Result of FASTA (omim) for
pF1KB3864
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3864, 1142 aa
1>>>pF1KB3864 1142 - 1142 aa - 1142 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.0985+/-0.000371; mu= 0.5512+/- 0.023
mean_var=270.5503+/-56.243, 0's: 0 Z-trim(122.1): 128 B-trim: 909 in 2/55
Lambda= 0.077974
statistics sampled from 39597 (39735) to 39597 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.466), width: 16
Scan time: 16.310
The best scores are: opt bits E(85289)
XP_005246847 (OMIM: 106195) PREDICTED: anion excha (1034) 5382 619.6 3.1e-176
XP_011509967 (OMIM: 106195) PREDICTED: anion excha (1206) 5382 619.6 3.5e-176
NP_005061 (OMIM: 106195) anion exchange protein 3 (1232) 5382 619.6 3.5e-176
NP_963868 (OMIM: 106195) anion exchange protein 3 (1259) 5382 619.7 3.6e-176
XP_005246846 (OMIM: 106195) PREDICTED: anion excha (1259) 5382 619.7 3.6e-176
NP_001313488 (OMIM: 106195) anion exchange protein (1259) 5382 619.7 3.6e-176
XP_011509969 (OMIM: 106195) PREDICTED: anion excha ( 741) 4828 557.2 1.4e-157
NP_001186623 (OMIM: 109280) anion exchange protein (1227) 3445 401.7 1.4e-110
NP_001186622 (OMIM: 109280) anion exchange protein (1232) 3445 401.8 1.4e-110
NP_001186621 (OMIM: 109280) anion exchange protein (1241) 3445 401.8 1.4e-110
NP_003031 (OMIM: 109280) anion exchange protein 2 (1241) 3445 401.8 1.4e-110
XP_005257650 (OMIM: 109270,110500,112010,112050,16 ( 846) 1539 187.2 3.6e-46
NP_000333 (OMIM: 109270,110500,112010,112050,16690 ( 911) 1539 187.2 3.8e-46
XP_011523431 (OMIM: 109270,110500,112010,112050,16 ( 881) 1224 151.8 1.7e-35
XP_016865424 (OMIM: 610207) PREDICTED: anion excha (1019) 1113 139.4 1.1e-31
NP_001245355 (OMIM: 610207) anion exchange protein ( 945) 1107 138.7 1.7e-31
XP_016865428 (OMIM: 610207) PREDICTED: anion excha ( 969) 1107 138.7 1.7e-31
XP_016863017 (OMIM: 603353) PREDICTED: sodium bica ( 800) 1012 127.9 2.4e-28
XP_016863018 (OMIM: 603353) PREDICTED: sodium bica ( 800) 1012 127.9 2.4e-28
NP_001245309 (OMIM: 603353) sodium bicarbonate cot (1090) 1012 128.0 3.1e-28
NP_001308036 (OMIM: 603353) sodium bicarbonate cot (1095) 1012 128.0 3.1e-28
XP_011532567 (OMIM: 603353) PREDICTED: sodium bica (1099) 1012 128.0 3.1e-28
XP_005265657 (OMIM: 603353) PREDICTED: sodium bica (1113) 1012 128.0 3.1e-28
XP_016863016 (OMIM: 603353) PREDICTED: sodium bica (1118) 1012 128.0 3.1e-28
XP_011532565 (OMIM: 603353) PREDICTED: sodium bica (1122) 1012 128.0 3.2e-28
XP_005265655 (OMIM: 603353) PREDICTED: sodium bica (1126) 1012 128.0 3.2e-28
NP_001245308 (OMIM: 603353) sodium bicarbonate cot (1131) 1012 128.0 3.2e-28
NP_001308037 (OMIM: 603353) sodium bicarbonate cot (1135) 1012 128.0 3.2e-28
XP_016863015 (OMIM: 603353) PREDICTED: sodium bica (1135) 1012 128.0 3.2e-28
XP_011532563 (OMIM: 603353) PREDICTED: sodium bica (1201) 1012 128.0 3.3e-28
NP_001308035 (OMIM: 603353) sodium bicarbonate cot (1206) 1012 128.0 3.3e-28
NP_001308034 (OMIM: 603353) sodium bicarbonate cot (1210) 1012 128.0 3.3e-28
NP_003606 (OMIM: 603353) sodium bicarbonate cotran (1214) 1012 128.1 3.4e-28
XP_011532560 (OMIM: 603353) PREDICTED: sodium bica (1223) 1012 128.1 3.4e-28
NP_001308033 (OMIM: 603353) sodium bicarbonate cot (1246) 1012 128.1 3.4e-28
XP_011532558 (OMIM: 603353) PREDICTED: sodium bica (1250) 1012 128.1 3.4e-28
XP_006713484 (OMIM: 603353) PREDICTED: sodium bica (1255) 1012 128.1 3.4e-28
NP_001308032 (OMIM: 603353) sodium bicarbonate cot (1259) 1012 128.1 3.5e-28
XP_011530692 (OMIM: 603345,604278) PREDICTED: elec ( 893) 985 124.9 2.2e-27
XP_016864282 (OMIM: 603345,604278) PREDICTED: elec ( 907) 985 124.9 2.2e-27
XP_016864281 (OMIM: 603345,604278) PREDICTED: elec (1004) 985 125.0 2.4e-27
NP_003750 (OMIM: 603345,604278) electrogenic sodiu (1035) 985 125.0 2.4e-27
NP_001091954 (OMIM: 603345,604278) electrogenic so (1079) 985 125.0 2.5e-27
NP_001128214 (OMIM: 603345,604278) electrogenic so (1094) 985 125.0 2.5e-27
XP_016860043 (OMIM: 605556) PREDICTED: sodium-driv ( 616) 977 123.9 3e-27
XP_016860042 (OMIM: 605556) PREDICTED: sodium-driv ( 895) 977 124.0 4e-27
XP_016860041 (OMIM: 605556) PREDICTED: sodium-driv ( 913) 977 124.0 4.1e-27
XP_016860040 (OMIM: 605556) PREDICTED: sodium-driv ( 943) 977 124.0 4.2e-27
XP_016860033 (OMIM: 605556) PREDICTED: sodium-driv (1085) 977 124.1 4.7e-27
XP_016860032 (OMIM: 605556) PREDICTED: sodium-driv (1086) 977 124.1 4.7e-27
>>XP_005246847 (OMIM: 106195) PREDICTED: anion exchange (1034 aa)
initn: 5380 init1: 5380 opt: 5382 Z-score: 3285.1 bits: 619.6 E(85289): 3.1e-176
Smith-Waterman score: 5382; 96.5% identity (97.5% similar) in 854 aa overlap (291-1142:184-1034)
270 280 290 300 310 320
pF1KB3 RLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQG
: : :... : ::. . .:. ..
XP_005 EEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTL---PGIAHLVVETMIVSDQ
160 170 180 190 200 210
330 340 350 360 370
