Result of FASTA (omim) for
pF1KB3700
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3700, 640 aa
1>>>pF1KB3700 640 - 640 aa - 640 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3361+/-0.000417; mu= 18.9540+/- 0.026
mean_var=67.9240+/-13.807, 0's: 0 Z-trim(111.8): 75 B-trim: 1087 in 2/51
Lambda= 0.155619
statistics sampled from 20420 (20506) to 20420 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.24), width: 16
Scan time: 10.110
The best scores are: opt bits E(85289)
NP_004046 (OMIM: 193235,602537) calpain-5 [Homo sa ( 640) 4451 1008.8 0
XP_016873712 (OMIM: 193235,602537) PREDICTED: calp ( 676) 4451 1008.8 0
XP_011543527 (OMIM: 193235,602537) PREDICTED: calp ( 680) 4451 1008.8 0
NP_055104 (OMIM: 300146) calpain-6 [Homo sapiens] ( 641) 2066 473.4 1.1e-132
NP_775110 (OMIM: 114240,253600) calpain-3 isoform ( 729) 895 210.5 1.7e-53
XP_006715050 (OMIM: 604822) PREDICTED: calpain-11 ( 650) 825 194.8 8.3e-49
XP_006715048 (OMIM: 604822) PREDICTED: calpain-11 ( 724) 825 194.8 9.1e-49
NP_008989 (OMIM: 604822) calpain-11 [Homo sapiens] ( 739) 825 194.8 9.3e-49
XP_006715047 (OMIM: 604822) PREDICTED: calpain-11 ( 740) 825 194.8 9.3e-49
XP_011512577 (OMIM: 604822) PREDICTED: calpain-11 ( 743) 825 194.8 9.3e-49
XP_011512576 (OMIM: 604822) PREDICTED: calpain-11 ( 744) 825 194.8 9.3e-49
NP_005177 (OMIM: 114220,616907) calpain-1 catalyti ( 714) 823 194.3 1.2e-48
XP_011543594 (OMIM: 114220,616907) PREDICTED: calp ( 714) 823 194.3 1.2e-48
XP_006718761 (OMIM: 114220,616907) PREDICTED: calp ( 714) 823 194.3 1.2e-48
NP_001185797 (OMIM: 114220,616907) calpain-1 catal ( 714) 823 194.3 1.2e-48
NP_001185798 (OMIM: 114220,616907) calpain-1 catal ( 714) 823 194.3 1.2e-48
NP_001739 (OMIM: 114230) calpain-2 catalytic subun ( 700) 788 186.5 2.8e-46
NP_006606 (OMIM: 606401) calpain-9 isoform 1 [Homo ( 690) 746 177.0 1.9e-43
XP_011542319 (OMIM: 606401) PREDICTED: calpain-9 i ( 721) 746 177.1 2e-43
NP_057536 (OMIM: 606401) calpain-9 isoform 2 [Homo ( 664) 738 175.2 6.4e-43
XP_011542320 (OMIM: 606401) PREDICTED: calpain-9 i ( 695) 738 175.2 6.7e-43
XP_011542588 (OMIM: 114230) PREDICTED: calpain-2 c ( 447) 730 173.3 1.6e-42
NP_077320 (OMIM: 114240,253600) calpain-3 isoform ( 815) 692 165.0 9.8e-40
NP_000061 (OMIM: 114240,253600) calpain-3 isoform ( 821) 692 165.0 9.9e-40
NP_001139540 (OMIM: 114230) calpain-2 catalytic su ( 622) 659 157.5 1.3e-37
XP_016855587 (OMIM: 606401) PREDICTED: calpain-9 i ( 693) 639 153.0 3.3e-36
XP_016855588 (OMIM: 606401) PREDICTED: calpain-9 i ( 495) 634 151.8 5.4e-36
XP_011542322 (OMIM: 606401) PREDICTED: calpain-9 i ( 526) 634 151.8 5.7e-36
XP_016881854 (OMIM: 608839) PREDICTED: calpain-12 ( 503) 601 144.4 9.3e-34
XP_016881852 (OMIM: 608839) PREDICTED: calpain-12 ( 565) 601 144.4 1e-33
XP_016881851 (OMIM: 608839) PREDICTED: calpain-12 ( 590) 601 144.4 1.1e-33
XP_016881850 (OMIM: 608839) PREDICTED: calpain-12 ( 604) 601 144.5 1.1e-33
XP_016881849 (OMIM: 608839) PREDICTED: calpain-12 ( 652) 601 144.5 1.2e-33
XP_016881848 (OMIM: 608839) PREDICTED: calpain-12 ( 676) 601 144.5 1.2e-33
XP_016881847 (OMIM: 608839) PREDICTED: calpain-12 ( 698) 601 144.5 1.2e-33
XP_016881846 (OMIM: 608839) PREDICTED: calpain-12 ( 699) 601 144.5 1.2e-33
XP_016881845 (OMIM: 608839) PREDICTED: calpain-12 ( 702) 601 144.5 1.2e-33
NP_653292 (OMIM: 608839) calpain-12 [Homo sapiens] ( 719) 601 144.5 1.2e-33
XP_016881844 (OMIM: 608839) PREDICTED: calpain-12 ( 723) 601 144.5 1.3e-33
XP_011531167 (OMIM: 610229) PREDICTED: calpain-14 ( 684) 538 130.3 2.2e-29
XP_011531166 (OMIM: 610229) PREDICTED: calpain-14 ( 684) 538 130.3 2.2e-29
XP_011531165 (OMIM: 610229) PREDICTED: calpain-14 ( 684) 538 130.3 2.2e-29
NP_001138594 (OMIM: 610229) calpain-14 isoform 1 [ ( 684) 538 130.3 2.2e-29
XP_011531465 (OMIM: 610228) PREDICTED: calpain-13 ( 433) 520 126.2 2.4e-28
XP_016860755 (OMIM: 610228) PREDICTED: calpain-13 ( 665) 520 126.3 3.5e-28
XP_016860754 (OMIM: 610228) PREDICTED: calpain-13 ( 669) 520 126.3 3.5e-28
