FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3604, 500 aa 1>>>pF1KB3604 500 - 500 aa - 500 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2725+/-0.000872; mu= 18.3798+/- 0.052 mean_var=66.3555+/-13.210, 0's: 0 Z-trim(106.2): 17 B-trim: 14 in 1/48 Lambda= 0.157448 statistics sampled from 8841 (8851) to 8841 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.272), width: 16 Scan time: 3.010 The best scores are: opt bits E(32554) CCDS10534.1 ABAT gene_id:18|Hs108|chr16 ( 500) 3406 782.7 0 CCDS54792.1 ETNPPL gene_id:64850|Hs108|chr4 ( 441) 303 77.8 2.7e-14 CCDS82944.1 ETNPPL gene_id:64850|Hs108|chr4 ( 459) 303 77.8 2.8e-14 CCDS54793.1 ETNPPL gene_id:64850|Hs108|chr4 ( 493) 303 77.8 3e-14 CCDS3682.1 ETNPPL gene_id:64850|Hs108|chr4 ( 499) 303 77.9 3e-14 CCDS4434.1 PHYKPL gene_id:85007|Hs108|chr5 ( 450) 267 69.6 7.9e-12 >>CCDS10534.1 ABAT gene_id:18|Hs108|chr16 (500 aa) initn: 3406 init1: 3406 opt: 3406 Z-score: 4178.6 bits: 782.7 E(32554): 0 Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 500 aa overlap (1-500:1-500) 10 20 30 40 50 60 pF1KB3 MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF 430 440 450 460 470 480 490 500 pF1KB3 RDHHAHLFLNIFSDILADFK :::::::::::::::::::: CCDS10 RDHHAHLFLNIFSDILADFK 490 500 >>CCDS54792.1 ETNPPL gene_id:64850|Hs108|chr4 (441 aa) initn: 234 init1: 126 opt: 303 Z-score: 370.1 bits: 77.8 E(32554): 2.7e-14 Smith-Waterman score: 326; 26.6% identity (55.9% similar) in 331 aa overlap (188-496:54-375) 160 170 180 190 200 210 pF1KB3 LITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAF : ..: . : : : .... :. CCDS54 RFLHDNIVEYAKRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQD--VITLDHAY 30 40 50 60 70 80 220 230 240 250 260 270 pF1KB3 HGRTMGCLATTHSKAIHKIDIPSFDWPIAPFP---RLKYPLEEFVKENQQEEARCL-EEV ::. . . . : . :. . .:: : : :: .:.. . : .:: CCDS54 HGHLSSLIEISPYKFQKGKDVKKEFVHVAPTPDTYRGKY------REDHADSASAYADEV 90 100 110 120 130 280 290 300 310 320 330 pF1KB3 EDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGG . .: ... . .:..:.: .:: ::. .:.:. . .. : .:..::::.: : CCDS54 KKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFG 140 150 160 170 180 190 340 350 360 370 380 pF1KB3 CTGK-FWAHEHWGLDDPADVMTFSKKMMTGG-----FFHKE--EFRPNAPYRIFNTWLGD .:: ::. . .: : :..:..: : .: :: : .. .. :::. :. CCDS54 RVGKHFWSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGN 200 210 220 230 240 250 390 400 410 420 430 440 pF1KB3 PSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTP : . . :..::. ::: .:: ..:. :: :: : .:. .:: : : ..: CCDS54 PVSCAVGLAVLDIIENEDLQGNAKRVGN-YLTELLKKQKAKHTLIGDIRGIGLFIGIDLV 260 270 280 290 300 310 450 460 470 480 490 pF1KB3 DDSIR--------NKLILIARNKGVVLGGCGDKS--IRFRPTLVFRDHHAHLFLNIFSDI : .. ...: ..: :.:.. : . ....: . : .. :..... .. : CCDS54 KDHLKRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRI 320 330 340 350 360 370 500 pF1KB3 LADFK : CCDS54 LTVLEEAMGTKTESVTSENTPCKTKMLKEAHIELLRDSTTDSKENPSRKRNGMCTDTHSL 380 390 400 410 420 430 >>CCDS82944.1 ETNPPL gene_id:64850|Hs108|chr4 (459 aa) initn: 234 init1: 126 opt: 303 Z-score: 369.9 bits: 77.8 E(32554): 2.8e-14 Smith-Waterman score: 339; 25.1% identity (53.2% similar) in 434 aa overlap (85-496:1-393) 60 70 80 90 100 110 pF1KB3 SQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLK . : .:...:: .... : :. ::...: CCDS82 MFDENGEQYLDCINNVAHV--GHCHPGVVK 10 20 120 130 140 150 160 170 pF1KB3 LIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKT . : . .: : .:.:: .. : .. :. .: :: .:. ::. CCDS82 AALK-QMELLNTNSRFL----HDNIVEYAKR-LSATLPEKLSVCYFTNSGSEANDLALR- 30 40 50 60 70 80 180 190 200 210 220 230 pF1KB3 IFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIH . : : : .... :.::. . . . : . CCDS82 -----------------------LARQFRGHQD--VITLDHAYHGHLSSLIEISPYKFQK 