FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3734, 461 aa 1>>>pF1KB3734 461 - 461 aa - 461 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7657+/-0.000981; mu= 7.9859+/- 0.059 mean_var=171.3576+/-34.913, 0's: 0 Z-trim(110.3): 96 B-trim: 0 in 0/53 Lambda= 0.097977 statistics sampled from 11439 (11536) to 11439 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.354), width: 16 Scan time: 3.150 The best scores are: opt bits E(32554) CCDS529.1 PIK3R3 gene_id:8503|Hs108|chr1 ( 461) 3122 453.5 2.2e-127 CCDS76155.1 PIK3R3 gene_id:8503|Hs108|chr1 ( 507) 2875 418.6 7.5e-117 CCDS3995.1 PIK3R1 gene_id:5295|Hs108|chr5 ( 454) 2385 349.3 4.9e-96 CCDS3993.1 PIK3R1 gene_id:5295|Hs108|chr5 ( 724) 2269 333.0 6e-91 CCDS3994.1 PIK3R1 gene_id:5295|Hs108|chr5 ( 424) 2251 330.3 2.3e-90 CCDS12371.1 PIK3R2 gene_id:5296|Hs108|chr19 ( 728) 2155 316.9 4.3e-86 CCDS56374.1 PIK3R1 gene_id:5295|Hs108|chr5 ( 361) 1944 286.9 2.4e-77 CCDS76154.1 PIK3R3 gene_id:8503|Hs108|chr1 ( 402) 1737 257.6 1.7e-68 >>CCDS529.1 PIK3R3 gene_id:8503|Hs108|chr1 (461 aa) initn: 3122 init1: 3122 opt: 3122 Z-score: 2400.6 bits: 453.5 E(32554): 2.2e-127 Smith-Waterman score: 3122; 99.8% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: CCDS52 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 370 380 390 400 410 420 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::::::::::::::::: CCDS52 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 430 440 450 460 >>CCDS76155.1 PIK3R3 gene_id:8503|Hs108|chr1 (507 aa) initn: 2875 init1: 2875 opt: 2875 Z-score: 2211.3 bits: 418.6 E(32554): 7.5e-117 Smith-Waterman score: 2875; 99.5% identity (99.8% similar) in 428 aa overlap (34-461:80-507) 10 20 30 40 50 60 pF1KB3 TVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDA : :::::::::::::::::::::::::::: CCDS76 TASSAAINPATRAMGINNTHTDTTIVWIFPPQALPPKPPKPMTSAVPNGMKDSSVSLQDA 50 60 70 80 90 100 70 80 90 100 110 120 pF1KB3 EWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 EWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYG 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB3 FSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 FSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQE 170 180 190 200 210 220 190 200 210 220 230 240 pF1KB3 YHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 YHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIER 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB3 FRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLI :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: CCDS76 FRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLI 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB3 QLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 QLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDI 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB3 NRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 NRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYS 410 420 430 440 450 460 430 440 450 460 pF1KB3 SLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::::::::::::::::::::::::::::::::: CCDS76 SLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 470 480 490 500 >>CCDS3995.1 PIK3R1 gene_id:5295|Hs108|chr5 (454 aa) initn: 1587 init1: 1587 opt: 2385 Z-score: 1837.6 bits: 349.3 E(32554): 4.9e-96 Smith-Waterman score: 2385; 78.0% identity (93.0% similar) in 455 aa overlap (1-455:1-451) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL ::::::.:. : .. .. . .:.:.::::::::::::::::: :... ::: ....:: CCDS39 MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKP-TTVANNGM-NNNMSL 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG ::::::::::::::::.:::: :::::::::::::.::::::::::::::::::.:::: CCDS39 QDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK ::::::::::.:::::::::..::::::::::::::.::::.:::::.::::::.::::: CCDS39 KYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :.::..:.::::.:::::::::::::::::::::::::::::::::::::.:::..:::: CCDS39 LHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEY 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::.:.::::::::.::: ::::::::..:: ::. :::.:::::: . :::::.:::::: CCDS39 IEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV ::::::: :::.:.::..::::::.:: ::: ::.....: . :.::.:::.::::: : CCDS39 DLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NENTEDQYSLVEDDEDLPHHDEKTWNV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN . :: .::.:: :: ::.::.:::::.::::::::.::::::::: .:: ::::::::: CCDS39 GSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYN 360 370 380 390 400 