FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3606, 198 aa 1>>>pF1KB3606 198 - 198 aa - 198 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8070+/-0.000336; mu= 15.2871+/- 0.021 mean_var=50.6689+/-10.094, 0's: 0 Z-trim(114.3): 25 B-trim: 342 in 1/49 Lambda= 0.180179 statistics sampled from 24101 (24126) to 24101 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.283), width: 16 Scan time: 5.860 The best scores are: opt bits E(85289) NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sap ( 198) 1332 353.6 1.2e-97 NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo ( 199) 1101 293.5 1.5e-79 NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 1101 293.5 1.5e-79 NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 1101 293.5 1.5e-79 NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 1101 293.5 1.5e-79 NP_006397 (OMIM: 300927) peroxiredoxin-4 precursor ( 271) 957 256.2 3.5e-68 XP_005274495 (OMIM: 300927) PREDICTED: peroxiredox ( 257) 953 255.1 7e-68 XP_016884719 (OMIM: 300927) PREDICTED: peroxiredox ( 350) 929 248.9 6.9e-66 XP_016884720 (OMIM: 300927) PREDICTED: peroxiredox ( 336) 925 247.9 1.4e-65 NP_006784 (OMIM: 604769) thioredoxin-dependent per ( 256) 881 236.4 3e-62 NP_001289201 (OMIM: 604769) thioredoxin-dependent ( 198) 549 150.0 2.3e-36 NP_004896 (OMIM: 602316) peroxiredoxin-6 [Homo sap ( 224) 189 56.5 3.8e-08 NP_036226 (OMIM: 606583) peroxiredoxin-5, mitochon ( 214) 125 39.8 0.0037 >>NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sapiens (198 aa) initn: 1332 init1: 1332 opt: 1332 Z-score: 1873.9 bits: 353.6 E(85289): 1.2e-97 Smith-Waterman score: 1332; 100.0% identity (100.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS 130 140 150 160 170 180 190 pF1KB3 DTIKPNVDDSKEYFSKHN :::::::::::::::::: NP_005 DTIKPNVDDSKEYFSKHN 190 >>NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo sapi (199 aa) initn: 1099 init1: 1002 opt: 1101 Z-score: 1549.4 bits: 293.5 E(85289): 1.5e-79 Smith-Waterman score: 1101; 77.8% identity (96.0% similar) in 198 aa overlap (1-197:1-198) 10 20 30 40 50 pF1KB3 MASGNARIGKPAPDFKATAVV-DGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFS :.::::.::.:::.::::::. :: ::...::::::::::.::::::::::::::::::: NP_001 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 NRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLK .:::.:.::.:.:.:.::::.: ::::.:::.:.:::::.::::..: : ...:::::: NP_001 DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPG .::::..::::::: ::.:::::::::::::::::.::::::::.::.:::::::::::: NP_001 ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG 130 140 150 160 170 180 180 190 pF1KB3 SDTIKPNVDDSKEYFSKHN ::::::.:. :::::::. NP_001 SDTIKPDVQKSKEYFSKQK 190 >>NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa) initn: 1099 init1: 1002 opt: 1101 Z-score: 1549.4 bits: 293.5 E(85289): 1.5e-79 Smith-Waterman score: 1101; 77.8% identity (96.0% similar) in 198 aa overlap (1-197:1-198) 10 20 30 40 50 pF1KB3 MASGNARIGKPAPDFKATAVV-DGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFS :.::::.::.:::.::::::. :: ::...::::::::::.::::::::::::::::::: NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 NRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLK .:::.:.::.:.:.:.::::.: ::::.:::.:.:::::.::::..: : ...:::::: NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPG .::::..::::::: ::.:::::::::::::::::.::::::::.::.:::::::::::: NP_859 ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG 130 140 150 160 170 180 180 190 pF1KB3 SDTIKPNVDDSKEYFSKHN ::::::.:. :::::::. NP_859 SDTIKPDVQKSKEYFSKQK 190 >>NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa) initn: 1099 init1: 1002 opt: 1101 Z-score: 1549.4 bits: 293.5 E(85289): 1.5e-79 Smith-Waterman score: 1101; 77.8% identity (96.0% similar) in 198 aa overlap (1-197:1-198) 10 20 30 40 50 pF1KB3 MASGNARIGKPAPDFKATAVV-DGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFS :.::::.::.:::.::::::. :: ::...::::::::::.::::::::::::::::::: NP_002 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 NRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLK .:::.:.::.:.:.:.::::.: ::::.:::.:.:::::.::::..: : ...:::::: NP_002 DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPG .::::..::::::: ::.:::::::::::::::::.::::::::.::.:::::::::::: NP_002 ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG 130 140 150 160 170 180 180 190 pF1KB3 SDTIKPNVDDSKEYFSKHN ::::::.:. :::::::. NP_002 SDTIKPDVQKSKEYFSKQK 190 >>NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa) initn: 1099 init1: 1002 opt: 1101 Z-score: 1549.4 bits: 293.5 E(85289): 1.5e-79 Smith-Waterman score: 1101; 77.8% identity (96.0% similar) in 198 aa overlap (1-197:1-198) 10 20 30 40 50 pF1KB3 MASGNARIGKPAPDFKATAVV-DGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFS :.::::.::.:::.::::::. :: ::...::::::::::.::::::::::::::::::: NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 NRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLK .:::.:.::.:.:.:.::::.: ::::.:::.:.:::::.::::..: : ...:::::: NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPG .::::..::::::: ::.:::::::::::::::::.::::::::.::.:::::::::::: NP_859 ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG 130 140 150 160 170 180 180 190 pF1KB3 SDTIKPNVDDSKEYFSKHN ::::::.:. :::::::. NP_859 SDTIKPDVQKSKEYFSKQK 190 >>NP_006397 (OMIM: 300927) peroxiredoxin-4 precursor [Ho (271 aa) initn: 960 init1: 944 opt: 957 Z-score: 1345.0 bits: 256.2 E(85289): 3.5e-68 Smith-Waterman score: 957; 70.5% identity (90.2% similar) in 193 aa