FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3954, 1466 aa 1>>>pF1KB3954 1466 - 1466 aa - 1466 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2346+/-0.0015; mu= 6.4735+/- 0.092 mean_var=805.1643+/-165.461, 0's: 0 Z-trim(114.9): 277 B-trim: 0 in 0/54 Lambda= 0.045199 statistics sampled from 15203 (15463) to 15203 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.475), width: 16 Scan time: 6.440 The best scores are: opt bits E(32554) CCDS2297.1 COL3A1 gene_id:1281|Hs108|chr2 (1466) 11021 735.8 2.2e-211 CCDS11561.1 COL1A1 gene_id:1277|Hs108|chr17 (1464) 6618 448.7 5.8e-125 CCDS8759.1 COL2A1 gene_id:1280|Hs108|chr12 (1418) 6387 433.6 2e-120 CCDS41778.1 COL2A1 gene_id:1280|Hs108|chr12 (1487) 6371 432.6 4.1e-120 CCDS33350.1 COL5A2 gene_id:1290|Hs108|chr2 (1499) 5609 383.0 3.8e-105 CCDS34682.1 COL1A2 gene_id:1278|Hs108|chr7 (1366) 4355 301.1 1.5e-80 CCDS75932.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 4186 290.3 3.6e-77 CCDS6982.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 4184 290.2 3.9e-77 CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690) 4110 285.3 1.1e-75 CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767) 4110 285.3 1.1e-75 CCDS778.1 COL11A1 gene_id:1301|Hs108|chr1 (1806) 4110 285.3 1.1e-75 CCDS43452.1 COL11A2 gene_id:1302|Hs108|chr6 (1650) 3828 266.9 3.6e-70 CCDS12222.1 COL5A3 gene_id:50509|Hs108|chr19 (1745) 3492 245.0 1.5e-63 CCDS42828.1 COL4A4 gene_id:1286|Hs108|chr2 (1690) 3284 231.4 1.7e-59 CCDS9511.1 COL4A1 gene_id:1282|Hs108|chr13 (1669) 3262 230.0 4.7e-59 CCDS41907.1 COL4A2 gene_id:1284|Hs108|chr13 (1712) 2882 205.2 1.4e-51 CCDS2773.1 COL7A1 gene_id:1294|Hs108|chr3 (2944) 2862 204.3 4.4e-51 CCDS42829.1 COL4A3 gene_id:1285|Hs108|chr2 (1670) 2851 203.2 5.5e-51 CCDS76010.1 COL4A6 gene_id:1288|Hs108|chrX (1707) 2797 199.7 6.3e-50 CCDS41297.1 COL16A1 gene_id:1307|Hs108|chr1 (1604) 2744 196.2 6.7e-49 CCDS76008.1 COL4A6 gene_id:1288|Hs108|chrX (1633) 2730 195.3 1.3e-48 CCDS76009.1 COL4A6 gene_id:1288|Hs108|chrX (1666) 2730 195.3 1.3e-48 CCDS14542.1 COL4A6 gene_id:1288|Hs108|chrX (1690) 2730 195.3 1.3e-48 CCDS14541.1 COL4A6 gene_id:1288|Hs108|chrX (1691) 2730 195.3 1.3e-48 CCDS6802.1 COL27A1 gene_id:85301|Hs108|chr9 (1860) 2613 187.7 2.7e-46 CCDS6376.1 COL22A1 gene_id:169044|Hs108|chr8 (1626) 2558 184.1 3e-45 CCDS41353.1 COL24A1 gene_id:255631|Hs108|chr1 (1714) 2296 167.0 4.3e-40 CCDS14543.1 COL4A5 gene_id:1287|Hs108|chrX (1685) 2216 161.8 1.6e-38 CCDS35366.1 COL4A5 gene_id:1287|Hs108|chrX (1691) 2216 161.8 1.6e-38 CCDS42971.1 COL18A1 gene_id:80781|Hs108|chr21 (1339) 1957 144.7 1.7e-33 CCDS42972.1 COL18A1 gene_id:80781|Hs108|chr21 (1519) 1957 144.8 1.8e-33 CCDS77643.1 COL18A1 gene_id:80781|Hs108|chr21 (1754) 1957 144.9 2e-33 CCDS450.1 COL9A2 gene_id:1298|Hs108|chr1 ( 689) 1933 142.7 3.7e-33 CCDS4970.1 COL19A1 gene_id:1310|Hs108|chr6 (1142) 1919 142.1 8.9e-33 CCDS47447.1 COL9A1 gene_id:1297|Hs108|chr6 ( 678) 1804 134.3 1.2e-30 CCDS4971.1 COL9A1 gene_id:1297|Hs108|chr6 ( 921) 1803 134.4 1.5e-30 CCDS13505.1 COL9A3 gene_id:1299|Hs108|chr20 ( 684) 1693 127.0 1.9e-28 CCDS5105.1 COL10A1 gene_id:1300|Hs108|chr6 ( 680) 1617 122.1 5.8e-27 CCDS2934.1 COL8A1 gene_id:1295|Hs108|chr3 ( 744) 1577 119.5 3.7e-26 CCDS44419.1 COL13A1 gene_id:1305|Hs108|chr10 ( 717) 1568 118.9 5.4e-26 CCDS44424.2 COL13A1 gene_id:1305|Hs108|chr10 ( 695) 1559 118.3 8.1e-26 CCDS43553.1 COL28A1 gene_id:340267|Hs108|chr7 (1125) 1546 117.8 1.9e-25 CCDS7554.1 COL17A1 gene_id:1308|Hs108|chr10 (1497) 1532 117.1 4e-25 CCDS58922.1 COL25A1 gene_id:84570|Hs108|chr4 ( 645) 1494 114.0 1.5e-24 CCDS44427.2 COL13A1 gene_id:1305|Hs108|chr10 ( 645) 1474 112.7 3.6e-24 CCDS55025.1 COL21A1 gene_id:81578|Hs108|chr6 ( 957) 1452 111.6 1.2e-23 CCDS83099.1 COL21A1 gene_id:81578|Hs108|chr6 ( 954) 1444 111.0 1.7e-23 CCDS44428.2 COL13A1 gene_id:1305|Hs108|chr10 ( 610) 1368 105.8 4.2e-22 CCDS35081.1 COL15A1 gene_id:1306|Hs108|chr9 (1388) 1344 104.8 1.9e-21 CCDS4436.1 COL23A1 gene_id:91522|Hs108|chr5 ( 540) 1251 98.0 7.9e-20 >>CCDS2297.1 COL3A1 gene_id:1281|Hs108|chr2 (1466 aa) initn: 11021 init1: 11021 opt: 11021 Z-score: 3908.7 bits: 735.8 E(32554): 2.2e-211 Smith-Waterman score: 11021; 99.9% identity (100.0% similar) in 1466 aa overlap (1-1466:1-1466) 10 20 30 40 50 60 pF1KB3 MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 LCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 GDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 ERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 ERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 PRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 SNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 ANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 AAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 AAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 SPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 SPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 GPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 GPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 PKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 TPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 TPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB3 EGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 EGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB3 VAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 VAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB3 KDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 KDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB3 PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB3 LPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 LPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAG 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB3 SRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 SRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB3 PVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB3 GAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 GAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPAR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB3 NCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 NCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB3 AEKKHVWFGESMDGGFQFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMD ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: CCDS22 AEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMD 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KB3 QASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 QASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLP 1390 1400 1410 1420 1430 1440 1450 1460 pF1KB3 IVDIAPYDIGGPDQEFGVDVGPVCFL :::::::::::::::::::::::::: CCDS22 IVDIAPYDIGGPDQEFGVDVGPVCFL 1450 1460 >>CCDS11561.1 COL1A1 gene_id:1277|Hs108|chr17 (1464 aa) initn: 8206 init1: 4979 opt: 6618 Z-score: 2357.0 bits: 448.7 E(32554): 5.8e-125 Smith-Waterman score: 6622; 61.9% identity (74.1% similar) in 1487 aa overlap (1-1466:1-1464) 10 20 30 40 pF1KB3 MMSFVQKGSWLLLALLHPTIILA--QQEA-VEGG--------CSHLGQSYADRDVWKPEP :.::: . :: :: : .:. :.:. ::: : . : : ::::::::: CCDS11 MFSFV---DLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEP 10 20 30 40 50 50 60 70 80 90 100 pF1KB3 CQICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPT-RPPNG-QGPQG- :.:::::.:.:::::.:::. . .::. :.: :::: :::. .:: . .: .::.: CCDS11 CRICVCDNGKVLCDDVICDETK-NCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGD 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB3 --PKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTG-PQNYSPQYD-SYDVKS :.: :: : :::.: :: :: :: :: ::::: : : :..:: . .:: :: CCDS11 TGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPG-----PPGLGGNFAPQLSYGYDEKS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB3 GVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIG .::.. ::: :: :: : :: ::.:: :.::::::::. : ::: :: : : CCDS11 ---TGGIS-VPGPMGPSGPRGLPGP---PGAPGPQGFQGPPGEPGEPGASGPMGPRGPPG 180 190 200 210 220 230 240 250 260 270 280 pF1KB3 PSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPG : : : :::.:.:::::::: ::: : .: : :.:::::::::.: .: ::..: : CCDS11 PPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAG 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB3 LKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAG ::: : :::::::: ::::: :::::::: :: ::::::::: :. : ::: :: : : CCDS11 PKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPG 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB3 FPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAG :::. :::::.:: : ::.: : :::::: : ::: :: : :: .:.::.:: : : CCDS11 FPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPG 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB3 IPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKG : ::::. ::::: :: : .: :: .:..:::: :.::. : .:: : .:. : :: : CCDS11 IAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAG 410 420 430 440 450 460 470 480 490 500 510 520 pF1KB3 EDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAG :.:: :. :::: .:::: ::::.:: :: : .:. : ::::::::.::::::.:. : CCDS11 EEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPG 470 480 490 500 510 520 530 540 550 560 570 580 pF1KB3 EPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPG : :: : : :: .:. ::::.:: ::: :::: :..:::::::: : ::: ::::::: CCDS11 EAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPG 530 540 550 560 570 580 590 600 610 620 630 640 pF1KB3 PKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQG ::: : ::: :::: :: :: :: ::.::.: ::::::.::.:..:. :: : :.:: CCDS11 PKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQG 590 600 610 620 630 640 650 660 670 680 690 700 pF1KB3 LPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPG ::: .::::: ::::: : :: :::: :..:. : ::::: : : : ::. : :: CCDS11 LPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPG 650 660 670 680 690 700 710 720 730 740 750 760 pF1KB3 PEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRG .:.:: :: :: ::. :.:::::::::::. : ::::::.:. : :::: ::::: :: CCDS11 NDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRG 710 720 730 740 750 760 770 780 790 800 810 820 pF1KB3 PTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPG ::::::::::: ::::::.: : : .: ::.::.::: :::::::: : :: .:.:: CCDS11 LTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPG 770 780 790 800 810 820 830 840 850 860 870 880 pF1KB3 GKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPG .::: : : ::..:::: ::: : :: : : :.:: ::: : :::.::::: : : CCDS11 AKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVG 830 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 PPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPG ::: .:: ::::: : ::.: :: :.:: : :: :: : : ::::::::.:: : CCDS11 PPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAG 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KB3 APGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPG ::: : ::.: ::..: ::. : :: :: : .:: :: : .: :::::::::.: :: CCDS11 APGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPG 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KB3 LAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSG ::: :: ::.: ::..: ::::::::.::::::.: : ::::: :: ::::::::::: CCDS11 LAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSG 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KB3 DRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPG ::::.::::::: ::.:.:: ::::::::::::::.: :::::::: : : :: :: CCDS11 DRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPG 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KB3 PAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPG :.:: :. :::::::: : .: ::::: .: ::::::::::: :. : : :: :: CCDS11 SPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPG 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KB3 QPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKINTD-EIMTSLKSV :::::::.: : . . ::: . :: . . . : :. :.:::. CCDS11 PPGPPGPPSA------GFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSL 1190 1200 1210 1220 1230 1250 1260 1270 1280 1290 1300 pF1KB3 NGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGET . :::.. ::.::::::::.:::::.:: . ::::::.::::::.::::::::::::::: CCDS11 SQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGET 1240 1250 1260 1270 1280 1290 1310 1320 1330 1340 1350 pF1KB3 CISANPLNVPRKHWW-TDSSAEKKHVWFGESMDGGFQFSYGNP-ELPEDVLDVQLAFLRL :. . .: .:.:. . . .:.:::::::: :::: ::. : :: .::.:::: CCDS11 CVYPTQPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGSDPADVA-IQLTFLRL 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 pF1KB3 LSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTK .:..::::::::::::.::::: .::.:::: :.:::: :..:::::.:::.: ::::. CCDS11 MSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTVDGCTS 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 pF1KB3 HTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL ::: :.:::.::.: :. ::::.:.:: :.:.:::::: :::::::: CCDS11 HTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPVCFL 1420 1430 1440 1450 1460 >>CCDS8759.1 COL2A1 gene_id:1280|Hs108|chr12 (1418 aa) initn: 4885 init1: 4885 opt: 6387 Z-score: 2275.7 bits: 433.6 E(32554): 2e-120 Smith-Waterman score: 6387; 61.8% identity (75.6% similar) in 1412 aa overlap (67-1466:23-1418) 40 50 60 70 80 90 pF1KB3 QSYADRDVWKPEPCQICVCDSGSVLCDDIICDDQELDCPNPEIPFGECC----AVCPQPP :. :.. :.:. :: : :. : CCDS87 MIRLGAPQTLVLLTLLVAAVLRCQGQDVRQPGPKGQKGEPGDIKDIVGPKGP 10 20 30 40 50 100 110 120 130 140 pF1KB3 TAPTRPPNGQGPQGPKGDPGPPGIPG---RNGDPGIPGQPGSPGSPGPPGICESCPTG-P .: : . :::.: .:: : : :: :.:.:: ::.:: :: ::::: : : CCDS87 PGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPG-----PPGLG 60 70 80 90 100 150 160 170 180 190 200 pF1KB3 QNYSPQY-DSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPG :.. :. ..: :.: : :. . :: :: :: :::: . :.:: :.:: ::::: CCDS87 GNFAAQMAGGFDEKAGGAQLGV--MQGPMGPMGPRGPPGPA---GAPGPQGFQGNPGEPG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB3 QAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRG . : ::: :: : :: : : :::.:.::. :::: ::: : .: : ::.::.::::: CCDS87 EPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRG 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB3 FDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARG . : .: :::.::::.:::.: :::::.:::::::: :::::: : :::::::::: : CCDS87 YPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPG 230 240 250 260 270 280 330 340 350 360 370 380 pF1KB3 SDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPG : ::: :: : ::::.::::::.::.:. : .:: : ::::: : : : : :: CCDS87 PAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPG 290 300 310 320 330 340 390 400 410 420 430 440 pF1KB3 INGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRG .: ::.:: : :: ::::. : :::::: ::.: : .: .:::: : ::: ::.: CCDS87 TDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKG 350 360 370 380 390 400 450 460 470 480 490 500 pF1KB3 ERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAG : : :: :.:: ::.:: :. ::::. : : ::::::: :: : .:. : :: : CCDS87 EPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPG 410 420 430 440 450 460 510 520 530 540 550 560 pF1KB3 ERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPG ::: : :::.:: :.::: : :: :: ::. : :: : .:: :: :. ::.::::::: CCDS87 ERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPG 470 480 490 500 510 520 570 580 590 600 610 620 pF1KB3 PSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGG :.: :::::::::::::: .: ::: ::.: ::.:: .: :::.:::: :::::.::.: CCDS87 PQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAG 530 540 550 560 570 580 630 640 650 660 670 680 pF1KB3 DKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPG ..:. : :::.:.::::: :::::.::::. : :.::::: : .:. : ::::: :: CCDS87 ERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPG 590 600 610 620 630 640 690 700 710 720 730 740 pF1KB3 LAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPG : : :: : :: .: :::.:: ::::: : :::::::::::. : :::::.:. : CCDS87 AQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVG 650 660 670 680 690 700 750 760 770 780 790 800 pF1KB3 GPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPG : .:.::::: :: ::::::::::: :.::: : :: : :: ::.::::::::::: CCDS87 EKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPG 710 720 730 740 750 760 810 820 830 840 850 860 pF1KB3 PAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPG :::: : :: .:.::.:::.: :.::..: :: :: :. :: :: : : :: ::. : CCDS87 PAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQG 770 780 790 800 810 820 870 880 890 900 910 920 pF1KB3 GPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAG :::.::::: : :::::::::::::: : ::::: : :..: :: : : .: :: CCDS87 PPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAG 830 840 850 860 870 880 930 940 950 960 970 980 pF1KB3 QPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANG ::::: :: .:: :: :: : :..: ::..: ::. : :: :: : .:: :: :: : CCDS87 PPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPG 890 900 910 920 930 940 990 1000 1010 1020 1030 1040 pF1KB3 LSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPG ::.:::::: : :::.: ::::::.:.::.:: :::::. : ::::::.:. ::::::: CCDS87 ASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPG 950 960 970 980 990 1000 1050 1060 1070 1080 1090 1100 pF1KB3 HPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKG :: :::.::.::.:::::.: :: : ::::.:: :::::::::::.:: : :.:: CCDS87 PPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKG 1010 1020 1030 1040 1050 1060 1110 1120 1130 1140 1150 1160 pF1KB3 HRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRG :::: : : :: :::.:.::: : ::.::::: :: :: ::::..: ::::::::::: CCDS87 HRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRG 1070 1080 1090 1100 1110 1120 1170 1180 1190 1200 1210 1220 pF1KB3 NRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYY--GDEPM :: : : ::.:: :::::: ::: :. .:.::.: .. : : .:. CCDS87 RSGETGPAGPPGNPG---PPGPPGPPGP---GIDMSAFAGLGPREKGPDPLQYMRADQAA 1130 1140 1150 1160 1170 1230 1240 1250 1260 1270 1280 pF1KB3 D-FKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQG .. . :. ..:::.:.::::. ::.::::::::.:::::.:::: :::.::.::::: CCDS87 GGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQG 1180 1190 1200 1210 1220 1230 1290 1300 1310 1320 1330 1340 pF1KB3 CKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPE : :::.::::::::::::. :: :::.:.::...: ::::.::::...:::.::::. . CCDS87 CTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDN 1240 1250 1260 1270 1280 1290 1350 1360 1370 1380 1390 1400 pF1KB3 LPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEG : .. .::..::::::...::::::::::::::.:.:.::.:::: ..:::. :..::: CCDS87 LAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEG 1300 1310 1320 1330 1340 1350 1410 1420 1430 1440 1450 1460 pF1KB3 NSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVC ::.::::.:.::::::::.:.:::.:::..:. ::::.::::.:::::.::::::.:::: CCDS87 NSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVC 1360 1370 1380 1390 1400 1410 pF1KB3 FL :: CCDS87 FL >>CCDS41778.1 COL2A1 gene_id:1280|Hs108|chr12 (1487 aa) initn: 4885 init1: 4885 opt: 6371 Z-score: 2269.9 bits: 432.6 E(32554): 4.1e-120 Smith-Waterman score: 6681; 61.0% identity (74.9% similar) in 1504 aa overlap (1-1466:1-1487) 10 20 30 40 50 pF1KB3 MMSFVQKGSWLLLALLHPTIILAQQEAVE--GGCSHLGQSYADRDVWKPEPCQICVCDSG :. . . .::.:: ... : . :. :.: . :: : :.::::::::.:::::.: CCDS41 MIRLGAPQTLVLLTLLVAAVLRCQGQDVQEAGSCVQDGQRYNDKDVWKPEPCRICVCDTG 10 20 30 40 50 60 60 70 80 90 pF1KB3 SVLCDDIICDDQELDCPNPEIPFGECCAVCP--------QP-P-------------TAPT .::::::::.: . :: .::::::::: .:: :: : ..: CCDS41 TVLCDDIICEDVK-DCLSPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPK 70 80 90 100 110 100 110 120 130 140 pF1KB3 RPPNGQGP---QGPKGD------PGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTG ::. ::: :::.:: : :: ::.:.:: ::.:: :: ::::: : : CCDS41 GPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPG-----PPG 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB3 -PQNYSPQY-DSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGE :.. :. ..: :.: : :. . :: :: :: :::: . :.:: :.:: ::: CCDS41 LGGNFAAQMAGGFDEKAGGAQLGV--MQGPMGPMGPRGPPGPA---GAPGPQGFQGNPGE 180 190 200 210 220 210 220 230 240 250 260 pF1KB3 PGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGH ::. : ::: :: : :: : : :::.:.::. :::: ::: : .: : ::.::.::: CCDS41 PGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGH 230 240 250 260 270 280 270 280 290 300 310 320 pF1KB3 RGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGA ::. : .: :::.::::.:::.: :::::.:::::::: :::::: : :::::::::: CCDS41 RGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQ 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB3 RGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGP : : ::: :: : ::::.::::::.::.:. : .:: : ::::: : : : : CCDS41 PGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGN 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB3 PGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGP :: .: ::.:: : :: ::::. : :::::: ::.: : .: .:::: : ::: :: CCDS41 PGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGP 410 420 430 440 450 460 450 460 470 480 490 500 pF1KB3 RGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGP .:: : :: :.:: ::.:: :. ::::. : : ::::::: :: : .:. : :: CCDS41 KGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGA 470 480 490 500 510 520 510 520 530 540 550 560 pF1KB3 AGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGP :::: : :::.:: :.::: : :: :: ::. : :: : .:: :: :. ::.::::: CCDS41 PGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGP 530 540 550 560 570 580 570 580 590 600 610 620 pF1KB3 PGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGP :::.: :::::::::::::: .: ::: ::.: ::.:: .: :::.:::: :::::.:: CCDS41 PGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGP 590 600 610 620 630 640 630 640 650 660 670 680 pF1KB3 GGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGP .:..:. : :::.:.::::: :::::.::::. : :.::::: : .:. : ::::: CCDS41 AGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGS 650 660 670 680 690 700 690 700 710 720 730 740 pF1KB3 PGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGE :: : : :: : :: .: :::.:: ::::: : :::::::::::. : :::::.:. CCDS41 PGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGD 710 720 730 740 750 760 750 760 770 780 790 800 pF1KB3 PGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGP : : .:.::::: :: ::::::::::: :.::: : :: : :: ::.::::::::: CCDS41 VGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGP 770 780 790 800 810 820 810 820 830 840 850 860 pF1KB3 PGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGS :::::: : :: .:.::.:::.: :.::..: :: :: :. :: :: : : :: ::. CCDS41 PGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGA 830 840 850 860 870 880 870 880 890 900 910 920 pF1KB3 PGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGD : :::.::::: : :::::::::::::: : ::::: : :..: :: : : .: CCDS41 QGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGP 890 900 910 920 930 940 930 940 950 960 970 980 pF1KB3 AGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGA :: ::::: :: .:: :: :: : :..: ::..: ::. : :: :: : .:: :: :: CCDS41 AGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGA 950 960 970 980 990 1000 990 1000 1010 1020 1030 1040 pF1KB3 NGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGA : ::.:::::: : :::.: ::::::.:.::.:: :::::. : ::::::.:. ::::: CCDS41 PGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGA 1010 1020 1030 1040 1050 1060 