FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3608, 210 aa 1>>>pF1KB3608 210 - 210 aa - 210 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3953+/-0.000292; mu= 13.3638+/- 0.018 mean_var=66.4232+/-12.922, 0's: 0 Z-trim(117.4): 42 B-trim: 0 in 0/57 Lambda= 0.157367 statistics sampled from 29347 (29389) to 29347 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.345), width: 16 Scan time: 6.450 The best scores are: opt bits E(85289) NP_148937 (OMIM: 190040,213600,607174,607907,61548 ( 226) 1412 328.8 4.2e-90 NP_002599 (OMIM: 190040,213600,607174,607907,61548 ( 241) 1412 328.8 4.5e-90 NP_148983 (OMIM: 173430) platelet-derived growth f ( 196) 446 109.5 3.9e-24 XP_011513721 (OMIM: 173430) PREDICTED: platelet-de ( 210) 446 109.5 4.2e-24 NP_002598 (OMIM: 173430) platelet-derived growth f ( 211) 446 109.5 4.2e-24 XP_016867778 (OMIM: 173430) PREDICTED: platelet-de ( 224) 446 109.5 4.4e-24 XP_011513720 (OMIM: 173430) PREDICTED: platelet-de ( 234) 446 109.5 4.6e-24 XP_011513718 (OMIM: 173430) PREDICTED: platelet-de ( 249) 446 109.5 4.8e-24 XP_011513719 (OMIM: 173430) PREDICTED: platelet-de ( 241) 408 100.9 1.9e-21 XP_011513717 (OMIM: 173430) PREDICTED: platelet-de ( 256) 408 100.9 2e-21 NP_001230662 (OMIM: 601398) vascular endothelial g ( 188) 188 50.9 1.6e-06 NP_003368 (OMIM: 601398) vascular endothelial grow ( 207) 182 49.5 4.6e-06 NP_004460 (OMIM: 300091) vascular endothelial grow ( 354) 183 49.9 6.1e-06 NP_005420 (OMIM: 601528,615907) vascular endotheli ( 419) 177 48.5 1.8e-05 NP_001280572 (OMIM: 601121) placenta growth factor ( 169) 167 46.1 4.1e-05 NP_002623 (OMIM: 601121) placenta growth factor is ( 170) 167 46.1 4.1e-05 XP_016863944 (OMIM: 608452) PREDICTED: platelet-de ( 310) 166 46.0 8e-05 XP_011530426 (OMIM: 608452) PREDICTED: platelet-de ( 334) 166 46.0 8.5e-05 NP_057289 (OMIM: 608452) platelet-derived growth f ( 345) 166 46.0 8.7e-05 NP_001165095 (OMIM: 192240,603933) vascular endoth ( 215) 160 44.5 0.00015 NP_003367 (OMIM: 192240,603933) vascular endotheli ( 395) 160 44.7 0.00025 NP_001165094 (OMIM: 192240,603933) vascular endoth ( 232) 154 43.2 0.00041 NP_001273973 (OMIM: 192240,603933) vascular endoth ( 163) 152 42.7 0.00042 NP_001165098 (OMIM: 192240,603933) vascular endoth ( 174) 152 42.7 0.00044 NP_001165097 (OMIM: 192240,603933) vascular endoth ( 191) 152 42.7 0.00048 NP_001165100 (OMIM: 192240,603933) vascular endoth ( 191) 152 42.7 0.00048 NP_001191313 (OMIM: 192240,603933) vascular endoth ( 171) 151 42.5 0.00051 NP_001303939 (OMIM: 192240,603933) vascular endoth ( 213) 152 42.7 0.00052 NP_001165096 (OMIM: 192240,603933) vascular endoth ( 209) 151 42.5 0.0006 NP_001020537 (OMIM: 192240,603933) vascular endoth ( 412) 154 43.3 0.00067 NP_001020540 (OMIM: 192240,603933) vascular endoth ( 354) 152 42.8 0.00081 NP_001028928 (OMIM: 192240,603933) vascular endoth ( 371) 152 42.8 0.00084 NP_001020539 (OMIM: 192240,603933) vascular endoth ( 371) 152 42.8 0.00084 NP_001191314 (OMIM: 192240,603933) vascular endoth ( 351) 151 42.6 0.00094 NP_001020538 (OMIM: 192240,603933) vascular endoth ( 389) 151 42.6 0.001 NP_001193941 (OMIM: 601121) placenta growth factor ( 149) 145 41.1 0.0012 NP_001165101 (OMIM: 192240,603933) vascular endoth ( 137) 142 40.4 0.0017 NP_001165099 (OMIM: 192240,603933) vascular endoth ( 147) 142 40.4 0.0018 NP_001165093 (OMIM: 192240,603933) vascular endoth ( 317) 142 40.5 0.0035 NP_001020541 (OMIM: 192240,603933) vascular endoth ( 327) 142 40.5 0.0036 >>NP_148937 (OMIM: 190040,213600,607174,607907,615483) p (226 aa) initn: 1412 init1: 1412 opt: 1412 Z-score: 1738.5 bits: 328.8 E(85289): 4.2e-90 Smith-Waterman score: 1412; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:17-226) 10 20 30 40 pF1KB3 MLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELES :::::::::::::::::::::::::::::::::::::::::::: NP_148 MFIMGLGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELES 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 LARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 LARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 NRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 NRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGG 130 140 150 160 170 180 170 180 190 200 210 pF1KB3 SQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA :::::::::::::::::::::::::::::::::::::::::::::: NP_148 SQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 190 200 210 220 >>NP_002599 (OMIM: 190040,213600,607174,607907,615483) p (241 aa) initn: 1412 init1: 1412 opt: 1412 Z-score: 1738.1 bits: 328.8 E(85289): 4.5e-90 Smith-Waterman score: 1412; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:32-241) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDPGEEDGAELD :::::::::::::::::::::::::::::: NP_002 NRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB3 LNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVW 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB3 PPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB3 TVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 190 200 210 220 230 240 >>NP_148983 (OMIM: 173430) platelet-derived growth facto (196 aa) initn: 468 init1: 395 opt: 446 Z-score: 554.2 bits: 109.5 E(85289): 3.9e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:39-183) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. NP_148 LLGCGYLAHVLAEEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 10 20 30 40 50 60 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. NP_148 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 70 80 90 100 110 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : NP_148 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. NP_148 ATTSLNPDYREEDTDVR 180 190 >>XP_011513721 (OMIM: 173430) PREDICTED: platelet-derive (210 aa) initn: 484 init1: 395 opt: 446 Z-score: 553.7 bits: 109.5 E(85289): 4.2e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:38-182) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. XP_011 QKLSAPSLPPRPSEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 10 20 30 40 50 60 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. XP_011 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 70 80 90 100 110 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : XP_011 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. XP_011 ATTSLNPDYREEDTGRPRESGKKRKRKRLKPT 180 190 200 210 >>NP_002598 (OMIM: 173430) platelet-derived growth facto (211 aa) initn: 484 init1: 395 opt: 446 Z-score: 553.7 bits: 109.5 E(85289): 4.2e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:39-183) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. NP_002 LLGCGYLAHVLAEEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 10 20 30 40 50 60 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. NP_002 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 70 80 90 100 110 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : NP_002 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. NP_002 ATTSLNPDYREEDTGRPRESGKKRKRKRLKPT 180 190 200 210 >>XP_016867778 (OMIM: 173430) PREDICTED: platelet-derive (224 aa) initn: 484 init1: 395 opt: 446 Z-score: 553.3 bits: 109.5 E(85289): 4.4e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:52-196) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. XP_016 LLKNRGGEWGRPEEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 30 40 50 60 70 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. XP_016 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : XP_016 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. XP_016 ATTSLNPDYREEDTGRPRESGKKRKRKRLKPT 200 210 220 >>XP_011513720 (OMIM: 173430) PREDICTED: platelet-derive (234 aa) initn: 395 