pF1KB3 GR--GSPSVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTM
: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTM
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB3 ADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQ
280 290 300 310 320 330
440 450 460 470 480 490
pF1KB3 PAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAA
340 350 360 370 380 390
500 510 520 530 540 550
pF1KB3 YQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTT
400 410 420 430 440 450
560 570 580 590 600 610
pF1KB3 RGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQC
460 470 480 490 500 510
620 630 640 650 660 670
pF1KB3 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFS
520 530 540 550 560 570
680 690 700 710 720 730
pF1KB3 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFA
580 590 600 610 620 630
740 750 760 770 780 790
pF1KB3 FLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAAGLEPNGSALPPTEGPPSPRN
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_005 FLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRN
640 650 660 670 680 690
800 810 820 830 840 850
pF1KB3 QPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITD
700 710 720 730 740 750
860 870 880 890 900 910
pF1KB3 TYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITA
760 770 780 790 800 810
920 930 940 950 960 970
pF1KB3 LIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIA
820 830 840 850 860 870
980 990 1000 1010 1020 1030
pF1KB3 PGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS
880 890 900 910 920 930
1040 1050 1060 1070 1080 1090
pF1KB3 QRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLT
940 950 960 970 980 990
1100 1110 1120 1130 1140
pF1KB3 VPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
1000 1010 1020 1030
>>XP_011509967 (OMIM: 106195) PREDICTED: anion exchange (1206 aa)
initn: 5380 init1: 5380 opt: 5382 Z-score: 3284.1 bits: 619.6 E(85289): 3.5e-176
Smith-Waterman score: 6785; 89.9% identity (89.9% similar) in 1174 aa overlap (86-1142:33-1206)
60 70 80 90 100 110
pF1KB3 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
::::::::::::::::::::::::::::::
XP_011 CSVILPPPPIACPPAWGVHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
10 20 30 40 50 60
120 130 140 150 160 170
pF1KB3 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_011 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGTPQKAKFSIGSDEDDS
70 80 90 100 110 120
180 190 200 210 220 230
pF1KB3 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
130 140 150 160 170 180
240 250 260 270 280 290
pF1KB3 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
190 200 210 220 230 240
300 310 320
pF1KB3 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPS-----------------------------
:::::::::::::::::::::::::::::::
XP_011 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNEL
250 260 270 280 290 300
pF1KB3 ------------------------------------------------------------
XP_011 MLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLE
310 320 330 340 350 360
330 340 350
pF1KB3 ----------------------------VLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
::::::::::::::::::::::::::::::::
XP_011 QTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
370 380 390 400 410 420
360 370 380 390 400 410
pF1KB3 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KB3 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
490 500 510 520 530 540
480 490 500 510 520 530
pF1KB3 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
550 560 570 580 590 600
540 550 560 570 580 590
pF1KB3 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
610 620 630 640 650 660
600 610 620 630 640 650
pF1KB3 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
670 680 690 700 710 720
660 670 680 690 700 710
pF1KB3 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
730 740 750 760 770 780
720 730 740 750 760 770
pF1KB3 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_011 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDA
790 800 810 820 830 840
780 790 800 810 820 830
pF1KB3 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
850 860 870 880 890 900
840 850 860 870 880 890
pF1KB3 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
910 920 930 940 950 960
900 910 920 930 940 950
pF1KB3 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KB3 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KB3 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KB3 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
1150 1160 1170 1180 1190 1200
1140
pF1KB3 HMPV
::::
XP_011 HMPV
>>NP_005061 (OMIM: 106195) anion exchange protein 3 isof (1232 aa)
initn: 6784 init1: 5380 opt: 5382 Z-score: 3284.0 bits: 619.6 E(85289): 3.5e-176
Smith-Waterman score: 6739; 87.9% identity (87.9% similar) in 1201 aa overlap (59-1142:59-1232)
30 40 50 60 70 80
pF1KB3 PDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSAR
