Result of FASTA (omim) for
pF1KB3574
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3574, 432 aa
1>>>pF1KB3574 432 - 432 aa - 432 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5793+/-0.00047; mu= 15.3702+/- 0.029
mean_var=64.4673+/-13.031, 0's: 0 Z-trim(107.8): 60 B-trim: 104 in 1/52
Lambda= 0.159737
statistics sampled from 15758 (15818) to 15758 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.185), width: 16
Scan time: 8.600
The best scores are: opt bits E(85289)
NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 2801 654.9 1.1e-187
NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 2149 504.6 1.5e-142
NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 955 229.5 1.2e-59
NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 843 203.7 7.5e-52
NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 840 203.0 1.1e-51
NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 830 200.7 5.9e-51
NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 830 200.7 6e-51
XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 826 199.8 1.1e-50
NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 792 191.9 2.5e-48
NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 782 189.7 1.8e-47
NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 775 188.0 3.7e-47
XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 771 187.1 7.6e-47
XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 771 187.1 7.9e-47
NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 750 182.3 2.1e-45
NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 744 180.9 5.6e-45
XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 743 180.7 7.3e-45
XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 740 180.0 1.1e-44
XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 738 179.5 1.5e-44
XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 738 179.5 1.5e-44
NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 737 179.3 1.8e-44
XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 733 178.3 3.1e-44
XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 732 178.1 3.8e-44
NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 710 173.1 1.7e-42
XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 710 173.1 1.8e-42
XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 710 173.1 1.8e-42
NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 710 173.1 1.8e-42
NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 710 173.1 1.9e-42
XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 710 173.1 1.9e-42
NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 710 173.1 1.9e-42
XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 708 172.6 2.1e-42
XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 672 164.3 4.6e-40
XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 671 164.1 7.6e-40
XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 668 163.4 1.1e-39
XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 668 163.4 1.2e-39
XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 665 162.7 1.7e-39
XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 665 162.7 1.8e-39
XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 643 157.6 5.2e-38
XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 643 157.6 5.2e-38
XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 639 156.6 8.2e-38
XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 627 153.9 6.1e-37
XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 600 147.7 4.9e-35
XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 586 144.4 3.6e-34
NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 546 135.3 3.1e-31
NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 541 134.0 3.9e-31
XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 538 133.4 1.1e-30
NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 530 131.6 3.9e-30
XP_016882069 (OMIM: 231670,608801) PREDICTED: glut ( 442) 530 131.6 4e-30
XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 530 131.6 4e-30
XP_011526202 (OMIM: 231670,608801) PREDICTED: glut ( 443) 530 131.6 4e-30
XP_016877647 (OMIM: 243500,607036) PREDICTED: isov ( 308) 458 114.9 2.9e-25
>>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa)
initn: 2801 init1: 2801 opt: 2801 Z-score: 3490.4 bits: 654.9 E(85289): 1.1e-187
Smith-Waterman score: 2801; 100.0% identity (100.0% similar) in 432 aa overlap (1-432:1-432)
10 20 30 40 50 60
pF1KB3 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 TPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 MLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 KPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQ
370 380 390 400 410 420
430
pF1KB3 LNTIAKHIDAEY
::::::::::::
NP_001 LNTIAKHIDAEY
430
>>NP_001317103 (OMIM: 600301,610006) short/branched chai (330 aa)
initn: 2149 init1: 2149 opt: 2149 Z-score: 2680.2 bits: 504.6 E(85289): 1.5e-142
Smith-Waterman score: 2149; 100.0% identity (100.0% similar) in 330 aa overlap (103-432:1-330)
80 90 100 110 120 130
pF1KB3 QEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVD
::::::::::::::::::::::::::::::
NP_001 MGIEVDPEYGGTGASFLSTVLVIEELAKVD
10 20 30
140 150 160 170 180 190
pF1KB3 ASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRA
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB3 DKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENK
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB3 LGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYT
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB3 IPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKY
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB3 YASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
280 290 300 310 320 330
>>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa)
initn: 886 init1: 764 opt: 955 Z-score: 1191.6 bits: 229.5 E(85289): 1.2e-59
Smith-Waterman score: 955; 41.1% identity (72.0% similar) in 375 aa overlap (59-432:36-410)
30 40 50 60 70 80
pF1KB3 PPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSK
. ..:. .. . ::.... :... .:..
NP_000 LARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHL
10 20 30 40 50 60
90 100 110 120 130 140
pF1KB3 MEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINT
. . .. . ::....: : ::.: ..:. ....::... ::..:. ..:.:
NP_000 FPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLG
70 80 90 100 110 120
150 160 170 180 190 200
pF1KB3 LIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMW
: : :..::: ... .:. .:.: : ::: : :::. : .: : ::: .::::.: :
NP_000 PILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAW
130 140 150 160 170 180
210 220 230 240 250 260
pF1KB3 ISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFEN
:..: .:. .:.:..: .. :::..::: :::: .:: :.:::.:.::: : ::.
