FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3856, 1241 aa 1>>>pF1KB3856 1241 - 1241 aa - 1241 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4387+/-0.000371; mu= 8.6275+/- 0.023 mean_var=184.6669+/-37.049, 0's: 0 Z-trim(119.4): 137 B-trim: 13 in 1/59 Lambda= 0.094380 statistics sampled from 33280 (33437) to 33280 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.392), width: 16 Scan time: 14.680 The best scores are: opt bits E(85289) NP_001186621 (OMIM: 109280) anion exchange protein (1241) 8209 1131.1 0 NP_003031 (OMIM: 109280) anion exchange protein 2 (1241) 8209 1131.1 0 NP_001186623 (OMIM: 109280) anion exchange protein (1227) 8090 1114.9 0 NP_001186622 (OMIM: 109280) anion exchange protein (1232) 8090 1114.9 0 NP_005061 (OMIM: 106195) anion exchange protein 3 (1232) 4504 626.6 3e-178 XP_006716157 (OMIM: 109280) PREDICTED: anion excha ( 666) 4393 611.4 6.5e-174 NP_963868 (OMIM: 106195) anion exchange protein 3 (1259) 4342 604.6 1.3e-171 NP_001313488 (OMIM: 106195) anion exchange protein (1259) 4342 604.6 1.3e-171 XP_011509967 (OMIM: 106195) PREDICTED: anion excha (1206) 4330 602.9 4e-171 XP_005246846 (OMIM: 106195) PREDICTED: anion excha (1259) 4330 603.0 4.1e-171 XP_005246847 (OMIM: 106195) PREDICTED: anion excha (1034) 4123 574.7 1.1e-162 XP_011509969 (OMIM: 106195) PREDICTED: anion excha ( 741) 3298 462.3 5.4e-129 XP_016875730 (OMIM: 605024) PREDICTED: electroneut (1071) 1719 247.4 3.8e-64 XP_005265657 (OMIM: 603353) PREDICTED: sodium bica (1113) 1719 247.4 3.9e-64 XP_016863016 (OMIM: 603353) PREDICTED: sodium bica (1118) 1719 247.4 3.9e-64 XP_011532565 (OMIM: 603353) PREDICTED: sodium bica (1122) 1719 247.4 4e-64 NP_001035049 (OMIM: 605024) electroneutral sodium (1093) 1714 246.7 6.2e-64 NP_001245330 (OMIM: 605024) electroneutral sodium (1040) 1711 246.3 7.9e-64 NP_001245309 (OMIM: 603353) sodium bicarbonate cot (1090) 1705 245.5 1.4e-63 NP_001308036 (OMIM: 603353) sodium bicarbonate cot (1095) 1705 245.5 1.5e-63 XP_011532567 (OMIM: 603353) PREDICTED: sodium bica (1099) 1705 245.5 1.5e-63 XP_005265655 (OMIM: 603353) PREDICTED: sodium bica (1126) 1705 245.5 1.5e-63 NP_001245308 (OMIM: 603353) sodium bicarbonate cot (1131) 1705 245.5 1.5e-63 NP_001308037 (OMIM: 603353) sodium bicarbonate cot (1135) 1705 245.5 1.5e-63 XP_016860032 (OMIM: 605556) PREDICTED: sodium-driv (1086) 1700 244.8 2.3e-63 NP_071341 (OMIM: 605556) sodium-driven chloride bi (1088) 1700 244.8 2.3e-63 NP_001171487 (OMIM: 605556) sodium-driven chloride (1099) 1700 244.8 2.3e-63 XP_016860038 (OMIM: 605556) PREDICTED: sodium-driv (1100) 1700 244.8 2.3e-63 XP_011509813 (OMIM: 605556) PREDICTED: sodium-driv (1106) 1700 244.8 2.3e-63 XP_005246752 (OMIM: 605556) PREDICTED: sodium-driv (1117) 1700 244.8 2.4e-63 XP_016860035 (OMIM: 605556) PREDICTED: sodium-driv (1118) 1700 244.8 2.4e-63 XP_016860033 (OMIM: 605556) PREDICTED: sodium-driv (1085) 1696 244.3 3.4e-63 XP_016860031 (OMIM: 605556) PREDICTED: sodium-driv (1087) 1696 244.3 3.4e-63 XP_016860039 (OMIM: 605556) PREDICTED: sodium-driv (1098) 1696 244.3 3.4e-63 XP_011509814 (OMIM: 605556) PREDICTED: sodium-driv (1105) 1696 244.3 3.4e-63 XP_005257650 (OMIM: 109270,110500,112010,112050,16 ( 846) 1666 240.1 4.7e-62 NP_000333 (OMIM: 109270,110500,112010,112050,16690 ( 911) 1666 240.1 5e-62 XP_016860042 (OMIM: 605556) PREDICTED: sodium-driv ( 895) 1383 201.6 2e-50 XP_016860041 (OMIM: 605556) PREDICTED: sodium-driv ( 913) 1383 201.6 2e-50 XP_016863015 (OMIM: 603353) PREDICTED: sodium bica (1135) 1369 199.8 8.8e-50 XP_011532563 (OMIM: 603353) PREDICTED: sodium bica (1201) 1369 199.8 9.3e-50 NP_001308035 (OMIM: 603353) sodium bicarbonate cot (1206) 1369 199.8 9.3e-50 NP_001308034 (OMIM: 603353) sodium bicarbonate cot (1210) 1369 199.8 9.3e-50 NP_003606 (OMIM: 603353) sodium bicarbonate cotran (1214) 1369 199.8 9.3e-50 XP_011532560 (OMIM: 603353) PREDICTED: sodium bica (1223) 1369 199.8 9.4e-50 NP_001308033 (OMIM: 603353) sodium bicarbonate cot (1246) 1369 199.8 9.5e-50 XP_011532558 (OMIM: 603353) PREDICTED: sodium bica (1250) 1369 199.8 9.6e-50 XP_006713484 (OMIM: 603353) PREDICTED: sodium bica (1255) 1369 199.8 9.6e-50 NP_001308032 (OMIM: 603353) sodium bicarbonate cot (1259) 1369 199.8 9.6e-50 XP_016860040 (OMIM: 605556) PREDICTED: sodium-driv ( 943) 1347 196.7 6.1e-49 >>NP_001186621 (OMIM: 109280) anion exchange protein 2 i (1241 aa) initn: 8209 init1: 8209 