XP_011531462 (OMIM: 610228) PREDICTED: calpain-13 ( 669) 520 126.3 3.5e-28
NP_653176 (OMIM: 610228) calpain-13 [Homo sapiens] ( 669) 520 126.3 3.5e-28
XP_011531463 (OMIM: 610228) PREDICTED: calpain-13 ( 669) 520 126.3 3.5e-28
XP_016860753 (OMIM: 610228) PREDICTED: calpain-13 ( 669) 520 126.3 3.5e-28
>>NP_004046 (OMIM: 193235,602537) calpain-5 [Homo sapien (640 aa)
initn: 4451 init1: 4451 opt: 4451 Z-score: 5396.9 bits: 1008.8 E(85289): 0
Smith-Waterman score: 4451; 99.8% identity (100.0% similar) in 640 aa overlap (1-640:1-640)
10 20 30 40 50 60
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 FHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 NTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NLAIGFDIYKVEENRQYRMHSLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHT
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_004 NLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 GEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD
550 560 570 580 590 600
610 620 630 640
pF1KB3 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
::::::::::::::::::::::::::::::::::::::::
NP_004 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
610 620 630 640
>>XP_016873712 (OMIM: 193235,602537) PREDICTED: calpain- (676 aa)
initn: 4451 init1: 4451 opt: 4451 Z-score: 5396.6 bits: 1008.8 E(85289): 0
Smith-Waterman score: 4451; 99.8% identity (100.0% similar) in 640 aa overlap (1-640:37-676)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDP
::::::::::::::::::::::::::::::
XP_016 KEVNCFAPRWPQSPHLRTGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB3 LFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB3 ASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB3 HSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB3 RNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLA
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB3 FFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 CRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB3 IFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAAGSI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 IFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB3 YINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB3 LCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYR
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB3 KKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVH
610 620 630 640 650 660
640
pF1KB3 ILSSTSLMAV
::::::::::
XP_016 ILSSTSLMAV
670
>>XP_011543527 (OMIM: 193235,602537) PREDICTED: calpain- (680 aa)
initn: 4451 init1: 4451 opt: 4451 Z-score: 5396.5 bits: 1008.8 E(85289): 0
Smith-Waterman score: 4451; 99.8% identity (100.0% similar) in 640 aa overlap (1-640:41-680)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDP
::::::::::::::::::::::::::::::
XP_011 YLLSALSLQDLVLDWEPRGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDP
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB3 LFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB3 ASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB3 HSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETK
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB3 RNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB3 FFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDV
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB3 CRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB3 IFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAAGSI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_011 IFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSI
440 450 460 470 480 490
460 470 480 490 500 510
pF1KB3 YINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSS
500 510 520 530 540 550
520 530 540 550 560 570
pF1KB3 LCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYR
560 570 580 590 600 610
580 590 600 610 620 630
pF1KB3 KKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVH
620 630 640 650 660 670
640
pF1KB3 ILSSTSLMAV
