FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3557, 300 aa 1>>>pF1KB3557 300 - 300 aa - 300 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2441+/-0.000414; mu= 15.9473+/- 0.026 mean_var=63.6800+/-12.731, 0's: 0 Z-trim(111.1): 26 B-trim: 35 in 1/51 Lambda= 0.160721 statistics sampled from 19608 (19626) to 19608 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.23), width: 16 Scan time: 7.040 The best scores are: opt bits E(85289) NP_001032354 (OMIM: 606982) geranylgeranyl pyropho ( 300) 1976 467.0 2.1e-131 XP_011517739 (OMIM: 607429,614651) PREDICTED: deca ( 292) 174 49.1 1.2e-05 XP_016871500 (OMIM: 607429,614651) PREDICTED: deca ( 308) 174 49.1 1.3e-05 NP_055132 (OMIM: 607429,614651) decaprenyl-diphosp ( 415) 174 49.2 1.6e-05 NP_001308908 (OMIM: 607429,614651) decaprenyl-diph ( 245) 163 46.5 6.2e-05 >>NP_001032354 (OMIM: 606982) geranylgeranyl pyrophospha (300 aa) initn: 1976 init1: 1976 opt: 1976 Z-score: 2480.2 bits: 467.0 E(85289): 2.1e-131 Smith-Waterman score: 1976; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300) 10 20 30 40 50 60 pF1KB3 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 250 260 270 280 290 300 >>XP_011517739 (OMIM: 607429,614651) PREDICTED: decapren (292 aa) initn: 141 init1: 88 opt: 174 Z-score: 222.2 bits: 49.1 E(85289): 1.2e-05 Smith-Waterman score: 174; 21.6% identity (57.6% similar) in 250 aa overlap (49-294:42-286) 20 30 40 50 60 70 pF1KB3 LLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPV : ..::.:.:::. ::. :... ::: . XP_011 AFRPIIVALMARACNIHHNNSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHT 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB3 AHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTC ...:.: ... ... . . . . . .....:. . .: .:. :.. ..: . XP_011 VNKIWGEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENEN- 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB3 PTEEEYKAMVLQKTGGLFG---LAVGLMQLFSDYKEDLKPLLN-TLGLFFQIRDDYANLH .: ...::..:.. ::... . ... . ..:. ::. :: .. XP_011 ERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFT 140 150 160 170 180 190 200 210 220 230 240 250 pF1KB3 SKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDV : . .: :: : . :.. : . :: . . :.:. . :. . . :.. XP_011 SCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAM--IMRRFSLPGDVDRARQYVLQSD 200 210 220 230 240 260 270 280 290 300 pF1KB3 GSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE : . : .. .: ..:. .:: ::.. ::.. XP_011 G-VQQTTYLAQQYCHEAIREISKLRPSPERDALIQ-LSEIVLTRDK 250 260 270 280 290 >>XP_016871500 (OMIM: 607429,614651) PREDICTED: decapren (308 aa) initn: 141 init1: 88 opt: 174 Z-score: 221.9 bits: 49.1 E(85289): 1.3e-05 Smith-Waterman score: 174; 21.6% identity (57.6% similar) in 250 aa overlap (49-294:58-302) 20 30 40 50 60 70 pF1KB3 LLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPV : ..::.:.:::. ::. :... ::: . XP_016 AFRPIIVALMARACNIHHNNSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHT 30 40 50 60 70 80 80 90 100 110 120 130 pF1KB3 AHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTC ...:.: ... ... . . . . . .....:. . .: .:. :.. ..: . XP_016 VNKIWGEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENEN- 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB3 PTEEEYKAMVLQKTGGLFG---LAVGLMQLFSDYKEDLKPLLN-TLGLFFQIRDDYANLH .: ...::..:.. ::... . ... . ..:. ::. :: .. XP_016 ERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFT 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB3 SKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDV : . .: :: : . :.. : . :: . . :.:. . :. . . :.. XP_016 SCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAM--IMRRFSLPGDVDRARQYVLQSD 210 220 230 240 250 260 260 270 280 290 300 pF1KB3 GSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE : . : .. .: ..:. .:: ::.. ::.. XP_016 G-VQQTTYLAQQYCHEAIREISKLRPSPERDALIQ-LSEIVLTRDK 270 280 290 300 >>NP_055132 (OMIM: 607429,614651) decaprenyl-diphosphate (415 aa) initn: 141 init1: 88 opt: 174 Z-score: 219.9 bits: 49.2 E(85289): 1.6e-05 Smith-Waterman score: 174; 21.6% identity (57.6% similar) in 250 aa overlap (49-294:165-409) 20 30 40 50 60 70 pF1KB3 LLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPV : ..::.:.:::. ::. :... ::: . NP_055 AFRPIIVALMARACNIHHNNSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHT 140 150 160 170 180 190 80 90 100 110 120 130 pF1KB3 AHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTC ...:.: ... ... . . . . . .....:. . .: .:. :.. ..: . NP_055 VNKIWGEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENEN- 200 210 220 230 240 250 140 150 160 170 180 190 pF1KB3 PTEEEYKAMVLQKTGGLFG---LAVGLMQLFSDYKEDLKPLLN-TLGLFFQIRDDYANLH .: ...::..:.. ::... . ... . ..:. ::. :: .. NP_055 ERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFT 260 270 280 290 300 310 200 210 220 230 240 250 pF1KB3 SKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDV : . .: :: : . :.. : . :: . . :.:. . :. . . :.. NP_055 SCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAM--IMRRFSLPGDVDRARQYVLQSD 320 330 340 350 360 370 260 270 280 290 300 pF1KB3 GSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE : . : .. .: ..:. .:: ::.. ::.. NP_055 G-VQQTTYLAQQYCHEAIREISKLRPSPERDALIQ-LSEIVLTRDK 380 390 400 410 >>NP_001308908 (OMIM: 607429,614651) decaprenyl-diphosph (245 aa) initn: 130 init1: 77 opt: 163 Z-score: 209.6 bits: 46.5 E(85289): 6.2e-05 Smith-Waterman score: 163; 21.3% identity (57.4% similar) in 244 aa overlap (55-294:1-239) 30 40 50 60 70 80 pF1KB3 KQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYG :.:.:::. ::. :... ::: ....:.: NP_001 MIHTASLVHDDVIDDASSRRGKHTVNKIWG 10 20 30 90 100 110 120 130 140 pF1KB3 IPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEY ... ... . . . . . .....:. . .: .:. :.. ..: . .: NP_001 EKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENEN-ERFAHY 40 50 60 70 80 150 160 170 180 190 200 pF1KB3 KAMVLQKTGGLFG---LAVGLMQLFSDYKEDLKPLLN-TLGLFFQIRDDYANLHSKEYSE ...::..:.. ::... . ... . ..:. ::. :: .. : . NP_001 LEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQM 90 100 110 120 130 140 210 220 230 240 250 260 pF1KB3 NKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYT .: :: : . :.. : . :: . . :.:. . :. . . :.. : . : NP_001 GKPTSADLKLGLATGPVLFACQQFPEMNAM--IMRRFSLPGDVDRARQYVLQSDG-VQQT 150 160 170 180 190 200 270 280 290 300 pF1KB3 RNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE .. .: ..:. .:: ::.. ::.. NP_001 TYLAQQYCHEAIREISKLRPSPERDALIQ-LSEIVLTRDK 210 220 230 240 300 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:12:33 2016 done: Sat Nov 5 05:12:34 2016 Total Scan time: 7.040 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]