Result of FASTA (omim) for
pF1KB3680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3680, 951 aa
1>>>pF1KB3680 951 - 951 aa - 951 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4281+/-0.000449; mu= -12.9102+/- 0.028
mean_var=366.5176+/-75.473, 0's: 0 Z-trim(120.7): 69 B-trim: 333 in 1/57
Lambda= 0.066993
statistics sampled from 36257 (36332) to 36257 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.426), width: 16
Scan time: 13.550
The best scores are: opt bits E(85289)
NP_006687 (OMIM: 602848) bromodomain-containing pr ( 951) 6206 614.7 7.1e-175
XP_005271912 (OMIM: 602848) PREDICTED: bromodomain (1308) 6078 602.4 4.9e-171
XP_005271917 (OMIM: 602848) PREDICTED: bromodomain ( 936) 5984 593.2 2e-168
XP_005271913 (OMIM: 602848) PREDICTED: bromodomain (1293) 5975 592.4 4.8e-168
XP_011541412 (OMIM: 602848) PREDICTED: bromodomain (1175) 5200 517.5 1.6e-145
XP_016864460 (OMIM: 602848) PREDICTED: bromodomain ( 882) 5025 500.5 1.5e-140
XP_016864459 (OMIM: 602848) PREDICTED: bromodomain ( 897) 5025 500.5 1.6e-140
XP_011541411 (OMIM: 602848) PREDICTED: bromodomain (1254) 5025 500.6 2.1e-140
NP_001287891 (OMIM: 602848) bromodomain-containing ( 837) 4314 431.8 7.1e-120
NP_001287890 (OMIM: 602848) bromodomain-containing ( 862) 4314 431.8 7.3e-120
XP_005271918 (OMIM: 602848) PREDICTED: bromodomain ( 878) 4314 431.8 7.4e-120
NP_631938 (OMIM: 602848) bromodomain-containing pr (1235) 4186 419.5 5.2e-116
XP_016864462 (OMIM: 602848) PREDICTED: bromodomain ( 863) 4092 410.3 2.1e-113
XP_016864461 (OMIM: 602848) PREDICTED: bromodomain ( 881) 3592 362.0 7.6e-99
NP_001287895 (OMIM: 602848) bromodomain-containing ( 757) 3587 361.5 9.3e-99
XP_016864465 (OMIM: 602848) PREDICTED: bromodomain ( 808) 3578 360.6 1.8e-98
XP_005271914 (OMIM: 602848) PREDICTED: bromodomain (1238) 3464 349.7 5.3e-95
XP_005271916 (OMIM: 602848) PREDICTED: bromodomain (1165) 3450 348.4 1.3e-94
NP_001157798 (OMIM: 602848) bromodomain-containing ( 866) 3370 340.5 2.1e-92
XP_016864464 (OMIM: 602848) PREDICTED: bromodomain ( 824) 3133 317.6 1.6e-85
XP_016864458 (OMIM: 602848) PREDICTED: bromodomain (1181) 3133 317.7 2.2e-85
XP_016864463 (OMIM: 602848) PREDICTED: bromodomain ( 827) 2411 247.9 1.6e-64
XP_005255181 (OMIM: 180849,600140) PREDICTED: CREB (2427) 314 45.4 0.0041
>>NP_006687 (OMIM: 602848) bromodomain-containing protei (951 aa)
initn: 6206 init1: 6206 opt: 6206 Z-score: 3260.5 bits: 614.7 E(85289): 7.1e-175
Smith-Waterman score: 6206; 99.9% identity (99.9% similar) in 951 aa overlap (1-951:1-951)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_006 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
850 860 870 880 890 900
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
910 920 930 940 950
>>XP_005271912 (OMIM: 602848) PREDICTED: bromodomain-con (1308 aa)
initn: 6078 init1: 6078 opt: 6078 Z-score: 3191.6 bits: 602.4 E(85289): 4.9e-171
Smith-Waterman score: 6078; 99.8% identity (99.8% similar) in 934 aa overlap (1-934:1-934)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
850 860 870 880 890 900
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::::::::::::::::: :
XP_005 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLF
910 920 930 940 950 960
XP_005 SSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLL
970 980 990 1000 1010 1020
>--
initn: 596 init1: 437 opt: 577 Z-score: 318.2 bits: 70.7 E(85289): 5.5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1078-1278)
640 650 660 670 680 690
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
::: :: .... : : .. : :
XP_005 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
1050 1060 1070 1080 1090 1100
700 710 720 730 740 750
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
. : : . :. . .: : ::::: :.:::...:: .: ::.:.:... : .
