::::::::::::::::::::::::::: : : : XP_005 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGYVCAPPPPGAPGPPV 310 320 330 340 350 360 360 370 pF1KB3 AAAPA----PEWCPLAAQPQAL ::: . :.: : XP_005 AAATSACVLPQWPP 370 >>XP_011518691 (OMIM: 143023) PREDICTED: ras association (374 aa) initn: 2312 init1: 2312 opt: 2319 Z-score: 1449.8 bits: 276.9 E(85289): 5.2e-74 Smith-Waterman score: 2327; 94.7% identity (95.2% similar) in 374 aa overlap (1-365:1-374) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRG-----GPHDAELLEV ::::::::::::::::::::::::::::::::::::::::::::: : : : XP_011 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGYVCAPPPPGAPGPPV 310 320 330 340 350 360 360 370 pF1KB3 AAAPA----PEWCPLAAQPQAL ::: . :.: : XP_011 AAATSACVLPQWPP 370 >>XP_016873851 (OMIM: 143023) PREDICTED: ras association (320 aa) initn: 2197 init1: 2121 opt: 2121 Z-score: 1328.6 bits: 254.3 E(85289): 2.9e-67 Smith-Waterman score: 2121; 99.7% identity (99.7% similar) in 319 aa overlap (1-319:1-319) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA ::::::::::::::::: : XP_016 AALPPPPRPDRGPPGTQWPP 310 320 >>NP_001137466 (OMIM: 143023) ras association domain-con (320 aa) initn: 2197 init1: 2121 opt: 2121 Z-score: 1328.6 bits: 254.3 E(85289): 2.9e-67 Smith-Waterman score: 2121; 99.7% identity (99.7% similar) in 319 aa overlap (1-319:1-319) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA ::::::::::::::::: : NP_001 AALPPPPRPDRGPPGTQWPP 310 320 >>XP_005253206 (OMIM: 143023) PREDICTED: ras association (368 aa) initn: 2197 init1: 2121 opt: 2121 Z-score: 1327.7 bits: 254.3 E(85289): 3.2e-67 Smith-Waterman score: 2121; 99.7% identity (99.7% similar) in 319 aa overlap (1-319:49-367) 10 20 30 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTC :::::::::::::::::::::::::::::: XP_005 LRRAPPPSPGLVTLRPRDPCASRLLQLRTGMLLGLAAMELKVWVDGIQRVVCGVSEQTTC 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB3 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPS 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB3 LAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPG 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB3 CCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB3 DAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB3 RALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLG ::::::::::::::::::::::::::::::::::::::::::::::: : XP_005 RALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQWPP 320 330 340 350 360 340 350 360 370 pF1KB3 APSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL >>NP_001137465 (OMIM: 143023) ras association domain-con (337 aa) initn: 2114 init1: 2114 opt: 2114 Z-score: 1323.9 bits: 253.5 E(85289): 5.3e-67 Smith-Waterman score: 2114; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317) 10 20 30 40 50 60 pF1KB3 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPA ::::::::::::::::: NP_001 AALPPPPRPDRGPPGTQVGVVLGGGWEVRTWPSPTPS 310 320 330 373 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:35:49 2016 done: Fri Nov 4 02:35:51 2016 Total Scan time: 10.520 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]