FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3736, 451 aa 1>>>pF1KB3736 451 - 451 aa - 451 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1566+/-0.0003; mu= 19.9026+/- 0.019 mean_var=91.0461+/-20.953, 0's: 0 Z-trim(117.6): 430 B-trim: 2860 in 2/57 Lambda= 0.134414 statistics sampled from 29163 (29753) to 29163 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.349), width: 16 Scan time: 9.930 The best scores are: opt bits E(85289) NP_114142 (OMIM: 606916) probable G-protein couple ( 451) 2993 590.4 3.2e-168 XP_016857927 (OMIM: 606916) PREDICTED: probable G- ( 451) 2993 590.4 3.2e-168 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 452 97.7 6.8e-20 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 405 88.7 4.5e-17 XP_016856349 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_016856351 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_005245114 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_011507679 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_011507677 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_005245113 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_011507680 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 NP_722561 (OMIM: 612250) G-protein coupled recepto ( 529) 380 83.8 1.2e-15 NP_001254539 (OMIM: 612250) G-protein coupled rece ( 529) 380 83.8 1.2e-15 XP_016856350 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 XP_011507678 (OMIM: 612250) PREDICTED: G-protein c ( 529) 380 83.8 1.2e-15 NP_001254540 (OMIM: 612250) G-protein coupled rece ( 546) 380 83.8 1.3e-15 XP_005245112 (OMIM: 612250) PREDICTED: G-protein c ( 549) 380 83.8 1.3e-15 XP_016856348 (OMIM: 612250) PREDICTED: G-protein c ( 549) 380 83.8 1.3e-15 NP_001254538 (OMIM: 612250) G-protein coupled rece ( 549) 380 83.8 1.3e-15 XP_011507673 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_006711314 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_011507674 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_016856347 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_011507675 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_011507672 (OMIM: 612250) PREDICTED: G-protein c ( 552) 380 83.8 1.3e-15 XP_006711316 (OMIM: 612250) PREDICTED: G-protein c ( 609) 380 83.8 1.4e-15 NP_543141 (OMIM: 606917) probable G-protein couple ( 368) 348 77.4 7.1e-14 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 333 74.7 6.7e-13 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 331 74.2 7.9e-13 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 328 73.6 1.1e-12 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 328 73.6 1.1e-12 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 326 73.1 1.3e-12 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 326 73.1 1.3e-12 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 326 73.1 1.4e-12 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 328 73.7 1.4e-12 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 326 73.3 1.6e-12 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 326 73.3 1.7e-12 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 323 72.6 2.2e-12 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 312 70.4 9.1e-12 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 307 69.5 1.8e-11 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 303 68.7 3.2e-11 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 300 68.1 4.4e-11 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 299 67.8 4.5e-11 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 299 67.8 4.6e-11 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 300 68.1 4.6e-11 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 300 68.1 4.6e-11 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 299 67.9 4.7e-11 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 300 68.1 4.8e-11 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 299 67.9 4.9e-11 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 300 68.2 5e-11 >>NP_114142 (OMIM: 606916) probable G-protein coupled re (451 aa) initn: 2993 init1: 2993 opt: 2993 Z-score: 3141.0 bits: 590.4 E(85289): 3.2e-168 Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 451 aa overlap (1-451:1-451) 10 20 30 40 50 60 pF1KB3 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE 370 380 390 400 410 420 430 440 450 pF1KB3 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES ::::::::::::::::::::::::::::::: NP_114 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES 430 440 450 >>XP_016857927 (OMIM: 606916) PREDICTED: probable G-prot (451 aa) initn: 2993 init1: 2993 opt: 2993 Z-score: 3141.0 bits: 590.4 E(85289): 3.2e-168 Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 451 aa overlap (1-451:1-451) 10 20 30 40 50 60 pF1KB3 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE 370 380 390 400 410 420 430 440 450 pF1KB3 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES ::::::::::::::::::::::::::::::: XP_016 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES 430 440 450 >>NP_000862 (OMIM: 601109) 5-hydroxytryptamine receptor (440 aa) initn: 347 init1: 165 opt: 452 Z-score: 478.2 bits: 97.7 E(85289): 6.8e-20 Smith-Waterman score: 463; 31.7% identity (58.7% similar) in 407 aa overlap (19-411:2-379) 10 20 30 40 50 pF1KB3 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASES----VALFFMLLLDLTA ::. ::: ::...: : .. . :: . ... ::: NP_000 MVPE-PGP-TANSTPAWGAGPPSAPGGSGWVAAALCVVIALTA 10 20 30 40 60 70 80 90 100 110 pF1KB3 VAGNAAVMAVIAKTPALRKF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVA :.:. ..:.: ::::. :. : ::...:..:: :::. ::. . .... NP_000 -AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLN--ALYGRWVLARGL 50 60 70 80 90 120 130 140 150 160 170 pF1KB3 CRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMA : :. ..: : .::.. :...:: .. :.::..::: . ....:.: : :.: NP_000 CLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA-ALA 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB3 S-VPVLGRVSWEE---GAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCS : .:.: ..:.: . : :: : : : ::.: . : :.:: : .:: NP_000 SFLPLL--LGWHELGHARPPVPGQCRLLASLP-----FVLVASGLTFFLPSGAICFTYCR 160 170 180 190 200 210 240 250 260 270 280 pF1KB3 MFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTM---VTSSGAPQTTPHRTFGGGKAAV .. .:: :.: . : : : . : ::.:. : : :. . . . ... . ::.. NP_000 ILLAARKQAVQVASLTTGMAS--QASETLQVPRTPRPGVESADSRRLATKHSRKALKASL 220 230 240 250 260 290 300 310 320 330 340 pF1KB3 VLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQ .: . :.:.. :::.: .. :. . :: : . :.::.:: : ::..: . :. NP_000 TLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFD-VLTWLGYCNSTMNPIIYPLFMRD 270 280 290 300 310 320 350 360 370 380 390 400 pF1KB3 IRGELSKQFVCFFKPAPEEELRLPS-REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQE .. :.. : : : : : :..:. :. .. :. : ... :: : NP_000 FKRALGR-----FLPCP----RCPRERQASLASPSLRTSHSGPRPGLS-LQQVLPLPL-- 330 340 350 360 370 410 420 430 440 450 pF1KB3 PPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES :: : NP_000 PPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHP 380 390 400 410 420 430 >>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa) initn: 419 init1: 173 opt: 405 Z-score: 427.5 bits: 88.7 E(85289): 4.5e-17 Smith-Waterman score: 420; 26.2% identity (55.7% similar) in 465 aa overlap (12-446:65-515) 10 20 30 40 pF1KB3 MESSPIPQSSGNSSTLGRVPQTPGPS-TASGVPEVGLRDVA : :. :. : . : . ..:. :: :. NP_000 AAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGE-PGSAGAGGDVNGTAAVGGLVVS 40 50 60 70 80 90 50 60 70 80 90 pF1KB3 SESVAL-FFMLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLA ...:.. :. . : ::::: :. .: . :. . :. .: ..::: . :..:.. NP_000 AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB3 MLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLG .. .. ::.. : .. ..: . .:::. .:.:.:: : : ..: . :: NP_000 --ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTER 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB3 LVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYF .:..:. .:: ::... :.:: :.: .: :.. .. : ..: .: : NP_000 KAAAILALLWVVALVVSVGPLLG---WKEPVPPDERFCGI--TEEAG---YAVFSSVCSF 220 230 240 250 260 220 230 240 250 260 270 pF1KB3 LLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQR-SE---SLSSRSTMVTSSGAP- ::. .:.:.:: .. ::: .. . : . .. : . :: . :.. . ..:: NP_000 YLPMAVIVVMYCRVYVVARSTTRS---LEAGVKRERGKASEVVLRIHCRGAATGADGAHG 270 280 290 300 310 320 280 290 300 310 pF1KB3 -QTTPHRTFGGG------------KAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPIST ... .:: .. ::: .: : : :.:::.:.: .: : . NP_000 MRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS 330 340 350 360 370 380 320 330 340 350 360 370 pF1KB3 GQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEE--LRLPSREGSI : .:. :.::: ::..: : .:... . . . : . ... :. ... NP_000 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRA 390 400 410 420 430 440 380 390 400 410 420 430 pF1KB3 EENFLQF----LQGTGCPSESWVSRPLPSPKQEPPAV-DFRIP-GQIAEETSEFLEQQLT . :. .: . :. . ::.: :::.. ... : .. . : : : .: NP_000 STSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLL 450 460 470 480 490 500 440 450 pF1KB3 SDIIMSDSYLRPAASPRLES . . . :: .: NP_000 GPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYE 510 520 530 540 550 560 >>XP_016856349 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_016 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_016 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_016 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_016 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_016 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_016 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_016 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 >>XP_016856351 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_016 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_016 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_016 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_016 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_016 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_016 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_016 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 >>XP_005245114 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_005 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_005 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_005 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_005 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_005 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_005 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_005 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 >>XP_011507679 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_011 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_011 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_011 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_011 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_011 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_011 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_011 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 >>XP_011507677 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_011 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_011 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_011 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_011 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_011 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_011 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_011 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 >>XP_005245113 (OMIM: 612250) PREDICTED: G-protein coupl (529 aa) initn: 345 init1: 134 opt: 380 Z-score: 401.7 bits: 83.8 E(85289): 1.2e-15 Smith-Waterman score: 380; 27.1% identity (58.7% similar) in 317 aa overlap (49-359:34-340) 20 30 40 50 60 70 pF1KB3 VPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV- .... . . :: ...... : : . XP_005 NSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB3 -FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAI ::: : : ..: .. ..:... :: . . .:: : : . .: . . : ..:....: XP_005 KFVFSLTLSNFLLSVLVLPFVVTSS--IRREWIFGVVWCNFSALLYLLISSASMLTLGVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB3 NVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCS ..::: :..:: : ...: . .. .:: .:...: :..: : : : XP_005 AIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDE--FKWMCV 130 140 150 160 170 200 210 220 230 240 250 pF1KB3 LQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQ-HGPLPTWMETPRQR : . : .. .:. :.:..:: : .:::::: : . : . .: :: XP_005 AAWHREPGYTAFWQIWCALF---PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB3 SESLSSRSTMVTSSGAPQTTPHRTFGGG---KAAVVLLAVGGQFLLCWLPYFSFHLYVAL . .: :: ..:::. ... . . .. :: ...:.: : :.. : ::. :: XP_005 TGRKNS-STSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEAL 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB3 SAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPS .. . ..:. .::... . .:..:: :. .: :: .:: XP_005 WGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLG--MCFGDRYYREPFVQRQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB3 REGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTS XP_005 RTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 360 370 380 390 400 410 451 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:52:47 2016 done: Thu Nov 3 13:52:48 2016 Total Scan time: 9.930 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]