XP_005 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
1110 1120 1130 1140 1150
760 770 780 790 800 810
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
:.. : .::... :.: . .: . ..::... ::. :.::... ::.::.. ::::
XP_005 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
1160 1170 1180 1190 1200 1210
820 830 840 850 860 870
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_005 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
1220 1230 1240 1250 1260 1270
880 890 900 910 920 930
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
:::::
XP_005 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
1280 1290 1300
>>XP_005271917 (OMIM: 602848) PREDICTED: bromodomain-con (936 aa)
initn: 5983 init1: 5983 opt: 5984 Z-score: 3144.7 bits: 593.2 E(85289): 2e-168
Smith-Waterman score: 6067; 98.3% identity (98.3% similar) in 951 aa overlap (1-951:1-936)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
850 860 870 880 890 900
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::: ::::::::::::::::::
XP_005 KSLRGRDSTRKQDASEKD---------------GGTRGRRCAIEADMKMKK
910 920 930
>>XP_005271913 (OMIM: 602848) PREDICTED: bromodomain-con (1293 aa)
initn: 5975 init1: 5975 opt: 5975 Z-score: 3137.9 bits: 592.4 E(85289): 4.8e-168
Smith-Waterman score: 5975; 99.9% identity (99.9% similar) in 917 aa overlap (1-917:1-917)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
850 860 870 880 890 900
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::
XP_005 KSLRGRDSTRKQDASEKMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGNWR
910 920 930 940 950 960
>--
initn: 596 init1: 437 opt: 577 Z-score: 318.3 bits: 70.7 E(85289): 5.5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1063-1263)
640 650 660 670 680 690
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
::: :: .... : : .. : :
XP_005 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
1040 1050 1060 1070 1080
700 710 720 730 740 750
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
. : : . :. . .: : ::::: :.:::...:: .: ::.:.:... : .
XP_005 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
1090 1100 1110 1120 1130
760 770 780 790 800 810
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
:.. : .::... :.: . .: . ..::... ::. :.::... ::.::.. ::::
XP_005 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
1140 1150 1160 1170 1180 1190
820 830 840 850 860 870
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_005 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
1200 1210 1220 1230 1240 1250
880 890 900 910 920 930
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
:::::
XP_005 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
1260 1270 1280 1290
>>XP_011541412 (OMIM: 602848) PREDICTED: bromodomain-con (1175 aa)
initn: 5200 init1: 5200 opt: 5200 Z-score: 2733.7 bits: 517.5 E(85289): 1.6e-145
Smith-Waterman score: 5200; 99.8% identity (99.8% similar) in 801 aa overlap (134-934:1-801)
110 120 130 140 150 160
pF1KB3 RVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKAT
::::::::::::::::::::::::::::::
XP_011 MDSRLDELCNDIATKKKLEEEEAEVKRKAT
10 20 30
170 180 190 200 210 220
pF1KB3 DAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPST
40 50 60 70 80 90
230 240 250 260 270 280
pF1KB3 PVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPT
100 110 120 130 140 150
290 300 310 320 330 340
pF1KB3 SPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRL
160 170 180 190 200 210
350 360 370 380 390 400
pF1KB3 LEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESV
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB3 APVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDG
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 KEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEEND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEEND
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 DPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKV
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_011 DPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKV
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB3 EPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETP
460 470 480 490 500 510
650 660 670 680 690 700
pF1KB3 LTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGED
520 530 540 550 560 570
710 720 730 740 750 760
pF1KB3 EEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSS
580 590 600 610 620 630
770 780 790 800 810 820
pF1KB3 PASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQR
640 650 660 670 680 690
830 840 850 860 870 880
pF1KB3 PMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQ
700 710 720 730 740 750
890 900 910 920 930 940
pF1KB3 FLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAI
::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_011 FLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSE
760 770 780 790 800 810
950
pF1KB3 EADMKMKK
XP_011 QDHPNDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGG
820 830 840 850 860 870
>--
initn: 596 init1: 437 opt: 577 Z-score: 318.9 bits: 70.7 E(85289): 5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:945-1145)
640 650 660 670 680 690
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
::: :: .... : : .. : :
XP_011 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
920 930 940 950 960
700 710 720 730 740 750
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
. : : . :. . .: : ::::: :.:::...:: .: ::.:.:... : .
