FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3881, 369 aa 1>>>pF1KB3881 369 - 369 aa - 369 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6606+/-0.000355; mu= 16.0190+/- 0.022 mean_var=85.6965+/-16.484, 0's: 0 Z-trim(114.8): 168 B-trim: 73 in 1/54 Lambda= 0.138546 statistics sampled from 24715 (24885) to 24715 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.292), width: 16 Scan time: 8.330 The best scores are: opt bits E(85289) NP_002679 (OMIM: 602724) septin-5 isoform 1 [Homo ( 369) 2482 505.9 6e-143 XP_006722014 (OMIM: 603696) PREDICTED: septin-4 is ( 379) 1869 383.4 4.7e-106 NP_536341 (OMIM: 603696) septin-4 isoform 3 [Homo ( 459) 1869 383.4 5.5e-106 NP_001185642 (OMIM: 603696) septin-4 isoform 4 [Ho ( 470) 1869 383.4 5.6e-106 NP_004565 (OMIM: 603696) septin-4 isoform 1 [Homo ( 478) 1869 383.4 5.7e-106 XP_006722012 (OMIM: 603696) PREDICTED: septin-4 is ( 483) 1869 383.4 5.7e-106 NP_001243711 (OMIM: 603696) septin-4 isoform 5 [Ho ( 493) 1869 383.4 5.8e-106 XP_006722013 (OMIM: 603696) PREDICTED: septin-4 is ( 384) 1858 381.2 2.2e-105 XP_006722015 (OMIM: 603696) PREDICTED: septin-4 is ( 360) 1855 380.5 3.2e-105 NP_001009939 (OMIM: 602724) septin-5 isoform 2 [Ho ( 346) 1699 349.3 7.5e-96 XP_006722018 (OMIM: 603696) PREDICTED: septin-4 is ( 331) 1679 345.3 1.1e-94 XP_011523213 (OMIM: 603696) PREDICTED: septin-4 is ( 331) 1679 345.3 1.1e-94 XP_006722017 (OMIM: 603696) PREDICTED: septin-4 is ( 331) 1679 345.3 1.1e-94 XP_011523214 (OMIM: 603696) PREDICTED: septin-4 is ( 331) 1679 345.3 1.1e-94 NP_001243751 (OMIM: 603696) septin-4 isoform 6 [Ho ( 331) 1679 345.3 1.1e-94 NP_443070 (OMIM: 612897) septin-1 [Homo sapiens] ( 414) 1569 323.4 5.7e-88 XP_016878480 (OMIM: 612897) PREDICTED: septin-1 is ( 494) 1485 306.7 7.4e-83 NP_001307958 (OMIM: 601506) septin-2 isoform d [Ho ( 391) 1361 281.8 1.8e-75 NP_001269901 (OMIM: 601506) septin-2 isoform b [Ho ( 396) 1361 281.8 1.8e-75 XP_016859680 (OMIM: 601506) PREDICTED: septin-2 is ( 428) 1361 281.9 1.9e-75 XP_016859681 (OMIM: 601506) PREDICTED: septin-2 is ( 428) 1361 281.9 1.9e-75 NP_001307960 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 NP_001008491 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 XP_016859694 (OMIM: 601506) PREDICTED: septin-2 is ( 361) 1359 281.4 2.2e-75 NP_001307959 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 NP_001307962 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 XP_016859695 (OMIM: 601506) PREDICTED: septin-2 is ( 361) 1359 281.4 2.2e-75 NP_001307963 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 NP_001008492 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 NP_006146 (OMIM: 601506) septin-2 isoform a [Homo ( 361) 1359 281.4 2.2e-75 NP_004395 (OMIM: 601506) septin-2 isoform a [Homo ( 361) 1359 281.4 2.2e-75 NP_001307964 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 NP_001307961 (OMIM: 601506) septin-2 isoform a [Ho ( 361) 1359 281.4 2.2e-75 XP_016859679 (OMIM: 601506) PREDICTED: septin-2 is ( 436) 1346 278.9 1.6e-74 XP_016859678 (OMIM: 601506) PREDICTED: septin-2 is ( 441) 1346 278.9 1.6e-74 XP_016859683 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859692 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859686 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859691 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859689 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859682 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859690 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859685 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859688 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859693 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859687 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016859684 (OMIM: 601506) PREDICTED: septin-2 is ( 374) 1344 278.4 1.8e-74 XP_016868346 (OMIM: 603151) PREDICTED: septin-7 is ( 434) 1277 265.1 2.2e-70 XP_016868345 (OMIM: 603151) PREDICTED: septin-7 is ( 435) 1277 265.1 2.2e-70 NP_001011553 (OMIM: 603151) septin-7 isoform 2 [Ho ( 436) 1277 265.1 2.2e-70 >>NP_002679 (OMIM: 602724) septin-5 isoform 1 [Homo sapi (369 aa) initn: 2482 init1: 2482 opt: 2482 Z-score: 2687.3 bits: 505.9 E(85289): 6e-143 Smith-Waterman score: 2482; 100.0% identity (100.0% similar) in 369 aa overlap (1-369:1-369) 10 20 30 40 50 60 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 KVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 SAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQ 310 320 330 340 350 360 pF1KB3 RMKQQMQDQ ::::::::: NP_002 RMKQQMQDQ >>XP_006722014 (OMIM: 603696) PREDICTED: septin-4 isofor (379 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2025.0 bits: 383.4 E(85289): 4.7e-106 Smith-Waterman score: 1909; 76.4% identity (90.8% similar) in 368 aa overlap (12-368:11-377) 10 20 30 40 50 pF1KB3 MSTGLRYKSKLATPEDKQDI--DKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKS ..:::. . ::.::::::::::::::::::::::::::::::::::: XP_006 MDRSLGWQGNSVPEDRTEAGDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKS 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 TLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNN :::.::::::::.:::::.::::: ::::: ::.::::::::.:.::::::::::::::: XP_006 TLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 TECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKAL ::::::...:.::::::::::::::::::::::::::::::::::::::::.:: ::::: XP_006 TECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKAL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 HEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDREL :..:::::..:::: :.: :. . :..:::::..:::..::::.:::::::::: ::. : XP_006 HQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 KESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDV ::: :::::::::::::.:.:::::::::::::::: .::::::::.::.::::.::::: XP_006 KESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDV 240 250 260 270 280 290 300 310 320 330 340 pF1KB3 TCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPLPTPDAETEKLIRMKD : ..:::::::.:::.:: .:::..: . ::: .: : : ::::::: :: XP_006 TRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP-PGTDPETEKLIREKD 300 310 320 330 340 350 350 360 pF1KB3 EELRRMQEMLQRMKQQMQDQ ::::::::::.....::.. XP_006 EELRRMQEMLHKIQKQMKENY 360 370 >>NP_536341 (OMIM: 603696) septin-4 isoform 3 [Homo sapi (459 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2023.8 bits: 383.4 E(85289): 5.5e-106 Smith-Waterman score: 1909; 76.9% identity (91.2% similar) in 364 aa overlap (14-368:95-457) 10 20 30 40 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGF : :... ::.:::::::::::::::::::: NP_536 PQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGF 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB3 DFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLK ::::::::::::::::::.::::::::.:::::.::::: ::::: ::.::::::::.:. NP_536 DFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLR 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB3 LTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF :::::::::::::::::::::...:.:::::::::::::::::::::::::::::::::: NP_536 LTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB3 GHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPEC ::::::.:: ::::::..:::::..:::: :.: :. . :..:::::..:::..::::.: NP_536 GHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDC 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB3 DSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL ::::::::: ::. :::: :::::::::::::.:.:::::::::::::::: .::::::: NP_536 DSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKL 310 320 330 340 350 360 290 300 310 320 330 pF1KB3 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPL :.::.::::.:::::: ..:::::::.:::.:: .:::..: . ::: .: NP_536 RTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP- 370 380 390 400 410 420 340 350 360 pF1KB3 PTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ : : ::::::: ::::::::::::.....::.. NP_536 PGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY 430 440 450 >>NP_001185642 (OMIM: 603696) septin-4 isoform 4 [Homo s (470 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2023.6 bits: 383.4 E(85289): 5.6e-106 Smith-Waterman score: 1909; 76.9% identity (91.2% similar) in 364 aa overlap (14-368:106-468) 10 20 30 40 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGF : :... ::.:::::::::::::::::::: NP_001 PQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGF 80 90 100 110 120 130 50 60 70 80 90 100 pF1KB3 DFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLK ::::::::::::::::::.::::::::.:::::.::::: ::::: ::.::::::::.:. NP_001 DFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLR 140 150 160 170 180 190 110 120 130 140 150 160 pF1KB3 LTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF :::::::::::::::::::::...:.:::::::::::::::::::::::::::::::::: NP_001 LTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF 200 210 220 230 240 250 170 180 190 200 210 220 pF1KB3 GHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPEC ::::::.:: ::::::..:::::..:::: :.: :. . :..:::::..:::..::::.: NP_001 GHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDC 260 270 280 290 300 310 230 240 250 260 270 280 pF1KB3 DSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL ::::::::: ::. :::: :::::::::::::.:.:::::::::::::::: .::::::: NP_001 DSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKL 320 330 340 350 360 370 290 300 310 320 330 pF1KB3 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPL :.::.::::.:::::: ..:::::::.:::.:: .:::..: . ::: .: NP_001 RTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP- 380 390 400 410 420 430 340 350 360 pF1KB3 PTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ : : ::::::: ::::::::::::.....::.. NP_001 PGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY 440 450 460 470 >>NP_004565 (OMIM: 603696) septin-4 isoform 1 [Homo sapi (478 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2023.5 bits: 383.4 E(85289): 5.7e-106 Smith-Waterman score: 1909; 76.9% identity (91.2% similar) in 364 aa overlap (14-368:114-476) 10 20 30 40 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGF : :... ::.:::::::::::::::::::: NP_004 PQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGF 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB3 DFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLK ::::::::::::::::::.::::::::.:::::.::::: ::::: ::.::::::::.:. NP_004 DFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLR 150 160 170 180 190 200 110 120 130 140 150 160 pF1KB3 LTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF :::::::::::::::::::::...:.:::::::::::::::::::::::::::::::::: NP_004 LTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF 210 220 230 240 250 260 170 180 190 200 210 220 pF1KB3 GHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPEC ::::::.:: ::::::..:::::..:::: :.: :. . :..:::::..:::..::::.: NP_004 GHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDC 270 280 290 300 310 320 230 240 250 260 270 280 pF1KB3 DSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL ::::::::: ::. :::: :::::::::::::.:.:::::::::::::::: .::::::: NP_004 DSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKL 330 340 350 360 370 380 290 300 310 320 330 pF1KB3 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPL :.::.::::.:::::: ..:::::::.:::.:: .:::..: . ::: .: NP_004 RTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP- 390 400 410 420 430 440 340 350 360 pF1KB3 PTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ : : ::::::: ::::::::::::.....::.. NP_004 PGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY 450 460 470 >>XP_006722012 (OMIM: 603696) PREDICTED: septin-4 isofor (483 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2023.5 bits: 383.4 E(85289): 5.7e-106 Smith-Waterman score: 1909; 76.9% identity (91.2% similar) in 364 aa overlap (14-368:119-481) 10 20 30 40 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGF : :... ::.:::::::::::::::::::: XP_006 PQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGF 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB3 DFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLK ::::::::::::::::::.::::::::.:::::.::::: ::::: ::.::::::::.:. XP_006 DFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLR 150 160 170 180 190 200 110 120 130 140 150 160 pF1KB3 LTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF :::::::::::::::::::::...:.:::::::::::::::::::::::::::::::::: XP_006 LTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF 210 220 230 240 250 260 170 180 190 200 210 220 pF1KB3 GHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPEC ::::::.:: ::::::..:::::..:::: :.: :. . :..:::::..:::..::::.: XP_006 GHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDC 270 280 290 300 310 320 230 240 250 260 270 280 pF1KB3 DSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL ::::::::: ::. :::: :::::::::::::.:.:::::::::::::::: .::::::: XP_006 DSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKL 330 340 350 360 370 380 290 300 310 320 330 pF1KB3 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPL :.::.::::.:::::: ..:::::::.:::.:: .:::..: . ::: .: XP_006 RTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP- 390 400 410 420 430 440 340 350 360 pF1KB3 PTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ : : ::::::: ::::::::::::.....::.. XP_006 PGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY 450 460 470 480 >>NP_001243711 (OMIM: 603696) septin-4 isoform 5 [Homo s (493 aa) initn: 1900 init1: 1724 opt: 1869 Z-score: 2023.3 bits: 383.4 E(85289): 5.8e-106 Smith-Waterman score: 1909; 76.9% identity (91.2% similar) in 364 aa overlap (14-368:129-491) 10 20 30 40 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGF : :... ::.:::::::::::::::::::: NP_001 PQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGF 100 110 120 130 140 150 50 60 70 80 90 100 pF1KB3 DFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLK ::::::::::::::::::.::::::::.:::::.::::: ::::: ::.::::::::.:. NP_001 DFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLR 160 170 180 190 200 210 110 120 130 140 150 160 pF1KB3 LTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF :::::::::::::::::::::...:.:::::::::::::::::::::::::::::::::: NP_001 LTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPF 220 230 240 250 260 270 170 180 190 200 210 220 pF1KB3 GHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPEC ::::::.:: ::::::..:::::..:::: :.: :. . :..:::::..:::..::::.: NP_001 GHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDC 280 290 300 310 320 330 230 240 250 260 270 280 pF1KB3 DSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKL ::::::::: ::. :::: :::::::::::::.:.:::::::::::::::: .::::::: NP_001 DSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKL 340 350 360 370 380 390 290 300 310 320 330 pF1KB3 RNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPL :.::.::::.:::::: ..:::::::.:::.:: .:::..: . ::: .: NP_001 RTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP- 400 410 420 430 440 450 340 350 360 pF1KB3 PTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ : : ::::::: ::::::::::::.....::.. NP_001 PGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY 460 470 480 490 >>XP_006722013 (OMIM: 603696) PREDICTED: septin-4 isofor (384 aa) initn: 1900 init1: 1724 opt: 1858 Z-score: 2013.0 bits: 381.2 E(85289): 2.2e-105 Smith-Waterman score: 1898; 74.8% identity (88.9% similar) in 377 aa overlap (2-368:7-382) 10 20 30 40 50 pF1KB3 MSTGLRYKSKLATPEDKQDID-KQYVGFATLPNQVHRKSVKKGFDFTLMVAGESG : : : . . : . .: :.::::::::::::::::::::::::::::::: XP_006 MGPVPTSFGKRRGGPQTLPASPGGMDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 LGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGD :::::::.::::::::.:::::.::::: ::::: ::.::::::::.:.::::::::::: XP_006 LGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 AVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGF ::::::::::...:.::::::::::::::::::::::::::::::::::::::::.:: : XP_006 AVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 MKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQ :::::..:::::..:::: :.: :. . :..:::::..:::..::::.:::::::::: : XP_006 MKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 DRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHD :. :::: :::::::::::::.:.:::::::::::::::: .::::::::.::.::::.: XP_006 DQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQD 250 260 270 280 290 300 300 310 320 330 340 pF1KB3 LKDVTCDVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPLPTPDAETEKLI ::::: ..:::::::.:::.:: .:::..: . ::: .: : : :::::: XP_006 LKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP-PGTDPETEKLI 310 320 330 340 350 350 360 pF1KB3 RMKDEELRRMQEMLQRMKQQMQDQ : ::::::::::::.....::.. XP_006 REKDEELRRMQEMLHKIQKQMKENY 360 370 380 >>XP_006722015 (OMIM: 603696) PREDICTED: septin-4 isofor (360 aa) initn: 1900 init1: 1724 opt: 1855 Z-score: 2010.1 bits: 380.5 E(85289): 3.2e-105 Smith-Waterman score: 1895; 77.9% identity (91.6% similar) in 357 aa overlap (21-368:3-358) 10 20 30 40 50 60 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTL ::.::::::::::::::::::::::::::::::::::::: XP_006 MDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTL 10 20 30 40 70 80 90 100 110 120 pF1KB3 VHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTE :.::::::::.:::::.::::: ::::: ::.::::::::.:.::::::::::::::::: XP_006 VNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 CWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHE ::::...:.::::::::::::::::::::::::::::::::::::::::.:: ::::::. XP_006 CWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQ 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 KVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKE .:::::..:::: :.: :. . :..:::::..:::..::::.:::::::::: ::. ::: XP_006 RVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 SAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTC : :::::::::::::.:.:::::::::::::::: .::::::::.::.::::.:::::: XP_006 SIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTR 230 240 250 260 270 280 310 320 330 340 350 pF1KB3 DVHYENYRAHCIQQMT---------SKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEE ..:::::::.:::.:: .:::..: . ::: .: : : ::::::: :::: XP_006 ETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVP-PGTDPETEKLIREKDEE 290 300 310 320 330 340 360 pF1KB3 LRRMQEMLQRMKQQMQDQ ::::::::.....::.. XP_006 LRRMQEMLHKIQKQMKENY 350 360 >>NP_001009939 (OMIM: 602724) septin-5 isoform 2 [Homo s (346 aa) initn: 1699 init1: 1699 opt: 1699 Z-score: 1841.9 bits: 349.3 E(85289): 7.5e-96 Smith-Waterman score: 1699; 99.6% identity (100.0% similar) in 254 aa overlap (18-271:27-280) 10 20 30 40 50 pF1KB3 MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAG .::::::::::::::::::::::::::::::::: NP_001 MDSLAAPQDRLVEQLLSPRTQAQRRLKDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 ESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 FGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 VGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 KQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTH :::::::::::::::::::::::::::::::::::::::: NP_001 KQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEGALRLREAAQHAHPHAYARP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 MHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEE NP_001 QGRDVRRALRELPRALHPADDQQTDPGQPHGEPHPDPAAAHPGRRD 310 320 330 340 369 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:42:45 2016 done: Fri Nov 4 02:42:47 2016 Total Scan time: 8.330 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]