NP_000 ITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFED
190 200 210 220 230 240
270 280 290 300 310 320
pF1KB3 VKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLF
..:. .:::. : :.: :. .:. ::::::.: ::.:: .: .. : ..:. :: :
NP_000 CRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLT
250 260 270 280 290 300
330 340 350 360 370 380
pF1KB3 DFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIE
.: .: ..: .: ::.:::::. :: : . :::::::.::: ::: : . . :.
NP_000 KLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQ
310 320 330 340 350 360
390 400 410 420 430
pF1KB3 WMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
.::.::. ..:.:...:::.: ::::.:.:: .:: :. :
NP_000 ILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
370 380 390 400 410
>>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa)
initn: 789 init1: 453 opt: 843 Z-score: 1051.8 bits: 203.7 E(85289): 7.5e-52
Smith-Waterman score: 843; 33.7% identity (70.8% similar) in 418 aa overlap (23-432:15-425)
10 20 30 40 50
pF1KB3 MEGLAVRLLRGSRLLRRNFLTCLSSWKI-PPHVSKSSQ-SEALLNITNNGIHFAPLQTFT
..::.. :: .. :: ...:: . . .. ..
NP_002 MAEMATATRLLGWRVASWRLRPPLAGFVSQRAHSLLPVDDA------INGLS
10 20 30 40
60 70 80 90 100 110
pF1KB3 DEEMMIKSSVKKFAQEQIAPLVSTMDENSKME--KSVIQGLFQQGLMGIEVDPEYGGTGA
.:. ...... :: ::..:: .. .:...... . . : . :..:: . .:::.:
NP_002 EEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB3 SFLSTVLVIEELAKVDASVAV-FCEIQNTLINTLIRKHGTEEQKATYLPQLTT-EKVGSF
..: :::.::.......:.. . .: :: :.: .:.: :: :::.: . : .:..
NP_002 GYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVR-NGNEAQKEKYLPKLISGEYIGAL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB3 CLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVD--PTIGYKGI
.:: .:::: ..: .:.:.:..:.:::.:.::... : ...:.:..: . . .::
NP_002 AMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGI
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB3 TSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNE
:.:.:.. ::. .: .:::.:.:.:: : ::. :.: :::::. ..: ...:.
NP_002 TAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB3 GRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYN
:. .:. ::: :. .:.::::.. : ::... :: .: ..: . :.: : : .::
NP_002 ERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYN
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB3 AARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTI
.:. . :. :. . . :..: : :.. :. .:: :: .:.:. ...::::. :
NP_002 VAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEI
350 360 370 380 390 400
420 430
pF1KB3 YEGASNIQLNTIAKHIDAEY
:.:... .:.. ..:..
NP_002 GAGTSEVRRLVIGRAFNADFH
410 420
>>NP_001272971 (OMIM: 201450,607008) medium-chain specif (385 aa)
initn: 789 init1: 488 opt: 840 Z-score: 1048.8 bits: 203.0 E(85289): 1.1e-51
Smith-Waterman score: 840; 37.5% identity (70.6% similar) in 381 aa overlap (54-429:2-381)
30 40 50 60 70 80
pF1KB3 SSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTM
:: ::... ......:::.:.: :... .
NP_001 MLQEFTEQQKEFQATARKFAREEIIPVAAEY
10 20 30
90 100 110 120 130 140
pF1KB3 DENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQN
:..... .:. .. :::. .. . :: : . ... :. :::: ..: . : :
NP_001 DKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIE-GN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB3 TLINTLIRKHGTEEQKATYLPQLTTEKVG-SFCLSEAGAGSDSFALKTRADKEGDYYVLN
.: . : :...:: :: ..: : . ..:..: ::::: ..::.:.:.:: :..:
NP_001 SLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIIN
100 110 120 130 140 150
210 220 230 240 250
pF1KB3 GSKMWISSAEHAGLFLVMANVDP---TIGYKGITSFLVDRDTPGLHIGKPENKLGLRASS
:.::::... .:. ....: :: . . :..:.:.:. ::::..::. : ..: : :.
NP_001 GQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSD
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 TCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKER
: ..::.::::. :.: : :.: :.:.... : .:: .:::: .: . : ::
NP_001 TRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALER
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 IQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAG
::: : . :... ..:..: ..: ::. :: ...:. ::.:: .:..::.
