Result of FASTA (omim) for
pF1KB3618
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3618, 295 aa
1>>>pF1KB3618 295 - 295 aa - 295 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.5813+/-0.000348; mu= -8.1475+/- 0.022
mean_var=273.4794+/-54.201, 0's: 0 Z-trim(124.0): 13 B-trim: 399 in 1/55
Lambda= 0.077555
statistics sampled from 44878 (44892) to 44878 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.828), E-opt: 0.2 (0.526), width: 16
Scan time: 9.270
The best scores are: opt bits E(85289)
NP_002117 (OMIM: 142385) hepatic leukemia factor i ( 295) 2029 239.4 6.5e-63
XP_005257326 (OMIM: 142385) PREDICTED: hepatic leu ( 296) 2017 238.0 1.7e-62
NP_001317304 (OMIM: 142385) hepatic leukemia facto ( 210) 1438 173.2 4e-43
XP_011523007 (OMIM: 142385) PREDICTED: hepatic leu ( 211) 1426 171.8 1e-42
NP_001138870 (OMIM: 188595) thyrotroph embryonic f ( 273) 1002 124.4 2.4e-28
NP_003207 (OMIM: 188595) thyrotroph embryonic fact ( 303) 976 121.6 1.9e-27
NP_001343 (OMIM: 124097) D site-binding protein [H ( 325) 852 107.7 3.1e-23
XP_016881877 (OMIM: 124097) PREDICTED: D site-bind ( 182) 676 87.9 1.6e-17
>>NP_002117 (OMIM: 142385) hepatic leukemia factor isofo (295 aa)
initn: 2029 init1: 2029 opt: 2029 Z-score: 1250.5 bits: 239.4 E(85289): 6.5e-63
Smith-Waterman score: 2029; 100.0% identity (100.0% similar) in 295 aa overlap (1-295:1-295)
10 20 30 40 50 60
pF1KB3 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAK
190 200 210 220 230 240
250 260 270 280 290
pF1KB3 RSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
250 260 270 280 290
>>XP_005257326 (OMIM: 142385) PREDICTED: hepatic leukemi (296 aa)
initn: 1644 init1: 1596 opt: 2017 Z-score: 1243.2 bits: 238.0 E(85289): 1.7e-62
Smith-Waterman score: 2017; 99.7% identity (99.7% similar) in 296 aa overlap (1-295:1-296)
10 20 30 40 50 60
pF1KB3 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA
130 140 150 160 170 180
190 200 210 220 230
pF1KB3 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLK-DDKYWARRRKNNMAA
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_005 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNNMAA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB3 KRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
250 260 270 280 290
>>NP_001317304 (OMIM: 142385) hepatic leukemia factor is (210 aa)
initn: 1438 init1: 1438 opt: 1438 Z-score: 895.3 bits: 173.2 E(85289): 4e-43
Smith-Waterman score: 1438; 100.0% identity (100.0% similar) in 210 aa overlap (86-295:1-210)
60 70 80 90 100 110
pF1KB3 SPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQP
::::::::::::::::::::::::::::::
NP_001 MDLEEFLSENGIPPSPSQHDHSPHPPGLQP
10 20 30
120 130 140 150 160 170
pF1KB3 ASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGY
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB3 EPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKN
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB3 NMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
160 170 180 190 200 210
>>XP_011523007 (OMIM: 142385) PREDICTED: hepatic leukemi (211 aa)
initn: 1070 init1: 1005 opt: 1426 Z-score: 888.0 bits: 171.8 E(85289): 1e-42
Smith-Waterman score: 1426; 99.5% identity (99.5% similar) in 211 aa overlap (86-295:1-211)
60 70 80 90 100 110
pF1KB3 SPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQP
::::::::::::::::::::::::::::::
XP_011 MDLEEFLSENGIPPSPSQHDHSPHPPGLQP
10 20 30
120 130 140 150 160 170
pF1KB3 ASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGY
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB3 EPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLK-DDKYWARRRK
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 EPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRK
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB3 NNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGP
160 170 180 190 200 210
pF1KB3 L
:
XP_011 L
>>NP_001138870 (OMIM: 188595) thyrotroph embryonic facto (273 aa)
initn: 978 init1: 732 opt: 1002 Z-score: 629.9 bits: 124.4 E(85289): 2.4e-28
Smith-Waterman score: 1002; 56.8% identity (79.1% similar) in 278 aa overlap (21-295:6-273)
10 20 30 40 50
pF1KB3 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSP-TV
::.::::. : : .. : :.: ::: .::. . :.
