FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3797, 474 aa 1>>>pF1KB3797 474 - 474 aa - 474 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7419+/-0.000495; mu= 15.2399+/- 0.031 mean_var=72.5908+/-14.912, 0's: 0 Z-trim(107.7): 154 B-trim: 22 in 1/50 Lambda= 0.150534 statistics sampled from 15601 (15760) to 15601 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.185), width: 16 Scan time: 5.880 The best scores are: opt bits E(85289) NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 3136 691.1 1.7e-198 NP_000805 (OMIM: 137192,612269,617113) gamma-amino ( 473) 2552 564.3 2.6e-160 NP_000803 (OMIM: 137190,617153) gamma-aminobutyric ( 474) 2518 556.9 4.4e-158 NP_068712 (OMIM: 137192,612269,617113) gamma-amino ( 473) 2485 549.7 6.3e-156 NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 2382 527.4 3.6e-149 XP_011519730 (OMIM: 137192,612269,617113) PREDICTE ( 414) 2147 476.3 7e-134 NP_001178250 (OMIM: 137192,612269,617113) gamma-am ( 402) 2146 476.1 7.9e-134 NP_001265560 (OMIM: 137192,612269,617113) gamma-am ( 388) 2115 469.3 8.1e-132 NP_001178249 (OMIM: 137192,612269,617113) gamma-am ( 388) 2115 469.3 8.1e-132 XP_016863474 (OMIM: 137190,617153) PREDICTED: gamm ( 257) 1245 280.3 4.3e-75 XP_011529486 (OMIM: 300349) PREDICTED: gamma-amino ( 406) 1227 276.5 9.6e-74 NP_061028 (OMIM: 300349) gamma-aminobutyric acid r ( 632) 1227 276.6 1.4e-73 NP_000806 (OMIM: 137163,613060) gamma-aminobutyric ( 452) 1090 246.8 9.5e-65 XP_011539496 (OMIM: 137163,613060) PREDICTED: gamm ( 465) 1090 246.8 9.8e-65 XP_016856425 (OMIM: 137163,613060) PREDICTED: gamm ( 687) 1090 246.8 1.4e-64 NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 1031 234.0 7e-61 NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 1031 234.0 7.2e-61 XP_016866178 (OMIM: 137161) PREDICTED: gamma-amino ( 392) 1021 231.8 2.7e-60 NP_001243633 (OMIM: 137161) gamma-aminobutyric aci ( 392) 1021 231.8 2.7e-60 NP_001254511 (OMIM: 137161) gamma-aminobutyric aci ( 392) 1021 231.8 2.7e-60 NP_002034 (OMIM: 137162) gamma-aminobutyric acid r ( 465) 1003 227.9 4.8e-59 NP_055026 (OMIM: 602729) gamma-aminobutyric acid r ( 440) 998 226.8 9.6e-59 XP_011534015 (OMIM: 137162) PREDICTED: gamma-amino ( 421) 960 218.5 2.8e-56 XP_006724550 (OMIM: 305990) PREDICTED: glycine rec ( 436) 948 215.9 1.8e-55 XP_011543798 (OMIM: 305990) PREDICTED: glycine rec ( 436) 948 215.9 1.8e-55 XP_011543797 (OMIM: 305990) PREDICTED: glycine rec ( 436) 948 215.9 1.8e-55 NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 947 215.7 2.1e-55 NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 947 215.7 2.1e-55 NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 945 215.3 2.9e-55 XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 945 215.3 2.9e-55 NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 943 214.8 3.9e-55 XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 942 214.6 4.6e-55 NP_001036008 (OMIM: 600421) glycine receptor subun ( 449) 940 214.2 6.1e-55 NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 940 214.2 6.2e-55 NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 940 214.2 6.2e-55 NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 933 212.7 1.8e-54 NP_944494 (OMIM: 137164,607681,611277) gamma-amino ( 475) 933 212.7 1.8e-54 XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 929 211.8 3e-54 NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 896 204.6 4.7e-52 XP_011511977 (OMIM: 103780,137140) PREDICTED: gamm ( 511) 896 204.7 5.1e-52 NP_001317619 (OMIM: 103780,137140) gamma-aminobuty ( 511) 896 204.7 5.1e-52 NP_150092 (OMIM: 600233) gamma-aminobutyric acid r ( 467) 895 204.4 5.5e-52 XP_011519732 (OMIM: 600233) PREDICTED: gamma-amino ( 473) 895 204.4 5.5e-52 NP_000815 (OMIM: 138492,614619) glycine receptor s ( 497) 894 204.2 6.7e-52 NP_001159532 (OMIM: 138492,614619) glycine recepto ( 497) 894 204.2 6.7e-52 NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 886 202.5 2.1e-51 NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 886 202.5 2.1e-51 XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 886 202.5 2.1e-51 XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 886 202.5 2.1e-51 XP_016863475 (OMIM: 137190,617153) PREDICTED: gamm ( 247) 881 201.3 2.6e-51 >>NP_000804 (OMIM: 600232) gamma-aminobutyric acid recep (474 aa) initn: 3136 init1: 3136 opt: 3136 Z-score: 3684.5 bits: 691.1 E(85289): 1.7e-198 Smith-Waterman score: 3136; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB3 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 430 440 450 460 470 >>NP_000805 (OMIM: 137192,612269,617113) gamma-aminobuty (473 aa) initn: 2120 init1: 2120 opt: 2552 Z-score: 2999.1 bits: 564.3 E(85289): 2.6e-160 Smith-Waterman score: 2552; 79.8% identity (92.4% similar) in 475 aa overlap (1-474:1-473) 10 20 30 40 50 pF1KB3 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP :: . :::.: :...:.:: :::::::.:::.::::::.::::::::::::::::: NP_000 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD : :::::::::::::::::::::::::::: ::::::.:. ::::::::::::::::::: NP_000 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK ::::::::::::::: :.::::: .:::::::::...:....:::.::.::::::::.:: NP_000 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK ::::::::::::::::::.::::::.::::::::::::::: :::.:.:.:.. . . :. NP_000 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALE .: : ::::..::..::: .:. :.:: :.. ...: :.::::: ..::.. :: . NP_000 VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGD 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN : . .::..::::.::::: :::::::::::::::: :: .::.::.:::::::: NP_000 RSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 420 430 440 450 460 470 >>NP_000803 (OMIM: 137190,617153) gamma-aminobutyric aci (474 aa) initn: 2446 init1: 2152 opt: 2518 Z-score: 2959.1 bits: 556.9 E(85289): 4.4e-158 Smith-Waterman score: 2518; 78.8% identity (92.2% similar) in 477 aa overlap (1-474:1-474) 10 20 30 40 50 pF1KB3 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP :: :..: .:. :::..:. :: :.:.:.::::: :::::::::::::::::::::::: NP_000 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD : ::: ::.:::::::::::::::::::::.:.::::::. ::::::::::::::::::: NP_000 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK ::::::::::::: : ..:::::.:::::::::::::...::: :.::.::::::::.:: NP_000 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI :::::::::::::: ::::::::::::::::::::::::::::::::::.:::::::::: NP_000 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK :::::::.::::::::::.::::::.:::::::.::: ::.: : .. ::: .:..:: NP_000 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNK 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 M--DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNA . : : :::::::::.:: . ::.. ...::..:: .::..:::::: :...:: : NP_000 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-A 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 LERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN :.:: . .:.:.::::::::. ::::::::.::.:::.:::..::.::.:::::::. NP_000 LDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 420 430 440 450 460 470 >>NP_068712 (OMIM: 137192,612269,617113) gamma-aminobuty (473 aa) initn: 2089 init1: 2089 opt: 2485 Z-score: 2920.4 bits: 549.7 E(85289): 6.3e-156 Smith-Waterman score: 2485; 80.0% identity (92.2% similar) in 464 aa overlap (12-474:12-473) 10 20 30 40 50 pF1KB3 MWRVRKRGYFGIW-SFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP :: :. : . .:::::.:::.::::::.::::::::::::::::: NP_068 MCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD : :::::::::::::::::::::::::::: ::::::.:. ::::::::::::::::::: NP_068 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK ::::::::::::::: :.::::: .:::::::::...:....:::.::.::::::::.:: NP_068 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK ::::::::::::::::::.::::::.::::::::::::::: :::.:.:.:.. . . :. NP_068 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALE .: : ::::..::..::: .:. :.:: :.. ...: :.::::: ..::.. :: . NP_068 VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGD 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN : . .::..::::.::::: :::::::::::::::: :: .::.::.:::::::: NP_068 RSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 420 430 440 450 460 470 >>NP_068711 (OMIM: 600232) gamma-aminobutyric acid recep (512 aa) initn: 3124 init1: 2382 opt: 2382 