NP_001 KTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIAN
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 QTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAK-HIDAEY
: .. .. .:: :.. .::::: .::::: ::::.:.:: .:. :::
NP_001 QLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
340 350 360 370 380
>>NP_000007 (OMIM: 201450,607008) medium-chain specific (421 aa)
initn: 778 init1: 488 opt: 830 Z-score: 1035.7 bits: 200.7 E(85289): 5.9e-51
Smith-Waterman score: 830; 36.2% identity (68.2% similar) in 409 aa overlap (26-429:20-417)
10 20 30 40 50 60
pF1KB3 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE
:. :.. . : : : :. : ::..
NP_000 MAAGFGRCCRVLRSISRFHWR-SQHTKANRQREPGL-----GFSFE----FTEQ
10 20 30 40
70 80 90 100 110 120
pF1KB3 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS
. ......:::.:.: :... .:..... .:. .. :::. .. . :: : . ..
NP_000 QKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFD
50 60 70 80 90 100
130 140 150 160 170
pF1KB3 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVG-SFCLSEA
. :. :::: ..: . : :.: . : :...:: :: ..: : . ..:..:
NP_000 ACLISEELAYGCTGVQTAIE-GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB3 GAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDP---TIGYKGITSFL
::::: ..::.:.:.:: :..::.::::... .:. ....: :: . . :..:.:.
NP_000 GAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFI
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB3 VDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIG
:. ::::..::. : ..: : :.: ..::.::::. :.: : :.: :.:.... :
NP_000 VEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB3 IAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARL
.:: .:::: .: . : :: ::: : . :... ..:..: ..: ::. ::
NP_000 VAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB3 LEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGA
...:. ::.:: .:..::.: .. .. .:: :.. .::::: .::::: ::::.
NP_000 VDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGT
350 360 370 380 390 400
420 430
pF1KB3 SNIQLNTIAK-HIDAEY
:.:: .:. :::
NP_000 SQIQRLIVAREHIDKYKN
410 420
>>NP_001120800 (OMIM: 201450,607008) medium-chain specif (425 aa)
initn: 778 init1: 488 opt: 830 Z-score: 1035.7 bits: 200.7 E(85289): 6e-51
Smith-Waterman score: 830; 36.2% identity (68.2% similar) in 409 aa overlap (26-429:24-421)
10 20 30 40 50 60
pF1KB3 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE
:. :.. . : : : :. : ::..
NP_001 MAAGFGRCCRCSLQVLRSISRFHWR-SQHTKANRQREPGL-----GFSFE----FTEQ
10 20 30 40
70 80 90 100 110 120
pF1KB3 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS
. ......:::.:.: :... .:..... .:. .. :::. .. . :: : . ..
NP_001 QKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFD
50 60 70 80 90 100
130 140 150 160 170
pF1KB3 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVG-SFCLSEA
. :. :::: ..: . : :.: . : :...:: :: ..: : . ..:..:
NP_001 ACLISEELAYGCTGVQTAIE-GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB3 GAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDP---TIGYKGITSFL
::::: ..::.:.:.:: :..::.::::... .:. ....: :: . . :..:.:.
NP_001 GAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFI
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB3 VDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIG
:. ::::..::. : ..: : :.: ..::.::::. :.: : :.: :.:.... :
NP_001 VEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB3 IAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARL
.:: .:::: .: . : :: ::: : . :... ..:..: ..: ::. ::
NP_001 VAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB3 LEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGA
...:. ::.:: .:..::.: .. .. .:: :.. .::::: .::::: ::::.
NP_001 VDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGT
350 360 370 380 390 400
420 430
pF1KB3 SNIQLNTIAK-HIDAEY
:.:: .:. :::
NP_001 SQIQRLIVAREHIDKYKN
410 420
>>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa)
initn: 790 init1: 453 opt: 826 Z-score: 1031.0 bits: 199.8 E(85289): 1.1e-50
Smith-Waterman score: 826; 35.0% identity (71.5% similar) in 383 aa overlap (56-432:25-406)
30 40 50 60 70 80
pF1KB3 WKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDE
..: :. ..... :: ::..:: .. .:.
XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLAPKAQEIDR
10 20 30 40 50
90 100 110 120 130 140
pF1KB3 NSKME--KSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAV-FCEIQ
..... . . : . :..:: . .:::.: ..: :::.::.......:.. . .
XP_016 SNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHS
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB3 NTLINTLIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVL
: :: :.: .:.: :: :::.: . : .:.. .:: .:::: ..: .:.:.:..:.:
XP_016 NLCINQLVR-NGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYIL
120 130 140 150 160 170
210 220 230 240 250
pF1KB3 NGSKMWISSAEHAGLFLVMANVD--PTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASS
::.:.::... : ...:.:..: . . .:::.:.:.. ::. .: .:::.:.:.