::::::::::::::::::::::::::::::
NP_005 PDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSAR
30 40 50 60 70 80
90 100 110 120 130 140
pF1KB3 LPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGES
90 100 110 120 130 140
150 160 170 180 190 200
pF1KB3 EAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSS-----
150 160 170 180 190 200
210 220 230 240 250 260
pF1KB3 LRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSAL
::::::::::::::::::::::::::::::::::::::
NP_005 ----------------------SSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSAL
210 220 230 240
270 280 290 300 310 320
pF1KB3 GNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPS--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGL
250 260 270 280 290 300
pF1KB3 ------------------------------------------------------------
NP_005 APILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKP
310 320 330 340 350 360
330
pF1KB3 -------------------------------------------------------VLRTL
:::::
NP_005 HVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTL
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB3 LLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPH
430 440 450 460 470 480
400 410 420 430 440 450
pF1KB3 DPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVL
490 500 510 520 530 540
460 470 480 490 500 510
pF1KB3 LESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAI
550 560 570 580 590 600
520 530 540 550 560 570
pF1KB3 SEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSL
610 620 630 640 650 660
580 590 600 610 620 630
pF1KB3 ELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALS
670 680 690 700 710 720
640 650 660 670 680 690
pF1KB3 PAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKF
730 740 750 760 770 780
700 710 720 730 740 750
pF1KB3 CRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFY
790 800 810 820 830 840
760 770 780 790 800 810
pF1KB3 KLYKVFTEHPLLPFYPPEGALEGSLAAGLEPNGSALPPTEGPPSPRNQPNTALLSLILML
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_005 KLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILML
850 860 870 880 890 900
820 830 840 850 860 870
pF1KB3 GTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLS
910 920 930 940 950 960
880 890 900 910 920 930
pF1KB3 VTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKG
970 980 990 1000 1010 1020
940 950 960 970 980 990
pF1KB3 SGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQ
1030 1040 1050 1060 1070 1080
1000 1010 1020 1030 1040 1050
pF1KB3 RVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHH
1090 1100 1110 1120 1130 1140
1060 1070 1080 1090 1100 1110
pF1KB3 PEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQ
1150 1160 1170 1180 1190 1200
1120 1130 1140
pF1KB3 DRELQALDSEDAEPNFDEDGQDEYNELHMPV
:::::::::::::::::::::::::::::::
NP_005 DRELQALDSEDAEPNFDEDGQDEYNELHMPV
1210 1220 1230
>--
initn: 408 init1: 408 opt: 408 Z-score: 260.0 bits: 60.1 E(85289): 9.6e-08
Smith-Waterman score: 408; 100.0% identity (100.0% similar) in 58 aa overlap (1-58:1-58)
10 20 30 40 50 60
pF1KB3 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
NP_005 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
70 80 90 100 110 120
>>NP_963868 (OMIM: 106195) anion exchange protein 3 isof (1259 aa)
initn: 5380 init1: 5380 opt: 5382 Z-score: 3283.8 bits: 619.7 E(85289): 3.6e-176
Smith-Waterman score: 6797; 89.9% identity (89.9% similar) in 1174 aa overlap (86-1142:86-1259)
60 70 80 90 100 110
pF1KB3 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
::::::::::::::::::::::::::::::
NP_963 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
240 250 260 270 280 290
300 310 320
pF1KB3 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPS-----------------------------
:::::::::::::::::::::::::::::::
NP_963 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNEL
300 310 320 330 340 350
pF1KB3 ------------------------------------------------------------
NP_963 MLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLE
360 370 380 390 400 410
330 340 350
pF1KB3 ----------------------------VLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
::::::::::::::::::::::::::::::::
NP_963 QTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
420 430 440 450 460 470
360 370 380 390 400 410
pF1KB3 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
480 490 500 510 520 530
420 430 440 450 460 470
pF1KB3 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
540 550 560 570 580 590
480 490 500 510 520 530
pF1KB3 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
600 610 620 630 640 650
540 550 560 570 580 590
pF1KB3 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
660 670 680 690 700 710
600 610 620 630 640 650
pF1KB3 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
720 730 740 750 760 770
660 670 680 690 700 710
pF1KB3 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