::::::::::
XP_011 ILSSTSLMAV
680
>>NP_055104 (OMIM: 300146) calpain-6 [Homo sapiens] (641 aa)
initn: 2007 init1: 1187 opt: 2066 Z-score: 2503.1 bits: 473.4 E(85289): 1.1e-132
Smith-Waterman score: 2066; 47.0% identity (74.8% similar) in 640 aa overlap (5-637:5-638)
10 20 30 40 50
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYY-KGTPGPAVRWKRPKGICE
.: ...:.:. :...: . . :: :: : .:::.: . :: .: ::::. ::.
NP_055 MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVV-WKRPQDICD
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 DPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAG
::.:.: .::.:.: ::..:. .:.: : :: .:: : :.::. :::::::.: . :::
NP_055 DPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 IFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDG
::::.::.::::..::::: :::.:..:.. :.: :::: ::.::::::: :::.::::
NP_055 IFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 GNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAAD
. .: .::::: ..: .:. .: ... .. .:: .. :. ..:::: ::.. . .
NP_055 LTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 MEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTS
.:.. ::.:::.:..::.::.:::. :. :..::. :.::::: :..::.::::. :
NP_055 QEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEIS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 EEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARL
::::... :.:...:....:::::::..:: :: : . :: .:. : : .
NP_055 EEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNP---IFGRKELESV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 HGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPED--EVLICIQQRPKRSTRREG
: ::. .:: .::.::: :..:::.::::::: : ::: .:.. .::. :. :: :
NP_055 LGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTV--PEDGHKVIMSLQQKDLRTYRRMG
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 KGENLAIGFDIYKVEENRQYRMHSL--QHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTF
. .: :::...::: ::..:.: : :..:. : ::..:.::: .: ::..:: :
NP_055 RPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMF
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB3 EPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGL--KDSP
. :.:.:::::.:..:: . ::: :: : .::. :::..:::. : .: : : .
NP_055 QHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYAN
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB3 TGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLG
.: :..::: ..::: :::.: .....::::. . :: ::::: : . :.:::
NP_055 ETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLG
540 550 560 570 580 590
600 610 620 630 640
pF1KB3 QVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
:: : :::.. . :..:.:: ... . : .. ...:: .:
NP_055 QVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
600 610 620 630 640
>>NP_775110 (OMIM: 114240,253600) calpain-3 isoform c [H (729 aa)
initn: 1315 init1: 422 opt: 895 Z-score: 1081.4 bits: 210.5 E(85289): 1.7e-53
Smith-Waterman score: 1306; 42.2% identity (65.6% similar) in 500 aa overlap (9-490:57-528)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDS
..... :.. : ..:::. :: :: . :
NP_775 AQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB3 LYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQ
:.:. :::: :::.::...:: . :. ::..:.:::.:: . :. . :
NP_775 LFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLF
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB3 KVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEF
.::: : . :::::::.:::.:::::::::: ::: ::::.. .:: ::::
NP_775 RVIPH------DQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEF
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB3 WCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERM
: ::.::::::: : :.:: ::::..:. ::::::.: ... : .: ... :
NP_775 WSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR--DAPSD------MYKIM
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 LKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLD
:. ::.:.. :: .. ...:.:.:::::.::::.:: . .: ::.::.
