FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3659, 312 aa 1>>>pF1KB3659 312 - 312 aa - 312 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9051+/-0.000423; mu= 17.5841+/- 0.026 mean_var=63.7760+/-13.145, 0's: 0 Z-trim(111.2): 265 B-trim: 1552 in 2/47 Lambda= 0.160600 statistics sampled from 19389 (19677) to 19389 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.231), width: 16 Scan time: 6.420 The best scores are: opt bits E(85289) NP_003347 (OMIM: 601665,602044) mitochondrial unco ( 312) 2073 489.2 4.4e-138 NP_073714 (OMIM: 601665,602044) mitochondrial unco ( 275) 1828 432.4 4.9e-121 NP_003346 (OMIM: 601693,607447) mitochondrial unco ( 309) 1476 350.9 1.9e-96 XP_005263263 (OMIM: 113730,601665) PREDICTED: mito ( 306) 1186 283.7 3.2e-76 NP_068605 (OMIM: 113730,601665) mitochondrial brow ( 307) 1182 282.8 6.1e-76 XP_011530530 (OMIM: 113730,601665) PREDICTED: mito ( 277) 1040 249.8 4.5e-66 NP_004268 (OMIM: 613725) mitochondrial uncoupling ( 323) 613 151.0 3.1e-36 NP_001269127 (OMIM: 300242) brain mitochondrial ca ( 290) 605 149.1 1e-35 NP_001269125 (OMIM: 300242) brain mitochondrial ca ( 322) 605 149.1 1.1e-35 NP_001269124 (OMIM: 300242) brain mitochondrial ca ( 325) 605 149.1 1.1e-35 XP_011529704 (OMIM: 300242) PREDICTED: brain mitoc ( 334) 605 149.1 1.1e-35 NP_001010875 (OMIM: 610793) kidney mitochondrial c ( 291) 589 145.4 1.3e-34 XP_016876013 (OMIM: 610793) PREDICTED: kidney mito ( 291) 589 145.4 1.3e-34 NP_003553 (OMIM: 604165) mitochondrial 2-oxoglutar ( 314) 571 141.2 2.6e-33 XP_016885425 (OMIM: 300242) PREDICTED: brain mitoc ( 306) 566 140.1 5.6e-33 XP_016885428 (OMIM: 300242) PREDICTED: brain mitoc ( 338) 566 140.1 6.1e-33 XP_016885427 (OMIM: 300242) PREDICTED: brain mitoc ( 341) 566 140.1 6.1e-33 XP_016885426 (OMIM: 300242) PREDICTED: brain mitoc ( 350) 566 140.1 6.3e-33 NP_001190980 (OMIM: 613725) mitochondrial uncoupli ( 300) 565 139.8 6.5e-33 XP_005249540 (OMIM: 613725) PREDICTED: mitochondri ( 310) 565 139.8 6.7e-33 NP_001273735 (OMIM: 610793) kidney mitochondrial c ( 240) 560 138.6 1.2e-32 XP_005262546 (OMIM: 300242) PREDICTED: brain mitoc ( 224) 539 133.7 3.4e-31 NP_001158889 (OMIM: 604165) mitochondrial 2-oxoglu ( 303) 536 133.1 6.9e-31 XP_011533329 (OMIM: 610793) PREDICTED: kidney mito ( 216) 528 131.1 1.9e-30 NP_001273736 (OMIM: 610793) kidney mitochondrial c ( 216) 528 131.1 1.9e-30 NP_036272 (OMIM: 606794) mitochondrial dicarboxyla ( 287) 519 129.1 1e-29 XP_016879709 (OMIM: 606794) PREDICTED: mitochondri ( 244) 508 126.5 5.2e-29 XP_016885429 (OMIM: 300242) PREDICTED: brain mitoc ( 240) 500 124.7 1.9e-28 NP_001257817 (OMIM: 606794) mitochondrial dicarbox ( 296) 491 122.7 9.3e-28 NP_001158890 (OMIM: 604165) mitochondrial 2-oxoglu ( 263) 466 116.8 4.7e-26 NP_997231 (OMIM: 610817) solute carrier family 25 ( 304) 443 111.6 2.1e-24 XP_016876012 (OMIM: 610793) PREDICTED: kidney mito ( 293) 441 111.1 2.8e-24 XP_005266378 (OMIM: 610793) PREDICTED: kidney mito ( 293) 441 111.1 2.8e-24 XP_006719856 (OMIM: 610793) PREDICTED: kidney mito ( 293) 441 111.1 2.8e-24 XP_006719857 (OMIM: 610793) PREDICTED: kidney mito ( 293) 441 111.1 2.8e-24 XP_005266379 (OMIM: 610793) PREDICTED: kidney mito ( 254) 436 109.9 5.7e-24 XP_016885431 (OMIM: 300242) PREDICTED: brain mitoc ( 197) 426 107.5 2.3e-23 XP_016885430 (OMIM: 300242) PREDICTED: brain mitoc ( 197) 426 107.5 2.3e-23 XP_016885432 (OMIM: 300242) PREDICTED: brain mitoc ( 157) 404 102.3 6.6e-22 XP_016867001 (OMIM: 613725) PREDICTED: mitochondri ( 195) 399 101.2 1.8e-21 NP_001190981 (OMIM: 613725) mitochondrial uncoupli ( 245) 393 99.9 5.5e-21 NP_001307799 (OMIM: 610818) solute carrier family ( 300) 387 98.6 1.7e-20 XP_011533328 (OMIM: 610793) PREDICTED: kidney mito ( 218) 380 96.9 4.1e-20 