780 790 800 810 820 830
720 730 740 750 760 770
pF1KB3 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_963 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDA
840 850 860 870 880 890
780 790 800 810 820 830
pF1KB3 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
900 910 920 930 940 950
840 850 860 870 880 890
pF1KB3 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
960 970 980 990 1000 1010
900 910 920 930 940 950
pF1KB3 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
1020 1030 1040 1050 1060 1070
960 970 980 990 1000 1010
pF1KB3 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
1080 1090 1100 1110 1120 1130
1020 1030 1040 1050 1060 1070
pF1KB3 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
1140 1150 1160 1170 1180 1190
1080 1090 1100 1110 1120 1130
pF1KB3 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
1200 1210 1220 1230 1240 1250
1140
pF1KB3 HMPV
::::
NP_963 HMPV
>--
initn: 610 init1: 610 opt: 610 Z-score: 382.7 bits: 82.8 E(85289): 1.4e-14
Smith-Waterman score: 610; 100.0% identity (100.0% similar) in 85 aa overlap (1-85:1-85)
10 20 30 40 50 60
pF1KB3 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
:::::::::::::::::::::::::
NP_963 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
70 80 90 100 110 120
>>XP_005246846 (OMIM: 106195) PREDICTED: anion exchange (1259 aa)
initn: 5380 init1: 5380 opt: 5382 Z-score: 3283.8 bits: 619.7 E(85289): 3.6e-176
Smith-Waterman score: 6785; 89.9% identity (89.9% similar) in 1174 aa overlap (86-1142:86-1259)
60 70 80 90 100 110
pF1KB3 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
::::::::::::::::::::::::::::::
XP_005 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_005 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGTPQKAKFSIGSDEDDS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
240 250 260 270 280 290
300 310 320
pF1KB3 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPS-----------------------------
:::::::::::::::::::::::::::::::
XP_005 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNEL
300 310 320 330 340 350
pF1KB3 ------------------------------------------------------------
XP_005 MLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLE
360 370 380 390 400 410
330 340 350
pF1KB3 ----------------------------VLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
::::::::::::::::::::::::::::::::
XP_005 QTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
420 430 440 450 460 470
360 370 380 390 400 410
pF1KB3 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
480 490 500 510 520 530
420 430 440 450 460 470
pF1KB3 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
540 550 560 570 580 590
480 490 500 510 520 530
pF1KB3 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
600 610 620 630 640 650
540 550 560 570 580 590
pF1KB3 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
660 670 680 690 700 710
600 610 620 630 640 650
pF1KB3 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
720 730 740 750 760 770
660 670 680 690 700 710
pF1KB3 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
780 790 800 810 820 830
720 730 740 750 760 770
pF1KB3 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_005 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDA
840 850 860 870 880 890
780 790 800 810 820 830
pF1KB3 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
900 910 920 930 940 950
840 850 860 870 880 890
pF1KB3 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
960 970 980 990 1000 1010
900 910 920 930 940 950
pF1KB3 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
1020 1030 1040 1050 1060 1070
960 970 980 990 1000 1010
pF1KB3 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
1080 1090 1100 1110 1120 1130
1020 1030 1040 1050 1060 1070
pF1KB3 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
1140 1150 1160 1170 1180 1190
1080 1090 1100 1110 1120 1130
pF1KB3 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
1200 1210 1220 1230 1240 1250
1140
pF1KB3 HMPV
::::
XP_005 HMPV
>--
initn: 610 init1: 610 opt: 610 Z-score: 382.7 bits: 82.8 E(85289): 1.4e-14
Smith-Waterman score: 610; 100.0% identity (100.0% similar) in 85 aa overlap (1-85:1-85)
10 20 30 40 50 60
pF1KB3 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
:::::::::::::::::::::::::
XP_005 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
70 80 90 100 110 120
>>NP_001313488 (OMIM: 106195) anion exchange protein 3 i (1259 aa)
initn: 5380 init1: 5380 opt: 5382 Z-score: 3283.8 bits: 619.7 E(85289): 3.6e-176
Smith-Waterman score: 6797; 89.9% identity (89.9% similar) in 1174 aa overlap (86-1142:86-1259)
60 70 80 90 100 110
pF1KB3 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
::::::::::::::::::::::::::::::
NP_001 AWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDD
240 250 260 270 280 290
