FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3630, 193 aa 1>>>pF1KB3630 193 - 193 aa - 193 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5357+/-0.000369; mu= 12.0676+/- 0.023 mean_var=80.6668+/-15.761, 0's: 0 Z-trim(115.8): 394 B-trim: 1207 in 2/52 Lambda= 0.142800 statistics sampled from 26086 (26576) to 26086 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.312), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 1305 278.1 6.3e-75 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 1305 278.1 6.3e-75 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 1305 278.1 6.3e-75 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 1222 261.0 8.8e-70 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 1222 261.0 8.8e-70 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 1114 238.7 4.4e-63 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 936 202.0 4.7e-52 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 806 175.2 5.1e-44 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 726 158.8 5e-39 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 713 156.1 3.2e-38 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 713 156.1 3.2e-38 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 713 156.1 3.2e-38 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 702 153.8 1.6e-37 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 695 152.4 4.2e-37 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 690 151.4 8.6e-37 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 690 151.4 8.6e-37 NP_001300874 (OMIM: 165390) transforming protein R ( 112) 683 149.8 1.5e-36 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 684 150.1 2e-36 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 671 147.5 1.4e-35 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 670 147.3 1.6e-35 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 658 144.8 1e-34 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 658 144.8 1e-34 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 656 144.4 1.3e-34 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 656 144.4 1.3e-34 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 636 140.3 2.1e-33 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 609 134.6 8.3e-32 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 605 133.9 2e-31 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 602 133.2 2.1e-31 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 592 131.2 1e-30 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 590 130.7 1.3e-30 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 550 122.5 3.9e-28 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 546 121.8 8.5e-28 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 541 120.7 1.6e-27 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 522 116.7 2.3e-26 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 522 116.7 2.3e-26 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 522 116.7 2.3e-26 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 522 116.7 2.3e-26 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 522 116.7 2.3e-26 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 437 99.2 3.6e-21 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 378 87.1 2.1e-17 >>NP_001036143 (OMIM: 165380) rho-related GTP-binding pr (193 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1466.2 bits: 278.1 E(85289): 6.3e-75 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL ::::::::::::: NP_001 VRKNKRRRGCPIL 190 >>NP_786886 (OMIM: 165380) rho-related GTP-binding prote (193 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1466.2 bits: 278.1 E(85289): 6.3e-75 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_786 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_786 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_786 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL ::::::::::::: NP_786 VRKNKRRRGCPIL 190 >>NP_001036144 (OMIM: 165380) rho-related GTP-binding pr (193 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1466.2 bits: 278.1 E(85289): 6.3e-75 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL ::::::::::::: NP_001 VRKNKRRRGCPIL 190 >>NP_001655 (OMIM: 165390) transforming protein RhoA iso (193 aa) initn: 1222 init1: 1222 opt: 1222 Z-score: 1373.8 bits: 261.0 E(85289): 8.8e-70 Smith-Waterman score: 1222; 91.7% identity (98.4% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL .:..:.. :: .: NP_001 ARRGKKKSGCLVL 190 >>NP_001300870 (OMIM: 165390) transforming protein RhoA (193 aa) initn: 1222 init1: 1222 opt: 1222 Z-score: 1373.8 bits: 261.0 E(85289): 8.8e-70 Smith-Waterman score: 1222; 91.7% identity (98.4% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL .:..:.. :: .: NP_001 ARRGKKKSGCLVL 190 >>NP_004031 (OMIM: 165370) rho-related GTP-binding prote (196 aa) initn: 1127 init1: 1107 opt: 1114 Z-score: 1253.5 bits: 238.7 E(85289): 4.4e-63 Smith-Waterman score: 1114; 85.8% identity (95.3% similar) in 190 aa overlap (1-190:1-189) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT :::::::::.::::::::::::::::::.:::::::::::::.::::::::::::::::: NP_004 MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::.:::::::::::::.:::::::::::::::.:::: NP_004 AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.:::.: :::.:::::::...:: :: ::.:. ::::::::::::::::: ::::.:: NP_004 LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQ 130 140 150 160 170 180 190 pF1KB3 VRKNKRRRGCPIL : ... :: NP_004 KRYGSQN-GCINCCKVL 190 >>NP_001300872 (OMIM: 165390) transforming protein RhoA (187 aa) initn: 936 init1: 936 opt: 936 Z-score: 1055.6 bits: 202.0 E(85289): 4.7e-52 Smith-Waterman score: 936; 98.6% identity (100.0% similar) in 138 aa overlap (1-138:1-138) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.::::::::::::::: NP_001 LRNDEHTRRELAKMKQEPHCVARLECCGTILAQLQPPPPRFKRFPCLSLLSSWGYRRPLP 130 140 150 160 170 180 >>NP_001300873 (OMIM: 165390) transforming protein RhoA (173 aa) initn: 1084 init1: 806 opt: 806 Z-score: 911.3 bits: 175.2 E(85289): 5.1e-44 Smith-Waterman score: 1040; 81.3% identity (88.1% similar) in 193 aa overlap (1-193:1-173) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::. NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYV----------------- 10 20 30 40 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---EDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 110 120 130 140 150 160 190 pF1KB3 VRKNKRRRGCPIL .:..:.. :: .: NP_001 ARRGKKKSGCLVL 170 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 740 init1: 696 opt: 726 Z-score: 821.6 bits: 158.8 E(85289): 5e-39 Smith-Waterman score: 726; 57.7% identity (76.8% similar) in 194 aa overlap (1-193:1-192) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT : :: : :.::::: ::::::: .. . :: :.::::.:: :.. :::: :.:.:::: NP_008 MQAI--KCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::.:::.:.:::. :: :.::. :: :::.: :::.::::::.: : NP_008 AGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ ::.:. : ..: . : :. .: ::..:.: :::::: :..:.. ::. : :: : NP_008 LRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLC 120 130 140 150 160 170 190 pF1KB3 VRK-NKRRRGCPIL .::.: : .: NP_008 PPPVKKRKRKCLLL 180 190 >>XP_005252973 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 719 init1: 700 opt: 713 Z-score: 807.1 bits: 156.1 E(85289): 3.2e-38 Smith-Waterman score: 713; 56.1% identity (77.0% similar) in 187 aa overlap (7-193:5-191) 10 20 30 40 50 60 pF1KB3 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT : :.::::: ::::::: .. . ::. :.::::.:: :. :::. :.: :::: XP_005 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD ::::.::::: ::::.:.:...:::: :: : ::. .:: ::: : ::.:::.:::.::: XP_005 AGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ :: . : :.: .. : :. ..:. .:..: : :::::: ..::.::: :.:: :. XP_005 LRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN 120 130 140 150 160 170 190 pF1KB3 VRKNKRRRGCPIL :: :.: .: XP_005 PTPIKRGRSCILL 180 190 193 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:15:25 2016 done: Sat Nov 5 05:15:26 2016 Total Scan time: 5.910 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]