NP_000378 (OMIM: 212138,613698) mitochondrial carn ( 301) 354 90.9 3.4e-18 XP_011522148 (OMIM: 610818) PREDICTED: solute carr ( 291) 345 88.8 1.4e-17 NP_001269126 (OMIM: 300242) brain mitochondrial ca ( 353) 344 88.7 1.9e-17 XP_016880417 (OMIM: 606521,607196,613710) PREDICTE ( 215) 332 85.7 8.9e-17 XP_011523400 (OMIM: 606521,607196,613710) PREDICTE ( 215) 332 85.7 8.9e-17 XP_011529705 (OMIM: 300242) PREDICTED: brain mitoc ( 205) 330 85.2 1.2e-16 NP_005975 (OMIM: 190315,615182) tricarboxylate tra ( 311) 320 83.1 8.2e-16 >>NP_003347 (OMIM: 601665,602044) mitochondrial uncoupli (312 aa) initn: 2073 init1: 2073 opt: 2073 Z-score: 2599.9 bits: 489.2 E(85289): 4.4e-138 Smith-Waterman score: 2073; 100.0% identity (100.0% similar) in 312 aa overlap (1-312:1-312) 10 20 30 40 50 60 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA 250 260 270 280 290 300 310 pF1KB3 LMKVQMLRESPF :::::::::::: NP_003 LMKVQMLRESPF 310 >>NP_073714 (OMIM: 601665,602044) mitochondrial uncoupli (275 aa) initn: 1828 init1: 1828 opt: 1828 Z-score: 2293.9 bits: 432.4 E(85289): 4.9e-121 Smith-Waterman score: 1828; 100.0% identity (100.0% similar) in 275 aa overlap (1-275:1-275) 10 20 30 40 50 60 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA ::::::::::::::::::::::::::::::::::: NP_073 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 250 260 270 310 pF1KB3 LMKVQMLRESPF >>NP_003346 (OMIM: 601693,607447) mitochondrial uncoupli (309 aa) initn: 1412 init1: 778 opt: 1476 Z-score: 1852.4 bits: 350.9 E(85289): 1.9e-96 Smith-Waterman score: 1476; 72.2% identity (87.5% similar) in 313 aa overlap (1-312:1-309) 10 20 30 40 50 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR :::.: .::::: .:::::::::::.:::.::::::::::::::::.:. :... .::: NP_003 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR ::.:::::::::::: : ::::::::::::::::.:::::::::: :: ::....:. .: NP_003 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW .::: ::::.::. :::::::::::::. . : . :.:..:..::.::::::: :::: NP_003 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD ::: ::. :::::::::.::::..:. :: .:.::..::::.::::::::.::.::::: NP_003 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR ::::::::: ::: : : . :. .::: :::::: :::::::::::::::::::::: NP_003 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 240 250 260 270 280 290 300 310 pF1KB3 ALMKVQMLRESPF ::: . ::.:: NP_003 ALMAACTSREAPF 300 >>XP_005263263 (OMIM: 113730,601665) PREDICTED: mitochon (306 aa) initn: 1113 init1: 662 opt: 1186 Z-score: 1489.4 bits: 283.7 E(85289): 3.2e-76 Smith-Waterman score: 1186; 59.1% identity (82.8% similar) in 303 aa overlap (1-303:1-297) 10 20 30 40 50 60 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG : :: ::: ::..:....:: :::.::..::::::::::::.::: :. ...:.: XP_005 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI ::::: ..:.::: . :.:: ::::::.: ::.::::::.:.. : : .. :: ..: XP_005 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTA-GKETPSLGSKI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK ::: :::..:: .:::.:::::.::. :: . .:.::..::: :: ::. :::: XP_005 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV :: ::.::..:.::.:.::::..:: .. ..:.:. :::.:::. ::::::...::::: XP_005 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA ::::..::::::: : .: .:. ..::::::.::..:::::::::::.::: .::::: XP_005 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRE 240 250 260 270 280 290 310 pF1KB3 LMKVQMLRESPF : : XP_005 LSKSRQTMDCAT 300 >>NP_068605 (OMIM: 113730,601665) mitochondrial brown fa (307 aa) initn: 1257 init1: 662 opt: 1182 Z-score: 1484.3 bits: 282.8 E(85289): 6.1e-76 Smith-Waterman score: 1182; 58.7% identity (81.8% similar) in 303 aa overlap (1-303:1-298) 10 20 30 40 50 60 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG : :: ::: ::..:....:: :::.::..::::::::::::.::: :. ...:.: NP_068 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI ::::: ..:.::: . :.:: ::::::.: ::.::::::.:.. : :: ..: NP_068 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK ::: :::..:: .:::.:::::.::. :: . .:.::..::: :: ::. :::: NP_068 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV :: ::.::..:.::.:.::::..:: .. ..:.:. :::.:::. ::::::...::::: NP_068 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA ::::..::::::: : .: .:. ..::::::.::..:::::::::::.::: .::::: NP_068 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRE 240 250 260 270 280 290 310 pF1KB3 LMKVQMLRESPF : : NP_068 LSKSRQTMDCAT 300 >>XP_011530530 (OMIM: 113730,601665) PREDICTED: mitochon (277 aa) initn: 1044 init1: 528 opt: 1040 Z-score: 1307.2 bits: 249.8 E(85289): 4.5e-66 Smith-Waterman score: 1040; 56.8% identity (80.6% similar) in 278 aa overlap (1-278:1-273) 10 20 30 40 50 60 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG : :: ::: ::..:....:: :::.::..::::::::::::.::: :. ...:.: XP_011 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI ::::: ..:.::: . :.:: ::::::.: ::.::::::.:.. : :: ..: XP_011 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK ::: :::..:: .:::.:::::.::. :: . .:.::..::: :: ::. :::: XP_011 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV :: ::.::..:.::.:.::::..:: .. ..:.:. :::.:::. ::::::...::::: XP_011 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA ::::..::::::: : .: .:. ..::::::.:: : XP_011 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGKIPHIGK 240 250 260 270 310 pF1KB3 LMKVQMLRESPF >>NP_004268 (OMIM: 613725) mitochondrial uncoupling prot (323 aa) initn: 570 init1: 285 opt: 613 Z-score: 771.5 bits: 151.0 E(85289): 3.1e-36 Smith-Waterman score: 613; 35.5% identity (65.2% similar) in 310 aa overlap (14-312:20-323) 10 20 30 40 50 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQT-- : ::: .: :: :.:.::::: .:.:::.::: .. NP_004 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 -ARL-VQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKG :: . :::.. : : ... :: . ..:.. .. :.. ... :. :. ...: :. NP_004 GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS 70 80 90 100 110 120 120 130 140 150 160 pF1KB3 ADNS-SLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTI :. : ...: .:... :.:::.:::..: . . .. :. :. : NP_004 EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB3 AREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGF : :.:::: : .:::.: :.:: ....::: .:. :. : ::. : .:.. .:. NP_004 LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB3 CATVVASPVDVVKTRYMNSPPGQ------YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRL :.....:.::.:.: ::.: . : : ::.:. : :: ..:::: ::.::. NP_004 VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM 250 260 270 280 290 300 290 300 310 pF1KB3 GSWNVVMFVTYEQLKRALMKVQMLRESPF :..:...:::... .: ::: NP_004 TPWSMVFWLTYEKIR------EMSGVSPF 310 320 >>NP_001269127 (OMIM: 300242) brain mitochondrial carrie (290 aa) initn: 667 init1: 235 opt: 605 Z-score: 762.2 bits: 149.1 E(85289): 1e-35 Smith-Waterman score: 676; 38.8% identity (73.2% similar) in 291 aa overlap (17-299:9-287) 10 20 30 40 50 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARL--VQY :. .: :. :.. :::.: .:.:::.:: :... ::. ..: NP_001 MSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQG--QSID-ARFKEIKY 10 20 30 40 60 70 80 90 100 110 pF1KB3 RGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTT ::.. ... . . :: . :.:.. .: :: :...:.::.:.:.:.... . :.. : NP_001 RGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET-LLI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 RILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTM-DAYRTIAREEGVRG .. : ..:... : :.::::.:.:.::. : ..:.: .. : ..::.:: NP_001 NMICGVVSGVISSTIANPTDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 LWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASP ::.:..:. .: ::: .:. .::: :..:. .. :.. ::::.: :. ......: NP_001 LWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 VDVVKTRYMNSPP--GQ---YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFV ::::.::.::. :. : . .: ..:: .:: :.:::: :..:::: ::...:. NP_001 VDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFI 230 240 250 260 270 280 300 310 pF1KB3 TYEQLKRALMKVQMLRESPF ::::::: NP_001 TYEQLKRLQI 290 >>NP_001269125 (OMIM: 300242) brain mitochondrial carrie (322 aa) initn: 667 init1: 235 opt: 605 Z-score: 761.5 bits: 149.1 E(85289): 1.1e-35 Smith-Waterman score: 676; 38.8% identity (73.2% similar) in 291 aa overlap (17-299:41-319) 10 20 30 40 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGE :. .: :. :.. :::.: .:.:::.:: NP_001 FLRVKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQG- 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 NQAVQTARL--VQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQ :... ::. ..:::.. ... . . :: . :.:.. .: :: :...:.::.:.:.:. NP_001 -QSID-ARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKR 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTM- ... . :.. : .. : ..:... : :.::::.:.:.::. : ..:.: NP_001 LFVERLEDET-LLINMICGVVSGVISSTIANPTDVLKIRMQAQGSL--------FQGSMI 130 140 150 160 170 170 180 190 200 210 220 pF1KB3 DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVS .. : ..::.::::.:..:. .: ::: .:. .::: :..:. .. :.. :::: NP_001 GSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVS 180 190 200 210 220 230 230 240 250 260 270 pF1KB3 AFGAGFCATVVASPVDVVKTRYMNSPP--GQ---YFSPLDCMIKMVAQEGPTAFYKGFTP .: :. ......:::::.::.::. :. : . .: ..:: .:: :.:::: : NP_001 SFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWP 240 250 260 270 280 290 280 290 300 310 pF1KB3 SFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF ..:::: ::...:.::::::: NP_001 NWLRLGPWNIIFFITYEQLKRLQI 300 310 320 >>NP_001269124 (OMIM: 300242) brain mitochondrial carrie (325 aa) initn: 667 init1: 235 opt: 605 Z-score: 761.5 bits: 149.1 E(85289): 1.1e-35 Smith-Waterman score: 676; 38.8% identity (73.2% similar) in 291 aa overlap (17-299:44-322) 10 20 30 40 pF1KB3 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGE :. .: :. :.. :::.: .:.:::.:: NP_001 VKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQG- 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB3 NQAVQTARL--VQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQ :... ::. ..:::.. ... . . :: . :.:.. .: :: :...:.::.:.:.:. NP_001 -QSID-ARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKR 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB3 VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTM- ... . :.. : .. : ..:... : :.::::.:.:.::. : ..:.: NP_001 LFVERLEDET-LLINMICGVVSGVISSTIANPTDVLKIRMQAQGSL--------FQGSMI 140 150 160 170 180 170 180 190 200 210 220 pF1KB3 DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVS .. : ..::.::::.:..:. .: ::: .:. .::: :..:. .. :.. :::: NP_001 GSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVS 190 200 210 220 230 240 230 240 250 260 270 pF1KB3 AFGAGFCATVVASPVDVVKTRYMNSPP--GQ---YFSPLDCMIKMVAQEGPTAFYKGFTP .: :. ......:::::.::.::. :. : . .: ..:: .:: :.:::: : NP_001 SFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWP 250 260 270 280 290 300 280 290 300 310 pF1KB3 SFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF ..:::: ::...:.::::::: NP_001 NWLRLGPWNIIFFITYEQLKRLQI 310 320 312 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:18:28 2016 done: Sat Nov 5 05:18:29 2016 Total Scan time: 6.420 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]