300 310 320
pF1KB3 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPS-----------------------------
:::::::::::::::::::::::::::::::
NP_001 MKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNEL
300 310 320 330 340 350
pF1KB3 ------------------------------------------------------------
NP_001 MLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLE
360 370 380 390 400 410
330 340 350
pF1KB3 ----------------------------VLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
::::::::::::::::::::::::::::::::
NP_001 QTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNS
420 430 440 450 460 470
360 370 380 390 400 410
pF1KB3 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
480 490 500 510 520 530
420 430 440 450 460 470
pF1KB3 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY
540 550 560 570 580 590
480 490 500 510 520 530
pF1KB3 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAF
600 610 620 630 640 650
540 550 560 570 580 590
pF1KB3 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRD
660 670 680 690 700 710
600 610 620 630 640 650
pF1KB3 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTA
720 730 740 750 760 770
660 670 680 690 700 710
pF1KB3 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALV
780 790 800 810 820 830
720 730 740 750 760 770
pF1KB3 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 AAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDA
840 850 860 870 880 890
780 790 800 810 820 830
pF1KB3 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIG
900 910 920 930 940 950
840 850 860 870 880 890
pF1KB3 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVA
960 970 980 990 1000 1010
900 910 920 930 940 950
pF1KB3 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTA
1020 1030 1040 1050 1060 1070
960 970 980 990 1000 1010
pF1KB3 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLA
1080 1090 1100 1110 1120 1130
1020 1030 1040 1050 1060 1070
pF1KB3 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIAL
1140 1150 1160 1170 1180 1190
1080 1090 1100 1110 1120 1130
pF1KB3 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNEL
1200 1210 1220 1230 1240 1250
1140
pF1KB3 HMPV
::::
NP_001 HMPV
>--
initn: 610 init1: 610 opt: 610 Z-score: 382.7 bits: 82.8 E(85289): 1.4e-14
Smith-Waterman score: 610; 100.0% identity (100.0% similar) in 85 aa overlap (1-85:1-85)
10 20 30 40 50 60
pF1KB3 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
:::::::::::::::::::::::::
NP_001 KPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPS
70 80 90 100 110 120
>>XP_011509969 (OMIM: 106195) PREDICTED: anion exchange (741 aa)
initn: 4828 init1: 4828 opt: 4828 Z-score: 2950.3 bits: 557.2 E(85289): 1.4e-157
Smith-Waterman score: 4828; 99.9% identity (99.9% similar) in 741 aa overlap (402-1142:1-741)
380 390 400 410 420 430
pF1KB3 DGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVG
::::::::::::::::::::::::::::::
XP_011 MPGGDGHRGKSLKLLEKIPEDAEATVVLVG
10 20 30
440 450 460 470 480 490
pF1KB3 CVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSD
40 50 60 70 80 90
500 510 520 530 540 550
pF1KB3 KLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQ
100 110 120 130 140 150
560 570 580 590 600 610
pF1KB3 TKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLR
160 170 180 190 200 210
620 630 640 650 660 670
pF1KB3 DALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQP
220 230 240 250 260 270
680 690 700 710 720 730
pF1KB3 LLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISP
280 290 300 310 320 330
740 750 760 770 780 790
pF1KB3 FTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLAAGLEPNGSALPPTE
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 FTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTE
340 350 360 370 380 390
800 810 820 830 840 850
pF1KB3 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVL
400 410 420 430 440 450
860 870 880 890 900 910
pF1KB3 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIF
460 470 480 490 500 510
920 930 940 950 960 970
pF1KB3 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 METQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALT
520 530 540 550 560 570
980 990 1000 1010 1020 1030
pF1KB3 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTS
580 590 600 610 620 630
1040 1050 1060 1070 1080 1090
pF1KB3 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAF
640 650 660 670 680 690
1100 1110 1120 1130 1140
pF1KB3 PFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
700 710 720 730 740
>>NP_001186623 (OMIM: 109280) anion exchange protein 2 i (1227 aa)
initn: 3774 init1: 1663 opt: 3445 Z-score: 2106.4 bits: 401.7 E(85289): 1.4e-110
Smith-Waterman score: 3708; 53.6% identity (70.8% similar) in 1208 aa overlap (68-1142:54-1227)
40 50 60 70 80 90
pF1KB3 LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRR
:.:::.::..::: :::::..::: . :.