opt: 8209 Z-score: 6047.5 bits: 1131.1 E(85289): 0 Smith-Waterman score: 8209; 100.0% identity (100.0% similar) in 1241 aa overlap (1-1241:1-1241) 10 20 30 40 50 60 pF1KB3 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB3 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB3 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB3 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB3 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB3 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB3 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB3 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KB3 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV ::::::::::::::::::::::::::::::::::::::::: NP_001 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1210 1220 1230 1240 >>NP_003031 (OMIM: 109280) anion exchange protein 2 isof (1241 aa) initn: 8209 init1: 8209 opt: 8209 Z-score: 6047.5 bits: 1131.1 E(85289): 0 Smith-Waterman score: 8209; 100.0% identity (100.0% similar) in 1241 aa overlap (1-1241:1-1241) 10 20 30 40 50 60 pF1KB3 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB3 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB3 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB3 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB3 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB3 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB3 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB3 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KB3 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV ::::::::::::::::::::::::::::::::::::::::: NP_003 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1210 1220 1230 1240 >>NP_001186623 (OMIM: 109280) anion exchange protein 2 i (1227 aa) initn: 8090 init1: 8090 opt: 8090 Z-score: 5960.0 bits: 1114.9 E(85289): 0 Smith-Waterman score: 8090; 100.0% identity (100.0% similar) in 1224 aa overlap (18-1241:4-1227) 10 20 30 40 50 60 pF1KB3 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE ::::::::::::::::::::::::::::::::::::::::::: NP_001 MTQPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 10 20 30 40 70 80 90 100 110 120 pF1KB3 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB3 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB3 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB3 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB3 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB3 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB3 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB3 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KB3 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KB3 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KB3 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 pF1KB3 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV ::::::::::::::::::::::::::::::::::::::::: NP_001 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1190 1200 1210 1220 >>NP_001186622 (OMIM: 109280) anion exchange protein 2 i (1232 aa) initn: 8090 init1: 8090 opt: 8090 Z-score: 5960.0 bits: 1114.9 E(85289): 0 Smith-Waterman score: 8090; 100.0% identity (100.0% similar) in 1224 aa overlap (18-1241:9-1232) 10 20 30 40 50 60 pF1KB3 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE ::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFLLRPQPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 pF1KB3 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV ::::::::::::::::::::::::::::::::::::::::: NP_001 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1200 1210 1220 1230 >>NP_005061 (OMIM: 106195) anion exchange protein 3 isof (1232 aa) initn: 3774 init1: 1663 opt: 4504 Z-score: 3321.2 bits: 626.6 E(85289): 3e-178 Smith-Waterman score: 4623; 59.6% identity (77.9% similar) in 1267 aa overlap (8-1241:8-1232) 10 20 30 40 50 pF1KB3 MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSR : ::. . :. : : .: :.:.:.: .::.: :: ..... . NP_005 MANGVIPPPGGASPL--PQVRVPLEEPPLSPDV-EEEDDDLGKTLAVSRFGDLISKPPAW 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 GGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRR-----PGA :.:.:::.:.:::.::..::: :::::..::: . :. : .:. ::. .: NP_005 DPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSA 60 70 80 90 100 110 120 130 140 150 160 pF1KB3 SPTGETPTI-EEG------EEDEDEASEAEGARALTQPSPVSTPSSVQFFL--QEDDSAD :. :: : ::: ::.:.: :.:. ..: : .::....: . .:::: NP_005 PPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB3 RKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGR . :.. ..: : :: . .:. :... . .:.: .: : ..: NP_005 LPG-RAAVTKPLPSVGPHTDKSPQHSSSSPS----PRARASRLA-----------GEKSR 180 190 200 210 220 230 240 250 260 270 280 pF1KB3 PL-PKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED : :.: ::.:.:: :: : . .::::: ::: :..:::: :::::.:: NP_005 PWSPSA-----SYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLED 230 240 250 260 270 290 300 310 320 330 pF1KB3 VPGVRRHLVRKNAKGSTQSGREGREPGPTP-----RARPRAPHKPHEVFVELNELLLDKN ::::::::.: .. ::.:: : : .: . . . ..:::::::::::.::.. NP_005 NPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRS 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB3 QEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP :::.::::::::::::::::::::::::::::::::::::::::.::::.::::.: ::: NP_005 QEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLP 340 350 360 370 380 390 400 410 420 430 440 450 pF1KB3 GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAGSLGSLLGHH :.:: ::: :..::::. ::::.:::.::::::::.:.:: .: ::: :..:..:.::.: NP_005 GIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNH 400 410 420 430 440 450 460 470 480 490 500 510 pF1KB3 HGQGAESDPHVTEPLMG---GVPETRLEVERE-RELPPPAPPAGITRSKSKHELKLLEKI : ... : . : :. : : . . .: : : . :.:: ::::::: NP_005 HPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKS---LKLLEKI 460 470 480 490 500 520 530 540 550 560 570 pF1KB3 PENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYH ::.::::::::::: :: .:. ::::: ::: :..::::::::::::..:::: .. ::: NP_005 PEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYH 510 520 530 540 550 560 580 590 600 610 620 630 pF1KB3 EIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQ :.::::.:::::: :::::: ::.:.:::.::. ::: :.:.:::::.:..:::::: :: NP_005 ELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQ 570 580 590 600 610 620 640 650 660 670 680 pF1KB3 RQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQMVEAAGAAEDDPLRRTGRPFGGLIR :..:.::.: : .. : : .: : : :.. . .. ::::: ::: ::::.: NP_005 RELLRKRREREQTKVEMTTRG--GYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVR 630 640 650 660 670 680 690 700 710 720 730 740 pF1KB3 DVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMST ::::::::: ::.:::: ::.:::.:::::::::::::::::::::. :.::::::.:: NP_005 DVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVST 690 700 710 720 730 740 750 760 770 780 790 800 pF1KB3 ALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLM :. ::.: :::::::::.::::::::::::::.:: .. ::::.::::.:.::: ..: . NP_005 AVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLAL 750 760 770 780 790 800 810 820 830 840 850 860 pF1KB3 VALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGE :: :::::::..: :::::::::::::::::::::: :.: :::: ... ..:. NP_005 VAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGA-LEGSL 810 820 830 840 850 860 870 880 890 900 910 920 pF1KB3 NMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFF . :: : :.. .: : .::.:::::::::.:: ::::::::::::.::::. NP_005 D---AG----LEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFL 870 880 890 900 910 930 940 950 960 970 980 pF1KB3 PGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKS :. ::.:::::.::.::.:::::::: :::::::.::.:.:::.:.::.: : ::: NP_005 GGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSAR 920 930 940 950 960 970 990 1000 1010 1020 1030 1040 pF1KB3 PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICA ::: :::::. .::.::.::::::::::.::.:.: : : :::::::::::: ..::.:. NP_005 PFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCG 980 990 1000 1010 1020 1030 1050 1060 1070 1080 1090 1100 pF1KB3 LFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIG :::::::.:::::::::.:::::: :.::::::.::::.::::::.:.: :::::::.: NP_005 LFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMG 1040 1050 1060 1070 1080 1090 1110 1120 1130 1140 1150 1160 pF1KB3 DLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFT .::.::::::::::::::::::.:::. .:: :.::: ::::. :: ::.: :::::: NP_005 AVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFT 1100 1110 1120 1130 1140 1150 1170 1180 1190 1200 1210 1220 pF1KB3 ALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDE .:: :.::::.: ::::::::::.:.:::::: .: :.: :::.. ::...::: ::: NP_005 CIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDE 1160 1170 1180 1190 1200 1210 1230 1240 pF1KB3 REGVDEYNEMPMPV .: :::::. ::: NP_005 -DGQDEYNELHMPV 1220 1230 >>XP_006716157 (OMIM: 109280) PREDICTED: anion exchange (666 aa) initn: 4393 init1: 4393 opt: 4393 Z-score: 3243.3 bits: 611.4 E(85289): 6.5e-174 Smith-Waterman score: 4393; 100.0% identity (100.0% similar) in 658 aa overlap (1-658:1-658) 10 20 30 40 50 60 pF1KB3 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKDG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL XP_006 RGGRGS >>NP_963868 (OMIM: 106195) anion exchange protein 3 isof (1259 aa) initn: 3774 init1: 1663 opt: 4342 Z-score: 3201.8 bits: 604.6 E(85289): 1.3e-171 Smith-Waterman score: 4614; 59.0% identity (78.0% similar) in 1276 aa overlap (8-1241:8-1259) 10 20 30 40 50 pF1KB3 MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSR : ::. . :. : : .: :.:.:.: .::.: :: ..... . NP_963 MANGVIPPPGGASPL--PQVRVPLEEPPLSPDV-EEEDDDLGKTLAVSRFGDLISKPPAW 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 GGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRR-----PGA :.:.:::.:.:::.::..::: :::::..::: . :. : .:. ::. .: NP_963 DPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSA 60 70 80 90 100 110 120 130 140 150 160 pF1KB3 SPTGETPTI-EEG------EEDEDEASEAEGARALTQPSPVSTPSSVQFFL--QEDDSAD :. :: : ::: ::.:.: :.:. ..: : .::....: . .:::: NP_963 PPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPG 120 130 140 150 160 170 170 180 190 200 210 pF1KB3 RKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEAEA-VAVASG-------TAGG . :.. ..: : :: . .:. : .. ........ . .:..: .. . NP_963 LPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDGTTDLALSSPRLLCCLPSSPS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB3 DDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLD . :: :..: ::.:.:: :: : . .::::: ::: :..:::: NP_963 PRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLD 240 250 260 270 280 290 280 290 300 310 320 pF1KB3 LMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----RARPRAPHKPHEVFVE :::::.:: ::::::::.: .. ::.:: : : .: . . . ..::::::: NP_963 DMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVE 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB3 LNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVL ::::.::..:::.::::::::::::::::::::::::::::::::::::::::.::::.: NP_963 LNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAAL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB3 LDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAG :::.: ::::.:: ::: :..::::. ::::.:::.::::::::.:.:: .: ::: :.. NP_963 LDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB3 SLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-RELPPPAPPAGITRSKSK :..:.::.:: ... : . : :. : : . . .: : : . :.:: NP_963 SMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKS- 480 490 500 510 520 510 520 530 540 550 560 pF1KB3 HELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLG :::::::::.::::::::::: :: .:. ::::: ::: :..::::::::::::..:: NP_963 --LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLG 530 540 550 560 570 580 570 580 590 600 610 620 pF1KB3 PSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEE :: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::: :.:.:::::.:.. NP_963 PSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRD 590 600 610 620 630 640 630 640 650 660 670 pF1KB3 LLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQMVEAAGAAEDDPLRRT :::::: :::..:.::.: : .. : : .: : : :.. . .. ::::: :: NP_963 LLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLELGGSEATPEDDPLLRT 650 660 670 680 690 700 680 690 700 710 720 730 pF1KB3 GRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLI : ::::.:::::::::: ::.:::: ::.:::.:::::::::::::::::::::. :. NP_963 GSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLM 710 720 730 740 750 760 740 750 760 770 780 790 pF1KB3 GVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGF ::::::.:::. ::.: :::::::::.::::::::::::::.:: .. ::::.::::.:. NP_963 GVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL 770 780 790 800 810 820 800 810 820 830 840 850 pF1KB3 WLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSAS ::: ..: .:: :::::::..: :::::::::::::::::::::: :.: :::: NP_963 WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPP 830 840 850 860 870 880 860 870 880 890 900 910 pF1KB3 NSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFL ... ..:. . :: : :.. .: : .::.:::::::::.:: ::::::::: NP_963 EGA-LEGSLD---AG----LEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFL 890 900 910 920 930 920 930 940 950 960 970 pF1KB3 RKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGW :::.::::. :. ::.:::::.::.::.:::::::: :::::::.::.:.:::.:.::.: NP_963 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 940 950 960 970 980 990 980 990 1000 1010 1020 1030 pF1KB3 VINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLL : ::: ::: :::::. .::.::.::::::::::.::.:.: : : ::::::::::: NP_963 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1000 1010 1020 1030 1040 1050 1040 1050 1060 1070 1080 1090 pF1KB3 IVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVAL : ..::.:.:::::::.:::::::::.:::::: :.::::::.::::.::::::.:.: NP_963 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1060 1070 1080 1090 1100 1110 1100 1110 1120 1130 1140 1150 pF1KB3 LVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKV :::::::.: .::.::::::::::::::::::.:::. .:: :.::: ::::. :: :: NP_963 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV 1120 1130 1140 1150 1160 1170 1160 1170 1180 1190 1200 1210 pF1KB3 RTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDA .: :::::: .:: :.::::.: ::::::::::.:.:::::: .: :.: :::.. ::. NP_963 KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDS 1180 1190 1200 1210 1220 1230 1220 1230 1240 pF1KB3 NEAEPVFDEREGVDEYNEMPMPV ..::: ::: .: :::::. ::: NP_963 EDAEPNFDE-DGQDEYNELHMPV 1240 1250 >>NP_001313488 (OMIM: 106195) anion exchange protein 3 i (1259 aa) initn: 3774 init1: 1663 opt: 4342 Z-score: 3201.8 bits: 604.6 E(85289): 1.3e-171 Smith-Waterman score: 4614; 59.0% identity (78.0% similar) in 1276 aa overlap (8-1241:8-1259) 10 20 30 40 50 pF1KB3 MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSR : ::. . :. : : .: :.:.:.: .::.: :: ..... . NP_001 MANGVIPPPGGASPL--PQVRVPLEEPPLSPDV-EEEDDDLGKTLAVSRFGDLISKPPAW 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 GGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRR-----PGA :.:.:::.:.:::.::..::: :::::..::: . :. : .:. ::. .: NP_001 DPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSA 60 70 80 90 100 110 120 130 140 150 160 pF1KB3 SPTGETPTI-EEG------EEDEDEASEAEGARALTQPSPVSTPSSVQFFL--QEDDSAD :. :: : ::: ::.:.: :.:. ..: : .::....: . .:::: NP_001 PPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPG 120 130 140 150 160 170 170 180 190 200 210 pF1KB3 RKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEAEA-VAVASG-------TAGG . :.. ..: : :: . .:. : .. ........ . .:..: .. . NP_001 LPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDGTTDLALSSPRLLCCLPSSPS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB3 DDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLD . :: :..: ::.:.:: :: : . .::::: ::: :..:::: NP_001 PRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLD 240 250 260 270 280 290 280 290 300 310 320 pF1KB3 LMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----RARPRAPHKPHEVFVE :::::.:: ::::::::.: .. ::.:: : : .: . . . ..::::::: NP_001 DMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVE 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB3 LNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVL ::::.::..:::.::::::::::::::::::::::::::::::::::::::::.::::.: NP_001 LNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAAL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB3 LDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAG :::.: ::::.:: ::: :..::::. ::::.:::.::::::::.:.:: .: ::: :.. NP_001 LDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB3 SLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-RELPPPAPPAGITRSKSK :..:.::.:: ... : . : :. : : . . .: : : . :.:: NP_001 SMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKS- 480 490 500 510 520 510 520 530 540 550 560 pF1KB3 HELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLG :::::::::.::::::::::: :: .:. ::::: ::: :..::::::::::::..:: NP_001 --LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLG 530 540 550 560 570 580 570 580 590 600 610 620 pF1KB3 PSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEE :: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::: :.:.:::::.:.. NP_001 PSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRD 590 600 610 620 630 640 630 640 650 660 670 pF1KB3 LLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQMVEAAGAAEDDPLRRT :::::: :::..:.::.: : .. : : .: : : :.. . .. ::::: :: NP_001 LLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLELGGSEATPEDDPLLRT 650 660 670 680 690 700 680 690 700 710 720 730 pF1KB3 GRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLI : ::::.:::::::::: ::.:::: ::.:::.:::::::::::::::::::::. :. NP_001 GSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLM 710 720 730 740 750 760 740 750 760 770 780 790 pF1KB3 GVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGF ::::::.:::. ::.: :::::::::.::::::::::::::.:: .. ::::.::::.:. NP_001 GVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL 770 780 790 800 810 820 800 810 820 830 840 850 pF1KB3 WLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSAS ::: ..: .:: :::::::..: :::::::::::::::::::::: :.: :::: NP_001 WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPP 830 840 850 860 870 880 860 870 880 890 900 910 pF1KB3 NSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFL ... ..:. . :: : :.. .: : .::.:::::::::.:: ::::::::: NP_001 EGA-LEGSLD---AG----LEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFL 890 900 910 920 930 920 930 940 950 960 970 pF1KB3 RKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGW :::.::::. :. ::.:::::.::.::.:::::::: :::::::.::.:.:::.:.::.: NP_001 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 940 950 960 970 980 990 980 990 1000 1010 1020 1030 pF1KB3 VINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLL : ::: ::: :::::. .::.::.::::::::::.::.:.: : : ::::::::::: NP_001 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1000 1010 1020 1030 1040 1050 1040 1050 1060 1070 1080 1090 pF1KB3 IVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVAL : ..::.:.:::::::.:::::::::.:::::: :.::::::.::::.::::::.:.: NP_001 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1060 1070 1080 1090 1100 1110 1100 1110 1120 1130 1140 1150 pF1KB3 LVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKV :::::::.: .::.::::::::::::::::::.:::. .:: :.::: ::::. :: :: NP_001 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV 1120 1130 1140 1150 1160 1170 1160 1170 1180 1190 1200 1210 pF1KB3 RTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDA .: :::::: .:: :.::::.: ::::::::::.:.:::::: .: :.: :::.. ::. NP_001 KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDS 1180 1190 1200 1210 1220 1230 1220 1230 1240 pF1KB3 NEAEPVFDEREGVDEYNEMPMPV ..::: ::: .: :::::. ::: NP_001 EDAEPNFDE-DGQDEYNELHMPV 1240 1250 >>XP_011509967 (OMIM: 106195) PREDICTED: anion exchange (1206 aa) initn: 3641 init1: 1663 opt: 4330 Z-score: 3193.2 bits: 602.9 E(85289): 4e-171 Smith-Waterman score: 4469; 60.2% identity (78.6% similar) in 1207 aa overlap (74-1241:21-1206) 50 60 70 80 90 100 pF1KB3 VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPG ::..::: :::::..::: . :. : . XP_011 MPCSVILPPPPIACPPAWGVHRHTSHHTHHPLSARLPPPHKLRRLPPTSA 10 20 30 40 50 110 120 130 140 150 pF1KB3 RKPRRR-----PGASPTGETPTI-EEG------EEDEDEASEAEGARALTQPSPVSTPSS :. ::. .: :. :: : ::: ::.:.: :.:. ..: .::.. XP_011 RHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGTPQK 60 70 80 90 100 110 160 170 180 190 200 pF1KB3 VQFFL--QEDDSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEAEA-VAV ..: . .:::: . :.. ..: : :: . .:. : .. ........ . .:. XP_011 AKFSIGSDEDDSPGLPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDGTTDLAL 120 130 140 150 160 210 220 230 240 250 pF1KB3 ASG-------TAGGDDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQALLPRVPT .: .. . . :: :..: ::.:.:: :: : . .::: XP_011 SSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPT 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 DEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----RA :: ::: :..:::: :::::.:: ::::::::.: .. ::.:: : : .: . XP_011 DEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB3 RPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRS . . ..:::::::::::.::..:::.::::::::::::::::::::::::::::::::: XP_011 KKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRS 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB3 LLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD :::::::.::::.::::.: ::::.:: ::: :..::::. ::::.:::.::::::::.: XP_011 LLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPND 350 360 370 380 390 400 440 450 460 470 480 pF1KB3 EKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-RELP .:: .: ::: :..:..:.::.:: ... : . : :. : : . . .: : XP_011 DKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEKP 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 PPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVL : . :.:: :::::::::.::::::::::: :: .:. ::::: ::: :..:: XP_011 LHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVL 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 EVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLD ::::::::::..:::: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::: XP_011 EVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLD 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 CSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQMV :.:.:::::.:..:::::: :::..:.::.: : .. : : .: : : :.. XP_011 GSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLELG 590 600 610 620 630 670 680 690 700 710 720 pF1KB3 EAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAI . .. ::::: ::: ::::.:::::::::: ::.:::: ::.:::.::::::::::: XP_011 GSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAI 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB3 TFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSS ::::::::::. :.::::::.:::. ::.: :::::::::.::::::::::::::.:: . XP_011 TFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRA 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB3 NHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLV . ::::.::::.:.::: ..: .:: :::::::..: :::::::::::::::::::::: XP_011 QDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLY 760 770 780 790 800 810 850 860 870 880 890 900 pF1KB3 KIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLS :.: :::: ... ..:. . :: : :.. .: : .::.:::::::: XP_011 KVFTEHPLLPFYPPEGA-LEGSLD---AG----LEPNGSALPPTEGPPSPRNQPNTALLS 820 830 840 850 860 870 910 920 930 940 950 960 pF1KB3 LVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSV :.:: ::::::::::::.::::. :. ::.:::::.::.::.:::::::: :::::::.: XP_011 LILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTV 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KB3 PSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKER :.:.:::.:.::.: : ::: ::: :::::. .::.::.::::::::::.::.:.: : XP_011 PTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKAR 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KB3 MLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQ : :::::::::::: ..::.:.:::::::.:::::::::.:::::: :.::::::.:: XP_011 RLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQ 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 pF1KB3 EVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLM ::.::::::.:.: :::::::.: .::.::::::::::::::::::.:::. .:: :.:: XP_011 EVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILM 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 pF1KB3 PPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVL : ::::. :: ::.: :::::: .:: :.::::.: ::::::::::.:.:::::: .: XP_011 PAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLL 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 pF1KB3 TRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV :.: :::.. ::...::: ::: .: :::::. ::: XP_011 PRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1180 1190 1200 >>XP_005246846 (OMIM: 106195) PREDICTED: anion exchange (1259 aa) initn: 3774 init1: 1663 opt: 4330 Z-score: 3193.0 bits: 603.0 E(85289): 4.1e-171 Smith-Waterman score: 4602; 58.9% identity (77.9% similar) in 1276 aa overlap (8-1241:8-1259) 10 20 30 40 50 pF1KB3 MSSAPRRPAKGADSFCTPE---PESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSR : ::. . :. : : .: :.:.:.: .::.: :: ..... . XP_005 MANGVIPPPGGASPL--PQVRVPLEEPPLSPDV-EEEDDDLGKTLAVSRFGDLISKPPAW 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 GGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRR-----PGA :.:.:::.:.:::.::..::: :::::..::: . :. : .:. ::. .: XP_005 DPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSA 60 70 80 90 100 110 120 130 140 150 160 pF1KB3 SPTGETPTI-EEG------EEDEDEASEAEGARALTQPSPVSTPSSVQFFL--QEDDSAD :. :: : ::: ::.:.: :.:. ..: .::....: . .:::: XP_005 PPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGTPQKAKFSIGSDEDDSPG 120 130 140 150 160 170 170 180 190 200 210 pF1KB3 RKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEAEA-VAVASG-------TAGG . :.. ..: : :: . .:. : .. ........ . .:..: .. . XP_005 LPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDGTTDLALSSPRLLCCLPSSPS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB3 DDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLD . :: :..: ::.:.:: :: : . .::::: ::: :..:::: XP_005 PRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLD 240 250 260 270 280 290 280 290 300 310 320 pF1KB3 LMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----RARPRAPHKPHEVFVE :::::.:: ::::::::.: .. ::.:: : : .: . . . ..::::::: XP_005 DMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKKKKKKLDRRPHEVFVE 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB3 LNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVL ::::.::..:::.::::::::::::::::::::::::::::::::::::::::.::::.: XP_005 LNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAAL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB3 LDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAG :::.: ::::.:: ::: :..::::. ::::.:::.::::::::.:.:: .: ::: :.. XP_005 LDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB3 SLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-RELPPPAPPAGITRSKSK :..:.::.:: ... : . : :. : : . . .: : : . :.:: XP_005 SMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKS- 480 490 500 510 520 510 520 530 540 550 560 pF1KB3 HELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLG :::::::::.::::::::::: :: .:. ::::: ::: :..::::::::::::..:: XP_005 --LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLG 530 540 550 560 570 580 570 580 590 600 610 620 pF1KB3 PSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEE :: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::: :.:.:::::.:.. XP_005 PSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRD 590 600 610 620 630 640 630 640 650 660 670 pF1KB3 LLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQMVEAAGAAEDDPLRRT :::::: :::..:.::.: : .. : : .: : : :.. . .. ::::: :: XP_005 LLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLELGGSEATPEDDPLLRT 650 660 670 680 690 700 680 690 700 710 720 730 pF1KB3 GRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLI : ::::.:::::::::: ::.:::: ::.:::.:::::::::::::::::::::. :. XP_005 GSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLM 710 720 730 740 750 760 740 750 760 770 780 790 pF1KB3 GVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGF ::::::.:::. ::.: :::::::::.::::::::::::::.:: .. ::::.::::.:. XP_005 GVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL 770 780 790 800 810 820 800 810 820 830 840 850 pF1KB3 WLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSAS ::: ..: .:: :::::::..: :::::::::::::::::::::: :.: :::: XP_005 WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPP 830 840 850 860 870 880 860 870 880 890 900 910 pF1KB3 NSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFL ... ..:. . :: : :.. .: : .::.:::::::::.:: ::::::::: XP_005 EGA-LEGSLD---AG----LEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFL 890 900 910 920 930 920 930 940 950 960 970 pF1KB3 RKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGW :::.::::. :. ::.:::::.::.::.:::::::: :::::::.::.:.:::.:.::.: XP_005 RKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSW 940 950 960 970 980 990 980 990 1000 1010 1020 1030 pF1KB3 VINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLL : ::: ::: :::::. .::.::.::::::::::.::.:.: : : ::::::::::: XP_005 FIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL 1000 1010 1020 1030 1040 1050 1040 1050 1060 1070 1080 1090 pF1KB3 IVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVAL : ..::.:.:::::::.:::::::::.:::::: :.::::::.::::.::::::.:.: XP_005 IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIAS 1060 1070 1080 1090 1100 1110 1100 1110 1120 1130 1140 1150 pF1KB3 LVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKV :::::::.: .::.::::::::::::::::::.:::. .:: :.::: ::::. :: :: XP_005 LVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKV 1120 1130 1140 1150 1160 1170 1160 1170 1180 1190 1200 1210 pF1KB3 RTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDA .: :::::: .:: :.::::.: ::::::::::.:.:::::: .: :.: :::.. ::. XP_005 KTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDS 1180 1190 1200 1210 1220 1230 1220 1230 1240 pF1KB3 NEAEPVFDEREGVDEYNEMPMPV ..::: ::: .: :::::. ::: XP_005 EDAEPNFDE-DGQDEYNELHMPV 1240 1250 1241 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:04:05 2016 done: Thu Nov 3 14:04:07 2016 Total Scan time: 14.680 Total Display time: 0.610 Function used was FASTA [36.3.4 Apr, 2011]