1050 1060 1070 1080 1090 1100 pF1KB3 PGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGI :: :: :::.::.::.:::::.: :: : ::::.:: :::::::::::.:: : :. CCDS41 PGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGL 1070 1080 1090 1100 1110 1120 1110 1120 1130 1140 1150 1160 pF1KB3 KGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGP :::::: : : :: :::.:.::: : ::.::::: :: :: ::::..: ::::::::: CCDS41 KGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGP 1130 1140 1150 1160 1170 1180 1170 1180 1190 1200 1210 1220 pF1KB3 RGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYY--GDE :: :: : : ::.:: :::::::: : :. .:.::.: .. : : .:. CCDS41 RGRSGETGPAGPPGNPGPPGPPGPPG---P---GIDMSAFAGLGPREKGPDPLQYMRADQ 1190 1200 1210 1220 1230 1240 1230 1240 1250 1260 1270 1280 pF1KB3 PMD-FKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPN .. . :. ..:::.:.::::. ::.::::::::.:::::.:::: :::.::.::: CCDS41 AAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPN 1250 1260 1270 1280 1290 1300 1290 1300 1310 1320 1330 1340 pF1KB3 QGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGN ::: :::.::::::::::::. :: :::.:.::...: ::::.::::...:::.::::. CCDS41 QGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGD 1310 1320 1330 1340 1350 1360 1350 1360 1370 1380 1390 1400 pF1KB3 PELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKA .: .. .::..::::::...::::::::::::::.:.:.::.:::: ..:::. :..: CCDS41 DNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRA 1370 1380 1390 1400 1410 1420 1410 1420 1430 1440 1450 1460 pF1KB3 EGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGP ::::.::::.:.::::::::.:.:::.:::..:. ::::.::::.:::::.::::::.:: CCDS41 EGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGP 1430 1440 1450 1460 1470 1480 pF1KB3 VCFL :::: CCDS41 VCFL >>CCDS33350.1 COL5A2 gene_id:1290|Hs108|chr2 (1499 aa) initn: 9022 init1: 4379 opt: 5609 Z-score: 2001.3 bits: 383.0 E(32554): 3.8e-105 Smith-Waterman score: 5859; 55.0% identity (70.0% similar) in 1501 aa overlap (11-1466:13-1499) 10 20 30 40 50 pF1KB3 MMSFVQKGSWLLLALLHPTI-ILAQQEAVEGG------CSHLGQSYADRDVWKPEPCQ .:..:: . : ::.: . : :.. :: : .::.::: ::: CCDS33 MMANWAEARPLLILIVLLGQFVSIKAQEEDEDEGYGEEIACTQNGQMYLNRDIWKPAPCQ 10 20 30 40 50 60 60 70 80 90 pF1KB3 ICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPP------------------- :::::.:..::: : :.: ::: .: : :::: :: : : CCDS33 ICVCDNGAILCDKIECQDV-LDCADPVTPPGECCPVCSQTPGGGNTNFGRGRKGQKGEPG 70 80 90 100 110 100 110 120 130 pF1KB3 -----------TAPTRPPNGQGPQG---PKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPP .:. ::..:::.: ::: ::: : : .:.::.:::::.:: :: : CCDS33 LVPVVTGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHP 120 130 140 150 160 170 140 150 160 170 180 190 pF1KB3 GICESCPTG-PQNYSPQYDSYDVKSGVAVGGLAG-YPGPAGPPGPPGPPGTSGHPGSPGS . . : : . .: :. . : :::. :. .: .:: .:: :: :: : .:. :. : CCDS33 S--HPGPDGLSRPFSAQMAGLDEKSGL--GSQVGLMPGSVGPVGPRGPQGLQGQQGGAG- 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB3 PGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGI : :::::::. :: :: : : :: : :.::: :: : ::: :. : :: .: : CCDS33 P--TGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGFPGA 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB3 PGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGA ::.::.::::: : .: :::.:::: ::: : : :: ::.:::: :::::: : :: CCDS33 PGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGA 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB3 AGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGH : :: : :. : :: : ::..::::.:: :::.::.:. : .: ::::: :: : CCDS33 PGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGARGPEGPQGQRGETGPPGP 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB3 AGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGK .:. : :: : .:.::.:: : : : :: : : ::: :..: :.:: :.:: CCDS33 VGSPGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAGPPGSPGPQGSTGPQGIRGQPGDPGV 420 430 440 450 460 470 440 450 460 470 480 490 pF1KB3 NGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGP : ::: ::.:: : :: : : ::.:: : :.::. : :: .::::::: :: : CCDS33 PGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGNRGFPGS 480 490 500 510 520 530 500 510 520 530 540 550 pF1KB3 NGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGS .:.:: :: :::: : .::.:. :.::: : :: :: ::. :.:: : .:: :: :. CCDS33 DGLPGPKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGA 540 550 560 570 580 590 560 570 580 590 600 610 pF1KB3 QGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGP ::.::::::: : ::::: ::.:::::..: ::: :: :. : :: .: :::.::.:: CCDS33 PGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGP 600 610 620 630 640 650 620 630 640 650 660 670 pF1KB3 QGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGD .:: :: : .:..:. ::::: :.::::: :::::.::::. : :: :: : : .:. CCDS33 SGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGDPGAVGPLGPRGE 660 670 680 690 700 710 680 690 700 710 720 730 pF1KB3 AGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGS : ::::: ::..: :: .: :: ::.: ::. :: : :: .: ::::::::::: :. CCDS33 RGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGERGIAGT 720 730 740 750 760 770 740 750 760 770 780 790 pF1KB3 PGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGS ::::::.: : ::.:. :.:: :: ::.::::::: :.::: : :: : : ::. CCDS33 PGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGN 780 790 800 810 820 830 800 810 820 830 840 850 pF1KB3 PGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGP :: :::.:: : .:: : : .:.:: ::: : ::.::..: :: : :. :: :: : CCDS33 PGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGV 840 850 860 870 880 890 860 870 880 890 900 910 pF1KB3 QGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGS :.:: ::. : :::.::::. : :::: : ::: :: : :::.:::: :. :. : CCDS33 PGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGR 900 910 920 930 940 950 920 930 940 950 960 970 pF1KB3 PGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGV : :: : : ::.::.:: .: :: :: : :: :: ::..: ::. : :: :: : CCDS33 VGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGP 960 970 980 990 1000 1010 980 990 1000 1010 1020 1030 pF1KB3 KGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGE : :: : .: .:..::::: : :: : .:::: .: :.:: :::::. : .::::. CCDS33 AGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGD 1020 1030 1040 1050 1060 1070 1040 1050 1060 1070 1080 1090 pF1KB3 NGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGE : : ::. : :: ::::: : .:.::. : :: : :: ::.:: :::::::::::. CCDS33 PGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGD 1080 1090 1100 1110 1120 1130 1100 1110 1120 1130 1140 1150 pF1KB3 TGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGH :.:: : :::::: : : :: ::: :.::. : ::: ::::: :: :: ::.:. : CCDS33 HGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGP 1140 1150 1160 1170 1180 1190 1160 1170 1180 1190 1200 1210 pF1KB3 PGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGF ::::::: ::. :: : :: : ::.:::::::: :: ...: : : :. CCDS33 LGPIGPPGVRGSVGEAGPEG-P--PGEPGPPGPPGPPGHLTAALGD--IMGHYDESMPDP 1200 1210 1220 1230 1240 1220 1230 1240 1250 1260 1270 pF1KB3 APYYGDEPM--DFKINTDE-IMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELK : . .. : : .:: . ..:::...:::.. :::::.:.:::.: :::.:: . CCDS33 LPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHSAKQ 1250 1260 1270 1280 1290 1300 1280 1290 1300 1310 1320 1330 pF1KB3 SGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMD :::::.::::: :::::.:::::::::::::: .:::: ::...: ..: ::.: .:. CCDS33 SGEYWIDPNQGSVEDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDMN 1310 1320 1330 1340 1350 1360 1340 1350 1360 1370 1380 1390 pF1KB3 GGFQFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLM : ::.::. . :. .. .:..::::::..::::::: ::::..:::. . :.:::. : CCDS33 RGSQFAYGDHQSPNTAI-TQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVLK 1370 1380 1390 1400 1410 1420 1400 1410 1420 1430 1440 1450 pF1KB3 GSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPD :.:. ..::::: .: : ::.: :.:..:. .::::::::....::::.:.:: :.:: : CCDS33 GANDLDIKAEGNIRFRYIVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDLAPVDVGGTD 1430 1440 1450 1460 1470 1480 1460 pF1KB3 QEFGVDVGPVCFL :::::..:::::. CCDS33 QEFGVEIGPVCFV 1490 >>CCDS34682.1 COL1A2 gene_id:1278|Hs108|chr7 (1366 aa) initn: 7063 init1: 4225 opt: 4355 Z-score: 1559.7 bits: 301.1 E(32554): 1.5e-80 Smith-Waterman score: 5494; 56.5% identity (70.0% similar) in 1388 aa overlap (84-1465:18-1365) 60 70 80 90 100 110 pF1KB3 VCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGP : :.: : : . : .::.:. :: CCDS34 MLSFVDTRTLLLLAVTLCLATC-QSLQEETVRKGPAGDRGPRGERGP 10 20 30 40 120 130 140 150 160 170 pF1KB3 PGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYP :: :::.:. : : :: :: :::::. : :.. :::. .::..: : CCDS34 PGPPGRDGEDGPTGPPGPPGPPGPPGL------GG-NFAAQYDG----KGVGLG-----P 50 60 70 80 90 180 190 200 210 220 230 pF1KB3 GPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGES :: : :: ::::.. :.:: :.::: ::::. : .:: : : :: : ::.::. CCDS34 GPMGLMGPRGPPGAA---GAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHP 100 110 120 130 140 240 250 260 270 280 290 pF1KB3 GRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGEN :.::::::::. :: : .: : ::.::.:: :: .: .: ::. ::::.::: : :::: CCDS34 GKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGEN 150 160 170 180 190 200 300 310 320 330 340 350 pF1KB3 GAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEV :.:: : :: :::::: : :: :::::.::. : : :: : : ::::.:: :::. CCDS34 GTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEI 210 220 230 240 250 260 360 370 380 390 400 410 pF1KB3 GPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGAR : .:. : : : ::: : : .: :::: :: :: :.:: : :. ::::: : : CCDS34 GAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPR 270 280 290 300 310 320 420 430 440 450 460 470 pF1KB3 GPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEP : :::.:: :: : :: .:::: :.::: : .:: : :: : :: .::.:: : :: CCDS34 GIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEA 330 340 350 360 370 380 480 490 500 510 520 530 pF1KB3 GANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGP :. : :: : ::.:: :: : .: : :: : ::: :::: :: :. :: : :: CCDS34 GSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLM 390 400 410 420 430 440 540 550 560 570 580 590 pF1KB3 GMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKN : ::.:::::. : :: :: : : .::::: ::.: ::.:: .::::::: : :::: CCDS34 GPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKN 450 460 470 480 490 500 600 610 620 630 640 650 pF1KB3 GERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGEN :..: : : .: :: .:..: :::::: : : ::. ::::: :.::::: .:: :: CCDS34 GDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEV 510 520 530 540 550 560 660 670 680 690 700 710 pF1KB3 GKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPP ::::: : .:. : :: : .:. : ::: : : .: : :: .:::::.:.:: : CCDS34 GKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVV 570 580 590 600 610 620 720 730 740 750 760 770 pF1KB3 GPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPA : :.:: : .:.:::::. : :: ::.::::: : : ::.:: :: : .: :::: CCDS34 GAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPA 630 640 650 660 670 680 780 790 800 810 820 830 pF1KB3 GQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEK : ::.::.:: : : ::::::::::::.:: :: :: : : :.::.:::::: : : CCDS34 GATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPK 690 700 710 720 730 740 840 850 860 870 880 890 pF1KB3 GEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNG---NP ::.: : .:: :..::::: :: : : ::. : :: .::::: : :::: .: : CCDS34 GENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPP 750 760 770 780 790 800 900 910 920 930 940 950 pF1KB3 GPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIA :::::.:. : :: : : .: : :. :: : ::. : .: :. ::::.::: CCDS34 GPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGP---Q 810 820 830 840 850 860 960 970 980 990 1000 1010 pF1KB3 GITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEP :. :: :. : :: : :: :: :. :: : : : : ::::: : ::. :. :: CCDS34 GLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEA 870 880 890 900 910 920 1020 1030 1040 1050 1060 1070 pF1KB3 GRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPA :::::::.:: :::::.:: ::.:: :. : :: : ::: :::::::: :.:::.::. CCDS34 GRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPS 930 940 950 960 970 980 1080 1090 1100 1110 1120 1130 pF1KB3 GPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAI ::.: : .: :: :::: :::::: ::.: :. : .: : : :: : :.::: CCDS34 GPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAP 990 1000 1010 1020 1030 1040 1140 1150 1160 1170 1180 1190 pF1KB3 GSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPP :: ::::::::.::::: :::: .:::: .:: : :: .:..: : : :: ::::::: CCDS34 GSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAG-P--PGPPGPPGPP 1050 1060 1070 1080 1090 1100 1200 1210 1220 1230 1240 pF1KB3 GAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMD---FKINTDEIMTSLKSVNGQIES :. : :: .: . : : : .:.: . .. . :. ..:::.:.:::. CCDS34 GVSG---GGYD------FGYD--GDF--YRADQPRSAPSLRPKDYEVDATLKSLNNQIET 1110 1120 1130 1140 1250 1260 1270 1280 1290 1300 pF1KB3 LISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANP :..:.::::::::.::::.. ::: .:: ::.:::::: .:::::.:.. :::::: :.: CCDS34 LLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQP 1150 1160 1170 1180 1190 1200 1310 1320 1330 1340 1350 1360 pF1KB3 LNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVQLAFLRLLSSRASQN :.: :.:. :: .:::::.::....: :: :. . . .::::.:::.. :::: CCDS34 ENIPAKNWYR-SSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQN 1210 1220 1230 1240 1250 1260 1370 1380 1390 1400 1410 1420 pF1KB3 ITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKT :::::::::::::. .::.:::. :.:::. :. :::::.:::::: :::.:.:.::.:: CCDS34 ITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKT 1270 1280 1290 1300 1310 1320 1430 1440 1450 1460 pF1KB3 VFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL ..::.: : :::..:::: :::: :::: ::.::::: CCDS34 IIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK 1330 1340 1350 1360 >>CCDS75932.1 COL5A1 gene_id:1289|Hs108|chr9 (1838 aa) initn: 3273 init1: 3273 opt: 4186 Z-score: 1499.0 bits: 290.3 E(32554): 3.6e-77 Smith-Waterman score: 4249; 46.2% identity (59.8% similar) in 1435 aa overlap (98-1466:470-1837) 70 80 90 100 110 pF1KB3 DDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGI---------PG :: ::.:: : ::::: :: CCDS75 TIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPP---GPEGPAGLPGPPGTMGPTGQVGDPG 440 450 460 470 480 490 120 130 140 150 160 170 pF1KB3 RNGDPGIPGQPGSPGSPGPPGICESCPT---GPQNYSPQYDSYDVKSGVAVGGLAGYPGP . : :: :: ::. : ::::: : : . . . ... . : . : . CCDS75 ERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAIL--QQAR 500 510 520 530 540 550 180 190 200 210 220 230 pF1KB3 AGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGR . :: :: : .:.:: : :: : ::::..::.:: :. :: ::::: :. :: CCDS75 LALRGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPR---GVQGPPGPAGKPGRRGR 560 570 580 590 600 610 240 250 260 270 280 290 pF1KB3 PGRPGERGLPG---PPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGE : : ::.:: : : .: :. :.:: ::::: . : .: :: :.. :: CCDS75 AGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRG------DPGPSGPPGPPGDD---GE 620 630 640 650 660 300 310 320 330 340 350 pF1KB3 NGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGE : : .:::: ::: :: : : .: ::::::::..:. :.:: ::. CCDS75 RGDDGEVGPRGLPGE---PGPRGLLGPKG---------PPGPPGPPGVTGMDGQPGPKGN 670 680 690 700 710 360 370 380 390 400 410 pF1KB3 VGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGA ::: : :: :::.:.:: :: : :: :::: : :: : :: ::. :: CCDS75 VGPQGEPGP---PGQQGNPGAQGLPGPQGAIGPPG---------EKGPLGKPGLPGMPGA 720 730 740 750 420 430 440 450 460 470 pF1KB3 RGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGE :::: : .: :: .:: : :: .: : ::::: .: :: :. :.::: :.:: :: CCDS75 DGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGF 760 770 780 790 800 810 480 490 500 510 520 530 pF1KB3 PGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPG- : :. : :: : :: :: ::.: :. :: :. : :: : .: : :: : :: CCDS75 KGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGR 820 830 840 850 860 870 540 550 560 570 580 pF1KB3 -GP-GMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGN--- :: : :.:: ::. : : : ::. : :. :: :: : :: :. : :::::: CCDS75 QGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGG 880 890 900 910 920 930 590 600 610 620 630 640 pF1KB3 DGAPGKNGERG--GPGGP----GPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGL :: : :::: :: :: ::.:::: :. : : :: : : .: :::::: :. CCDS75 DGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGV 940 950 960 970 980 990 650 660 670 680 690 pF1KB3 ---QGLPGTGGPPGENGKPGEPGPKGDAGAPG---APGGKGD---AGAPGERGPPGLAGA :: : :: :: :.:: ::: :. : :: : ::: :: ::. ::::: : CCDS75 VGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGF 1000 1010 1020 1030 1040 1050 700 710 720 730 740 pF1KB3 PGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQG---------MPGERGGLGSPGPKGD :: :: :: : : :: ::::::: ::.:: .: .::. : : ::: :. CCDS75 PGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGE 1060 1070 1080 1090 1100 1110 750 760 770 780 790 pF1KB3 KGEPGGPGADGVPGKDGPRGPTG---PIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGE :: :: : .: :.:: .::.: : :: :: :. ::::: : :: : : .: : CCDS75 KGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGP 1120 1130 1140 1150 1160 1170 800 810 820 830 840 850 pF1KB3 RGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGV : ::: :: : :: : .:::: .:..: :.::. :: : :::: : : ::: : CCDS75 PGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGE 1180 1190 1200 1210 1220 1230 860 870 880 890 900 910 pF1KB3 KGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGV ::: :. : : : :: :: : ::..: :::: :.:: : : :..: :: :: CCDS75 KGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGE 1240 1250 1260 1270 1280 1290 920 930 940 950 960 970 pF1KB3 SGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGE .:: : :. :::: : .: : ::: :::: ::.::::: : :. CCDS75 GGPPGPKGERGEKGESGPSGAAGPPGP------------KGPPGDDGPKGSPGPVGFPGD 1300 1310 1320 1330 1340 980 990 1000 1010 1020 1030 pF1KB3 SGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGS : :: : .:. :::: .: : : .: :: :.:: .: ::. : :: : .:..: CCDS75 PGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGE 1350 1360 1370 1380 1390 1400 1040 1050 1060 1070 1080 1090 pF1KB3 PGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPG------PQGPRGD :: : : :::: .:: : .: :. :: : : :::.: .: :: : :: : CCDS75 KGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGP 1410 1420 1430 1440 1450 1460 1100 1110 1120 1130 1140 pF1KB3 KGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGP------VGPSGP : : .: .: ::..: :: : : :: :..: : ::: : :: .::::: CCDS75 PGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGP 1470 1480 1490 1500 1510 1520 1150 1160 1170 1180 1190 1200 pF1KB3 PGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGA---PGPCCGGVGAAA : : : ::: :: : .:. : : .: :::: :::::::: : : .. CCDS75 IGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRN 1530 1540 1550 1560 1570 1580 1210 1220 1230 1240 1250 1260 pF1KB3 IAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRD : . :. :.. .:. . .::. ::.:.. .::.. : :...::::.:.: CCDS75 IDASQLLDDGN-----GENYVDYADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKD 1590 1600 1610 1620 1630 1640 1270 1280 1290 1300 1310 1320 pF1KB3 LKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETG-ETCISANPLNVPRK--HWWTDSSA :..:::.. .:::::::::::. :..::.::. .: ::. . . : .: CCDS75 LQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVFPDKKSEGSKMARW----PK 1650 1660 1670 1680 1690 1330 1340 1350 1360 1370 1380 pF1KB3 EKKHVWFGESMDGGFQFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQ :. .:... :.. .:: . : . : ::..::::::. : ::.:::: .:.:..: CCDS75 EQPSTWYSQYKRGSL-LSYVDAE-GNPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQDA 1700 1710 1720 1730 1740 1750 1390 1400 1410 1420 1430 1440 pF1KB3 ASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPI :.:. :::...:::. :.. ..: . : :::. . : ..:::.: : :. ..:: CCDS75 ATGSYDKALRFLGSNDEEMSYDNNPYIRALV--DGCATKKG-YQKTVLEIDTPKVEQVPI 1760 1770 1780 1790 1800 1810 1450 1460 pF1KB3 VDIAPYDIGGPDQEFGVDVGPVCFL ::: :.: .:.:: .:::.::. CCDS75 VDIMFNDFGEASQKFGFEVGPACFMG 1820 1830 >>CCDS6982.1 COL5A1 gene_id:1289|Hs108|chr9 (1838 aa) initn: 3273 init1: 3273 opt: 4184 Z-score: 1498.3 bits: 290.2 E(32554): 3.9e-77 Smith-Waterman score: 4247; 46.4% identity (59.7% similar) in 1433 aa overlap (98-1466:470-1837) 70 80 90 100 110 pF1KB3 DDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGI---------PG :: ::.:: : ::::: :: CCDS69 TIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPP---GPEGPAGLPGPPGTMGPTGQVGDPG 440 450 460 470 480 490 120 130 140 150 160 170 pF1KB3 RNGDPGIPGQPGSPGSPGPPGICESCPT---GPQNYSPQYDSYDVKSGVAVGGLAGYPGP . : :: :: ::. : ::::: : : . . . ... . : . : . CCDS69 ERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAIL--QQAR 500 510 520 530 540 550 180 190 200 210 220 230 pF1KB3 AGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGR . :: :: : .:.:: : :: : ::::..::.:: :. :: ::::: :. :: CCDS69 LALRGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPR---GVQGPPGPAGKPGRRGR 560 570 580 590 600 610 240 250 260 270 280 290 pF1KB3 PGRPGERGLPG---PPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGE : : ::.:: : : .: :. :.:: ::::: . : .: :: :.. :: CCDS69 AGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRG------DPGPSGPPGPPGDD---GE 620 630 640 650 660 300 310 320 330 340 350 pF1KB3 NGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGE : : .:::: ::: :: : : .: ::::::::..:. :.:: ::. CCDS69 RGDDGEVGPRGLPGE---PGPRGLLGPKG---------PPGPPGPPGVTGMDGQPGPKGN 670 680 690 700 710 360 370 380 390 400 410 pF1KB3 VGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGA ::: : :: :::.:.:: :: : :: :::: : :: : :: ::. :: CCDS69 VGPQGEPGP---PGQQGNPGAQGLPGPQGAIGPPG---------EKGPLGKPGLPGMPGA 720 730 740 750 420 430 440 450 460 470 pF1KB3 RGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGE :::: : .: :: .:: : :: .: : ::::: .: :: :. :.::: :.:: :: CCDS69 DGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGF 760 770 780 790 800 810 480 490 500 510 520 530 pF1KB3 PGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPG- : :. : :: : :: :: ::.: :. :: :. : :: : .: : :: : :: CCDS69 KGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGR 820 830 840 850 860 870 540 550 560 570 580 pF1KB3 -GP-GMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGN--- :: : :.:: ::. : : : ::. : :. :: :: : :: :. : :::::: CCDS69 QGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGG 880 890 900 910 920 930 590 600 610 620 630 640 pF1KB3 DGAPGKNGERG--GPGGP----GPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGL :: : :::: :: :: ::.:::: :. : : :: : : .: :::::: :. CCDS69 DGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGV 940 950 960 970 980 990 650 660 670 680 690 pF1KB3 ---QGLPGTGGPPGENGKPGEPGPKGDAGAPG---APGGKGD---AGAPGERGPPGLAGA :: : :: :: :.:: ::: :. : :: : ::: :: ::. ::::: : CCDS69 VGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGF 1000 1010 1020 1030 1040 1050 700 710 720 730 740 pF1KB3 PGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQG---------MPGERGGLGSPGPKGD :: :: :: : : :: ::::::: ::.:: .: .::. : : ::: :. CCDS69 PGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGE 1060 1070 1080 1090 1100 1110 750 760 