410 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::::::::.:::::::::::: :::::.:: CCDS39 LYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 420 430 440 450 >>CCDS3993.1 PIK3R1 gene_id:5295|Hs108|chr5 (724 aa) initn: 1615 init1: 1615 opt: 2269 Z-score: 1746.3 bits: 333.0 E(32554): 6e-91 Smith-Waterman score: 2269; 76.9% identity (90.4% similar) in 450 aa overlap (7-455:279-721) 10 20 30 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDP-P : : . . . . ::: . : .: : CCDS39 KLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTE---WNERQPAP 250 260 270 280 290 300 40 50 60 70 80 90 pF1KB3 ALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTK ::::::::: : : ::: ....::::::::::::::::::.:::: :::::::::::: CCDS39 ALPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTK 310 320 330 340 350 360 100 110 120 130 140 150 pF1KB3 MQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVK :.::::::::::::::::::.::::::::::::::.:::::::::..::::::::::::: CCDS39 MHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVK 370 380 390 400 410 420 160 170 180 190 200 210 pF1KB3 LMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTA :.::::.:::::.::::::.::::::.::..:.::::.:::::::::::::::::::::: CCDS39 LLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTA 430 440 450 460 470 480 220 230 240 250 260 270 pF1KB3 IEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKM :::::::::::::::.:::..::::::.:.::::::::.::: ::::::::..:: ::. CCDS39 IEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRR 490 500 510 520 530 540 280 290 300 310 320 330 pF1KB3 RLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNE :::.:::::: . :::::.::::::::::::: :::.:.::..::::::.:: ::: :: CCDS39 RLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NE 550 560 570 580 590 600 340 350 360 370 380 390 pF1KB3 DADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSV .....: . :.::.:::.::::: : . :: .::.:: :: ::.::.:::::.::::::: CCDS39 NTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSV 610 620 630 640 650 660 400 410 420 430 440 450 pF1KB3 VADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ :.::::::::: .:: ::::::::::::::::::::::.:::::::::::: :::::.:: CCDS39 VVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ 670 680 690 700 710 720 460 pF1KB3 MPSLCR CCDS39 QRR >>CCDS3994.1 PIK3R1 gene_id:5295|Hs108|chr5 (424 aa) initn: 1587 init1: 1587 opt: 2251 Z-score: 1735.7 bits: 330.3 E(32554): 2.3e-90 Smith-Waterman score: 2251; 80.2% identity (94.0% similar) in 419 aa overlap (37-455:7-421) 10 20 30 40 50 60 pF1KB3 SMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWY :::::::: :... ::: ....:::::::: CCDS39 MHNLQTLPPKPPKP-TTVANNGM-NNNMSLQDAEWY 10 20 30 70 80 90 100 110 120 pF1KB3 WGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSD ::::::::::.:::: :::::::::::::.::::::::::::::::::.:::::::::: CCDS39 WGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB3 PLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHS ::::.:::::::::..::::::::::::::.::::.:::::.::::::.::::::.::.. CCDS39 PLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNT 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB3 QYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRR :.::::.:::::::::::::::::::::::::::::::::::::.:::..::::::.:.: CCDS39 QFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKR 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB3 EGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLR :::::::.::: ::::::::..:: ::. :::.:::::: . :::::.:::::::::::: CCDS39 EGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB3 KIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRV : :::.:.::..::::::.:: ::: ::.....: . :.::.:::.::::: : . :: CCDS39 KTRDQYLMWLTQKGVRQKKLNEWLG--NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRN 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB3 QAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLK .::.:: :: ::.::.:::::.::::::::.::::::::: .:: ::::::::::::::: CCDS39 KAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLK 340 350 360 370 380 390 430 440 450 460 pF1KB3 ELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::.:::::::::::: :::::.:: CCDS39 ELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 400 410 420 >>CCDS12371.1 PIK3R2 gene_id:5296|Hs108|chr19 (728 aa) initn: 2138 init1: 1601 opt: 2155 Z-score: 1659.1 bits: 316.9 E(32554): 4.3e-86 Smith-Waterman score: 2155; 72.5% identity (91.6% similar) in 429 aa overlap (31-457:296-721) 10 20 30 40 50 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPK--PMTSAVPNGMKDSSV :. :::::::::: : .... :: : CCDS12 PGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANG--GSPP 270 280 290 300 310 320 60 70 80 90 100 110 pF1KB3 SLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHR ::::::::::::::::::.:::: :::::::::::.:.::.:::::::::::::::..:: CCDS12 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHR 330 340 350 360 370 380 120 130 140 150 160 170 pF1KB3 DGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVG ::.::::.:::: :::.:::::.:::::::: :::..:.::::.:::::.::::...::: CCDS12 DGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVG 390 400 410 420 430 440 180 190 200 210 220 230 pF1KB3 KKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSK .:. ::.:::.::.:::.:::::::::::.:::::::::::::::::::: .:::. :: CCDS12 AQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSK 450 460 470 480 490 500 240 250 260 270 280 290 pF1KB3 EYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSI ::.:::::::::::..::..: ..::::..:::.:. .:::.:. :: :::::::.:::. CCDS12 EYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSL 510 520 530 540 550 560 300 310 320 330 340 350 pF1KB3 KPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTW ::::.::::::::.::::..::.:::..: ::::::: :. : . :....:::..:.:: CCDS12 KPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQ-YALMEDEDDLPHHEERTW 570 580 590 600 610 620 360 370 380 390 400 410 pF1KB3 FVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEP .: :::.:::..: :: ::.:::::::..::::::::.::..:::::: :: :.::::: CCDS12 YVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEP 630 640 650 660 670 680 420 430 440 450 460 pF1KB3 YNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::.::::::::::..:::::::.:.: ::.::.: : CCDS12 YNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR 690 700 710 720 >>CCDS56374.1 PIK3R1 gene_id:5295|Hs108|chr5 (361 aa) initn: 1350 init1: 1350 opt: 1944 Z-score: 1502.1 bits: 286.9 E(32554): 2.4e-77 Smith-Waterman score: 1944; 80.6% identity (94.4% similar) in 360 aa overlap (96-455:1-358) 70 80 90 100 110 120 pF1KB3 YWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFS :.::::::::::::::::::.::::::::: CCDS56 MHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 10 20 30 130 140 150 160 170 180 pF1KB3 DPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYH :::::.:::::::::..::::::::::::::.::::.:::::.::::::.::::::.::. CCDS56 DPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYN 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB3 SQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFR .:.::::.:::::::::::::::::::::::::::::::::::::.:::..::::::.:. CCDS56 TQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFK 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB3 REGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQL ::::::::.::: ::::::::..:: ::. :::.:::::: . :::::.::::::::::: CCDS56 REGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQL 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB3 RKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINR :: :::.:.::..::::::.:: ::: ::.....: . :.::.:::.::::: : . :: CCDS56 RKTRDQYLMWLTQKGVRQKKLNEWLG--NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNR 220 230 240 250 260 370 380 390 400 410 420 pF1KB3 VQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSL .::.:: :: ::.::.:::::.::::::::.::::::::: .:: :::::::::::::: CCDS56 NKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSL 270 280 290 300 310 320 430 440 450 460 pF1KB3 KELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::.:::::::::::: :::::.:: CCDS56 KELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 330 340 350 360 >>CCDS76154.1 PIK3R3 gene_id:8503|Hs108|chr1 (402 aa) initn: 1737 init1: 1737 opt: 1737 Z-score: 1343.3 bits: 257.6 E(32554): 1.7e-68 Smith-Waterman score: 2619; 87.2% identity (87.2% similar) in 461 aa overlap (1-461:1-402) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::::::::::::::: CCDS76 IERFRREGNEKEIER--------------------------------------------- 250 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV :::::::::::::::::::::::::::::::::::::::::::::: CCDS76 --------------WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 260 270 280 290 300 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 310 320 330 340 350 360 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::::::::::::::::: CCDS76 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 370 380 390 400 461 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:52:12 2016 done: Thu Nov 3 13:52:13 2016 Total Scan time: 3.150 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]