NP_001 LHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRK
30 40 50 60 70 80
100 110 120 130 140 150
pF1KB3 LPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPP
: .:. ::. .: :. :: : ::: ::.:.: :.:. ..: :
NP_001 TPQGPGRKPRRR-----PGASPTGETPTI-EEG------EEDEDEASEAEGARALTQPSP
90 100 110 120 130
160 170 180 190 200 210
pF1KB3 SGTPQKAKFSIGSDEDDSPGLPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDG
.::....: . .:::: . :.. ..: : :: . .:. : .. ........
NP_001 VSTPSSVQFFL--QEDDSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEA
140 150 160 170 180
220 230 240 250 260 270
pF1KB3 TTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGP
. .:..: .. . . :: :..: ::.:.:: :: : .
NP_001 EA-VAVASG-------TAGGDDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQAL
190 200 210 220 230
280 290 300 310 320
pF1KB3 EQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR----------
.::::: ::: :..:::: :::::.:: ::::::::.: .. ::.::
NP_001 LPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPR
240 250 260 270 280 290
pF1KB3 -------------------------------------------------GSP--------
:.:
NP_001 ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR
300 310 320 330 340 350
330
pF1KB3 ----------------------------------------------SVLRTLLLKHSHPN
.:::.::::::::.
NP_001 SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS
360 370 380 390 400 410
340 350 360 370 380 390
pF1KB3 DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK
:.:: .: ::: :..:..:.::.:: ... : . : :. : : . . .:
NP_001 DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-REL
420 430 440 450 460 470
400 410 420 430 440 450
pF1KB3 PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV
: : . :.:: :::::::::.::::::::::: :: .:. ::::: ::: :..:
NP_001 PPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV
480 490 500 510 520 530
460 470 480 490 500 510
pF1KB3 LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL
:::::::::::..:::: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::
NP_001 LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL
540 550 560 570 580 590
520 530 540 550 560 570
pF1KB3 DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLEL
: :.:.:::::.:..:::::: :::..:.::.: : .. : : .: : : :..
NP_001 DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQM
600 610 620 630 640
580 590 600 610 620 630
pF1KB3 GGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPA
. .. ::::: ::: ::::.:::::::::: ::.:::: ::.:::.::::::::::
NP_001 VEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPA
650 660 670 680 690 700
640 650 660 670 680 690
pF1KB3 ITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCR
:::::::::::. :.::::::.:::. ::.: :::::::::.::::::::::::::.::
NP_001 ITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCS
710 720 730 740 750 760
700 710 720 730 740 750
pF1KB3 AQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKL
.. ::::.::::.:.::: ..: .:: :::::::..: ::::::::::::::::::::::
NP_001 SNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKL
770 780 790 800 810 820
760 770 780 790 800
pF1KB3 YKVFTEHPLLPFYPPEGA-LEGSLA---AG----LEPNGSALPPTEGPPSPRNQPNTALL
:.: :::: ... ..:. :: : :.. .: : .::.:::::::
NP_001 VKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALL
830 840 850 860 870 880
810 820 830 840 850 860
pF1KB3 SLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLT
::.:: ::::::::::::.::::. :. ::.:::::.::.::.:::::::: :::::::.
NP_001 SLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLS
890 900 910 920 930 940
870 880 890 900 910 920
pF1KB3 VPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKA
::.:.:::.:.::.: : ::: ::: :::::. .::.::.::::::::::.::.:.:
NP_001 VPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKE
950 960 970 980 990 1000
930 940 950 960 970 980
pF1KB3 RRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQI
: : :::::::::::: ..::.:.:::::::.:::::::::.:::::: :.::::::.:
NP_001 RMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKI
1010 1020 1030 1040 1050 1060
990 1000 1010 1020 1030 1040
pF1KB3 QEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIL
:::.::::::.:.: :::::::.: .::.::::::::::::::::::.:::. .:: :.:
NP_001 QEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLL
1070 1080 1090 1100 1110 1120
1050 1060 1070 1080 1090 1100
pF1KB3 MPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCL
:: ::::. :: ::.: :::::: .:: :.::::.: ::::::::::.:.:::::: .
NP_001 MPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVV
1130 1140 1150 1160 1170 1180
1110 1120 1130 1140
pF1KB3 LPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV
: :.: :::.. ::...::: ::: .: :::::. :::
NP_001 LTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
1190 1200 1210 1220
>>NP_001186622 (OMIM: 109280) anion exchange protein 2 i (1232 aa)
initn: 3774 init1: 1663 opt: 3445 Z-score: 2106.4 bits: 401.8 E(85289): 1.4e-110
Smith-Waterman score: 3708; 53.6% identity (70.8% similar) in 1208 aa overlap (68-1142:59-1232)
40 50 60 70 80 90
pF1KB3 LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRR
:.:::.::..::: :::::..::: . :.
