FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3969, 192 aa 1>>>pF1KB3969 192 - 192 aa - 192 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0783+/-0.000408; mu= 15.3644+/- 0.026 mean_var=90.4589+/-18.739, 0's: 0 Z-trim(114.6): 284 B-trim: 1536 in 2/53 Lambda= 0.134849 statistics sampled from 24198 (24598) to 24198 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.288), width: 16 Scan time: 5.590 The best scores are: opt bits E(85289) NP_065078 (OMIM: 604496) NF-kappa-B inhibitor-inte ( 192) 1244 251.6 5.6e-67 XP_005265133 (OMIM: 604496) PREDICTED: NF-kappa-B ( 192) 1244 251.6 5.6e-67 XP_005265135 (OMIM: 604496) PREDICTED: NF-kappa-B ( 192) 1244 251.6 5.6e-67 XP_005265134 (OMIM: 604496) PREDICTED: NF-kappa-B ( 192) 1244 251.6 5.6e-67 XP_005257308 (OMIM: 604497) PREDICTED: NF-kappa-B ( 191) 907 186.1 3e-47 NP_001001349 (OMIM: 604497) NF-kappa-B inhibitor-i ( 191) 907 186.1 3e-47 NP_001138399 (OMIM: 604497) NF-kappa-B inhibitor-i ( 191) 907 186.1 3e-47 NP_060065 (OMIM: 604497) NF-kappa-B inhibitor-inte ( 191) 907 186.1 3e-47 NP_001138400 (OMIM: 604497) NF-kappa-B inhibitor-i ( 135) 369 81.2 7.7e-16 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 297 67.4 1.6e-11 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 297 67.4 1.6e-11 NP_001138401 (OMIM: 604497) NF-kappa-B inhibitor-i ( 97) 282 64.2 7.7e-11 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 285 65.1 8.1e-11 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 285 65.1 8.1e-11 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 285 65.1 8.5e-11 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 285 65.1 9.2e-11 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 284 64.9 9.3e-11 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 282 64.5 1.2e-10 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 282 64.5 1.2e-10 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 267 61.6 1e-09 NP_789765 (OMIM: 109800,137550,162900,163200,18847 ( 170) 261 60.3 1.9e-09 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 260 60.2 2.5e-09 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 260 60.2 2.5e-09 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 260 60.2 2.5e-09 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 260 60.3 2.7e-09 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 260 60.3 2.7e-09 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 260 60.3 2.7e-09 NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 258 59.7 2.9e-09 XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 258 59.8 3e-09 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 248 57.8 1.2e-08 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 248 57.8 1.2e-08 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 244 57.1 2e-08 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 243 56.9 2.3e-08 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 243 56.9 2.6e-08 NP_001272989 (OMIM: 605693) ras-related protein Ra ( 203) 241 56.5 3.2e-08 NP_001272988 (OMIM: 605693) ras-related protein Ra ( 203) 241 56.5 3.2e-08 NP_055303 (OMIM: 605693) ras-related protein Rab-3 ( 203) 241 56.5 3.2e-08 NP_001272990 (OMIM: 605693) ras-related protein Ra ( 203) 241 56.5 3.2e-08 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 233 55.0 9.9e-08 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 233 55.0 1e-07 NP_005605 (OMIM: 601293) GTP-binding protein Rheb ( 184) 231 54.5 1.2e-07 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 228 54.0 1.7e-07 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 228 54.0 1.7e-07 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 228 54.0 1.7e-07 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 228 54.0 1.7e-07 >>NP_065078 (OMIM: 604496) NF-kappa-B inhibitor-interact (192 aa) initn: 1244 init1: 1244 opt: 1244 Z-score: 1323.4 bits: 251.6 E(85289): 5.6e-67 Smith-Waterman score: 1244; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP 130 140 150 160 170 180 190 pF1KB3 GRKNKGNSNSEN :::::::::::: NP_065 GRKNKGNSNSEN 190 >>XP_005265133 (OMIM: 604496) PREDICTED: NF-kappa-B inhi (192 aa) initn: 1244 init1: 1244 opt: 1244 Z-score: 1323.4 bits: 251.6 E(85289): 5.6e-67 Smith-Waterman score: 1244; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP 130 140 150 160 170 180 190 pF1KB3 GRKNKGNSNSEN :::::::::::: XP_005 GRKNKGNSNSEN 190 >>XP_005265135 (OMIM: 604496) PREDICTED: NF-kappa-B inhi (192 aa) initn: 1244 init1: 1244 opt: 1244 Z-score: 1323.4 bits: 251.6 E(85289): 5.6e-67 Smith-Waterman score: 1244; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP 130 140 150 160 170 180 190 pF1KB3 GRKNKGNSNSEN :::::::::::: XP_005 GRKNKGNSNSEN 190 >>XP_005265134 (OMIM: 604496) PREDICTED: NF-kappa-B inhi (192 aa) initn: 1244 init1: 1244 opt: 1244 Z-score: 1323.4 bits: 251.6 E(85289): 5.6e-67 