Result of FASTA (omim) for
pF1KB3596
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3596, 503 aa
1>>>pF1KB3596 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.5967+/-0.000773; mu= -23.6769+/- 0.045
mean_var=830.4097+/-190.551, 0's: 0 Z-trim(114.2): 105 B-trim: 0 in 0/51
Lambda= 0.044507
statistics sampled from 23800 (23893) to 23800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.28), width: 16
Scan time: 9.350
The best scores are: opt bits E(85289)
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 3390 234.4 6e-61
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 3372 233.2 1.3e-60
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2940 205.4 2.7e-52
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2922 204.2 6.1e-52
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2922 204.2 6.1e-52
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 2314 165.3 3.8e-40
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 2202 158.0 5.2e-38
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 2196 157.7 7.1e-38
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 2100 151.4 4.2e-36
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 2100 151.5 4.7e-36
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2073 149.7 1.6e-35
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1773 130.4 9.6e-30
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1695 125.5 3.5e-28
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1695 125.5 3.5e-28
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1695 125.5 3.5e-28
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1695 125.5 3.5e-28
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1695 125.6 3.6e-28
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1655 123.0 2.1e-27
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1655 123.0 2.1e-27
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1655 123.0 2.1e-27
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1565 117.0 9.6e-26
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1511 113.7 1.3e-24
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1511 113.7 1.3e-24
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1511 113.7 1.3e-24
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1434 108.8 3.9e-23
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1434 108.8 3.9e-23
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1434 108.8 3.9e-23
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1421 107.9 6.8e-23
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1421 107.9 6.8e-23
NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1421 108.0 7.2e-23
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1302 100.1 1.1e-20
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1264 97.8 6.6e-20
XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312) 895 73.9 7.6e-13
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 808 68.6 5e-11
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 808 68.6 5e-11
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 808 68.7 5.2e-11
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 808 68.7 5.3e-11
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 808 68.7 5.4e-11
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 800 68.0 6.1e-11
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 800 68.1 7e-11
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 800 68.1 7e-11
>>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type (503 aa)
initn: 3390 init1: 3390 opt: 3390 Z-score: 1215.2 bits: 234.4 E(85289): 6e-61
Smith-Waterman score: 3390; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
430 440 450 460 470 480
490 500
pF1KB3 ARLTALRIKKTLSQLSQQEGIKM
:::::::::::::::::::::::
NP_004 ARLTALRIKKTLSQLSQQEGIKM
490 500
>>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t (507 aa)
initn: 2626 init1: 2626 opt: 3372 Z-score: 1208.9 bits: 233.2 E(85289): 1.3e-60
Smith-Waterman score: 3372; 99.2% identity (99.2% similar) in 507 aa overlap (1-503:1-507)
10 20 30 40 50 60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
10 20 30 40 50 60
70 80 90 100 110
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT----VK
:::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTGPFSVK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 SSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 LKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB3 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB3 VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB3 RHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB3 IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY
430 440 450 460 470 480
480 490 500
pF1KB3 ANGAARLTALRIKKTLSQLSQQEGIKM
:::::::::::::::::::::::::::
NP_001 ANGAARLTALRIKKTLSQLSQQEGIKM
490 500
>>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta (434 aa)
initn: 2940 init1: 2940 opt: 2940 Z-score: 1059.7 bits: 205.4 E(85289): 2.7e-52
Smith-Waterman score: 2940; 100.0% identity (100.0% similar) in 434 aa overlap (70-503:1-434)
40 50 60 70 80 90
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
::::::::::::::::::::::::::::::
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
10 20 30
100 110 120 130 140 150
pF1KB3 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB3 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB3 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB3 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB3 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB3 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
340 350 360 370 380 390
460 470 480 490 500
pF1KB3 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
400 410 420 430
>>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2626 init1: 2626 opt: 2922 Z-score: 1053.4 bits: 204.2 E(85289): 6.1e-52
Smith-Waterman score: 2922; 99.1% identity (99.1% similar) in 438 aa overlap (70-503:1-438)
40 50 60 70 80 90
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
::::::::::::::::::::::::::::::
XP_016 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
10 20 30
100 110 120 130 140 150
pF1KB3 CCNQDHCNKIELPTT----VKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 CCNQDHCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB3 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB3 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB3 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB3 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB3 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
340 350 360 370 380 390
460 470 480 490 500
pF1KB3 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
400 410 420 430
>>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2626 init1: 2626 opt: 2922 Z-score: 1053.4 bits: 204.2 E(85289): 6.1e-52
Smith-Waterman score: 2922; 99.1% identity (99.1% similar) in 438 aa overlap (70-503:1-438)
40 50 60 70 80 90
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
::::::::::::::::::::::::::::::
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
10 20 30
100 110 120 130 140 150
pF1KB3 CCNQDHCNKIELPTT----VKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 CCNQDHCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB3 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB3 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB3 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB3 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFES
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB3 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIP
340 350 360 370 380 390
460 470 480 490 500
pF1KB3 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
400 410 420 430
>>NP_004293 (OMIM: 601300) activin receptor type-1B isof (505 aa)
initn: 2285 init1: 1991 opt: 2314 Z-score: 841.8 bits: 165.3 E(85289): 3.8e-40
Smith-Waterman score: 2314; 69.5% identity (84.1% similar) in 511 aa overlap (2-503:3-505)
10 20 30 40 50
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
:.: :. :..:.::...... :. :: : : : . :.:: ::: :.::.
NP_004 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTT-VK
. : :: ...:.: .:: : : .. .:.:: :.::.:.: :. .:
NP_004 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 SS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
:.. :::::...::::: :. : ....: :.: : :.: . :::: .