overlap (6-198:79-271) 10 20 30 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKG :.:.:::: ...:::.:: :::.::.::.: NP_006 EECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRG 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB3 KYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGG ::.:.::::::::::::::::::..: :.::... ::.. ::::::::::::::::..:: NP_006 KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGG 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB3 LGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEA :::. ::::.:.:...:.:::: : : . ::::::: ::.:::::.:::::::::::. NP_006 LGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDET 170 180 190 200 210 220 160 170 180 190 pF1KB3 LRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN :::::::::::.:::::::::::::.:: :. . .::.: : NP_006 LRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN 230 240 250 260 270 >>XP_005274495 (OMIM: 300927) PREDICTED: peroxiredoxin-4 (257 aa) initn: 960 init1: 944 opt: 953 Z-score: 1339.7 bits: 255.1 E(85289): 7e-68 Smith-Waterman score: 953; 69.6% identity (89.7% similar) in 194 aa overlap (5-198:64-257) 10 20 30 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYK :. ..:::: ...:::.:: :::.::.::. XP_005 EAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLTDYR 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB3 GKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEG :::.:.::::::::::::::::::..: :.::... ::.. ::::::::::::::::..: XP_005 GKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQG 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB3 GLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDE ::::. ::::.:.:...:.:::: : : . ::::::: ::.:::::.::::::::::: XP_005 GLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDE 160 170 180 190 200 210 160 170 180 190 pF1KB3 ALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN .:::::::::::.:::::::::::::.:: :. . .::.: : XP_005 TLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN 220 230 240 250 >>XP_016884719 (OMIM: 300927) PREDICTED: peroxiredoxin-4 (350 aa) initn: 916 init1: 916 opt: 929 Z-score: 1303.9 bits: 248.9 E(85289): 6.9e-66 Smith-Waterman score: 929; 73.0% identity (92.7% similar) in 178 aa overlap (6-183:79-256) 10 20 30 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKG :.:.:::: ...:::.:: :::.::.::.: XP_016 EECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRG 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB3 KYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGG ::.:.::::::::::::::::::..: :.::... ::.. ::::::::::::::::..:: XP_016 KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGG 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB3 LGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEA :::. ::::.:.:...:.:::: : : . ::::::: ::.:::::.:::::::::::. XP_016 LGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDET 170 180 190 200 210 220 160 170 180 190 pF1KB3 LRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN :::::::::::.:::::::::::::.:. XP_016 LRLVQAFQYTDKHGEVCPAGWKPGSETVSIYICFYVELMVRVEKNAGRAQWLTPVIPALW 230 240 250 260 270 280 >>XP_016884720 (OMIM: 300927) PREDICTED: peroxiredoxin-4 (336 aa) initn: 916 init1: 916 opt: 925 Z-score: 1298.6 bits: 247.9 E(85289): 1.4e-65 Smith-Waterman score: 925; 72.1% identity (92.2% similar) in 179 aa overlap (5-183:64-242) 10 20 30 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYK :. ..:::: ...:::.:: :::.::.::. XP_016 EAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLTDYR 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB3 GKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEG :::.:.::::::::::::::::::..: :.::... ::.. ::::::::::::::::..: XP_016 GKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQG 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB3 GLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDE ::::. ::::.:.:...:.:::: : : . ::::::: ::.:::::.::::::::::: XP_016 GLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDE 160 170 180 190 200 210 160 170 180 190 pF1KB3 ALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN .:::::::::::.:::::::::::::.:. XP_016 TLRLVQAFQYTDKHGEVCPAGWKPGSETVSIYICFYVELMVRVEKNAGRAQWLTPVIPAL 220 230 240 250 260 270 >>NP_006784 (OMIM: 604769) thioredoxin-dependent peroxid (256 aa) initn: 879 init1: 879 opt: 881 Z-score: 1238.6 bits: 236.4 E(85289): 3e-62 Smith-Waterman score: 881; 65.4% identity (89.0% similar) in 191 aa overlap (8-198:65-255) 10 20 30 pF1KB3 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKY . . :: ::.::::.: ::...:.:.:::: NP_006 CGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKY 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB3 VVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLG .:::::::::::::::::.:::..:..:. ..:::..:::::.:.::::::::::.:::: NP_006 LVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLG 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB3 PLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALR .:: ::.:.:...:.::::: :.: ::::::: .::.....::::::::::.:.:: NP_006 HMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLR 160 170 180 190 200 210 160 170 180 190 pF1KB3 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN ::.::::.. :::::::.: : : ::::. :::::.: : NP_006 LVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ 220 230 240 250 198 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:14:13 2016 done: Sat Nov 5 05:14:14 2016 Total Scan time: 5.860 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]