90 100 110 240 250 260 270 280 290 pF1KB3 KIDIPSFDWPIAPFP---RLKYPLEEFVKENQQEEARCL-EEVEDLIVKYRKKKKTVAGI :. . .:: : : :: .:.. . : .::. .: ... . .:.. CCDS82 GKDVKKEFVHVAPTPDTYRGKY------REDHADSASAYADEVKKIIEDAHNSGRKIAAF 120 130 140 150 160 170 300 310 320 330 340 pF1KB3 IVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGK-FWAHEHWGLDDP :.: .:: ::. .:.:. . .. : .:..::::.: : .:: ::. . .: : CCDS82 IAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFGRVGKHFWSFQMYGEDFV 180 190 200 210 220 230 350 360 370 380 390 400 pF1KB3 ADVMTFSKKMMTGG-----FFHKE--EFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKRE :..:..: : .: :: : .. .. :::. :.: . . :..::. : CCDS82 PDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAVLDIIENE 240 250 260 270 280 290 410 420 430 440 450 pF1KB3 DLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIR--------NKLI :: .:: ..:. :: :: : .:. .:: : : ..: : .. ...: CCDS82 DLQGNAKRVGN-YLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHLKRTPATAEAQHII 300 310 320 330 340 460 470 480 490 500 pF1KB3 LIARNKGVVLGGCGDKS--IRFRPTLVFRDHHAHLFLNIFSDILADFK ..: :.:.. : . ....: . : .. :..... .. :: CCDS82 YKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRILTVLEEAMGTKTESVTS 350 360 370 380 390 400 CCDS82 ENTPCKTKMLKEAHIELLRDSTTDSKENPSRKRNGMCTDTHSLLSKRLKT 410 420 430 440 450 >>CCDS54793.1 ETNPPL gene_id:64850|Hs108|chr4 (493 aa) initn: 234 init1: 126 opt: 303 Z-score: 369.4 bits: 77.8 E(32554): 3e-14 Smith-Waterman score: 326; 26.6% identity (55.9% similar) in 331 aa overlap (188-496:106-427) 160 170 180 190 200 210 pF1KB3 LITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAF : ..: . : : : .... :. CCDS54 RFLHDNIVEYAKRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQD--VITLDHAY 80 90 100 110 120 130 220 230 240 250 260 270 pF1KB3 HGRTMGCLATTHSKAIHKIDIPSFDWPIAPFP---RLKYPLEEFVKENQQEEARCL-EEV ::. . . . : . :. . .:: : : :: .:.. . : .:: CCDS54 HGHLSSLIEISPYKFQKGKDVKKEFVHVAPTPDTYRGKY------REDHADSASAYADEV 140 150 160 170 180 280 290 300 310 320 330 pF1KB3 EDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGG . .: ... . .:..:.: .:: ::. .:.:. . .. : .:..::::.: : CCDS54 KKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFG 190 200 210 220 230 240 340 350 360 370 380 pF1KB3 CTGK-FWAHEHWGLDDPADVMTFSKKMMTGG-----FFHKE--EFRPNAPYRIFNTWLGD .:: ::. . .: : :..:..: : .: :: : .. .. :::. :. CCDS54 RVGKHFWSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGN 250 260 270 280 290 300 390 400 410 420 430 440 pF1KB3 PSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTP : . . :..::. ::: .:: ..:. :: :: : .:. .:: : : ..: CCDS54 PVSCAVGLAVLDIIENEDLQGNAKRVGN-YLTELLKKQKAKHTLIGDIRGIGLFIGIDLV 310 320 330 340 350 360 450 460 470 480 490 pF1KB3 DDSIR--------NKLILIARNKGVVLGGCGDKS--IRFRPTLVFRDHHAHLFLNIFSDI : .. ...: ..: :.:.. : . ....: . : .. :..... .. : CCDS54 KDHLKRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRI 370 380 390 400 410 420 500 pF1KB3 LADFK : CCDS54 LTVLEEAMGTKTESVTSENTPCKTKMLKEAHIELLRDSTTDSKENPSRKRNGMCTDTHSL 430 440 450 460 470 480 >>CCDS3682.1 ETNPPL gene_id:64850|Hs108|chr4 (499 aa) initn: 234 init1: 126 opt: 303 Z-score: 369.3 bits: 77.9 E(32554): 3e-14 Smith-Waterman score: 347; 25.3% identity (53.3% similar) in 435 aa overlap (84-496:40-433) 60 70 80 90 100 110 pF1KB3 RSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALL :. : .:...:: .... : :. ::... CCDS36 TLGLRKKHIGPSCKVFFASDPIKIVRAQRQYMFDENGEQYLDCINNVAHV--GHCHPGVV 10 20 30 40 50 60 120 130 140 150 160 170 pF1KB3 KLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALK : . : . .: : .:.:: .. : .. :. .: :: .:. ::. CCDS36 KAALK-QMELLNTNSRFLH----DNIVEYAKR-LSATLPEKLSVCYFTNSGSEANDLALR 70 80 90 100 110 120 180 190 200 210 220 230 