FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3848, 134 aa 1>>>pF1KB3848 134 - 134 aa - 134 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7943+/-0.000292; mu= -3.6610+/- 0.018 mean_var=213.2394+/-41.804, 0's: 0 Z-trim(124.1): 9 B-trim: 0 in 0/59 Lambda= 0.087830 statistics sampled from 44996 (45005) to 44996 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.828), E-opt: 0.2 (0.528), width: 16 Scan time: 5.690 The best scores are: opt bits E(85289) XP_016864453 (OMIM: 605033) PREDICTED: complexin-2 ( 134) 880 122.4 2.2e-28 XP_005265856 (OMIM: 605033) PREDICTED: complexin-2 ( 134) 880 122.4 2.2e-28 XP_005265855 (OMIM: 605033) PREDICTED: complexin-2 ( 134) 880 122.4 2.2e-28 NP_006641 (OMIM: 605033) complexin-2 [Homo sapiens ( 134) 880 122.4 2.2e-28 NP_001008221 (OMIM: 605033) complexin-2 [Homo sapi ( 134) 880 122.4 2.2e-28 XP_011532721 (OMIM: 605033) PREDICTED: complexin-2 ( 134) 880 122.4 2.2e-28 NP_006642 (OMIM: 194190,605032) complexin-1 [Homo ( 134) 744 105.2 3.4e-23 XP_011511693 (OMIM: 194190,605032) PREDICTED: comp ( 119) 652 93.5 9.9e-20 >>XP_016864453 (OMIM: 605033) PREDICTED: complexin-2 iso (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: XP_016 LKYLPGPLQDMFKK 130 >>XP_005265856 (OMIM: 605033) PREDICTED: complexin-2 iso (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: XP_005 LKYLPGPLQDMFKK 130 >>XP_005265855 (OMIM: 605033) PREDICTED: complexin-2 iso (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: XP_005 LKYLPGPLQDMFKK 130 >>NP_006641 (OMIM: 605033) complexin-2 [Homo sapiens] (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: NP_006 LKYLPGPLQDMFKK 130 >>NP_001008221 (OMIM: 605033) complexin-2 [Homo sapiens] (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: NP_001 LKYLPGPLQDMFKK 130 >>XP_011532721 (OMIM: 605033) PREDICTED: complexin-2 iso (134 aa) initn: 880 init1: 880 opt: 880 Z-score: 630.6 bits: 122.4 E(85289): 2.2e-28 Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK :::::::::::::: XP_011 LKYLPGPLQDMFKK 130 >>NP_006642 (OMIM: 194190,605032) complexin-1 [Homo sapi (134 aa) initn: 744 init1: 744 opt: 744 Z-score: 537.5 bits: 105.2 E(85289): 3.4e-23 Smith-Waterman score: 744; 84.3% identity (92.5% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :.::::::::::::::::::::.::::::: :::::::::::: :::::::.:.:::::: NP_006 MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV ::: ::::::.:::::.::: .::.: :::::::::::: ::::: :::.::::::: NP_006 AVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTV 70 80 90 100 110 120 130 pF1KB3 LKYLPGPLQDMFKK .::::::::::.:: NP_006 IKYLPGPLQDMLKK 130 >>XP_011511693 (OMIM: 194190,605032) PREDICTED: complexi (119 aa) initn: 652 init1: 652 opt: 652 Z-score: 475.2 bits: 93.5 E(85289): 9.9e-20 Smith-Waterman score: 652; 83.2% identity (91.6% similar) in 119 aa overlap (16-134:1-119) 10 20 30 40 50 60 pF1KB3 MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE :::::::.::::::: :::::::::::: :::::::.:.:::::: XP_011 MGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAERE 10 20 30 40 70 80 90 100 110 120 pF1KB3 KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV ::: ::::::.:::::.::: .::.: :::::::::::: ::::: :::.::::::: XP_011 AVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTV 50 60 70 80 90 100 130 pF1KB3 LKYLPGPLQDMFKK .::::::::::.:: XP_011 IKYLPGPLQDMLKK 110 134 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:25:15 2016 done: Sat Nov 5 05:25:16 2016 Total Scan time: 5.690 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]