NP_775 KKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVP--------FKGEKVK
260 270 280 290 300
280 290 300 310 320 330
pF1KB3 MIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDII
..:::::::. :::: ::: ..:. :.:.:. .. : .::::::..:: .:: .
NP_775 LVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 KCRVINTSHLSIH-KTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY----IFE
: . . : . .:: . .: :. : .::: : :::. :::: . :
NP_775 ICNLTADALQSDKLQTWTVSVNEGRWV-----RGCSAGGCRNFPDTFWTNPQYRLKLLEE
370 380 390 400 410
400 410 420 430 440
pF1KB3 VKKPEDEVLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQH----
:.: .:: ..:. .:. :. : . ..::: ::.: .. . . ::.
NP_775 DDDPDDSEVICSFLVALMQKNRRKDRKLGASL-FTIGFAIYEVPKEMHGNKQHLQKDFFL
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB3 ----KAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRL
:: .. ::: : : : : ..:::.:.:.:: . :::.::::..
NP_775 YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVEN
480 490 500 510 520 530
510 520 530 540 550 560
pF1KB3 DEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTP
NP_775 TISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTH
540 550 560 570 580 590
>>XP_006715050 (OMIM: 604822) PREDICTED: calpain-11 isof (650 aa)
initn: 1053 init1: 390 opt: 825 Z-score: 997.2 bits: 194.8 E(85289): 8.3e-49
Smith-Waterman score: 1149; 38.2% identity (65.5% similar) in 519 aa overlap (8-498:62-550)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDD
. .:.. :: : :. ::::::::: .
XP_006 PTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB3 SLYYKGTPGPA------VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLA
:: .: :: . :.::: : ..: ...:::: :. :: .:.::..:: .::.
XP_006 SLGFKDL-GPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB3 SRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCH
. .: .:.: . : . : : :::::::..:.::.::.::.:::::: :..:.. :
XP_006 TCPKLLYRVVP--RGQSF---KKN-YAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVH
160 170 180 190 200
160 170 180 190 200 210
pF1KB3 SNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKR
:. :.::: ::.:::::::.: :.::.::.: ..: ::::::.. ..: .
XP_006 STERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQL--------QRPP
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 NQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAF
..:.. . :. :..:.. ::.... ...:. ::.::::.:: .. :.
XP_006 QNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVH--------
260 270 280 290 300
280 290 300 310 320 330
pF1KB3 FKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVC
.... .::.:::::. :::: :::...::..:... . .. . .::::::...:
XP_006 YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQL-LHKTEDGEFWMSYQDFL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 RYFTDIIKCRVINTSHLSIHKT-WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
:: . : . . . .:. :. . .:.: : . .::: :: ::. :::.
XP_006 NNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWR-----RGSSAGGCRNHPGTFWTNPQF
370 380 390 400 410 420
400 410 420 430
pF1KB3 ---IFEVKKPEDE----VLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQ--
. : :::. :..: ..:. : .:..: .. .::: .: : .. :
XP_006 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQG-AQLQTIGFVLYAVPKEFQNI
430 440 450 460 470 480
440 450 460 470 480
pF1KB3 YRMH-------SLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT
.: . : .. . :. ::: : . : :.:.:::.:::: . ..:::::::
XP_006 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB3 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKV
. :. ::
XP_006 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
550 560 570 580 590 600
>>XP_006715048 (OMIM: 604822) PREDICTED: calpain-11 isof (724 aa)
initn: 1053 init1: 390 opt: 825 Z-score: 996.5 bits: 194.8 E(85289): 9.1e-49
Smith-Waterman score: 1149; 38.2% identity (65.5% similar) in 519 aa overlap (8-498:62-550)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDD
. .:.. :: : :. ::::::::: .
XP_006 PTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB3 SLYYKGTPGPA------VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLA
:: .: :: . :.::: : ..: ...:::: :. :: .:.::..:: .::.