NP_004 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
.:. ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_004 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_004 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
:::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_004 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
:::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_004 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
420 430 440 450 460 470
480 490 500
pF1KB3 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
:::::::::::::::::::::::::: :: .:.
NP_004 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
480 490 500
>>NP_064732 (OMIM: 601300) activin receptor type-1B isof (453 aa)
initn: 2181 init1: 1991 opt: 2202 Z-score: 803.4 bits: 158.0 E(85289): 5.2e-38
Smith-Waterman score: 2202; 74.7% identity (87.7% similar) in 446 aa overlap (67-503:13-453)
40 50 60 70 80 90
pF1KB3 FCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVT
: :: ...:.: .:: : : ..
NP_064 MVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLR
10 20 30
100 110 120 130 140
pF1KB3 TTYCCNQDHCNKIEL--PTT-VKSS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYIC
.:.:: :.::.:.: :. .: :.. :::::...::::: :. : ....:
NP_064 NTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB3 HNRTVIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVL
:.: : :.: . :::: . .:. ::.::.::..::::::::::.::::.::::::
NP_064 HQR-VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB3 QESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN
:: ::::::::::::.::: .:::::::::::::::::::::::::::::::::::::::
NP_064 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB3 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKP
:::::::::::::::::::::::::::::::.:::::::::.::::::::::::::::::
NP_064 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB3 AIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDS
.::::::::::::::::: : :::::::::::..:::::::::.::::::::::::::..
NP_064 GIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDET
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB3 INMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCE
::::::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.
NP_064 INMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB3 QKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
::::::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
NP_064 QKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
400 410 420 430 440 450
>>NP_660302 (OMIM: 608981) activin receptor type-1C isof (493 aa)
initn: 2141 init1: 1892 opt: 2196 Z-score: 800.9 bits: 157.7 E(85289): 7.1e-38
Smith-Waterman score: 2202; 67.7% identity (81.7% similar) in 504 aa overlap (3-502:4-492)
10 20 30 40 50
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
: .: : :::: :::: : :: :.: : :: ..:::: :.: :..::
NP_660 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKS
:. : . :.. .: . : :. .:: : :: : ::.: .:::. .
NP_660 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASPN
60 70 80 90 100
120 130 140 150 160 170
pF1KB3 SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRV--PNEEDPSLDRPFISEGT
.: :::.::: .:. :::.. :. :: :. :..: ... :: :.: . ... :
NP_660 APKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGK
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB3 TLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFS
::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::::
NP_660 TLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB3 SREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY
::.::::::::::::::::::::::::::::::::::::::::::.:::.:::.:::::
NP_660 SRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB3 TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA
::: :::::::: ::::::::::::::::::::::::.::::::::: :: :::::::
NP_660 IVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB3 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC
:.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.:::::::
NP_660 VKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB3 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW
:.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::::
NP_660 SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECW
410 420 430 440 450 460
480 490 500
pF1KB3 YANGAARLTALRIKKTLSQLSQQEGIKM
::::::::::::::::.::: .: :
NP_660 YANGAARLTALRIKKTISQLCVKEDCKA
470 480 490
>>XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF-beta (357 aa)
initn: 2100 init1: 2100 opt: 2100 Z-score: 769.1 bits: 151.4 E(85289): 4.2e-36
Smith-Waterman score: 2258; 82.3% identity (82.3% similar) in 434 aa overlap (70-503:1-357)
40 50 60 70 80 90
pF1KB3 LCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
::::::::::::::::::::::::::::::
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTY
10 20 30
100 110 120 130 140 150
pF1KB3 CCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVP
:::::::::::::::
XP_011 CCNQDHCNKIELPTT---------------------------------------------
40
160 170 180 190 200 210
pF1KB3 NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV
::::::::::::::::::::::::::::
XP_011 --------------------------------GLPLLVQRTIARTIVLQESIGKGRFGEV
50 60 70
220 230 240 250 260 270
pF1KB3 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
80 90 100 110 120 130
280 290 300 310 320 330
pF1KB3 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNI
140 150 160 170 180 190
340 350 360 370 380 390
pF1KB3 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA
200 210 220 230 240 250
400 410 420 430 440 450
pF1KB3 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ
260 270 280 290 300 310
460 470 480 490 500
pF1KB3 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
320 330 340 350
>>NP_001124388 (OMIM: 132800,190181) TGF-beta receptor t (426 aa)
initn: 2100 init1: 2100 opt: 2100 Z-score: 768.3 bits: 151.5 E(85289): 4.7e-36
Smith-Waterman score: 2708; 84.7% identity (84.7% similar) in 503 aa overlap (1-503:1-426)
10 20 30 40 50 60
pF1KB3 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT------
70 80 90 100 110
130 140 150 160 170 180
pF1KB3 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KB3 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------GLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
120 130 140 150 160
250 260 270 280 290 300
pF1KB3 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
170 180 190 200 210 220
310 320 330 340 350 360
pF1KB3 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
230 240 250 260 270 280
370 380 390 400 410 420
pF1KB3 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
290 300 310 320 330 340
430 440 450 460 470 480
pF1KB3 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
350 360 370 380 390 400
490 500
pF1KB3 ARLTALRIKKTLSQLSQQEGIKM
:::::::::::::::::::::::
NP_001 ARLTALRIKKTLSQLSQQEGIKM
410 420
503 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:31:04 2016 done: Thu Nov 3 13:31:06 2016
Total Scan time: 9.350 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]