NP_001 LHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRK
30 40 50 60 70 80
100 110 120 130 140 150
pF1KB3 LPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPP
: .:. ::. .: :. :: : ::: ::.:.: :.:. ..: :
NP_001 TPQGPGRKPRRR-----PGASPTGETPTI-EEG------EEDEDEASEAEGARALTQPSP
90 100 110 120 130
160 170 180 190 200 210
pF1KB3 SGTPQKAKFSIGSDEDDSPGLPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDG
.::....: . .:::: . :.. ..: : :: . .:. : .. ........
NP_001 VSTPSSVQFFL--QEDDSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEA
140 150 160 170 180 190
220 230 240 250 260 270
pF1KB3 TTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGP
. .:..: .. . . :: :..: ::.:.:: :: : .
NP_001 EA-VAVASG-------TAGGDDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQAL
200 210 220 230 240
280 290 300 310 320
pF1KB3 EQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR----------
.::::: ::: :..:::: :::::.:: ::::::::.: .. ::.::
NP_001 LPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPR
250 260 270 280 290 300
pF1KB3 -------------------------------------------------GSP--------
:.:
NP_001 ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR
310 320 330 340 350 360
330
pF1KB3 ----------------------------------------------SVLRTLLLKHSHPN
.:::.::::::::.
NP_001 SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB3 DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK
:.:: .: ::: :..:..:.::.:: ... : . : :. : : . . .:
NP_001 DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-REL
430 440 450 460 470
400 410 420 430 440 450
pF1KB3 PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV
: : . :.:: :::::::::.::::::::::: :: .:. ::::: ::: :..:
NP_001 PPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV
480 490 500 510 520 530
460 470 480 490 500 510
pF1KB3 LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL
:::::::::::..:::: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::
NP_001 LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL
540 550 560 570 580 590
520 530 540 550 560 570
pF1KB3 DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLEL
: :.:.:::::.:..:::::: :::..:.::.: : .. : : .: : : :..
NP_001 DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQM
600 610 620 630 640 650
580 590 600 610 620 630
pF1KB3 GGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPA
. .. ::::: ::: ::::.:::::::::: ::.:::: ::.:::.::::::::::
NP_001 VEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPA
660 670 680 690 700 710
640 650 660 670 680 690
pF1KB3 ITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCR
:::::::::::. :.::::::.:::. ::.: :::::::::.::::::::::::::.::
NP_001 ITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCS
720 730 740 750 760 770
700 710 720 730 740 750
pF1KB3 AQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKL
.. ::::.::::.:.::: ..: .:: :::::::..: ::::::::::::::::::::::
NP_001 SNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKL
780 790 800 810 820 830
760 770 780 790 800
pF1KB3 YKVFTEHPLLPFYPPEGA-LEGSLA---AG----LEPNGSALPPTEGPPSPRNQPNTALL
:.: :::: ... ..:. :: : :.. .: : .::.:::::::
NP_001 VKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALL
840 850 860 870 880 890
810 820 830 840 850 860
pF1KB3 SLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLT
::.:: ::::::::::::.::::. :. ::.:::::.::.::.:::::::: :::::::.
NP_001 SLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLS
900 910 920 930 940 950
870 880 890 900 910 920
pF1KB3 VPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKA
::.:.:::.:.::.: : ::: ::: :::::. .::.::.::::::::::.::.:.:
NP_001 VPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKE
960 970 980 990 1000 1010
930 940 950 960 970 980
pF1KB3 RRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQI
: : :::::::::::: ..::.:.:::::::.:::::::::.:::::: :.::::::.:
NP_001 RMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKI
1020 1030 1040 1050 1060 1070
990 1000 1010 1020 1030 1040
pF1KB3 QEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIL
:::.::::::.:.: :::::::.: .::.::::::::::::::::::.:::. .:: :.:
NP_001 QEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLL
1080 1090 1100 1110 1120 1130
1050 1060 1070 1080 1090 1100
pF1KB3 MPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCL
:: ::::. :: ::.: :::::: .:: :.::::.: ::::::::::.:.:::::: .
NP_001 MPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVV
1140 1150 1160 1170 1180 1190
1110 1120 1130 1140
pF1KB3 LPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV
: :.: :::.. ::...::: ::: .: :::::. :::
NP_001 LTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
1200 1210 1220 1230
>>NP_001186621 (OMIM: 109280) anion exchange protein 2 i (1241 aa)
initn: 3774 init1: 1663 opt: 3445 Z-score: 2106.3 bits: 401.8 E(85289): 1.4e-110
Smith-Waterman score: 3708; 53.6% identity (70.8% similar) in 1208 aa overlap (68-1142:68-1241)
40 50 60 70 80 90
pF1KB3 LGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRR
:.:::.::..::: :::::..::: . :.
