FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3912, 153 aa 1>>>pF1KB3912 153 - 153 aa - 153 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8123+/-0.0003; mu= 14.6133+/- 0.019 mean_var=63.8017+/-12.995, 0's: 0 Z-trim(117.4): 38 B-trim: 0 in 0/53 Lambda= 0.160568 statistics sampled from 29361 (29411) to 29361 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.345), width: 16 Scan time: 5.430 The best scores are: opt bits E(85289) NP_000609 (OMIM: 147440,608747) insulin-like growt ( 153) 1058 253.0 1.4e-67 NP_001104753 (OMIM: 147440,608747) insulin-like gr ( 158) 934 224.3 6.4e-59 NP_001104755 (OMIM: 147440,608747) insulin-like gr ( 195) 934 224.3 7.5e-59 NP_001104754 (OMIM: 147440,608747) insulin-like gr ( 137) 902 216.8 9.7e-57 XP_016874752 (OMIM: 147440,608747) PREDICTED: insu ( 170) 903 217.1 9.8e-57 XP_016874751 (OMIM: 147440,608747) PREDICTED: insu ( 175) 779 188.4 4.4e-48 XP_016874748 (OMIM: 147440,608747) PREDICTED: insu ( 212) 779 188.5 5.2e-48 XP_016874750 (OMIM: 147440,608747) PREDICTED: insu ( 179) 778 188.2 5.3e-48 NP_001007140 (OMIM: 130650,147470,180860,194070,61 ( 180) 317 81.4 7.5e-16 NP_000603 (OMIM: 130650,147470,180860,194070,61648 ( 180) 317 81.4 7.5e-16 NP_001278791 (OMIM: 130650,147470,180860,194070,61 ( 180) 317 81.4 7.5e-16 NP_001278790 (OMIM: 130650,147470,180860,194070,61 ( 180) 317 81.4 7.5e-16 NP_001121070 (OMIM: 130650,147470,180860,194070,61 ( 236) 317 81.5 9.2e-16 >>NP_000609 (OMIM: 147440,608747) insulin-like growth fa (153 aa) initn: 1058 init1: 1058 opt: 1058 Z-score: 1334.3 bits: 253.0 E(85289): 1.4e-67 Smith-Waterman score: 1058; 100.0% identity (100.0% similar) in 153 aa overlap (1-153:1-153) 10 20 30 40 50 60 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 70 80 90 100 110 120 130 140 150 pF1KB3 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM ::::::::::::::::::::::::::::::::: NP_000 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM 130 140 150 >>NP_001104753 (OMIM: 147440,608747) insulin-like growth (158 aa) initn: 934 init1: 934 opt: 934 Z-score: 1178.8 bits: 224.3 E(85289): 6.4e-59 Smith-Waterman score: 934; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 70 80 90 100 110 120 130 140 150 pF1KB3 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :::::::::::::: NP_001 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 130 140 150 >>NP_001104755 (OMIM: 147440,608747) insulin-like growth (195 aa) initn: 934 init1: 934 opt: 934 Z-score: 1177.6 bits: 224.3 E(85289): 7.5e-59 Smith-Waterman score: 934; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 70 80 90 100 110 120 130 140 150 pF1KB3 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :::::::::::::: NP_001 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRR 130 140 150 160 170 180 >>NP_001104754 (OMIM: 147440,608747) insulin-like growth (137 aa) initn: 902 init1: 902 opt: 902 Z-score: 1139.6 bits: 216.8 E(85289): 9.7e-57 Smith-Waterman score: 902; 100.0% identity (100.0% similar) in 132 aa overlap (22-153:6-137) 10 20 30 40 50 60 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD ::::::::::::::::::::::::::::::::::::::: NP_001 MITPTVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 10 20 30 40 70 80 90 100 110 120 pF1KB3 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 50 60 70 80 90 100 130 140 150 pF1KB3 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM ::::::::::::::::::::::::::::::::: NP_001 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM 110 120 130 >>XP_016874752 (OMIM: 147440,608747) PREDICTED: insulin- (170 aa) initn: 903 init1: 903 opt: 903 Z-score: 1139.6 bits: 217.1 E(85289): 9.8e-57 Smith-Waterman score: 903; 99.2% identity (100.0% similar) in 133 aa overlap (21-153:38-170) 10 20 30 40 50 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGP .::::::::::::::::::::::::::::: XP_016 HVEKKKKKKFKVQVISTTPGKPGLESSLGKEVKMHTMSSSHLFYLALCLLTFTSSATAGP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA 70 80 90 100 110 120 120 130 140 150 pF1KB3 PLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM ::::::::::::::::::::::::::::::::::::::::::: XP_016 PLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM 130 140 150 160 170 >>XP_016874751 (OMIM: 147440,608747) PREDICTED: insulin- (175 aa) initn: 779 init1: 779 opt: 779 Z-score: 984.2 bits: 188.4 E(85289): 4.4e-48 Smith-Waterman score: 779; 99.1% identity (100.0% similar) in 114 aa overlap (21-134:38-151) 10 20 30 40 50 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGP .::::::::::::::::::::::::::::: XP_016 HVEKKKKKKFKVQVISTTPGKPGLESSLGKEVKMHTMSSSHLFYLALCLLTFTSSATAGP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA 70 80 90 100 110 120 120 130 140 150 pF1KB3 PLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :::::::::::::::::::::::: XP_016 PLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 130 140 150 160 170 >>XP_016874748 (OMIM: 147440,608747) PREDICTED: insulin- (212 aa) initn: 779 init1: 779 opt: 779 Z-score: 983.0 bits: 188.5 E(85289): 5.2e-48 Smith-Waterman score: 779; 99.1% identity (100.0% similar) in 114 aa overlap (21-134:38-151) 10 20 30 40 50 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGP .::::::::::::::::::::::::::::: XP_016 HVEKKKKKKFKVQVISTTPGKPGLESSLGKEVKMHTMSSSHLFYLALCLLTFTSSATAGP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCA 70 80 90 100 110 120 120 130 140 150 pF1KB3 PLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :::::::::::::::::::::::: XP_016 PLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQ 130 140 150 160 170 180 >>XP_016874750 (OMIM: 147440,608747) PREDICTED: insulin- (179 aa) initn: 778 init1: 778 opt: 778 Z-score: 982.8 bits: 188.2 E(85289): 5.3e-48 Smith-Waterman score: 778; 100.0% identity (100.0% similar) in 113 aa overlap (22-134:6-118) 10 20 30 40 50 60 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD ::::::::::::::::::::::::::::::::::::::: XP_016 MITPTVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 10 20 30 40 70 80 90 100 110 120 pF1KB3 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 50 60 70 80 90 100 130 140 150 pF1KB3 VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :::::::::::::: XP_016 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRR 110 120 130 140 150 160 >>NP_001007140 (OMIM: 130650,147470,180860,194070,616489 (180 aa) initn: 319 init1: 168 opt: 317 Z-score: 405.6 bits: 81.4 E(85289): 7.5e-16 Smith-Waterman score: 317; 58.2% identity (74.5% similar) in 98 aa overlap (27-121:5-94) 10 20 30 40 50 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAG--P-ETLCGAE :..: : :.. :.:.: :. : :::::.: NP_001 MGIPMGKSMLVLLTF--LAFASCCIAAYRPSETLCGGE 10 20 30 60 70 80 90 100 110 pF1KB3 LVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKS :::.::::::::::::..:.. :::. :::.::::::::: :: ::: :::: NP_001 LVDTLQFVCGDRGFYFSRPASR--VSRRS--RGIVEECCFRSCDLALLETYCA--TPAKS 40 50 60 70 80 90 120 130 140 150 pF1KB3 ARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :.: NP_001 ERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFR 100 110 120 130 140 150 >>NP_000603 (OMIM: 130650,147470,180860,194070,616489) i (180 aa) initn: 319 init1: 168 opt: 317 Z-score: 405.6 bits: 81.4 E(85289): 7.5e-16 Smith-Waterman score: 317; 58.2% identity (74.5% similar) in 98 aa overlap (27-121:5-94) 10 20 30 40 50 pF1KB3 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAG--P-ETLCGAE :..: : :.. :.:.: :. : :::::.: NP_000 MGIPMGKSMLVLLTF--LAFASCCIAAYRPSETLCGGE 10 20 30 60 70 80 90 100 110 pF1KB3 LVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKS :::.::::::::::::..:.. :::. :::.::::::::: :: ::: :::: NP_000 LVDTLQFVCGDRGFYFSRPASR--VSRRS--RGIVEECCFRSCDLALLETYCA--TPAKS 40 50 60 70 80 90 120 130 140 150 pF1KB3 ARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM :.: NP_000 ERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFR 100 110 120 130 140 150 153 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:10:09 2016 done: Thu Nov 3 14:10:10 2016 Total Scan time: 5.430 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]