XP_006 SLGFKDL-GPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB3 SRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCH
. .: .:.: . : . : : :::::::..:.::.::.::.:::::: :..:.. :
XP_006 TCPKLLYRVVP--RGQSF---KKN-YAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVH
160 170 180 190 200
160 170 180 190 200 210
pF1KB3 SNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKR
:. :.::: ::.:::::::.: :.::.::.: ..: ::::::.. ..: .
XP_006 STERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQL--------QRPP
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 NQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAF
..:.. . :. :..:.. ::.... ...:. ::.::::.:: .. :.
XP_006 QNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVH--------
260 270 280 290 300
280 290 300 310 320 330
pF1KB3 FKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVC
.... .::.:::::. :::: :::...::..:... . .. . .::::::...:
XP_006 YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQL-LHKTEDGEFWMSYQDFL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 RYFTDIIKCRVINTSHLSIHKT-WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
:: . : . . . .:. :. . .:.: : . .::: :: ::. :::.
XP_006 NNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWR-----RGSSAGGCRNHPGTFWTNPQF
370 380 390 400 410 420
400 410 420 430
pF1KB3 ---IFEVKKPEDE----VLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQ--
. : :::. :..: ..:. : .:..: .. .::: .: : .. :
XP_006 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQG-AQLQTIGFVLYAVPKEFQNI
430 440 450 460 470 480
440 450 460 470 480
pF1KB3 YRMH-------SLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT
.: . : .. . :. ::: : . : :.:.:::.:::: . ..:::::::
XP_006 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB3 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKV
. :. ::
XP_006 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
550 560 570 580 590 600
>>NP_008989 (OMIM: 604822) calpain-11 [Homo sapiens] (739 aa)
initn: 1053 init1: 390 opt: 825 Z-score: 996.4 bits: 194.8 E(85289): 9.3e-49
Smith-Waterman score: 1149; 38.2% identity (65.5% similar) in 519 aa overlap (8-498:61-549)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDD
. .:.. :: : :. ::::::::: .
NP_008 PTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB3 SLYYKGTPGPA------VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLA
:: .: :: . :.::: : ..: ...:::: :. :: .:.::..:: .::.
NP_008 SLGFKDL-GPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLT
100 110 120 130 140
100 110 120 130 140 150
pF1KB3 SRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCH
. .: .:.: . : . : : :::::::..:.::.::.::.:::::: :..:.. :
NP_008 TCPKLLYRVVP--RGQSF---KKN-YAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVH
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB3 SNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKR
:. :.::: ::.:::::::.: :.::.::.: ..: ::::::.. ..: .
NP_008 STERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQL--------QRPP
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 NQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAF
..:.. . :. :..:.. ::.... ...:. ::.::::.:: .. :.
NP_008 QNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVH--------
260 270 280 290 300
280 290 300 310 320 330
pF1KB3 FKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVC
.... .::.:::::. :::: :::...::..:... . .. . .::::::...:
NP_008 YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQL-LHKTEDGEFWMSYQDFL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 RYFTDIIKCRVINTSHLSIHKT-WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
:: . : . . . .:. :. . .:.: : . .::: :: ::. :::.
NP_008 NNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWR-----RGSSAGGCRNHPGTFWTNPQF
370 380 390 400 410 420
400 410 420 430
pF1KB3 ---IFEVKKPEDE----VLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQ--
. : :::. :..: ..:. : .:..: .. .::: .: : .. :
NP_008 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQG-AQLQTIGFVLYAVPKEFQNI
430 440 450 460 470 480
440 450 460 470 480
pF1KB3 YRMH-------SLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT
.: . : .. . :. ::: : . : :.:.:::.:::: . ..:::::::
NP_008 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB3 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKV
. :. ::
NP_008 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
550 560 570 580 590 600
>>XP_006715047 (OMIM: 604822) PREDICTED: calpain-11 isof (740 aa)
initn: 1053 init1: 390 opt: 825 Z-score: 996.4 bits: 194.8 E(85289): 9.3e-49
Smith-Waterman score: 1149; 38.2% identity (65.5% similar) in 519 aa overlap (8-498:62-550)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDD
. .:.. :: : :. ::::::::: .