770 780 790 pF1KB3 KGEPGGPGADGVPGKDGPRGPTG---PIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGE :: :: : .: :.:: .::.: : :: :: :. ::::: : :: : : .: : CCDS69 KGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGP 1120 1130 1140 1150 1160 1170 800 810 820 830 840 850 pF1KB3 RGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGV : ::: :: : :: : .:::: .:..: :.::. :: : :::: : : ::: : CCDS69 PGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGE 1180 1190 1200 1210 1220 1230 860 870 880 890 900 910 pF1KB3 KGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGV ::: :. : : : :: :: : ::..: :::: :.:: : : :..: :: :: CCDS69 KGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGE 1240 1250 1260 1270 1280 1290 920 930 940 950 960 970 pF1KB3 SGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGE .:: : :. :::: : .: : ::: :::: ::.::::: : :. CCDS69 GGPPGPKGERGEKGESGPSGAAGPPGP------------KGPPGDDGPKGSPGPVGFPGD 1300 1310 1320 1330 1340 980 990 1000 1010 1020 1030 pF1KB3 SGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGS : :: : .:. :::: .: : : .: :: :.:: .: ::. : :: : .:..: CCDS69 PGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGE 1350 1360 1370 1380 1390 1400 1040 1050 1060 1070 1080 1090 pF1KB3 PGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPG------PQGPRGD :: : : :::: .:: : .: :. :: : : :::.: .: :: : :: : CCDS69 KGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGP 1410 1420 1430 1440 1450 1460 1100 1110 1120 1130 1140 pF1KB3 KGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGP------VGPSGP : : .: .: ::..: :: : : :: :..: : ::: : :: .::::: CCDS69 PGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGP 1470 1480 1490 1500 1510 1520 1150 1160 1170 1180 1190 1200 pF1KB3 PGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGA---PGPCCGGVGAAA : : : ::: :: : .:. : : .: :::: :::::::: : : .. CCDS69 IGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRN 1530 1540 1550 1560 1570 1580 1210 1220 1230 1240 1250 1260 pF1KB3 IAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRD : . :. :.. .:. . .::. ::.:.. .::.. : :...::::.:.: CCDS69 IDASQLLDDGN-----GENYVDYADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKD 1590 1600 1610 1620 1630 1640 1270 1280 1290 1300 1310 1320 pF1KB3 LKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETG-ETCISANPLNVPRKHWWTDSSAEK :..:::.. .:::::::::::. :..::.::. .: ::. : . . :. :. CCDS69 LQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVF--PDKKSEGARITSWPKEN 1650 1660 1670 1680 1690 1330 1340 1350 1360 1370 1380 pF1KB3 KHVWFGESMDGGFQFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQAS ::.: : . .:: . : . : ::..::::::. : ::.:::: .:.:..: :. CCDS69 PGSWFSEFKRGKL-LSYVDAE-GNPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQDAAT 1700 1710 1720 1730 1740 1750 1390 1400 1410 1420 1430 1440 pF1KB3 GNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVD :. :::...:::. :.. ..: . : :::. . : ..:::.: : :. ..:::: CCDS69 GSYDKALRFLGSNDEEMSYDNNPYIRALV--DGCATKKG-YQKTVLEIDTPKVEQVPIVD 1760 1770 1780 1790 1800 1810 1450 1460 pF1KB3 IAPYDIGGPDQEFGVDVGPVCFL : :.: .:.:: .:::.::. CCDS69 IMFNDFGEASQKFGFEVGPACFMG 1820 1830 >>CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690 aa) initn: 3181 init1: 3181 opt: 4110 Z-score: 1472.5 bits: 285.3 E(32554): 1.1e-75 Smith-Waterman score: 4269; 46.5% identity (61.5% similar) in 1420 aa overlap (82-1466:313-1689) 60 70 80 90 100 pF1KB3 ICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCP----QPPTAPTRPPNGQGPQGP :: .: : . : .:. : . .:: : CCDS78 SVTEGPTVTEETIAQTEINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGL 290 300 310 320 330 340 110 120 130 140 150 160 pF1KB3 KGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPT---GPQNYSPQYDSYDVKSGV .: :::: :: : :: :: ::. : ::::: : : . .: .. .... . CCDS78 QGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQA 350 360 370 380 390 400 170 180 190 200 210 220 pF1KB3 AVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPS . . . ::::: : .:.:: :.:: .: :: :. : :: :: :. :: CCDS78 IL-----QQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGD--P-GPQGPRGVQGPP 410 420 430 440 450 230 240 250 260 270 280 pF1KB3 GPAGKDGESGRPGRPGERGLPGPPGIKGPAG---IPGFPGMKGHRGFDGRNGEKGETGAP ::.:: :. :::: : ::.:: :: :: : .::.:: ::::: : .: : : CCDS78 GPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDD 460 470 480 490 500 510 290 300 310 320 330 340 pF1KB3 GLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTA :..::.: : : :: :::: : :: :: :: : : :: : :. :: : :: CCDS78 GMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPP 520 530 540 550 560 570 350 360 370 380 390 400 pF1KB3 GFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPA : :.:: .: :: : : : : .:.:: : ::.:::: :: .:. : :: .:: CCDS78 GQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGP- 580 590 600 610 620 630 410 420 430 440 450 460 pF1KB3 GIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAK :: : .: :: : ::.:. ::.:. :: :..: : : : .:. : : : . CCDS78 --PGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPR 640 650 660 670 680 690 470 480 490 500 510 520 pF1KB3 GEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAA :::: .: :. : .: :: .:. : : : : : ::..:: : : :: : :: CCDS78 GEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPG--FP-GAN 700 710 720 730 740 530 540 550 560 570 pF1KB3 GEPGRDGVPGGPGMRGMPGSPGGP-------GSDGKPGPPGSQGESGRPGPPGPSGPRGQ :: : :: : :: ::. : : :: : ::::: :..: .: ::::: ::.: CCDS78 GEKGARGVAGKPGPRGQRG-PTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGP 750 760 770 780 790 800 580 590 600 610 620 pF1KB3 PGVMGFPGPKGNDGAPGKNG------ERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGD : .::::::: : :::.: .:: : : :::: .: .::::: : ::: :. CCDS78 QGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGE 810 820 830 840 850 860 630 640 650 660 670 680 pF1KB3 KGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGL .: ::::: : :::::..: ..: :.:::.: .: : : .: ::::: :: CCDS78 RGHPGPPGPPGEQGLPGAAG---KEGAKGDPGPQGISGKDGPAGLRG---FPGERGLPGA 870 880 890 900 910 920 690 700 710 720 730 740 pF1KB3 AGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGG :::::.:: :: :: : .: :: :.::: : :.::. : : ::: :.:: :: CCDS78 QGAPGLKGGEGPQGPP---GPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE 930 940 950 960 970 750 760 770 780 790 800 pF1KB3 PGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPG- : .: :.:: .::.: :: ::::.::. :. : : :: : .:. :: : :::: CCDS78 KGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGL 980 990 1000 1010 1020 1030 810 820 830 840 850 860 pF1KB3 --PAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGS :.: :: : .:::: .:..: :.::. : : :::: : : ::: : ::: :. CCDS78 QGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGD 1040 1050 1060 1070 1080 1090 870 880 890 900 910 920 pF1KB3 PGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG---KDGPPGPAGNTGAPGSPGVSGP : : : :: :: :: :..: :::: :: : . : :: ::: : :: ::.:: CCDS78 VGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGP 1100 1110 1120 1130 1140 1150 930 940 950 960 970 980 pF1KB3 KGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGK ::. :. :: : ::: ::::: :: : : : : .: :: ::: : ::: : : .: CCDS78 KGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGD 1160 1170 1180 1190 1200 1210 990 1000 1010 1020 1030 1040 pF1KB3 PGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGA : .: :. :::::.: :: : ::. : ::. : ::.: :: .:: :. : CCDS78 KGEDGDPGQPGPPGPSGE---AGPPGPPGKRGPPGAAGAEGRQGE---KGAKGEAGAEGP 1220 1230 1240 1250 1260 1270 1050 1060 1070 1080 1090 1100 pF1KB3 PGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGA :: : :: ::.: : : :: ::.: : :: ::. : :::.:: : : :. :. CCDS78 PGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGS 1280 1290 1300 1310 1320 1330 1110 1120 1130 1140 1150 1160 pF1KB3 AGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGP : ::: :: : : :: :..: : :: : : : .: :: : : ::: : CCDS78 KGEKGH---PGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGL 1340 1350 1360 1370 1380 1170 1180 1190 1200 1210 pF1KB3 PGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAG----GFAP :::.: .:..:: : :. :. : :::::.::: : . ....:. :. CCDS78 PGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGP--PGEVIQPLPILSSKKTRRHTEGMQA 1390 1400 1410 1420 1430 1440 1220 1230 1240 1250 1260 1270 pF1KB3 YYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYW :. .:.. . .::. ::.:.. .:: . : :.. ::::.:.::.. ::.. .:::: CCDS78 DADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYW 1450 1460 1470 1480 1490 1500 1280 1290 1300 1310 1320 1330 pF1KB3 VDPNQGCKLDAIKVFCNMETG-ETCISANPLNVP-RKHWWTDSSAEKKHVWFGESMDGGF .::::::. :..::.::. .: :::: . . : : :: ::.: : . CCDS78 IDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPK---EKPGSWFSEFKRGKL 1510 1520 1530 1540 1550 1560 1340 1350 1360 1370 1380 1390 pF1KB3 QFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSN .:: . : ... ::..::.::.. : ::.::::..: :..: .::. :::...::: CCDS78 -LSYLDVE-GNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSN 1570 1580 1590 1600 1610 1620 1400 1410 1420 1430 1440 1450 pF1KB3 EGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEF . :.. . :. : : : :::... : . :::.: : : ..::::. :.: .:.: CCDS78 DEEMSYD-NNPFIKT-LYDGCASRKG-YEKTVIEINTPKIDQVPIVDVMINDFGDQNQKF 1630 1640 1650 1660 1670 1460 pF1KB3 GVDVGPVCFL : .::::::: CCDS78 GFEVGPVCFLG 1680 1690 >>CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767 aa) initn: 3181 init1: 3181 opt: 4110 Z-score: 1472.4 bits: 285.3 E(32554): 1.1e-75 Smith-Waterman score: 4269; 46.5% identity (61.5% similar) in 1420 aa overlap (82-1466:390-1766) 60 70 80 90 100 pF1KB3 ICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCP----QPPTAPTRPPNGQGPQGP :: .: : . : .:. : . .:: : CCDS53 EEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGL 360 370 380 390 400 410 110 120 130 140 150 160 pF1KB3 KGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPT---GPQNYSPQYDSYDVKSGV .: :::: :: : :: :: ::. : ::::: : : . .: .. .... . CCDS53 QGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQA 420 430 440 450 460 470 170 180 190 200 210 220 pF1KB3 AVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPS . . . ::::: : .:.:: :.:: .: :: :. : :: :: :. :: CCDS53 IL-----QQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGD--P-GPQGPRGVQGPP 480 490 500 510 520 530 230 240 250 260 270 280 pF1KB3 GPAGKDGESGRPGRPGERGLPGPPGIKGPAG---IPGFPGMKGHRGFDGRNGEKGETGAP ::.:: :. :::: : ::.:: :: :: : .::.:: ::::: : .: : : CCDS53 GPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDD 540 550 560 570 580 590 290 300 310 320 330 340 pF1KB3 GLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTA :..::.: : : :: :::: : :: :: :: : : :: : :. :: : :: CCDS53 GMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPP 600 610 620 630 640 650 350 360 370 380 390 400 pF1KB3 GFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPA : :.:: .: :: : : : : .:.:: : ::.:::: :: .:. : :: .:: CCDS53 GQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGP- 660 670 680 690 700 710 410 420 430 440 450 460 pF1KB3 GIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAK :: : .: :: : ::.:. ::.:. :: :..: : : : .:. : : : . CCDS53 --PGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPR 720 730 740 750 760 470 480 490 500 510 520 pF1KB3 GEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAA :::: .: :. : .: :: .:. : : : : : ::..:: : : :: : :: CCDS53 GEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPG--FP-GAN 770 780 790 800 810 820 530 540 550 560 570 pF1KB3 GEPGRDGVPGGPGMRGMPGSPGGP-------GSDGKPGPPGSQGESGRPGPPGPSGPRGQ :: : :: : :: ::. : : :: : ::::: :..: .: ::::: ::.: CCDS53 GEKGARGVAGKPGPRGQRG-PTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGP 830 840 850 860 870 880 580 590 600 610 620 pF1KB3 PGVMGFPGPKGNDGAPGKNG------ERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGD : .::::::: : :::.: .:: : : :::: .: .::::: : ::: :. CCDS53 QGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGE 890 900 910 920 930 940 630 640 650 660 670 680 pF1KB3 KGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGL .: ::::: : :::::..: ..: :.:::.: .: : : .: ::::: :: CCDS53 RGHPGPPGPPGEQGLPGAAG---KEGAKGDPGPQGISGKDGPAGLRG---FPGERGLPGA 950 960 970 980 990 690 700 710 720 730 740 pF1KB3 AGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGG :::::.:: :: :: : .: :: :.::: : :.::. : : ::: :.:: :: CCDS53 QGAPGLKGGEGPQGPP---GPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE 1000 1010 1020 1030 1040 1050 750 760 770 780 790 800 pF1KB3 PGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPG- : .: :.:: .::.: :: ::::.::. :. : : :: : .:. :: : :::: CCDS53 KGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGL 1060 1070 1080 1090 1100 1110 810 820 830 840 850 860 pF1KB3 --PAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGS :.: :: : .:::: .:..: :.::. : : :::: : : ::: : ::: :. CCDS53 QGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGD 1120 1130 1140 1150 1160 1170 870 880 890 900 910 920 pF1KB3 PGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG---KDGPPGPAGNTGAPGSPGVSGP : : : :: :: :: :..: :::: :: : . : :: ::: : :: ::.:: CCDS53 VGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGP 1180 1190 1200 1210 1220 1230 930 940 950 960 970 980 pF1KB3 KGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGK ::. :. :: : ::: ::::: :: : : : : .: :: ::: : ::: : : .: CCDS53 KGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGD 1240 1250 1260 1270 1280 1290 990 1000 1010 1020 1030 1040 pF1KB3 PGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGA : .: :. :::::.: :: : ::. : ::. : ::.: :: .:: :. : CCDS53 KGEDGDPGQPGPPGPSGE---AGPPGPPGKRGPPGAAGAEGRQGE---KGAKGEAGAEGP 1300 1310 1320 1330 1340 1050 1060 1070 1080 1090 1100 pF1KB3 PGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGA :: : :: ::.: : : :: ::.: : :: ::. : :::.:: : : :. :. CCDS53 PGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGS 1350 1360 1370 1380 1390 1400 1110 1120 1130 1140 1150 1160 pF1KB3 AGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGP : ::: :: : : :: :..: : :: : : : .: :: : : ::: : CCDS53 KGEKGH---PGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGL 1410 1420 1430 1440 1450 1460 1170 1180 1190 1200 1210 pF1KB3 PGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAG----GFAP :::.: .:..:: : :. :. : :::::.::: : . ....:. :. CCDS53 PGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGP--PGEVIQPLPILSSKKTRRHTEGMQA 1470 1480 1490 1500 1510 1520 1220 1230 1240 1250 1260 1270 pF1KB3 YYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYW :. .:.. . .::. ::.:.. .:: . : :.. ::::.:.::.. ::.. .:::: CCDS53 DADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYW 1530 1540 1550 1560 1570 1580 1280 1290 1300 1310 1320 1330 pF1KB3 VDPNQGCKLDAIKVFCNMETG-ETCISANPLNVP-RKHWWTDSSAEKKHVWFGESMDGGF .::::::. :..::.::. .: :::: . . : : :: ::.: : . CCDS53 IDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPK---EKPGSWFSEFKRGKL 1590 1600 1610 1620 1630 1640 1340 1350 1360 1370 1380 1390 pF1KB3 QFSYGNPELPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSN .:: . : ... ::..::.::.. : ::.::::..: :..: .::. :::...::: CCDS53 -LSYLDVE-GNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSN 1650 1660 1670 1680 1690 1400 1410 1420 1430 1440 1450 pF1KB3 EGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEF . :.. . :. : : : :::... : . :::.: : : ..::::. :.: .:.: CCDS53 DEEMSYD-NNPFIKT-LYDGCASRKG-YEKTVIEINTPKIDQVPIVDVMINDFGDQNQKF 1700 1710 1720 1730 1740 1750 1460 pF1KB3 GVDVGPVCFL : .::::::: CCDS53 GFEVGPVCFLG 1760 1466 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 22:50:38 2016 done: Wed Nov 2 22:50:39 2016 Total Scan time: 6.440 Total Display time: 0.850 Function used was FASTA [36.3.4 Apr, 2011]