XP_011 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
970 980 990 1000 1010 1020
760 770 780 790 800 810
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
:.. : .::... :.: . .: . ..::... ::. :.::... ::.::.. ::::
XP_011 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
1030 1040 1050 1060 1070 1080
820 830 840 850 860 870
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_011 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
1090 1100 1110 1120 1130 1140
880 890 900 910 920 930
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
:::::
XP_011 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
1150 1160 1170
>>XP_016864460 (OMIM: 602848) PREDICTED: bromodomain-con (882 aa)
initn: 5127 init1: 5009 opt: 5025 Z-score: 2644.1 bits: 500.5 E(85289): 1.5e-140
Smith-Waterman score: 5576; 92.5% identity (92.6% similar) in 951 aa overlap (1-951:1-882)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
730 740 750 760
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
:::::::::::::::::
XP_016 -------------------------------------------PMDLSTIKKNIENGLIR
770 780
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
790 800 810 820 830 840
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::: ::::::::::::::::::
XP_016 KSLRGRDSTRKQDASEKD---------------GGTRGRRCAIEADMKMKK
850 860 870 880
>>XP_016864459 (OMIM: 602848) PREDICTED: bromodomain-con (897 aa)
initn: 5009 init1: 5009 opt: 5025 Z-score: 2644.0 bits: 500.5 E(85289): 1.6e-140
Smith-Waterman score: 5715; 94.1% identity (94.2% similar) in 951 aa overlap (1-951:1-897)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
730 740 750 760
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
:::::::::::::::::
XP_016 -------------------------------------------PMDLSTIKKNIENGLIR
770 780
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
790 800 810 820 830 840
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
850 860 870 880 890
>>XP_011541411 (OMIM: 602848) PREDICTED: bromodomain-con (1254 aa)
initn: 5691 init1: 5009 opt: 5025 Z-score: 2641.8 bits: 500.6 E(85289): 2.1e-140
Smith-Waterman score: 5587; 93.9% identity (94.0% similar) in 934 aa overlap (1-934:1-880)
10 20 30 40 50 60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
730 740 750 760
790 800 810 820 830 840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
:::::::::::::::::
XP_011 -------------------------------------------PMDLSTIKKNIENGLIR
770 780
850 860 870 880 890 900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
790 800 810 820 830 840
910 920 930 940 950
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
:::::::::::::::::::::::::::::::: :
XP_011 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLF
850 860 870 880 890 900
XP_011 SSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLL
910 920 930 940 950 960
>--
initn: 596 init1: 437 opt: 577 Z-score: 318.5 bits: 70.7 E(85289): 5.3e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1024-1224)
640 650 660 670 680 690
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
::: :: .... : : .. : :
XP_011 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
1000 1010 1020 1030 1040
700 710 720 730 740 750
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
. : : . :. . .: : ::::: :.:::...:: .: ::.:.:... : .