NP_001 MDMPEVLKSLLEHSLPWPEKRTD---KEKGKEKLEEDEAAAASTM
10 20 30 40
60 70 80 90 100 110
pF1KB3 PQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPP--GLQPAS
:: : : .::::.::::..:.::::::.::: ::::: ::.. :. : :.
NP_001 AVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB3 SAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP
::. :. . : ..: ..:. . .: : .:.:::::::. ..: :...:
NP_001 SASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDVNFNP
110 120 130 140 150
180 190 200 210 220 230
pF1KB3 DPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNM
:::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:::.::.:::.
NP_001 DPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNV
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB3 AAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:::
NP_001 AAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
220 230 240 250 260 270
>>NP_003207 (OMIM: 188595) thyrotroph embryonic factor i (303 aa)
initn: 961 init1: 732 opt: 976 Z-score: 613.6 bits: 121.6 E(85289): 1.9e-27
Smith-Waterman score: 995; 56.5% identity (79.5% similar) in 278 aa overlap (21-295:38-303)
10 20 30 40 50
pF1KB3 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKL
::..:.::: : .: ..:.: :::
NP_003 KKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENP---P--REARLDKEKGKEKLE
10 20 30 40 50 60
60 70 80 90 100
pF1KB3 DDESNSP-TVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPH
.::. . :. :: : : .::::.::::..:.::::::.::: ::::: ::.. :.
NP_003 EDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 PP--GLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPD
: :. ::. :. . : ..: ..:. . .: : .:.:::::::.
NP_003 LPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPN
130 140 150 160 170
170 180 190 200 210 220
pF1KB3 TIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDK
..: :...::::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:
NP_003 CVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB3 YWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAK
::.::.:::.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:
NP_003 YWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSK
240 250 260 270 280 290
290
pF1KB3 YEARHGPL
::...:::
NP_003 YETKYGPL
300
>>NP_001343 (OMIM: 124097) D site-binding protein [Homo (325 aa)
initn: 847 init1: 673 opt: 852 Z-score: 538.1 bits: 107.7 E(85289): 3.1e-23
Smith-Waterman score: 854; 46.3% identity (67.3% similar) in 324 aa overlap (7-295:10-325)
10 20 30 40 50
pF1KB3 MEKMSRPLPL---NPTFIPPPYGVL---RSLLENPLKLPLHHEDAFSKDKDKEKKLD
: :: .:. :: :.: ::::.. : : . . . :.:... :
NP_001 MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSK-PKEPASCLLKEKERKAALP
10 20 30 40 50
60 70 80
pF1KB3 D--------ESNSPT-------------------VPQSAFLGPTLWDKTLPYDGDTFQLE
:. .:. :: ..:.: ::..:::. :: .:
NP_001 AATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPF-GD---VE
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB3 YMDLEEFLSENGIPPSPSQHDH-SPHP-PGLQPASSAAPSVMDLSSRASAPLHPGIPSPN
:.::. :: :.:.:::: ::.: :. :: : .:. .: :.: : .
NP_001 YVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAAL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB3 CMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSE
: : : ..:.::::.::::..: . .::::::::::::::.: ::::...:::
NP_001 GTASGHRAGL---TSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSE
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB3 EELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEK
:::::::..:::::. .:.. ::.:::.:: ::: ::::::::::::::::..::.::::
NP_001 EELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEK
240 250 260 270 280 290
270 280 290
pF1KB3 ENSALRQEVADLRKELGKCKNILAKYEARHGPL
::. :::::. .:.::.. . .:..:.:.:: :
NP_001 ENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL
300 310 320
>>XP_016881877 (OMIM: 124097) PREDICTED: D site-binding (182 aa)
initn: 663 init1: 663 opt: 676 Z-score: 435.4 bits: 87.9 E(85289): 1.6e-17
Smith-Waterman score: 676; 62.1% identity (87.6% similar) in 153 aa overlap (143-295:30-182)
120 130 140 150 160 170
pF1KB3 LQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVP
: .. : .. ..:.::::.::::..:
XP_016 MPRLGQWWAEGPRGGARGRCPPRVCWRHCCGSARCRSAMWSLTSRDTPSPVDPDTVEVL
10 20 30 40 50
180 190 200 210 220 230
pF1KB3 VGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARR
. .::::::::::::::.: ::::...::::::::::..:::::. .:.. ::.:::.::
XP_016 MTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRR
60 70 80 90 100 110
240 250 260 270 280 290
pF1KB3 RKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARH
::: ::::::::::::::::..::.::::::. :::::. .:.::.. . .:..:.:.:
XP_016 YKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQH
120 130 140 150 160 170
pF1KB3 GPL
: :
XP_016 GAL
180
295 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:01:35 2016 done: Fri Nov 4 21:01:37 2016
Total Scan time: 9.270 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]