FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3734, 461 aa 1>>>pF1KB3734 461 - 461 aa - 461 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9625+/-0.00038; mu= 6.9969+/- 0.024 mean_var=193.8475+/-40.990, 0's: 0 Z-trim(118.4): 161 B-trim: 1717 in 1/55 Lambda= 0.092118 statistics sampled from 31075 (31283) to 31075 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.367), width: 16 Scan time: 9.880 The best scores are: opt bits E(85289) XP_016858103 (OMIM: 606076) PREDICTED: phosphatidy ( 461) 3122 427.5 3.8e-119 NP_001107644 (OMIM: 606076) phosphatidylinositol 3 ( 461) 3122 427.5 3.8e-119 NP_003620 (OMIM: 606076) phosphatidylinositol 3-ki ( 461) 3122 427.5 3.8e-119 NP_001290357 (OMIM: 606076) phosphatidylinositol 3 ( 478) 3122 427.5 3.9e-119 NP_001290356 (OMIM: 606076) phosphatidylinositol 3 ( 507) 2875 394.7 3.1e-109 NP_001315578 (OMIM: 606076) phosphatidylinositol 3 ( 417) 2794 383.8 4.7e-106 NP_001315577 (OMIM: 606076) phosphatidylinositol 3 ( 417) 2794 383.8 4.7e-106 NP_001315580 (OMIM: 606076) phosphatidylinositol 3 ( 417) 2794 383.8 4.7e-106 NP_001315579 (OMIM: 606076) phosphatidylinositol 3 ( 417) 2794 383.8 4.7e-106 NP_001315582 (OMIM: 606076) phosphatidylinositol 3 ( 380) 2541 350.2 5.8e-96 NP_852556 (OMIM: 171833,269880,615214,616005) phos ( 454) 2385 329.5 1.1e-89 NP_001315581 (OMIM: 606076) phosphatidylinositol 3 ( 404) 2287 316.4 8.7e-86 XP_011541795 (OMIM: 171833,269880,615214,616005) P ( 615) 2269 314.2 6.2e-85 XP_016865075 (OMIM: 171833,269880,615214,616005) P ( 633) 2269 314.2 6.4e-85 NP_852664 (OMIM: 171833,269880,615214,616005) phos ( 724) 2269 314.3 7e-85 XP_005248599 (OMIM: 171833,269880,615214,616005) P ( 724) 2269 314.3 7e-85 XP_016865074 (OMIM: 171833,269880,615214,616005) P ( 724) 2269 314.3 7e-85 NP_852665 (OMIM: 171833,269880,615214,616005) phos ( 424) 2251 311.7 2.5e-84 NP_005018 (OMIM: 603157,603387) phosphatidylinosit ( 728) 2152 298.7 3.4e-80 NP_001315583 (OMIM: 606076) phosphatidylinositol 3 ( 305) 2038 283.2 6.5e-76 NP_001229395 (OMIM: 171833,269880,615214,616005) p ( 361) 1944 270.8 4.2e-72 NP_001290358 (OMIM: 606076) phosphatidylinositol 3 ( 402) 1737 243.3 8.8e-64 >>XP_016858103 (OMIM: 606076) PREDICTED: phosphatidylino (461 aa) initn: 3122 init1: 3122 opt: 3122 Z-score: 2260.1 bits: 427.5 E(85289): 3.8e-119 Smith-Waterman score: 3122; 99.8% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 370 380 390 400 410 420 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::::::::::::::::: XP_016 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 430 440 450 460 >>NP_001107644 (OMIM: 606076) phosphatidylinositol 3-kin (461 aa) initn: 3122 init1: 3122 opt: 3122 Z-score: 2260.1 bits: 427.5 E(85289): 3.8e-119 Smith-Waterman score: 3122; 99.8% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 370 380 390 400 410 420 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::::::::::::::::: NP_001 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 430 440 450 460 >>NP_003620 (OMIM: 606076) phosphatidylinositol 3-kinase (461 aa) initn: 3122 init1: 3122 opt: 3122 Z-score: 2260.1 bits: 427.5 E(85289): 3.8e-119 Smith-Waterman score: 3122; 99.8% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_003 IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN 370 380 390 400 410 420 430 440 450 460 pF1KB3 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::::::::::::::::: NP_003 LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 430 440 450 460 >>NP_001290357 (OMIM: 606076) phosphatidylinositol 3-kin (478 aa) initn: 3122 init1: 3122 opt: 3122 Z-score: 2259.9 bits: 427.5 E(85289): 3.9e-119 Smith-Waterman score: 3122; 99.8% identity (100.0% similar) in 461 aa overlap (1-461:18-478) 10 20 30 40 pF1KB3 MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPK ::::::::::::::::::::::::::::::::::::::::::: NP_001 MPAVPPPGAVGWRLSGAMYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 PMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 LRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRY 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB3 QQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB3 KIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 KIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB3 QALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB3 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB3 CVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 430 440 450 460 470 >>NP_001290356 (OMIM: 606076) phosphatidylinositol 3-kin (507 aa) initn: 2875 init1: 2875 opt: 2875 Z-score: 2082.1 bits: 394.7 E(85289): 3.1e-109 Smith-Waterman score: 2875; 99.5% identity (99.8% similar) in 428 aa overlap (34-461:80-507) 10 20 30 40 50 60 pF1KB3 TVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDA : :::::::::::::::::::::::::::: NP_001 TASSAAINPATRAMGINNTHTDTTIVWIFPPQALPPKPPKPMTSAVPNGMKDSSVSLQDA 50 60 70 80 90 100 70 80 90 100 110 120 pF1KB3 EWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYG 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB3 FSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQE 170 180 190 200 210 220 190 200 210 220 230 240 pF1KB3 YHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIER 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB3 FRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLI :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_001 FRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLI 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB3 QLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDI 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB3 NRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYS 410 420 430 440 450 460 430 440 450 460 pF1KB3 SLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::::::::::::::::::::::::::::::::: NP_001 SLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 470 480 490 500 >>NP_001315578 (OMIM: 606076) phosphatidylinositol 3-kin (417 aa) initn: 2794 init1: 2794 opt: 2794 Z-score: 2025.1 bits: 383.8 E(85289): 4.7e-106 Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 417 aa overlap (45-461:1-417) 20 30 40 50 60 70 pF1KB3 WREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREE :::::::::::::::::::::::::::::: NP_001 MTSAVPNGMKDSSVSLQDAEWYWGDISREE 10 20 30 80 90 100 110 120 130 pF1KB3 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB3 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLV ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB3 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ 340 350 360 370 380 390 440 450 460 pF1KB3 TSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::: NP_001 TSLVQHNDSLNVRLAYPVHAQMPSLCR 400 410 >>NP_001315577 (OMIM: 606076) phosphatidylinositol 3-kin (417 aa) initn: 2794 init1: 2794 opt: 2794 Z-score: 2025.1 bits: 383.8 E(85289): 4.7e-106 Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 417 aa overlap (45-461:1-417) 20 30 40 50 60 70 pF1KB3 WREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREE :::::::::::::::::::::::::::::: NP_001 MTSAVPNGMKDSSVSLQDAEWYWGDISREE 10 20 30 80 90 100 110 120 130 pF1KB3 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB3 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLV ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB3 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ 340 350 360 370 380 390 440 450 460 pF1KB3 TSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::: NP_001 TSLVQHNDSLNVRLAYPVHAQMPSLCR 400 410 >>NP_001315580 (OMIM: 606076) phosphatidylinositol 3-kin (417 aa) initn: 2794 init1: 2794 opt: 2794 Z-score: 2025.1 bits: 383.8 E(85289): 4.7e-106 Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 417 aa overlap (45-461:1-417) 20 30 40 50 60 70 pF1KB3 WREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREE :::::::::::::::::::::::::::::: NP_001 MTSAVPNGMKDSSVSLQDAEWYWGDISREE 10 20 30 80 90 100 110 120 130 pF1KB3 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB3 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLV ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB3 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ 340 350 360 370 380 390 440 450 460 pF1KB3 TSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::: NP_001 TSLVQHNDSLNVRLAYPVHAQMPSLCR 400 410 >>NP_001315579 (OMIM: 606076) phosphatidylinositol 3-kin (417 aa) initn: 2794 init1: 2794 opt: 2794 Z-score: 2025.1 bits: 383.8 E(85289): 4.7e-106 Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 417 aa overlap (45-461:1-417) 20 30 40 50 60 70 pF1KB3 WREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREE :::::::::::::::::::::::::::::: NP_001 MTSAVPNGMKDSSVSLQDAEWYWGDISREE 10 20 30 80 90 100 110 120 130 pF1KB3 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB3 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLV ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB3 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ 340 350 360 370 380 390 440 450 460 pF1KB3 TSLVQHNDSLNVRLAYPVHAQMPSLCR ::::::::::::::::::::::::::: NP_001 TSLVQHNDSLNVRLAYPVHAQMPSLCR 400 410 >>NP_001315582 (OMIM: 606076) phosphatidylinositol 3-kin (380 aa) initn: 2541 init1: 2541 opt: 2541 Z-score: 1843.9 bits: 350.2 E(85289): 5.8e-96 Smith-Waterman score: 2541; 99.7% identity (100.0% similar) in 380 aa overlap (82-461:1-380) 60 70 80 90 100 110 pF1KB3 GMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNK :::::::::::::::::::::::::::::: NP_001 MPDGTFLVRDASTKMQGDYTLTLRKGGNNK 10 20 30 120 130 140 150 160 170 pF1KB3 LIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKE 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB3 DNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCH 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB3 TQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREI :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 TQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREI 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB3 DKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLP 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB3 HYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTAR 280 290 300 310 320 330 420 430 440 450 460 pF1KB3 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR 340 350 360 370 380 461 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:52:13 2016 done: Thu Nov 3 13:52:15 2016 Total Scan time: 9.880 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]