init1: 395 opt: 446 Z-score: 553.0 bits: 109.5 E(85289): 4.6e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:77-221) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. XP_011 LLGCGYLAHVLAEEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 50 60 70 80 90 100 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. XP_011 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 110 120 130 140 150 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : XP_011 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. XP_011 ATTSLNPDYREEDTDVR 220 230 >>XP_011513718 (OMIM: 173430) PREDICTED: platelet-derive (249 aa) initn: 411 init1: 395 opt: 446 Z-score: 552.6 bits: 109.5 E(85289): 4.8e-24 Smith-Waterman score: 446; 48.1% identity (69.5% similar) in 154 aa overlap (5-153:77-221) 10 20 30 pF1KB3 MLSDHSIRSFDDLQRLLHGDP-GEEDGAELDLNM :::: ::::::. : : ::. :: .. XP_011 LLGCGYLAHVLAEEAEIPREVIERLARSQIHSIR---DLQRLLEIDSVGSEDS--LDTSL 50 60 70 80 90 100 40 50 60 70 80 pF1KB3 TRSHSGGELESLARGR----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV :.:. . . . : : :. : ::. ::::: ..:: : .: :.::::. XP_011 -RAHGVHATKHVPEKRPLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLI 110 120 130 140 150 90 100 110 120 130 140 pF1KB3 WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC :::::::.::.::::. .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : XP_011 WPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECAC 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB3 ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG :.. XP_011 ATTSLNPDYREEDTGRPRESGKKRKRKRLKPT 220 230 240 >>XP_011513719 (OMIM: 173430) PREDICTED: platelet-derive (241 aa) initn: 424 init1: 395 opt: 408 Z-score: 506.2 bits: 100.9 E(85289): 1.9e-21 Smith-Waterman score: 408; 44.9% identity (70.3% similar) in 138 aa overlap (21-153:94-228) 10 20 30 40 pF1KB3 MLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMT-RSHSGGELESLARGR ::.. .: .:. . :.:. . . . : XP_011 CSGRGSRDPPRGDREAGPQSDPQHPGPPATPGDRLRSEDSLDTSLRAHGVHATKHVPEKR 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB3 ----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNN : :. : ::. ::::: ..:: : .: :.::::.:::::::.::.::::. XP_011 PLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNT 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB3 RNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGS .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : :.. XP_011 SSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTDV 190 200 210 220 230 240 170 180 190 200 210 pF1KB3 QEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA XP_011 R >>XP_011513717 (OMIM: 173430) PREDICTED: platelet-derive (256 aa) initn: 440 init1: 395 opt: 408 Z-score: 505.8 bits: 100.9 E(85289): 2e-21 Smith-Waterman score: 408; 44.9% identity (70.3% similar) in 138 aa overlap (21-153:94-228) 10 20 30 40 pF1KB3 MLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMT-RSHSGGELESLARGR ::.. .: .:. . :.:. . . . : XP_011 CSGRGSRDPPRGDREAGPQSDPQHPGPPATPGDRLRSEDSLDTSLRAHGVHATKHVPEKR 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB3 ----RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNN : :. : ::. ::::: ..:: : .: :.::::.:::::::.::.::::. XP_011 PLPIRRKRSIEEAVPAV---CKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNT 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB3 RNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGS .:.:.:..:. : :.: :.: ::::: .:.. : ::.:: : : :.. XP_011 SSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGR 190 200 210 220 230 240 170 180 190 200 210 pF1KB3 QEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA XP_011 PRESGKKRKRKRLKPT 250 210 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:42:56 2016 done: Sat Nov 5 21:42:57 2016 Total Scan time: 6.450 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]