FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3698, 375 aa 1>>>pF1KB3698 375 - 375 aa - 375 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3828+/-0.0004; mu= 16.9271+/- 0.025 mean_var=122.2634+/-33.739, 0's: 0 Z-trim(112.5): 521 B-trim: 1106 in 1/53 Lambda= 0.115991 statistics sampled from 20760 (21445) to 20760 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.251), width: 16 Scan time: 6.920 The best scores are: opt bits E(85289) NP_001091671 (OMIM: 601805) G-protein coupled estr ( 375) 2492 428.8 1e-119 NP_001035055 (OMIM: 601805) G-protein coupled estr ( 375) 2492 428.8 1e-119 NP_001496 (OMIM: 601805) G-protein coupled estroge ( 375) 2492 428.8 1e-119 NP_000625 (OMIM: 146929,609423) C-X-C chemokine re ( 350) 488 93.4 8.7e-19 NP_001328 (OMIM: 601470,607339,609423,613784) CX3C ( 355) 476 91.4 3.5e-18 NP_005192 (OMIM: 601834) C-C chemokine receptor ty ( 355) 476 91.4 3.5e-18 NP_001164642 (OMIM: 601470,607339,609423,613784) C ( 355) 476 91.4 3.5e-18 NP_001164643 (OMIM: 601470,607339,609423,613784) C ( 355) 476 91.4 3.5e-18 NP_001164645 (OMIM: 601470,607339,609423,613784) C ( 387) 476 91.4 3.7e-18 NP_001295397 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_065110 (OMIM: 605666) cysteinyl leukotriene rec ( 346) 465 89.5 1.2e-17 NP_001295398 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001295399 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001295405 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001295394 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001295400 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001295396 (OMIM: 605666) cysteinyl leukotriene ( 346) 465 89.5 1.2e-17 NP_001548 (OMIM: 146928) C-X-C chemokine receptor ( 360) 464 89.4 1.4e-17 XP_016859480 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 464 89.4 1.4e-17 XP_016859479 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 464 89.4 1.4e-17 XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 464 89.4 1.4e-17 XP_005246587 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 464 89.4 1.4e-17 NP_001161770 (OMIM: 146928) C-X-C chemokine recept ( 360) 464 89.4 1.4e-17 NP_005499 (OMIM: 604836) C-C chemokine receptor ty ( 360) 438 85.0 2.9e-16 XP_016861176 (OMIM: 604836) PREDICTED: C-C chemoki ( 360) 438 85.0 2.9e-16 XP_011532371 (OMIM: 601267) PREDICTED: C-C chemoki ( 360) 430 83.7 7.4e-16 NP_001116868 (OMIM: 601267) C-C chemokine receptor ( 360) 430 83.7 7.4e-16 NP_001286 (OMIM: 601159) C-C chemokine receptor ty ( 355) 423 82.5 1.6e-15 NP_113597 (OMIM: 601835) C-C chemokine receptor ty ( 374) 419 81.9 2.7e-15 NP_004358 (OMIM: 601835) C-C chemokine receptor ty ( 374) 419 81.9 2.7e-15 NP_001116513 (OMIM: 601267) C-C chemokine receptor ( 374) 414 81.0 4.8e-15 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 413 80.9 5.3e-15 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 413 80.9 5.3e-15 NP_001495 (OMIM: 300574) C-X-C chemokine receptor ( 368) 412 80.7 6e-15 XP_005262313 (OMIM: 300574) PREDICTED: C-X-C chemo ( 378) 412 80.7 6.1e-15 XP_016884924 (OMIM: 300574) PREDICTED: C-X-C chemo ( 415) 412 80.8 6.5e-15 NP_001136269 (OMIM: 300574) C-X-C chemokine recept ( 415) 412 80.8 6.5e-15 NP_001158152 (OMIM: 601268) C-C chemokine receptor ( 373) 411 80.5 6.8e-15 NP_847898 (OMIM: 601268) C-C chemokine receptor ty ( 376) 409 80.2 8.7e-15 XP_016861174 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 409 80.2 9.2e-15 XP_016861175 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 409 80.2 9.2e-15 NP_057641 (OMIM: 606065) atypical chemokine recept ( 350) 408 80.0 9.3e-15 NP_848540 (OMIM: 606065) atypical chemokine recept ( 350) 408 80.0 9.3e-15 NP_003458 (OMIM: 162643,193670) C-X-C chemokine re ( 352) 404 79.3 1.5e-14 XP_011531637 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 404 79.3 1.5e-14 XP_006713023 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 404 79.3 1.5e-14 NP_847899 (OMIM: 601268) C-C chemokine receptor ty ( 355) 404 79.3 1.5e-14 NP_001828 (OMIM: 601268) C-C chemokine receptor ty ( 355) 404 79.3 1.5e-14 NP_001008540 (OMIM: 162643,193670) C-X-C chemokine ( 356) 404 79.3 1.5e-14 NP_001154888 (OMIM: 603071) uracil nucleotide/cyst ( 339) 401 78.8 2.1e-14 >>NP_001091671 (OMIM: 601805) G-protein coupled estrogen (375 