XP_011 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
1050 1060 1070 1080 1090 1100
760 770 780 790 800 810
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
:.. : .::... :.: . .: . ..::... ::. :.::... ::.::.. ::::
XP_011 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
1110 1120 1130 1140 1150
820 830 840 850 860 870
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_011 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
1160 1170 1180 1190 1200 1210
880 890 900 910 920 930
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
:::::
XP_011 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
1220 1230 1240 1250
>>NP_001287891 (OMIM: 602848) bromodomain-containing pro (837 aa)
initn: 4309 init1: 4309 opt: 4314 Z-score: 2273.1 bits: 431.8 E(85289): 7.1e-120
Smith-Waterman score: 5136; 91.4% identity (91.5% similar) in 894 aa overlap (58-951:17-837)
30 40 50 60 70 80
pF1KB3 ASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGE
: :. :::::::::::::::::::::::::
NP_001 MVHPREAMFSIFCHEKWRSKLHCASQYSELLETTETPKRKRGEKGE
10 20 30 40
90 100 110 120 130 140
pF1KB3 VVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB3 KKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTT
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB3 MEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPP
::::::::
NP_001 MEEATSGV----------------------------------------------------
170
270 280 290 300 310 320
pF1KB3 SPLLSELLKKGSLLPTSPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNT
:::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------NESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNT
180 190 200 210
330 340 350 360 370 380
pF1KB3 VAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPA
220 230 240 250 260 270
390 400 410 420 430 440
pF1KB3 LPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRS
280 290 300 310 320 330
450 460 470 480 490 500
pF1KB3 GVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVL
340 350 360 370 380 390
510 520 530 540 550 560
pF1KB3 DVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEEMENKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 DVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKG
400 410 420 430 440 450
570 580 590 600 610 620
pF1KB3 IHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAG
460 470 480 490 500 510
630 640 650 660 670 680
pF1KB3 EIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEE
520 530 540 550 560 570
690 700 710 720 730 740
pF1KB3 SGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIH
580 590 600 610 620 630
750 760 770 780 790 800
pF1KB3 NATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQ
640 650 660 670 680 690
810 820 830 840 850 860
pF1KB3 PVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVY
700 710 720 730 740 750
870 880 890 900 910 920
pF1KB3 HMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAF
760 770 780 790 800 810
930 940 950
pF1KB3 LLSLFDGGTRGRRCAIEADMKMKK
::::::::::::::::::::::::
NP_001 LLSLFDGGTRGRRCAIEADMKMKK
820 830
>>NP_001287890 (OMIM: 602848) bromodomain-containing pro (862 aa)
initn: 4309 init1: 4309 opt: 4314 Z-score: 2272.9 bits: 431.8 E(85289): 7.3e-120
Smith-Waterman score: 5286; 91.9% identity (91.9% similar) in 912 aa overlap (40-951:24-862)
10 20 30 40 50 60
pF1KB3 LLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYS
::::::::::::::::::::::::::::::
NP_001 MVHPREAMFSIFCHEKWRSKLVRVSVSRAIKPFAEPGRPPDWFSQKHCASQYS
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 ELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 QAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 DSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPV
::::::::::::::::::::::::::
NP_001 DSASPGGDYPLGDLTPTTMEEATSGV----------------------------------
180 190
250 260 270 280 290 300
pF1KB3 TDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHLNSTGVLLEV
:::::::::::::::::::::
NP_001 ---------------------------------------NESEMAVASGHLNSTGVLLEV
200 210 220
310 320 330 340 350 360
pF1KB3 GGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKL
230 240 250 260 270 280
370 380 390 400 410 420
pF1KB3 VPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMD
290 300 310 320 330 340
430 440 450 460 470 480
pF1KB3 SSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETV
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB3 GDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAP
410 420 430 440 450 460
550 560 570 580 590 600
pF1KB3 EMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEP
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEP
470 480 490 500 510 520
610 620 630 640 650 660
pF1KB3 PELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDP
530 540 550 560 570 580
670 680 690 700 710 720
pF1KB3 LEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLS
590 600 610 620 630 640
730 740 750 760 770 780
pF1KB3 EMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAI
650 660 670 680 690 700
790 800 810 820 830 840
pF1KB3 MLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDI
710 720 730 740 750 760
850 860 870 880 890 900
pF1KB3 MLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDST
770 780 790 800 810 820
910 920 930 940 950
pF1KB3 RKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
830 840 850 860
951 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:37:19 2016 done: Thu Nov 3 13:37:21 2016
Total Scan time: 13.550 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]