pF1KB3 TIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAI . : : : .... :.::. . . . : CCDS36 ------------------------LARQFRGHQD--VITLDHAYHGHLSSLIEISPYKFQ 130 140 150 240 250 260 270 280 pF1KB3 HKIDIPSFDWPIAPFP---RLKYPLEEFVKENQQEEARCL-EEVEDLIVKYRKKKKTVAG . :. . .:: : : :: .:.. . : .::. .: ... . .:. CCDS36 KGKDVKKEFVHVAPTPDTYRGKY------REDHADSASAYADEVKKIIEDAHNSGRKIAA 160 170 180 190 200 290 300 310 320 330 340 pF1KB3 IIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGK-FWAHEHWGLDD .:.: .:: ::. .:.:. . .. : .:..::::.: : .:: ::. . .: : CCDS36 FIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFGRVGKHFWSFQMYGEDF 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB3 PADVMTFSKKMMTGG-----FFHKE--EFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKR :..:..: : .: :: : .. .. :::. :.: . . :..::. CCDS36 VPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAVLDIIEN 270 280 290 300 310 320 410 420 430 440 450 pF1KB3 EDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIR--------NKL ::: .:: ..:. :: :: : .:. .:: : : ..: : .. ... CCDS36 EDLQGNAKRVGN-YLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHLKRTPATAEAQHI 330 340 350 360 370 380 460 470 480 490 500 pF1KB3 ILIARNKGVVLGGCGDKS--IRFRPTLVFRDHHAHLFLNIFSDILADFK : ..: :.:.. : . ....: . : .. :..... .. :: CCDS36 IYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRILTVLEEAMGTKTESVT 390 400 410 420 430 440 CCDS36 SENTPCKTKMLKEAHIELLRDSTTDSKENPSRKRNGMCTDTHSLLSKRLKT 450 460 470 480 490 >>CCDS4434.1 PHYKPL gene_id:85007|Hs108|chr5 (450 aa) initn: 145 init1: 121 opt: 267 Z-score: 325.8 bits: 69.6 E(32554): 7.9e-12 Smith-Waterman score: 331; 24.3% identity (53.3% similar) in 441 aa overlap (80-500:37-437) 50 60 70 80 90 100 pF1KB3 VPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSH ..:.:. : .: ...: :... : :. : CCDS44 PKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHV--GHCH 10 20 30 40 50 60 110 120 130 140 150 160 pF1KB3 PALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNE : ... .. :: . .: : .:.:. : : . :. . . . :: .:. CCDS44 PLVVQAAHE-QNQVLNTNSRYLH----DNIVD-YAQRLSETLPEQLCVFYFLNSGSEAND 70 80 90 100 110 170 180 190 200 210 220 pF1KB3 NALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH :: : : .. : : .:. :.::. .. : CCDS44 LAL-----------RLARHYT-------------GHQDVVVLDH--AYHGH-LSSLIDIS 120 130 140 150 230 240 250 260 270 280 pF1KB3 SKAIHKIDIPSFDW-PIAPFP-RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTV ....: . .: .::.: . : .: .. . .::. .. . ..: . . CCDS44 PYKFRNLDGQK-EWVHVAPLPDTYRGPYRE---DHPNPAMAYANEVKRVVSSAQEKGRKI 160 170 180 190 200 290 300 310 320 330 340 pF1KB3 AGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGK-FWAHEHWGL :....: . : ::. .: .. . :: : .:..::.:.: : .:: ::: . : CCDS44 AAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGK 210 220 230 240 250 260 350 360 370 380 390 pF1KB3 DDPADVMTFSKKMMTGGFFHK-EEFRPNA------PYRIFNTWLGDPSKNLLLAEVINII : :..:..:.. .: .: : . :::. :.: . . :.:.. CCDS44 DFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVL 270 280 290 300 310 320 400 410 420 430 440 450 pF1KB3 KREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDT-PDDSIRNKLI---- ..:.: ..:. .:. :. : . . ..: ... ::: : : . : :.. :. CCDS44 EKEQLQDHATSVGSFLMQLLGQQKIKHP-IVGDVRGVGLFIGVDLIKDEATRTPATEEAA 330 340 350 360 370 380 460 470 480 490 500 pF1KB3 -LIARNK-GVVL---GGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK :..: : . :: : : . ..:.: . : .:. . .. ::.:.. CCDS44 YLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTDMEEKVRSCETL 390 400 410 420 430 440 CCDS44 RLQP 450 500 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:13:34 2016 done: Sat Nov 5 05:13:34 2016 Total Scan time: 3.010 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]