Smith-Waterman score: 1244; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP 130 140 150 160 170 180 190 pF1KB3 GRKNKGNSNSEN :::::::::::: XP_005 GRKNKGNSNSEN 190 >>XP_005257308 (OMIM: 604497) PREDICTED: NF-kappa-B inhi (191 aa) initn: 923 init1: 885 opt: 907 Z-score: 969.1 bits: 186.1 E(85289): 3e-47 Smith-Waterman score: 907; 71.4% identity (93.1% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::.::::::: :::::.::::::::::..: : ::.::.:..:.::::::.::...: XP_005 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::..:.:::.: :: .::.:::::... ::::::::::::::: ::::::.:::::: XP_005 DTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : ::.:::.:: .:::.:::::::.::::.:.::..:.:::. ::::..::::::.::: XP_005 KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL- 130 140 150 160 170 190 pF1KB3 GRKNKGNSNSEN .:::::... XP_005 SRKNKGSGSLDG 180 190 >>NP_001001349 (OMIM: 604497) NF-kappa-B inhibitor-inter (191 aa) initn: 923 init1: 885 opt: 907 Z-score: 969.1 bits: 186.1 E(85289): 3e-47 Smith-Waterman score: 907; 71.4% identity (93.1% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::.::::::: :::::.::::::::::..: : ::.::.:..:.::::::.::...: NP_001 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::..:.:::.: :: .::.:::::... ::::::::::::::: ::::::.:::::: NP_001 DTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : ::.:::.:: .:::.:::::::.::::.:.::..:.:::. ::::..::::::.::: NP_001 KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL- 130 140 150 160 170 190 pF1KB3 GRKNKGNSNSEN .:::::... NP_001 SRKNKGSGSLDG 180 190 >>NP_001138399 (OMIM: 604497) NF-kappa-B inhibitor-inter (191 aa) initn: 923 init1: 885 opt: 907 Z-score: 969.1 bits: 186.1 E(85289): 3e-47 Smith-Waterman score: 907; 71.4% identity (93.1% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::.::::::: :::::.::::::::::..: : ::.::.:..:.::::::.::...: NP_001 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::..:.:::.: :: .::.:::::... ::::::::::::::: ::::::.:::::: NP_001 DTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : ::.:::.:: .:::.:::::::.::::.:.::..:.:::. ::::..::::::.::: NP_001 KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL- 130 140 150 160 170 190 pF1KB3 GRKNKGNSNSEN .:::::... NP_001 SRKNKGSGSLDG 180 190 >>NP_060065 (OMIM: 604497) NF-kappa-B inhibitor-interact (191 aa) initn: 923 init1: 885 opt: 907 Z-score: 969.1 bits: 186.1 E(85289): 3e-47 Smith-Waterman score: 907; 71.4% identity (93.1% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::.::::::: :::::.::::::::::..: : ::.::.:..:.::::::.::...: NP_060 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :::::..:.:::.: :: .::.:::::... ::::::::::::::: ::::::.:::::: NP_060 DTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : ::.:::.:: .:::.:::::::.::::.:.::..:.:::. ::::..::::::.::: NP_060 KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL- 130 140 150 160 170 190 pF1KB3 GRKNKGNSNSEN .:::::... NP_060 SRKNKGSGSLDG 180 190 >>NP_001138400 (OMIM: 604497) NF-kappa-B inhibitor-inter (135 aa) initn: 625 init1: 336 opt: 369 Z-score: 405.3 bits: 81.2 E(85289): 7.7e-16 Smith-Waterman score: 521; 50.3% identity (65.6% similar) in 189 aa overlap (1-189:1-132) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :::.::::::: :::::.::::::::::..: : ::.::.:..:.::::::.:: NP_001 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQ---- 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :.:::::: NP_001 ----------------------------------------------------VTIVVLGN 60 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : ::.:::.:: .:::.:::::::.::::.:.::..:.:::. ::::..::::::.::: NP_001 KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPL- 70 80 90 100 110 120 190 pF1KB3 GRKNKGNSNSEN .:::::... NP_001 SRKNKGSGSLDG 130 >>NP_004976 (OMIM: 109800,114480,137215,163200,190070,21 (188 aa) initn: 221 init1: 161 opt: 297 Z-score: 327.9 bits: 67.4 E(85289): 1.6e-11 Smith-Waterman score: 297; 32.3% identity (62.9% similar) in 186 aa overlap (6-191:5-184) 10 20 30 40 50 60 pF1KB3 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLY :.:: : .:::.:. ::. :: . : :.:: : .: : : : . NP_004 MTEYKLVVVGAGGVGKSALTIQLIQ-NHFVDEYD-PTIEDSYRKQVVID-GETCLLDIL 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 DTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGN :: : .: . .:. ..::. :...:: .::. .. ...: . ::...: .:..:: NP_004 DTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 KIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP : :: .: ::.. ::. :.: . . :... :. . . : :. .. . . : : NP_004 KCDLP-SRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMS--KD 120 130 140 150 160 170 190 pF1KB3 GRKNKGNSNSEN :.:.: .:... NP_004 GKKKKKKSKTKCVIM 180 192 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:29:30 2016 done: Sat Nov 5 05:29:31 2016 Total Scan time: 5.590 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]