XP_006 PTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB3 SLYYKGTPGPA------VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLA
:: .: :: . :.::: : ..: ...:::: :. :: .:.::..:: .::.
XP_006 SLGFKDL-GPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB3 SRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCH
. .: .:.: . : . : : :::::::..:.::.::.::.:::::: :..:.. :
XP_006 TCPKLLYRVVP--RGQSF---KKN-YAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVH
160 170 180 190 200
160 170 180 190 200 210
pF1KB3 SNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKR
:. :.::: ::.:::::::.: :.::.::.: ..: ::::::.. ..: .
XP_006 STERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQL--------QRPP
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 NQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAF
..:.. . :. :..:.. ::.... ...:. ::.::::.:: .. :.
XP_006 QNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVH--------
260 270 280 290 300
280 290 300 310 320 330
pF1KB3 FKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVC
.... .::.:::::. :::: :::...::..:... . .. . .::::::...:
XP_006 YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQL-LHKTEDGEFWMSYQDFL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB3 RYFTDIIKCRVINTSHLSIHKT-WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
:: . : . . . .:. :. . .:.: : . .::: :: ::. :::.
XP_006 NNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWR-----RGSSAGGCRNHPGTFWTNPQF
370 380 390 400 410 420
400 410 420 430
pF1KB3 ---IFEVKKPEDE----VLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQ--
. : :::. :..: ..:. : .:..: .. .::: .: : .. :
XP_006 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQG-AQLQTIGFVLYAVPKEFQNI
430 440 450 460 470 480
440 450 460 470 480
pF1KB3 YRMH-------SLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT
.: . : .. . :. ::: : . : :.:.:::.:::: . ..:::::::
XP_006 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB3 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKV
. :. ::
XP_006 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
550 560 570 580 590 600
>>XP_011512577 (OMIM: 604822) PREDICTED: calpain-11 isof (743 aa)
initn: 1053 init1: 390 opt: 825 Z-score: 996.3 bits: 194.8 E(85289): 9.3e-49
Smith-Waterman score: 1149; 38.2% identity (65.5% similar) in 519 aa overlap (8-498:65-553)
10 20 30
pF1KB3 MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDD
. .:.. :: : :. ::::::::: .
XP_011 PTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB3 SLYYKGTPGPA------VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLA
:: .: :: . :.::: : ..: ...:::: :. :: .:.::..:: .::.
XP_011 SLGFKDL-GPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB3 SRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCH
. .: .:.: . : . : : :::::::..:.::.::.::.:::::: :..:.. :
XP_011 TCPKLLYRVVP--RGQSF---KKN-YAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVH
160 170 180 190 200
160 170 180 190 200 210
pF1KB3 SNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKR
:. :.::: ::.:::::::.: :.::.::.: ..: ::::::.. ..: .
XP_011 STERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQL--------QRPP
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 NQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAF
..:.. . :. :..:.. ::.... ...:. ::.::::.:: .. :.
XP_011 QNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVH--------
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB3 FKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVC
.... .::.:::::. :::: :::...::..:... . .. . .::::::...:
XP_011 YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQL-LHKTEDGEFWMSYQDFL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB3 RYFTDIIKCRVINTSHLSIHKT-WEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQY
:: . : . . . .:. :. . .:.: : . .::: :: ::. :::.
XP_011 NNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWR-----RGSSAGGCRNHPGTFWTNPQF
380 390 400 410 420
400 410 420 430
pF1KB3 ---IFEVKKPEDE----VLIC-----IQQRPKRSTRREGKGENLAIGFDIYKVEENRQ--
. : :::. :..: ..:. : .:..: .. .::: .: : .. :
XP_011 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQG-AQLQTIGFVLYAVPKEFQNI
430 440 450 460 470 480
440 450 460 470 480
pF1KB3 YRMH-------SLQHKAAGSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT
.: . : .. . :. ::: : . : :.:.:::.:::: . ..:::::::
XP_011 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB3 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKV
. :. ::
XP_011 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
550 560 570 580 590 600
640 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:43:29 2016 done: Thu Nov 3 13:43:30 2016
Total Scan time: 10.110 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]