NP_001 LHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRK
40 50 60 70 80 90
100 110 120 130 140 150
pF1KB3 LPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPP
: .:. ::. .: :. :: : ::: ::.:.: :.:. ..: :
NP_001 TPQGPGRKPRRR-----PGASPTGETPTI-EEG------EEDEDEASEAEGARALTQPSP
100 110 120 130 140
160 170 180 190 200 210
pF1KB3 SGTPQKAKFSIGSDEDDSPGLPG-RAAVTKPLPSVGPHTDKSPQHS--SRPCSELRDGDG
.::....: . .:::: . :.. ..: : :: . .:. : .. ........
NP_001 VSTPSSVQFFL--QEDDSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQVEEAEA
150 160 170 180 190 200
220 230 240 250 260 270
pF1KB3 TTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGP
. .:..: .. . . :: :..: ::.:.:: :: : .
NP_001 EA-VAVASG-------TAGGDDGGASGRPLPKAQP--GHRSYNLQERRRIGSMTGAEQAL
210 220 230 240 250
280 290 300 310 320
pF1KB3 EQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR----------
.::::: ::: :..:::: :::::.:: ::::::::.: .. ::.::
NP_001 LPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPR
260 270 280 290 300 310
pF1KB3 -------------------------------------------------GSP--------
:.:
NP_001 ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR
320 330 340 350 360 370
330
pF1KB3 ----------------------------------------------SVLRTLLLKHSHPN
.:::.::::::::.
NP_001 SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB3 DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK
:.:: .: ::: :..:..:.::.:: ... : . : :. : : . . .:
NP_001 DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERE-REL
440 450 460 470 480
400 410 420 430 440 450
pF1KB3 PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV
: : . :.:: :::::::::.::::::::::: :: .:. ::::: ::: :..:
NP_001 PPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV
490 500 510 520 530 540
460 470 480 490 500 510
pF1KB3 LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL
:::::::::::..:::: .. ::::.::::.:::::: :::::: ::.:.:::.::. ::
NP_001 LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL
550 560 570 580 590 600
520 530 540 550 560 570
pF1KB3 DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRG--GYTAPGKELSLEL
: :.:.:::::.:..:::::: :::..:.::.: : .. : : .: : : :..
NP_001 DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--QGRLLPTGAGLEPKSAQDKAL-LQM
610 620 630 640 650 660
580 590 600 610 620 630
pF1KB3 GGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPA
. .. ::::: ::: ::::.:::::::::: ::.:::: ::.:::.::::::::::
NP_001 VEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPA
670 680 690 700 710 720
640 650 660 670 680 690
pF1KB3 ITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCR
:::::::::::. :.::::::.:::. ::.: :::::::::.::::::::::::::.::
NP_001 ITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCS
730 740 750 760 770 780
700 710 720 730 740 750
pF1KB3 AQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKL
.. ::::.::::.:.::: ..: .:: :::::::..: ::::::::::::::::::::::
NP_001 SNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKL
790 800 810 820 830 840
760 770 780 790 800
pF1KB3 YKVFTEHPLLPFYPPEGA-LEGSLA---AG----LEPNGSALPPTEGPPSPRNQPNTALL
:.: :::: ... ..:. :: : :.. .: : .::.:::::::
NP_001 VKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALL
850 860 870 880 890 900
810 820 830 840 850 860
pF1KB3 SLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLT
::.:: ::::::::::::.::::. :. ::.:::::.::.::.:::::::: :::::::.
NP_001 SLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLS
910 920 930 940 950 960
870 880 890 900 910 920
pF1KB3 VPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKA
::.:.:::.:.::.: : ::: ::: :::::. .::.::.::::::::::.::.:.:
NP_001 VPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKE
970 980 990 1000 1010 1020
930 940 950 960 970 980
pF1KB3 RRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQI
: : :::::::::::: ..::.:.:::::::.:::::::::.:::::: :.::::::.:
NP_001 RMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKI
1030 1040 1050 1060 1070 1080
990 1000 1010 1020 1030 1040
pF1KB3 QEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIL
:::.::::::.:.: :::::::.: .::.::::::::::::::::::.:::. .:: :.:
NP_001 QEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLL
1090 1100 1110 1120 1130 1140
1050 1060 1070 1080 1090 1100
pF1KB3 MPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCL
:: ::::. :: ::.: :::::: .:: :.::::.: ::::::::::.:.:::::: .
NP_001 MPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVV
1150 1160 1170 1180 1190 1200
1110 1120 1130 1140
pF1KB3 LPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV
: :.: :::.. ::...::: ::: .: :::::. :::
NP_001 LTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
1210 1220 1230 1240
1142 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:06:15 2016 done: Thu Nov 3 14:06:17 2016
Total Scan time: 16.310 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]