FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3946, 509 aa 1>>>pF1KB3946 509 - 509 aa - 509 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.6584+/-0.000451; mu= -22.4982+/- 0.028 mean_var=667.1116+/-138.572, 0's: 0 Z-trim(125.1): 59 B-trim: 0 in 0/62 Lambda= 0.049656 statistics sampled from 48082 (48152) to 48082 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.565), width: 16 Scan time: 8.980 The best scores are: opt bits E(85289) NP_000337 (OMIM: 114290,608160,616425) transcripti ( 509) 3554 269.3 1.9e-71 NP_008872 (OMIM: 602229,609136,611584,613266) tran ( 466) 1350 111.4 6e-24 NP_055402 (OMIM: 605923) transcription factor SOX- ( 446) 1178 99.0 3e-20 NP_071899 (OMIM: 610928,613674) transcription fact ( 414) 534 52.9 2.2e-06 NP_113627 (OMIM: 612202) transcription factor SOX- ( 388) 461 47.6 7.8e-05 NP_060889 (OMIM: 137940,601618,607823) transcripti ( 384) 430 45.4 0.00036 NP_009015 (OMIM: 604974) transcription factor SOX- ( 276) 423 44.8 0.0004 NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapi ( 233) 408 43.6 0.00074 NP_004180 (OMIM: 604747) transcription factor SOX- ( 240) 405 43.4 0.00088 NP_003097 (OMIM: 184429,189960,206900) transcripti ( 317) 407 43.7 0.00098 NP_005625 (OMIM: 300123,312000,313430) transcripti ( 446) 397 43.1 0.0021 NP_008874 (OMIM: 601947) transcription factor SOX- ( 315) 385 42.1 0.0029 NP_003098 (OMIM: 184430) transcription factor SOX- ( 474) 387 42.4 0.0035 NP_005977 (OMIM: 602148) transcription factor SOX- ( 391) 381 41.9 0.0041 NP_003099 (OMIM: 600898,615866) transcription fact ( 441) 379 41.8 0.005 >>NP_000337 (OMIM: 114290,608160,616425) transcription f (509 aa) initn: 3554 init1: 3554 opt: 3554 Z-score: 1403.8 bits: 269.3 E(85289): 1.9e-71 Smith-Waterman score: 3554; 100.0% identity (100.0% similar) in 509 aa overlap (1-509:1-509) 10 20 30 40 50 60 pF1KB3 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 KKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 PKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 NGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 QPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 SPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPI 430 440 450 460 470 480 490 500 pF1KB3 ADTSGVPSIPQTHSPQHWEQPVYTQLTRP ::::::::::::::::::::::::::::: NP_000 ADTSGVPSIPQTHSPQHWEQPVYTQLTRP 490 500 >>NP_008872 (OMIM: 602229,609136,611584,613266) transcri (466 aa) initn: 1439 init1: 805 opt: 1350 Z-score: 551.0 bits: 111.4 E(85289): 6e-24 Smith-Waterman score: 1682; 54.4% identity (72.1% similar) in 502 aa overlap (13-509:18-466) 10 20 30 40 50 pF1KB3 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPK :. . :: . .:... :..:. ::: . . . : NP_008 MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGG----GSGLRASPGPGELGKVKK 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 GEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVW . : :...:::::::::::::::.:::::::::::::::.::.:::::::::::::: NP_008 EQQD--GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQ ::::::::::::::::::::::::::::::::::.::::.:::::::.:::::::::::: NP_008 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 PRRRKSVKNGQAEAE----EATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEH-SGQ :::::. : .:.::: :: . . .: .:. . : : . : . :: ::: NP_008 PRRRKNGKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 SQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFD :.:::::::::::..: :::: ::.:: . :::. : ::: .:::::.: .:.::.:::: NP_008 SHGPPTPPTTPKTELQSGKADPKRDGRSMGEGGK-PHIDFGNVDIGEISHEVMSNMETFD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 VNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPP : :.::::::::::: : . ...::..:. :. ::. .:.:: :: : NP_008 VAELDQYLPPNGHPG----HVSSYSAAGYGLGSALAV-ASGHSAWISK----PPGVALPT 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 QAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQ .::. .: : .. .: :: .: ::..: NP_008 VSPPGVDAKAQVKTE-----TAGPQ---------------------------GPPHYTDQ 350 360 370 420 430 440 450 460 470 pF1KB3 QQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMN : .::::. ..::::. ..: :.: :.::.::: :. ::.:. ::..::::.:.::. NP_008 P--STSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHS-GQASGLYSAFSYMG 380 390 400 410 420 480 490 500 pF1KB3 PAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP :.:::.:: :.: : :: ::.::: :::::::: :.:: NP_008 PSQRPLYTAISDPS--PSGPQSHSPTHWEQPVYTTLSRP 430 440 450 460 >>NP_055402 (OMIM: 605923) transcription factor SOX-8 [H (446 aa) initn: 1081 init1: 586 opt: 1178 Z-score: 484.6 bits: 99.0 E(85289): 3e-20 Smith-Waterman score: 1339; 48.8% identity (67.6% similar) in 500 aa overlap (19-509:16-446) 10 20 30 40 50 pF1KB3 MNLLDPFMKMTDEQEKGLSG-APSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPD :: : : . ::: .. :: .::. . .:.: NP_055 MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDP- 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 LKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSS--KNKPHVKRPMNAFMVWAQ :. ...::.:::.:::::::::::.::::::: .:.. : :::::::::::::::: NP_055 --AEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 AARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPR :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: NP_055 AARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 RRKSVKNGQAEAEEATEQ-THISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPT ::::.: :..... ..: : . .:..:: .:... : :.:.::..:::: NP_055 RRKSAKAGHSDSDSGAELGPHPGGGAVYKA--------EAGLGDGHHHGDHTGQTHGPPT 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 PPTTPKTDVQPG--KADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEF :::::::..: . : .:: ::: ..::: ::: .:::.::::.:......:::.:: NP_055 PPTTPKTELQQAGAKPELKLEGRRPVDSGRQN-IDFSNVDISELSSEVMGTMDAFDVHEF 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 DQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPP ::::: .: :. : ::. : :.: :.:. :: :. :: .: : NP_055 DQYLPLGG-PA-PPEPGQA-YGGAY-------FHAGASPVWAHKS-APSA------SASP 290 300 310 320 360 370 380 390 400 410 pF1KB3 APQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHS . .::.: :::::: ::.::..: . : NP_055 TETGPPRP---------------------------------HIKTEQPSPGHYGDQPRGS 330 340 350 420 430 440 450 460 470 pF1KB3 PQQIAYSPFNLPHYSPSYP--PITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPA :. . : . .:. : :.. :: :: : : .::::. : . :::. . .: NP_055 PDYGSCS--GQSSATPAAPAGPFAGSQGDYGDLQ-ASSYYGAYPGYAPGLYQYPCFHSP- 360 370 380 390 400 410 480 490 500 pF1KB3 QRPMYTPIADTSGVPSIPQTHSP-QHWEQPVYTQLTRP .::. .:. . :. ..: .::: .::.::::: :::: NP_055 RRPYASPLLN--GL-ALPPAHSPTSHWDQPVYTTLTRP 420 430 440 >>NP_071899 (OMIM: 610928,613674) transcription factor S (414 aa) initn: 513 init1: 429 opt: 534 Z-score: 235.7 bits: 52.9 E(85289): 2.2e-06 Smith-Waterman score: 534; 34.6% identity (54.4% similar) in 344 aa overlap (92-426:55-389) 70 80 90 100 110 120 pF1KB3 KESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARR :. . : .:.. ...::::::::::. :. NP_071 AGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERK 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB3 KLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKS .::.: : :::::::: ::: :. :. .:::::::::::::::: .:::.:::.:::::. NP_071 RLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQ 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB3 VKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPT-PPTT :: . ..: . . :.: :: .. . . .. : ..: ::: :: NP_071 VKRLK-RVEGGFLHGLAEPQAA--ALGPEGGRVAMDGLGLQFP--EQGFPAGPPLLPPHM 150 160 170 180 190 250 260 270 280 290 pF1KB3 PK--TDVQP-GKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQY : : : : .: ::: .: .: : : . ... . .. . . . : NP_071 GGHYRDCQSLGAPPL--DGYPLPTPDTSP-LDGVDPDPAFFAAPMPGDCPAAGTYSYAQV 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB3 LPPNGHPGVPA--THGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPA : : :: : .. . .: :: ::... . .: . : : NP_071 SDYAGPPEPPAGPMHPRLGPEPAGPSIPGLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQ 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB3 PQAPPQPQAAPPQ--QPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQH : : : :: ::. ::. . : :.:.. .:: . :. . . NP_071 HQHQHQHQHHPPGPGQPSPPPEALPCRDGTD-PSQPAELLGEVDRTEFEQYLHFVCKPEM 320 330 340 350 360 370 420 430 440 450 460 470 pF1KB3 S-PQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPA . : : : ::: NP_071 GLPYQGHDSGVNLPDSHGAISSVVSDASSAVYYCNYPDV 380 390 400 410 >>NP_113627 (OMIM: 612202) transcription factor SOX-7 [H (388 aa) initn: 479 init1: 383 opt: 461 Z-score: 207.8 bits: 47.6 E(85289): 7.8e-05 Smith-Waterman score: 461; 32.5% identity (54.8% similar) in 323 aa overlap (89-406:32-341) 60 70 80 90 100 110 pF1KB3 DLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQA :: : :.. .. ...::::::::::. NP_113 ASLLGAYPWPEGLECPALDAELSDGQSPPAVPRP---PGDKGSESRIRRPMNAFMVWAKD 10 20 30 40 50 120 130 140 150 160 170 pF1KB3 ARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRR :..:: : : :::::::: ::: :. :. :.:::.:.::::::.:: .:.:.:::.::: NP_113 ERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRR 60 70 80 90 100 110 180 190 200 210 220 230 pF1KB3 RKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPP .:..: ... . . .: . .:: : ....: .. ::.: . : NP_113 KKQAKRLCKRVDPGFLLSSLSRDQ--NALPEKRSGSRGALGEKEDRGEYSPGTALPSLRG 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB3 TTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNI--ETFDVNEFDQ . . : . : : :: .. .:. : . .:. : . NP_113 CYHEGPAGGGGGGTPSSVDTYPYGLPTPP-EMSPLDVLEPEQTFFSSPCQEEHGHPRRIP 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB3 YLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAP .:: ::: : .. :. ..: : : : :: .: ::. : :: NP_113 HLP--GHPYSPE-YAPSPLHCSHPLGSLA-LGQSPGVSMMSP--VPGCPPS-PAYYSPAT 240 250 260 270 280 360 370 380 390 400 410 pF1KB3 QAPPQPQ-AAPPQQPAAPPQQPQAHTLTTLSSEP--GQSQRTHIKTEQLSPSHYSEQQQH : . . : : . ::..: .: ::. :. .:... .:.: NP_113 YHPLHSNLQAHLGQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQYLNTPGHPDSATGA 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB3 SPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQ NP_113 MALSGHVPVSQVTPTGPTETSLISVLADATATYYNSYSVS 350 360 370 380 >>NP_060889 (OMIM: 137940,601618,607823) transcription f (384 aa) initn: 459 init1: 391 opt: 430 Z-score: 195.9 bits: 45.4 E(85289): 0.00036 Smith-Waterman score: 468; 32.3% identity (52.9% similar) in 359 aa overlap (17-372:7-316) 10 20 30 40 50 60 pF1KB3 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDL : .. .: .: : .: :...::.. . : : NP_060 MQRSPPGYGAQDDPPARRDCAWAP-GHGAAADTRG-------LAAGPAAL 10 20 30 40 70 80 90 100 110 120 pF1KB3 KKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAAR . . : : . : . : : : . .. .. ...::::::::::. : NP_060 AAPAAPASPPSPQRSPPRSPEPGR-YGLSPAG-RGERQAADESRIRRPMNAFMVWAKDER 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 RKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK ..::.: : :::: ::: ::: :. :: .:::::::::::::::: .:::.:::.:::.: NP_060 KRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKK 110 120 130 140 150 160 190 200 210 220 230 pF1KB3 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPG-EHSGQSQGPPTPPT ...... :. . . : : :. .. :. : : .: : ::: NP_060 QARKARRLEPGLLLPGLAPPQPPPEPFPAASG-SARAFRELPPLGAEFDGL--GLPTPER 170 180 190 200 210 240 250 260 270 280 290 pF1KB3 TPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLP .: ..::.: . .: :: .: . . . . . : NP_060 SPLDGLEPGEAAF------FP-----PPAAPEDCALRPFRAPYAPTELSRD--------- 220 230 240 250 300 310 320 330 340 350 pF1KB3 PNGHPGVPATHGQVTYTGSYGISSTAATPAS--AGHVWMSKQQAPPPPPQQPPQAPPAPQ :.: :.: ... : : ::. :: .... .: : : : .:: :. NP_060 PGGCYGAPLAEALRT-----------APPAAPLAG-LYYGTLGTPGPYPG--PLSPP-PE 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 APPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQ ::: ..: : ::: NP_060 APPL-ESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPE 310 320 330 340 350 360 >>NP_009015 (OMIM: 604974) transcription factor SOX-21 [ (276 aa) initn: 422 init1: 396 opt: 423 Z-score: 195.0 bits: 44.8 E(85289): 0.0004 Smith-Waterman score: 433; 33.0% identity (57.2% similar) in 285 aa overlap (99-364:2-271) 70 80 90 100 110 120 pF1KB3 FPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYP :: ::::::::::::..: :::.:.. : NP_009 MSKPVDHVKRPMNAFMVWSRAQRRKMAQENP 10 20 30 130 140 150 160 170 180 pF1KB3 HLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRR-KSVKNGQA ..::.:.:: :: :.::.:::::::..::.:::..: :.::::::.:::. :.. . . NP_009 KMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDK 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB3 EAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQG--PPTPPTTPKTDV : . : .. . .:. : ..: : :.: . : : . ..:. . NP_009 FAFPV-------PYGLGGVADAEHPALKAGA------GLHAGAGGGLVPESLLANPEKAA 100 110 120 130 250 260 270 280 290 300 pF1KB3 QPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPN---G . : : .:... . : : . . . ... .. :: : NP_009 AAAAAAAARV--FFPQSAAAAAAAAAAAAAGSPYSLLDLGSKMAEISSSSSGLPYASSLG 140 150 160 170 180 190 310 320 330 340 350 pF1KB3 HP--GVPATHGQVTYTGSY-----GISSTAATPASAGHVWMSKQQAPPPPPQQPPQAP-- .: :. : :: .. ... : . . .:.. :.. . .: : : ::: : NP_009 YPTAGAGAFHGAAAAAAAAAAAAGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYIL 200 210 220 230 240 250 360 370 380 390 400 pF1KB3 -PA---PQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSE :. :: : : : NP_009 LPGMGKPQLDPYPAAYAAAL 260 270 >>NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapiens] (233 aa) initn: 448 init1: 379 opt: 408 Z-score: 190.2 bits: 43.6 E(85289): 0.00074 Smith-Waterman score: 408; 40.9% identity (66.1% similar) in 171 aa overlap (105-266:49-218) 80 90 100 110 120 130 pF1KB3 EAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAE :::::::::::..: ::..:.: :..::.: NP_008 ATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSE 20 30 40 50 60 70 140 150 160 170 180 pF1KB3 LSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRR-KSV-----KNGQAE .:: :: :.::.:.:::::::::.:::..: .:.:::::.:::. :: . ::.. NP_008 ISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGR 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB3 AEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGP---PTPPTTPKTDV .. :. .:. . . ..: .. :: . :.:. :.: . :..: NP_008 GNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSY-GSSHCKLEAPSPCSLPQSDP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB3 QPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPG . : . :: :. : NP_008 RLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL 200 210 220 230 >>NP_004180 (OMIM: 604747) transcription factor SOX-14 [ (240 aa) initn: 393 init1: 393 opt: 405 Z-score: 188.9 bits: 43.4 E(85289): 0.00088 Smith-Waterman score: 405; 33.6% identity (61.9% similar) in 244 aa overlap (99-333:2-236) 70 80 90 100 110 120 pF1KB3 FPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYP :: . :.::::::::::... :::.:.. : NP_004 MSKPSDHIKRPMNAFMVWSRGQRRKMAQENP 10 20 30 130 140 150 160 170 180 pF1KB3 HLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAE ..::.:.:: :: :.::.:.::::...::.:::.:: :.::::::.:::. :: . NP_004 KMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKP--KNLLKK 40 50 60 70 80 190 200 210 220 230 240 pF1KB3 AEEATEQTHISPNAIFKALQADSP-HSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQP . . ... . .:: : : .:.:. . .: :.. : . : . .: NP_004 DRYVFPLPYLGDTDPLKA--AGLPVGASDGL--LSAP-EKARAFLPPASAPYSLLDPAQF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KB3 GKADLKREGRPLPEG---GRQP---PIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPN ... ... :. .:. : : . ... .: :: .. .: :. : NP_004 SSSAIQKMGE-VPHTLATGALPYASTLGYQNGAFGSLSCPS-QHTHTHPSPTNPGYVVPC 150 160 170 180 190 200 310 320 330 340 350 pF1KB3 GHPGVPATHGQ--VTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAP . . :. : :.: :...:. : :..: NP_004 NCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM 210 220 230 240 360 370 380 390 400 410 pF1KB3 PQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIA >>NP_003097 (OMIM: 184429,189960,206900) transcription f (317 aa) initn: 398 init1: 372 opt: 407 Z-score: 188.1 bits: 43.7 E(85289): 0.00098 Smith-Waterman score: 407; 29.6% identity (58.8% similar) in 294 aa overlap (97-380:32-316) 70 80 90 100 110 120 pF1KB3 DKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKP-HVKRPMNAFMVWAQAARRKLAD :..::.: .:::::::::::... :::.:. NP_003 YNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQ 10 20 30 40 50 60 130 140 150 160 170 180 pF1KB3 QYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNG . :..::.:.:: :: :.::.:.:::::..::.:::. : :.::::::.:::. .:. NP_003 ENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRK--TKTL 70 80 90 100 110 190 200 210 220 230 240 pF1KB3 QAEAEEATEQTHISP--NAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKT . . . . ..: :.. ... . . ... ... : .. .: :.: . NP_003 MKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNG--SYSMMQDQ 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB3 DVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGH : . :. .: .... :. ::. . .: . :. ... .: NP_003 LGYPQHPGLNAHG-----AAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGT 180 190 200 210 220 230 310 320 330 340 350 pF1KB3 PGVP-ATHGQVTYT---GSYGI---SSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAP ::. .. :.:. . .: . :: . .: .:: . .. : : :: NP_003 PGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRL 240 250 260 270 280 290 360 370 380 390 400 410 pF1KB3 QAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQ . . :..: : : .: NP_003 HMSQHYQSGPVPGTAINGTLPLSHM 300 310 509 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:11:32 2016 done: Thu Nov 3 14:11:33 2016 Total Scan time: 8.980 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]