aa) initn: 2492 init1: 2492 opt: 2492 Z-score: 2270.3 bits: 428.8 E(85289): 1e-119 Smith-Waterman score: 2492; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB3 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI 310 320 330 340 350 360 370 pF1KB3 PDSTEQSDVRFSSAV ::::::::::::::: NP_001 PDSTEQSDVRFSSAV 370 >>NP_001035055 (OMIM: 601805) G-protein coupled estrogen (375 aa) initn: 2492 init1: 2492 opt: 2492 Z-score: 2270.3 bits: 428.8 E(85289): 1e-119 Smith-Waterman score: 2492; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB3 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI 310 320 330 340 350 360 370 pF1KB3 PDSTEQSDVRFSSAV ::::::::::::::: NP_001 PDSTEQSDVRFSSAV 370 >>NP_001496 (OMIM: 601805) G-protein coupled estrogen re (375 aa) initn: 2492 init1: 2492 opt: 2492 Z-score: 2270.3 bits: 428.8 E(85289): 1e-119 Smith-Waterman score: 2492; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB3 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVI 310 320 330 340 350 360 370 pF1KB3 PDSTEQSDVRFSSAV ::::::::::::::: NP_001 PDSTEQSDVRFSSAV 370 >>NP_000625 (OMIM: 146929,609423) C-X-C chemokine recept (350 aa) initn: 448 init1: 166 opt: 488 Z-score: 458.3 bits: 93.4 E(85289): 8.7e-19 Smith-Waterman score: 488; 31.6% identity (65.8% similar) in 275 aa overlap (68-332:48-313) 40 50 60 70 80 90 pF1KB3 LGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLY ..: ....:: :...: . : .. :.: NP_000 TGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVY 20 30 40 50 60 70 100 110 120 130 140 150 pF1KB3 FINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYI ..:::.:::... : . . . . . :: .::. .::.::....:. .: :::. NP_000 LLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYL 80 90 100 110 120 130 160 170 180 190 200 210 pF1KB3 ALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPF----TAVHLQHTDEACFCFADVRE :...: : .: . .: ... : : :.. .: :: : : .... .:. NP_000 AIVHATR-TLTQKRHLVKFVCLGCWGLSMNLSL-PFFLFRQAYHPNNSSPVCYEVLGNDT 140 150 160 170 180 190 220 230 240 250 260 pF1KB3 VQWLEV------TLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLV ..: : :.:::::. .. .::.. .:.: .:: . ...:.:.:.::::. NP_000 AKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQ-----KHRAMRVIFAVVLI 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB3 FFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFL :..:::: :. . . :.::: :.. .. : . ... .: .:::::.::.:. NP_000 FLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDA--TEILGFLHSCLNPIIYAFI 260 270 280 290 300 330 340 350 360 370 pF1KB3 GETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV :..:: NP_000 GQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 310 320 330 340 350 >>NP_001328 (OMIM: 601470,607339,609423,613784) CX3C che (355 aa) initn: 383 init1: 244 opt: 476 Z-score: 447.4 bits: 91.4 E(85289): 3.5e-18 Smith-Waterman score: 476; 33.4% identity (64.2% similar) in 296 aa overlap (56-338:28-308) 30 40 50 60 70 80 pF1KB3 TTSPELNLSHPLLGTALANGTGELSEHQQYVIG-LFLSCLYTIFLFPIGFVGNILILVVN :.: .::: .:.. .: ::.:::.:.. . NP_001 MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSV-IFAIGLVGNLLVVFAL 10 20 30 40 50 90 100 110 120 130 140 pF1KB3 ISFREKMTIPDLYFINLAVADLILVAD-SLIEVFNLHERYYDIAVLCTFMSLFLQVNMYS . .. .. :.:..:::..::..:: . . ..:. : .: : . :. ..... NP_001 TNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNA-MCKFTTAFFFIGFFG 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB3 SVFFLTWMSFDRYIALARAMRCSLFRT-KHHARLSCGLIWMASVSATLVPFTAVHLQHTD :.::.: .:.:::.:.. : :: .: . .: : .: :.. .. : .. :. . NP_001 SIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLG-VWAAAILVAAPQFMFTK-QKEN 120 130 140 150 160 170 210 220 230 240 250 pF1KB3 EACFCFADVREVQ---W-----LEVT-LGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPR : :..: :: : .:.. :::..:. :.. :: :...: . :. NP_001 E---CLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHK----- 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 RQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAA . ::...:: ::.:::. : : ::.: .. : . : ..:. :. ... .: NP_001 KAKAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSC--DMRKDLRLALSVTETVA 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB3 FSNSCLNPLIYSFLGETFRDKL-RLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFS ::. :::::::.: :: :: : .:: NP_001 FSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNF 290 300 310 320 330 340 >>NP_005192 (OMIM: 601834) C-C chemokine receptor type 8 (355 aa) initn: 308 init1: 308 opt: 476 Z-score: 447.4 bits: 91.4 E(85289): 3.5e-18 Smith-Waterman score: 476; 29.4% identity (63.4% similar) in 303 aa overlap (59-349:36-324) 30 40 50 60 70 80 pF1KB3 PELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFR :.:. .: . :: ....:: :...: . . NP_005 DLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCL-LFVFSLLGNSLVILVLVVCK 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB3 EKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFL . .: :.:..:::..::..: . .... : ... .:.: .: : ...:::.::. NP_005 KLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB3 TWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEA---C : :: :::.:...:. :: . . : .:.... :: .:. . . .... : NP_005 TLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMAT-IPLLVFYQVASEDGVLQC 130 140 150 160 170 180 210 220 230 240 250 pF1KB3 FCFADVREVQWLEVT------LGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALR . : . . ..: : ::...::.:. .:: :.. : : . : . ::.: NP_005 YSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHN-----KTKAIR 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 MILAVVLVFFVCWLPENVFI---SVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSN ..: ::.. .. :.: :: . :.: .. : : :. . . :.... .:.. NP_005 LVLIVVIASLLFWVPFNVVLFLTSLHSMH-ILDG---C--SISQQLTYATHVTEIISFTH 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV :.::.::.:.:: :. .: : ::. .: NP_005 CCVNPVIYAFVGEKFKKHLS-EIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSV 300 310 320 330 340 350 NP_005 DYIL >>NP_001164642 (OMIM: 601470,607339,609423,613784) CX3C (355 aa) initn: 383 init1: 244 opt: 476 Z-score: 447.4 bits: 91.4 E(85289): 3.5e-18 Smith-Waterman score: 476; 33.4% identity (64.2% similar) in 296 aa overlap (56-338:28-308) 30 40 50 60 70 80 pF1KB3 TTSPELNLSHPLLGTALANGTGELSEHQQYVIG-LFLSCLYTIFLFPIGFVGNILILVVN :.: .::: .:.. .: ::.:::.:.. . NP_001 MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSV-IFAIGLVGNLLVVFAL 10 20 30 40 50 90 100 110 120 130 140 pF1KB3 ISFREKMTIPDLYFINLAVADLILVAD-SLIEVFNLHERYYDIAVLCTFMSLFLQVNMYS . .. .. :.:..:::..::..:: . . ..:. : .: : . :. ..... NP_001 TNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNA-MCKFTTAFFFIGFFG 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB3 SVFFLTWMSFDRYIALARAMRCSLFRT-KHHARLSCGLIWMASVSATLVPFTAVHLQHTD :.::.: .:.:::.:.. : :: .: . .: : .: :.. .. : .. :. . NP_001 SIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLG-VWAAAILVAAPQFMFTK-QKEN 120 130 140 150 160 170 210 220 230 240 250 pF1KB3 EACFCFADVREVQ---W-----LEVT-LGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPR : :..: :: : .:.. :::..:. :.. :: :...: . :. NP_001 E---CLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHK----- 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 RQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAA . ::...:: ::.:::. : : ::.: .. : . : ..:. :. ... .: NP_001 KAKAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSC--DMRKDLRLALSVTETVA 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB3 FSNSCLNPLIYSFLGETFRDKL-RLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFS ::. :::::::.: :: :: : .:: NP_001 FSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNF 290 300 310 320 330 340 >>NP_001164643 (OMIM: 601470,607339,609423,613784) CX3C (355 aa) initn: 383 init1: 244 opt: 476 Z-score: 447.4 bits: 91.4 E(85289): 3.5e-18 Smith-Waterman score: 476; 33.4% identity (64.2% similar) in 296 aa overlap (56-338:28-308) 30 40 50 60 70 80 pF1KB3 TTSPELNLSHPLLGTALANGTGELSEHQQYVIG-LFLSCLYTIFLFPIGFVGNILILVVN :.: .::: .:.. .: ::.:::.:.. . NP_001 MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSV-IFAIGLVGNLLVVFAL 10 20 30 40 50 90 100 110 120 130 140 pF1KB3 ISFREKMTIPDLYFINLAVADLILVAD-SLIEVFNLHERYYDIAVLCTFMSLFLQVNMYS . .. .. :.:..:::..::..:: . . ..:. : .: : . :. ..... NP_001 TNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNA-MCKFTTAFFFIGFFG 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB3 SVFFLTWMSFDRYIALARAMRCSLFRT-KHHARLSCGLIWMASVSATLVPFTAVHLQHTD :.::.: .:.:::.:.. : :: .: . .: : .: :.. .. : .. :. . NP_001 SIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLG-VWAAAILVAAPQFMFTK-QKEN 