FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3655, 561 aa 1>>>pF1KB3655 561 - 561 aa - 561 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1582+/-0.00108; mu= 19.2600+/- 0.065 mean_var=63.4662+/-12.824, 0's: 0 Z-trim(102.7): 34 B-trim: 421 in 1/48 Lambda= 0.160992 statistics sampled from 7057 (7068) to 7057 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.566), E-opt: 0.2 (0.217), width: 16 Scan time: 2.840 The best scores are: opt bits E(32554) CCDS8805.1 SLC11A2 gene_id:4891|Hs108|chr12 ( 561) 3668 861.2 0 CCDS53793.1 SLC11A2 gene_id:4891|Hs108|chr12 ( 590) 3668 861.2 0 CCDS53791.1 SLC11A2 gene_id:4891|Hs108|chr12 ( 557) 3588 842.6 0 CCDS53792.1 SLC11A2 gene_id:4891|Hs108|chr12 ( 568) 3563 836.8 0 CCDS2415.1 SLC11A1 gene_id:6556|Hs108|chr2 ( 550) 2325 549.2 4.6e-156 >>CCDS8805.1 SLC11A2 gene_id:4891|Hs108|chr12 (561 aa) initn: 3668 init1: 3668 opt: 3668 Z-score: 4601.0 bits: 861.2 E(32554): 0 Smith-Waterman score: 3668; 100.0% identity (100.0% similar) in 561 aa overlap (1-561:1-561) 10 20 30 40 50 60 pF1KB3 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC 490 500 510 520 530 540 550 560 pF1KB3 GHTVSISKGLLTEEATRGYVK ::::::::::::::::::::: CCDS88 GHTVSISKGLLTEEATRGYVK 550 560 >>CCDS53793.1 SLC11A2 gene_id:4891|Hs108|chr12 (590 aa) initn: 3668 init1: 3668 opt: 3668 Z-score: 4600.7 bits: 861.2 E(32554): 0 Smith-Waterman score: 3668; 100.0% identity (100.0% similar) in 561 aa overlap (1-561:30-590) 10 20 30 pF1KB3 MVLGPEQKMSDDSVSGDHGESASLGNINPAY ::::::::::::::::::::::::::::::: CCDS53 MRKKQLKTEAAPHCELKSYSKNSATQVSTMVLGPEQKMSDDSVSGDHGESASLGNINPAY 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB3 SNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 SNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB3 SDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 SDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB3 MVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFF 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB3 GFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB3 HSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 HSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVV 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB3 EVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 EVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB3 YSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 YSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB3 FALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVA 490 500 510 520 530 540 520 530 540 550 560 pF1KB3 AVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 AVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK 550 560 570 580 590 >>CCDS53791.1 SLC11A2 gene_id:4891|Hs108|chr12 (557 aa) initn: 3588 init1: 3588 opt: 3588 Z-score: 4500.6 bits: 842.6 E(32554): 0 Smith-Waterman score: 3588; 99.8% identity (100.0% similar) in 550 aa overlap (12-561:8-557) 10 20 30 40 50 60 pF1KB3 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE .:::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MSTVDYLNSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC 480 490 500 510 520 530 550 560 pF1KB3 GHTVSISKGLLTEEATRGYVK ::::::::::::::::::::: CCDS53 GHTVSISKGLLTEEATRGYVK 540 550 >>CCDS53792.1 SLC11A2 gene_id:4891|Hs108|chr12 (568 aa) initn: 3563 init1: 3563 opt: 3563 Z-score: 4469.1 bits: 836.8 E(32554): 0 Smith-Waterman score: 3563; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543) 10 20 30 40 50 60 pF1KB3 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC 490 500 510 520 530 540 550 560 pF1KB3 GHTVSISKGLLTEEATRGYVK ::: CCDS53 GHTCHLGLTAQPELYLLNTMDADSLVSR 550 560 >>CCDS2415.1 SLC11A1 gene_id:6556|Hs108|chr2 (550 aa) initn: 2280 init1: 1437 opt: 2325 Z-score: 2915.3 bits: 549.2 E(32554): 4.6e-156 Smith-Waterman score: 2325; 63.6% identity (84.6% similar) in 547 aa overlap (14-558:1-546) 10 20 30 40 50 pF1KB3 MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEY-FATYFNEKISIPE ..::.: . :. . :.:. ::: .. ::..::: ::. CCDS24 MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPD 10 20 30 40 60 70 80 90 100 110 pF1KB3 EEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQ . . ::.::::::::::::::::.:::::::::::.::::::::::.:: ::..::: : CCDS24 TKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQ 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 RLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGR ::::::::::: :.:::: ::::::..::: .::::.:::::::::.:::.::::.:: CCDS24 RLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 IPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKG :::::::::::.::: :::::.:::::::::::.::::::::::::::...: :. .:.: CCDS24 IPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 MFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIE .:.::: :: :.. ::::::::.:::::.::::::::::...: . ..:::: ::.:: CCDS24 LFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 SCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTS-SPHAGLFPKDNSTLAVDIYK . ::: ::::::.::..::..::. :::. . ..:.:.: .: .:: .:.:.:::::. CCDS24 ATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 GGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSI :::.::: ::::::::::.:.:::::::::::::.::::::::: :.:::::::.:::: CCDS24 GGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSC 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB3 AIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRI ::.::.:::::.:.. :.:.::.::::::: ::::..:::::::. .:..::::: .. CCDS24 AILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKV 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB3 AGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFL . . .....:.::.:::: :. .: : : . .::....::::. :: : : .: : .:: CCDS24 VTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFL 470 480 490 500 510 520 540 550 560 pF1KB3 DCGHTVSISKGLLTEEATRGYVK . . ::: :: .: CCDS24 AHSSHHHFLYGLL-EEDQKGETSG 530 540 550 561 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:17:52 2016 done: Sat Nov 5 05:17:53 2016 Total Scan time: 2.840 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]