Z-score: 2799.0 bits: 527.4 E(85289): 3.6e-149 Smith-Waterman score: 3002; 92.5% identity (92.5% similar) in 506 aa overlap (1-468:1-506) 10 20 30 40 50 60 pF1KB3 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI 310 320 330 340 350 360 360 370 380 pF1KB3 -------------------------------------MDPHENILLSTLEIKNEMATSEA ::::::::::::::::::::::: NP_068 FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB3 VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD 430 440 450 460 470 480 450 460 470 pF1KB3 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN :::::::::::::::::::::::::: NP_068 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 490 500 510 >>XP_011519730 (OMIM: 137192,612269,617113) PREDICTED: g (414 aa) initn: 1756 init1: 1756 opt: 2147 Z-score: 2524.6 bits: 476.3 E(85289): 7e-134 Smith-Waterman score: 2147; 79.6% identity (92.7% similar) in 398 aa overlap (77-474:19-414) 50 60 70 80 90 100 pF1KB3 YDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLT . :::::::::: ::::::.:. :::::: XP_011 MQIPSLCDCALLFGSCHIIAKDYTLTMYFQQYWRDKRLAYSGIPLNLT 10 20 30 40 110 120 130 140 150 160 pF1KB3 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB3 YPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFST :::::::::::::::::::::::::::: :.::::: .:::::::::...:....:::.: XP_011 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFAT 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB3 GSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMT :.::::::::.::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMT 170 180 190 200 210 220 290 300 310 320 330 340 pF1KB3 TINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAA :::::::::::::::::::::::::::::::.::::::.::::::::::::::: :::.: XP_011 TINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTA 230 240 250 260 270 280 350 360 370 380 390 400 pF1KB3 SANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKA .:.:.. . . :..: : ::::..::..::: .:. :.:: :.. ...: :.::::: XP_011 KAKNDRSKSESNRVDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQ 290 300 310 320 330 340 410 420 430 440 450 460 pF1KB3 GLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNI ..::.. :: .: . .::..::::.::::: :::::::::::::::: :: .::.::. XP_011 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 350 360 370 380 390 400 470 pF1KB3 VYWLYYVN :::::::: XP_011 VYWLYYVN 410 >>NP_001178250 (OMIM: 137192,612269,617113) gamma-aminob (402 aa) initn: 1755 init1: 1755 opt: 2146 Z-score: 2523.6 bits: 476.1 E(85289): 7.9e-134 Smith-Waterman score: 2146; 80.3% identity (93.2% similar) in 395 aa overlap (80-474:10-402) 50 60 70 80 90 100 pF1KB3 RLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDN :::::::::: ::::::.:. ::::::::: NP_001 MWATYQTEEDYTLTMYFQQYWRDKRLAYSGIPLNLTLDN 10 20 30 110 120 130 140 150 160 pF1KB3 RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB3 DEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSY ::::::::::::::::::::::::: :.::::: .:::::::::...:....:::.::.: NP_001 DEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAY 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB3 PRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTIN :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTIN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB3 THLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASAN ::::::::::::::::::::::::::::.::::::.::::::::::::::: :::.:.:. NP_001 THLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB3 NEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLP :.. . . :..: : ::::..::..::: .:. :.:: :.. ...: :.::::: ..: NP_001 NDRSKSESNRVDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMP 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB3 RHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYW :.. :: .: . .::..::::.::::: :::::::::::::::: :: .::.::.::: NP_001 REGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYW 340 350 360 370 380 390 470 pF1KB3 LYYVN ::::: NP_001 LYYVN 400 >>NP_001265560 (OMIM: 137192,612269,617113) gamma-aminob (388 aa) initn: 1724 init1: 1724 opt: 2115 Z-score: 2487.5 bits: 469.3 E(85289): 8.1e-132 Smith-Waterman score: 2115; 80.0% identity (93.1% similar) in 390 aa overlap (85-474:1-388) 60 70 80 90 100 110 pF1KB3 FGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQ ::::: ::::::.:. :::::::::::::: NP_001 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQ 10 20 30 120 130 140 150 160 170 pF1KB3 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB3 TLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSL :::::::::::::::::::: :.::::: .:::::::::...:....:::.::.:::::: NP_001 TLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB3 SFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB3 TLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMR :::::::::::::::::::::::.::::::.::::::::::::::: :::.:.:.:.. . NP_001 TLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSK 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB3 LDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFG . :..: : ::::..::..::: .:. :.:: :.. ...: :.::::: ..::.. : NP_001 SESNRVDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG 280 290 300 310 320 420 430 440 450 460 470 pF1KB3 RNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN : .: . .::..::::.::::: :::::::::::::::: :: .::.::.:::::::: NP_001 RFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 330 340 350 360 370 380 >>NP_001178249 (OMIM: 137192,612269,617113) gamma-aminob (388 aa) initn: 1724 init1: 1724 opt: 2115 Z-score: 2487.5 bits: 469.3 E(85289): 8.1e-132 Smith-Waterman score: 2115; 80.0% identity (93.1% similar) in 390 aa overlap (85-474:1-388) 60 70 80 90 100 110 pF1KB3 FGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQ ::::: ::::::.:. :::::::::::::: NP_001 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQ 10 20 30 120 130 140 150 160 170 pF1KB3 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB3 TLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSL :::::::::::::::::::: :.::::: .:::::::::...:....:::.::.:::::: NP_001 TLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB3 SFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB3 TLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMR :::::::::::::::::::::::.::::::.::::::::::::::: :::.:.:.:.. . NP_001 TLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSK 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB3 LDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFG . :..: : ::::..::..::: .:. :.:: :.. ...: :.::::: ..::.. : NP_001 SESNRVDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG 280 290 300 310 320 420 430 440 450 460 470 pF1KB3 RNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN : .: . .::..::::.::::: :::::::::::::::: :: .::.::.:::::::: NP_001 RFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 330 340 350 360 370 380 >>XP_016863474 (OMIM: 137190,617153) PREDICTED: gamma-am (257 aa) initn: 1229 init1: 935 opt: 1245 Z-score: 1469.1 bits: 280.3 E(85289): 4.3e-75 Smith-Waterman score: 1245; 72.3% identity (90.4% similar) in 260 aa overlap (217-474:1-257) 190 200 210 220 230 240 pF1KB3 DIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFI ...::: :.::.::::::::.::::::::: XP_016 MVSKKVEFTTGAYPRLSLSFRLKRNIGYFI 10 20 30 250 260 270 280 290 300 pF1KB3 LQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAID ::::::: ::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 LQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAID 40 50 60 70 80 90 310 320 330 340 350 360 pF1KB3 MYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM--DPHE .::::::::::.::::::.:::::::.::: ::.: : .. ::: .:..::. : : XP_016 IYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNKVQVDAHG 100 110 120 130 140 370 380 390 400 410 420 pF1KB3 NILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQ :::::::::.:: . ::.. ...::..:: .::..:::::: :...:: ::.:: . XP_016 NILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-ALDRHGVP 150 160 170 180 190 200 430 440 450 460 470 pF1KB3 KKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN .:.:.::::::::. ::::::::.::.:::.:::..::.::.:::::::. XP_016 SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 210 220 230 240 250 474 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:58:21 2016 done: Thu Nov 3 13:58:22 2016 Total Scan time: 5.880 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]