120 130 140 150 160 170 210 220 230 240 250 pF1KB3 EACFCFADVREVQ---W-----LEVT-LGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPR : :..: :: : .:.. :::..:. :.. :: :...: . :. NP_001 E---CLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHK----- 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 RQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAA . ::...:: ::.:::. : : ::.: .. : . : ..:. :. ... .: NP_001 KAKAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSC--DMRKDLRLALSVTETVA 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB3 FSNSCLNPLIYSFLGETFRDKL-RLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFS ::. :::::::.: :: :: : .:: NP_001 FSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNF 290 300 310 320 330 340 >>NP_001164645 (OMIM: 601470,607339,609423,613784) CX3C (387 aa) initn: 383 init1: 244 opt: 476 Z-score: 446.9 bits: 91.4 E(85289): 3.7e-18 Smith-Waterman score: 476; 33.4% identity (64.2% similar) in 296 aa overlap (56-338:60-340) 30 40 50 60 70 80 pF1KB3 TTSPELNLSHPLLGTALANGTGELSEHQQYVIG-LFLSCLYTIFLFPIGFVGNILILVVN :.: .::: .:.. .: ::.:::.:.. . NP_001 AFTMDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSV-IFAIGLVGNLLVVFAL 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB3 ISFREKMTIPDLYFINLAVADLILVAD-SLIEVFNLHERYYDIAVLCTFMSLFLQVNMYS . .. .. :.:..:::..::..:: . . ..:. : .: : . :. ..... NP_001 TNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNA-MCKFTTAFFFIGFFG 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB3 SVFFLTWMSFDRYIALARAMRCSLFRT-KHHARLSCGLIWMASVSATLVPFTAVHLQHTD :.::.: .:.:::.:.. : :: .: . .: : .: :.. .. : .. :. . NP_001 SIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLG-VWAAAILVAAPQFMFTK-QKEN 150 160 170 180 190 200 210 220 230 240 250 pF1KB3 EACFCFADVREVQ---W-----LEVT-LGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPR : :..: :: : .:.. :::..:. :.. :: :...: . :. NP_001 E---CLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHK----- 210 220 230 240 250 260 270 280 290 300 310 pF1KB3 RQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAA . ::...:: ::.:::. : : ::.: .. : . : ..:. :. ... .: NP_001 KAKAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSC--DMRKDLRLALSVTETVA 260 270 280 290 300 310 320 330 340 350 360 370 pF1KB3 FSNSCLNPLIYSFLGETFRDKL-RLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFS ::. :::::::.: :: :: : .:: NP_001 FSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNF 320 330 340 350 360 370 >>NP_001295397 (OMIM: 605666) cysteinyl leukotriene rece (346 aa) initn: 377 init1: 151 opt: 465 Z-score: 437.5 bits: 89.5 E(85289): 1.2e-17 Smith-Waterman score: 465; 31.1% identity (66.4% similar) in 289 aa overlap (60-336:40-317) 30 40 50 60 70 80 pF1KB3 ELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFRE :. .: :..: : .:: : . : .. . NP_001 PSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFF-WGVLGNGLSIYVFLQPYK 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB3 KMTIPDLYFINLAVADLILVADSLIEVFNLHER-----YYDIAVLCTFMSLFLQVNMYSS : : .....:::..::.... .: . . : . :.: : .:: : :::::: NP_001 KSTSVNVFMLNLAISDLLFIS-TLPFRADYYLRGSNWIFGDLA--CRIMSYSLYVNMYSS 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB3 VFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTD-E ..::: .: :..:... .: . . : . ::.::. ...... . . :. . NP_001 IYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVT 130 140 150 160 170 180 210 220 230 240 250 pF1KB3 AC-----FCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHR-HRGLRPRRQKA .: . .: .. .... ...: ..:: ...:: ::.:::.... . ::: ..:: NP_001 SCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKA 190 200 210 220 230 240 260 270 280 290 300 310 pF1KB3 LRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNS : :. ....::.:.:: ... .::: : .. ::. ...: .: . ::: .:. NP_001 LTTIIITLIIFFLCFLPYHTLRTVHL---TTWKVGLCKDRLHKALVIT---LALAA-ANA 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 CLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV :.:::.: : ::.:.:.:. NP_001 CFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV 300 310 320 330 340 375 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:08:55 2016 done: Thu Nov 3 21:08:56 2016 Total Scan time: 6.920 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]