XP_016 NGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSN
180 190 200 210 220 230
260 270 280 290 300 310
pF1KB3 TCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKER
:: : ::. :.: :::::. ..: ...:. :. .:. ::: :. .:.::::.. :
XP_016 TCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVR
240 250 260 270 280 290
320 330 340 350 360 370
pF1KB3 IQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAG
::... :: .: ..: . :.: : : .::.:. . :. :. . . :..: :
XP_016 EAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECAT
300 310 320 330 340 350
380 390 400 410 420 430
pF1KB3 QTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
:.. :. .:: :: .:.:. ...::::. : :.:... .:.. ..:..
XP_016 QVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
360 370 380 390 400
>>NP_001289483 (OMIM: 201470,606885) short-chain specifi (408 aa)
initn: 737 init1: 615 opt: 792 Z-score: 988.6 bits: 191.9 E(85289): 2.5e-48
Smith-Waterman score: 792; 37.7% identity (67.0% similar) in 379 aa overlap (59-432:36-406)
30 40 50 60 70 80
pF1KB3 PPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSK
. ..:. .. . ::.... :... .:..
NP_001 LARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHL
10 20 30 40 50 60
90 100 110 120 130 140
pF1KB3 MEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINT
. . .. . ::....: : ::.: ..:. ....::... ::..:. ..:.:
NP_001 FPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLG
70 80 90 100 110 120
150 160 170 180 190 200
pF1KB3 LIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLN--GSK
: : :..::: ... .:. .:.: : ::: : :. : : ..:. :
NP_001 PILKFGSKEQKQAWVTPFTSGDKIGCFALSEPG---PSLLGPT-----GPIFALGQVGCP
130 140 150 160 170
210 220 230 240 250 260
pF1KB3 MWISSAEHAGLF-LVMANVD-PTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPL
:.: .: : :. : . .::..::: :::: .:: :.:::.:.::: :
NP_001 CPSSAATEACTFPRSRQRVSRPELLREGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB3 TFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFG
::. ..:. .:::. : :.: :. .:. ::::::.: ::.:: .: .. : ..:. ::
NP_001 IFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFG
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB3 KRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTS
: .: .: ..: .: ::.:::::. :: : . :::::::.::: ::: : .
NP_001 APLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISH
300 310 320 330 340 350
390 400 410 420 430
pF1KB3 KCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
. :. .::.::. ..:.:...:::.: ::::.:.:: .:: :. :
NP_001 QAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
360 370 380 390 400
>>NP_054768 (OMIM: 611103,611126) acyl-CoA dehydrogenase (621 aa)
initn: 647 init1: 335 opt: 782 Z-score: 973.3 bits: 189.7 E(85289): 1.8e-47
Smith-Waterman score: 782; 38.6% identity (69.3% similar) in 368 aa overlap (68-425:74-437)
40 50 60 70 80 90
pF1KB3 SEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGL
:.:: :.. .:...:. ... :
NP_054 FLGKIKKKEVFPFPEVSQDELNEINQFLGPVEKFFTEEVDS--RKIDQEGKIPDETLEKL
50 60 70 80 90 100
100 110 120 130 140 150
pF1KB3 FQQGLMGIEVDPEYGGTGASFLSTVLV-IEELAKVDASVAVFCEIQNTLINTLIRKHGTE
. ::.:..: :::: : : .:. . :. ..:.:..: .... : :::
NP_054 KSLGLFGLQVPEEYGGLG--FSNTMYSRLGEIISMDGSITVTLAAHQAIGLKGIILAGTE
110 120 130 140 150
160 170 180 190 200 210
pF1KB3 EQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGD--YYVLNGSKMWISSAEH
:::: :::.:.. :....:::.: ..:::. ....:: : .:.:::::.::...
NP_054 EQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVWITNGGL
160 170 180 190 200 210
220 230 240 250 260
pF1KB3 AGLFLVMAN---VDPTIGYKG-ITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVK
:..: :.:. :: . : ::.:.:.:: :. ::::.:::.:.:.:: . :::.:
NP_054 ANIFTVFAKTEVVDSDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCEVHFENTK
220 230 240 250 260 270
270 280 290 300 310 320
pF1KB3 VPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDF
.: ::::..: :.: :.. :: ::..... . :: . ...: : : ::.::: .:
NP_054 IPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEF
280 290 300 310 320 330
330 340 350 360 370 380
pF1KB3 QGLQHQVAHVATQLEAARLLTYNAARLLEA-GKPFIK-EASMAKYYASEIAGQTTSKCIE
.:.. : .: . . . .:: .: .:. : : . ::.:.: ..:: : : .:. ..
NP_054 GLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQ
340 350 360 370 380 390
390 400 410 420 430
pF1KB3 WMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
.::.:::.::: :. .::..: :.::...: ::
NP_054 ILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQAK
400 410 420 430 440 450
NP_054 VSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRF
460 470 480 490 500 510
432 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 12:18:28 2016 done: Sat Nov 5 12:18:29 2016
Total Scan time: 8.600 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]