FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3614, 418 aa 1>>>pF1KB3614 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1095+/-0.000424; mu= 18.5318+/- 0.026 mean_var=70.4330+/-14.257, 0's: 0 Z-trim(110.8): 45 B-trim: 246 in 1/53 Lambda= 0.152822 statistics sampled from 19219 (19261) to 19219 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.226), width: 16 Scan time: 8.290 The best scores are: opt bits E(85289) NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 2760 618.0 1.3e-176 NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 2760 618.0 1.3e-176 NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 2760 618.0 1.3e-176 NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 2760 618.0 1.3e-176 NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 ( 418) 2448 549.2 6.9e-156 XP_016868466 (OMIM: 610469) PREDICTED: AP-3 comple ( 418) 2448 549.2 6.9e-156 NP_001127768 (OMIM: 610469) AP-3 complex subunit m ( 418) 2448 549.2 6.9e-156 NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 1800 406.3 6.3e-113 XP_016868467 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 1776 401.0 2.1e-111 XP_016868468 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 1776 401.0 2.1e-111 NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 527 125.7 2.2e-28 NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 513 122.6 1.8e-27 NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 482 115.8 2.1e-25 XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 452 109.1 2e-23 NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 383 94.0 8e-19 NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 376 92.4 2.3e-18 NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 345 85.6 2.8e-16 NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 273 69.7 1.6e-11 NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 271 69.3 2.2e-11 XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 264 67.7 6.2e-11 XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 264 67.7 6.6e-11 XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 264 67.7 6.6e-11 XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 243 63.1 1.5e-09 XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 182 49.4 1.1e-05 XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 182 49.6 1.6e-05 XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 163 45.3 0.00023 >>NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 iso (418 aa) initn: 2760 init1: 2760 opt: 2760 Z-score: 3291.5 bits: 618.0 E(85289): 1.3e-176 Smith-Waterman score: 2760; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT 370 380 390 400 410 >>NP_001307193 (OMIM: 610366) AP-3 complex subunit mu-1 (418 aa) initn: 2760 init1: 2760 opt: 2760 Z-score: 3291.5 bits: 618.0 E(85289): 1.3e-176 Smith-Waterman score: 2760; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT 370 380 390 400 410 >>NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 iso (418 aa) initn: 2760 init1: 2760 opt: 2760 Z-score: 3291.5 bits: 618.0 E(85289): 1.3e-176 Smith-Waterman score: 2760; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT 370 380 390 400 410 >>NP_001307192 (OMIM: 610366) AP-3 complex subunit mu-1 (418 aa) initn: 2760 init1: 2760 opt: 2760 Z-score: 3291.5 bits: 618.0 E(85289): 1.3e-176 Smith-Waterman score: 2760; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT 370 380 390 400 410 >>NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 [Ho (418 aa) initn: 2448 init1: 2448 opt: 2448 Z-score: 2919.7 bits: 549.2 E(85289): 6.9e-156 Smith-Waterman score: 2448; 84.2% identity (96.9% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY ::::::::: :::::::::::::::.:::::::::::.:...::::::: ::::::.:.: NP_006 MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG : :.:::.::::::::::::::::::.:::::::: ::: .::::::.:::.:::::::: NP_006 RHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::.:::.::::.:::: ::::::: .::::.:::::::::: NP_006 FPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::.:::::::::::::. ::::::::::.::.:::::.:::::::::::::::::.::: NP_006 FDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN ::::::.::::::::::::.::.::.::::::::::::.:::...:: :::.::.::::. NP_006 RWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::.::: .::: ::::.:::.::..:::::::.:.::::::.::::::::: ..: NP_006 MGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :.:: ::.:::..:.:::::::::::::::::::::::::::::.::.:::::::::: NP_006 QAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT 370 380 390 400 410 >>XP_016868466 (OMIM: 610469) PREDICTED: AP-3 complex su (418 aa) initn: 2448 init1: 2448 opt: 2448 Z-score: 2919.7 bits: 549.2 E(85289): 6.9e-156 Smith-Waterman score: 2448; 84.2% identity (96.9% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY ::::::::: :::::::::::::::.:::::::::::.:...::::::: ::::::.:.: XP_016 MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG : :.:::.::::::::::::::::::.:::::::: ::: .::::::.:::.:::::::: XP_016 RHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::.:::.::::.:::: ::::::: .::::.:::::::::: XP_016 FPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::.:::::::::::::. ::::::::::.::.:::::.:::::::::::::::::.::: XP_016 FDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN ::::::.::::::::::::.::.::.::::::::::::.:::...:: :::.::.::::. XP_016 RWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::.::: .::: ::::.:::.::..:::::::.:.::::::.::::::::: ..: XP_016 MGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :.:: ::.:::..:.:::::::::::::::::::::::::::::.::.:::::::::: XP_016 QAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT 370 380 390 400 410 >>NP_001127768 (OMIM: 610469) AP-3 complex subunit mu-2 (418 aa) initn: 2448 init1: 2448 opt: 2448 Z-score: 2919.7 bits: 549.2 E(85289): 6.9e-156 Smith-Waterman score: 2448; 84.2% identity (96.9% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY ::::::::: :::::::::::::::.:::::::::::.:...::::::: ::::::.:.: NP_001 MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG : :.:::.::::::::::::::::::.:::::::: ::: .::::::.:::.:::::::: NP_001 RHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY :::::::::::::::::::::.:::.::::.:::: ::::::: .::::.:::::::::: NP_001 FPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::.:::::::::::::. ::::::::::.::.:::::.:::::::::::::::::.::: NP_001 FDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN ::::::.::::::::::::.::.::.::::::::::::.:::...:: :::.::.::::. NP_001 RWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::.::: .::: ::::.:::.::..:::::::.:.::::::.::::::::: ..: NP_001 MGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSL 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :.:: ::.:::..:.:::::::::::::::::::::::::::::.::.:::::::::: NP_001 QAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT 370 380 390 400 410 >>NP_001307194 (OMIM: 610366) AP-3 complex subunit mu-1 (364 aa) initn: 1790 init1: 1790 opt: 1800 Z-score: 2148.4 bits: 406.3 E(85289): 6.3e-113 Smith-Waterman score: 2309; 87.1% identity (87.1% similar) in 418 aa overlap (1-418:1-364) 10 20 30 40 50 60 pF1KB3 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG ::::::::::::::::::::::::::::::::::: NP_001 RDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFG------------------------- 70 80 90 130 140 150 160 170 180 pF1KB3 FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY ::::::::::::::::::::::::::::::: NP_001 -----------------------------SSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY 100 110 120 190 200 210 220 230 240 pF1KB3 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB3 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQN 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB3 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNL 250 260 270 280 290 300 370 380 390 400 410 pF1KB3 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT 310 320 330 340 350 360 >>XP_016868467 (OMIM: 610469) PREDICTED: AP-3 complex su (303 aa) initn: 1776 init1: 1776 opt: 1776 Z-score: 2120.9 bits: 401.0 E(85289): 2.1e-111 Smith-Waterman score: 1776; 84.2% identity (97.4% similar) in 303 aa overlap (116-418:1-303) 90 100 110 120 130 140 pF1KB3 VADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVN ::::::::::::::::::::::::::.::: XP_016 MLDNGFPLATESNILKELIKPPTILRTVVN 10 20 30 150 160 170 180 190 200 pF1KB3 SITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGV .::::.:::: ::::::: .::::.:::::::::::::.:::::::::::::. :::::: XP_016 TITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGV 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB3 IDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVS ::::.::.:::::.:::::::::::::::::.:::::::::.::::::::::::.::.:: XP_016 IDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVS 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB3 SQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTP .::::::::::::.:::...:: :::.::.::::.:::::::.::: .::: ::::.::: XP_016 AQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTP 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB3 TQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAIS .::..:::::::.:.::::::.::::::::: ..::.:: ::.:::..:.:::::::::: XP_016 SQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSLQAGASKPDENPTINLQFKIQQLAIS 220 230 240 250 260 270 390 400 410 pF1KB3 GLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::.::.:::::::::: XP_016 GLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT 280 290 300 >>XP_016868468 (OMIM: 610469) PREDICTED: AP-3 complex su (303 aa) initn: 1776 init1: 1776 opt: 1776 Z-score: 2120.9 bits: 401.0 E(85289): 2.1e-111 Smith-Waterman score: 1776; 84.2% identity (97.4% similar) in 303 aa overlap (116-418:1-303) 90 100 110 120 130 140 pF1KB3 VADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVN ::::::::::::::::::::::::::.::: XP_016 MLDNGFPLATESNILKELIKPPTILRTVVN 10 20 30 150 160 170 180 190 200 pF1KB3 SITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGV .::::.:::: ::::::: .::::.:::::::::::::.:::::::::::::. :::::: XP_016 TITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGV 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB3 IDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVS ::::.::.:::::.:::::::::::::::::.:::::::::.::::::::::::.::.:: XP_016 IDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVS 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB3 SQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTP .::::::::::::.:::...:: :::.::.::::.:::::::.::: .::: ::::.::: XP_016 AQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTP 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB3 TQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAIS .::..:::::::.:.::::::.::::::::: ..::.:: ::.:::..:.:::::::::: XP_016 SQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSLQAGASKPDENPTINLQFKIQQLAIS 220 230 240 250 260 270 390 400 410 pF1KB3 GLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT :::::::::::::::::::.::.:::::::::: XP_016 GLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT 280 290 300 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:14:48 2016 done: Sat Nov 5 05:14:49 2016 Total Scan time: 8.290 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]