FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3758, 594 aa 1>>>pF1KB3758 594 - 594 aa - 594 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6206+/-0.000916; mu= 2.4718+/- 0.055 mean_var=284.8390+/-56.247, 0's: 0 Z-trim(115.1): 16 B-trim: 19 in 1/53 Lambda= 0.075993 statistics sampled from 15671 (15684) to 15671 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.482), width: 16 Scan time: 4.600 The best scores are: opt bits E(32554) CCDS42339.1 HAP1 gene_id:9001|Hs108|chr17 ( 594) 3918 442.9 5.6e-124 CCDS42338.1 HAP1 gene_id:9001|Hs108|chr17 ( 602) 3892 440.0 4.1e-123 CCDS11406.1 HAP1 gene_id:9001|Hs108|chr17 ( 619) 2653 304.2 3.2e-82 >>CCDS42339.1 HAP1 gene_id:9001|Hs108|chr17 (594 aa) initn: 3918 init1: 3918 opt: 3918 Z-score: 2339.3 bits: 442.9 E(32554): 5.6e-124 Smith-Waterman score: 3918; 99.3% identity (99.8% similar) in 594 aa overlap (1-594:1-594) 10 20 30 40 50 60 pF1KB3 MRPRRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGTQF :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::.:: CCDS42 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: CCDS42 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAEELRTSLRR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIMRGEDFTPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 EELVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGL 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 GPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSSCR :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSSCR 550 560 570 580 590 >>CCDS42338.1 HAP1 gene_id:9001|Hs108|chr17 (602 aa) initn: 2676 init1: 2676 opt: 3892 Z-score: 2323.8 bits: 440.0 E(32554): 4.1e-123 Smith-Waterman score: 3892; 98.0% identity (98.5% similar) in 602 aa overlap (1-594:1-602) 10 20 30 40 50 60 pF1KB3 MRPRRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGTQF :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::.:: CCDS42 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LEE--------LLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALL ::: ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LEEVCTAFLIQLLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 GSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILEC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 VEQFLEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAE :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMETLPGFQETLAE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQVRGFEAEEGLMLAADIM 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB3 RGEDFTPAEELVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVT ::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB3 SALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGECPHGALPAASRTSCRSS 550 560 570 580 590 600 pF1KB3 CR :: CCDS42 CR >>CCDS11406.1 HAP1 gene_id:9001|Hs108|chr17 (619 aa) initn: 3904 init1: 2631 opt: 2653 Z-score: 1589.5 bits: 304.2 E(32554): 3.2e-82 Smith-Waterman score: 3858; 95.3% identity (95.8% similar) in 619 aa overlap (1-594:1-619) 10 20 30 40 50 60 pF1KB3 MRPRRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGTQF :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::.:: CCDS11 MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 GTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 YLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAHPCDAPKLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: CCDS11 SQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEAS 310 320 330 340 350 360 370 380 390 400 pF1KB3 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM-------------------- :::::::::::::::::::::::::::::::::::::::: CCDS11 QQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRMYGAETEKLQKQLASEKEIQM 370 380 390 400 410 420 410 420 430 440 450 pF1KB3 -----ETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QLQEEETLPGFQETLAEELRTSLRRMISDPVYFMERNYEMPRGDTSSLRYDFRYSEDREQ 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB3 VRGFEAEEGLMLAADIMRGEDFTPAEELVPQEELGAAKKVPAEEGVMEEAELVSEETEGW :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: CCDS11 VRGFEAEEGLMLAADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGW 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB3 EEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKGE 550 560 570 580 590 600 580 590 pF1KB3 CPHGALPAASRTSCRSSCR ::::::::::::::::::: CCDS11 CPHGALPAASRTSCRSSCR 610 594 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:40:07 2016 done: Fri Nov 4 02:40:08 2016 Total Scan time: 4.600 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]