FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3975, 629 aa 1>>>pF1KB3975 629 - 629 aa - 629 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.1705+/-0.000463; mu= -18.7652+/- 0.029 mean_var=778.7661+/-165.966, 0's: 0 Z-trim(124.8): 598 B-trim: 0 in 0/62 Lambda= 0.045959 statistics sampled from 46310 (47209) to 46310 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.554), width: 16 Scan time: 14.200 The best scores are: opt bits E(85289) XP_005259455 (OMIM: 604556,615812) PREDICTED: dual ( 629) 4331 302.6 2.7e-81 NP_004705 (OMIM: 604556,615812) dual specificity t ( 629) 4331 302.6 2.7e-81 NP_006475 (OMIM: 604556,615812) dual specificity t ( 601) 2596 187.6 1.1e-46 XP_016883775 (OMIM: 600855,614104) PREDICTED: dual ( 734) 2538 183.8 1.8e-45 XP_006724041 (OMIM: 600855,614104) PREDICTED: dual ( 763) 2538 183.8 1.9e-45 XP_006724039 (OMIM: 600855,614104) PREDICTED: dual ( 763) 2538 183.8 1.9e-45 XP_006724040 (OMIM: 600855,614104) PREDICTED: dual ( 763) 2538 183.8 1.9e-45 XP_011527785 (OMIM: 600855,614104) PREDICTED: dual ( 763) 2538 183.8 1.9e-45 NP_001387 (OMIM: 600855,614104) dual specificity t ( 763) 2538 183.8 1.9e-45 XP_011527784 (OMIM: 600855,614104) PREDICTED: dual ( 770) 2538 183.9 1.9e-45 NP_567824 (OMIM: 600855,614104) dual specificity t ( 584) 2519 182.5 3.7e-45 XP_011527787 (OMIM: 600855,614104) PREDICTED: dual ( 725) 2497 181.1 1.2e-44 XP_016883773 (OMIM: 600855,614104) PREDICTED: dual ( 754) 2497 181.1 1.2e-44 XP_016883774 (OMIM: 600855,614104) PREDICTED: dual ( 754) 2497 181.1 1.2e-44 NP_569120 (OMIM: 600855,614104) dual specificity t ( 754) 2497 181.1 1.2e-44 XP_006724042 (OMIM: 600855,614104) PREDICTED: dual ( 754) 2497 181.1 1.2e-44 XP_011527786 (OMIM: 600855,614104) PREDICTED: dual ( 761) 2497 181.1 1.2e-44 NP_006474 (OMIM: 604556,615812) dual specificity t ( 589) 2489 180.5 1.5e-44 NP_569122 (OMIM: 600855,614104) dual specificity t ( 529) 2455 178.2 6.6e-44 XP_005260990 (OMIM: 600855,614104) PREDICTED: dual ( 535) 1677 126.6 2.3e-28 NP_003574 (OMIM: 603496) dual specificity tyrosine ( 528) 982 80.5 1.7e-14 XP_016875521 (OMIM: 603496) PREDICTED: dual specif ( 528) 982 80.5 1.7e-14 NP_006473 (OMIM: 603496) dual specificity tyrosine ( 601) 982 80.6 1.8e-14 XP_011508363 (OMIM: 603497) PREDICTED: dual specif ( 553) 951 78.5 7.1e-14 XP_005273372 (OMIM: 603497) PREDICTED: dual specif ( 568) 951 78.5 7.3e-14 NP_001004023 (OMIM: 603497) dual specificity tyros ( 568) 951 78.5 7.3e-14 NP_003573 (OMIM: 603497) dual specificity tyrosine ( 588) 951 78.5 7.4e-14 NP_003836 (OMIM: 609181) dual specificity tyrosine ( 520) 935 77.4 1.4e-13 XP_016856095 (OMIM: 608003) PREDICTED: homeodomain ( 605) 752 65.3 7.1e-10 NP_689909 (OMIM: 608003) homeodomain-interacting p (1075) 752 65.6 1e-09 XP_016856094 (OMIM: 608003) PREDICTED: homeodomain (1209) 752 65.7 1.1e-09 NP_938009 (OMIM: 608003) homeodomain-interacting p (1210) 752 65.7 1.1e-09 XP_005270669 (OMIM: 608003) PREDICTED: homeodomain (1210) 752 65.7 1.1e-09 XP_005270670 (OMIM: 608003) PREDICTED: homeodomain (1210) 752 65.7 1.1e-09 XP_006710506 (OMIM: 608003) PREDICTED: homeodomain (1247) 752 65.7 1.1e-09 XP_005270668 (OMIM: 608003) PREDICTED: homeodomain (1256) 752 65.7 1.1e-09 XP_005270667 (OMIM: 608003) PREDICTED: homeodomain (1280) 752 65.7 1.2e-09 XP_005270666 (OMIM: 608003) PREDICTED: homeodomain (1281) 752 65.7 1.2e-09 NP_001106710 (OMIM: 606868) homeodomain-interactin (1171) 729 64.1 3.1e-09 XP_016867558 (OMIM: 606868) PREDICTED: homeodomain (1191) 729 64.1 3.2e-09 XP_006715998 (OMIM: 606868) PREDICTED: homeodomain (1191) 729 64.1 3.2e-09 NP_073577 (OMIM: 606868) homeodomain-interacting p (1198) 729 64.1 3.2e-09 XP_011514383 (OMIM: 606868) PREDICTED: homeodomain (1206) 729 64.1 3.2e-09 XP_011514382 (OMIM: 606868) PREDICTED: homeodomain (1349) 729 64.2 3.4e-09 XP_011514381 (OMIM: 606868) PREDICTED: homeodomain (1350) 729 64.2 3.4e-09 XP_011514380 (OMIM: 606868) PREDICTED: homeodomain (1376) 729 64.2 3.5e-09 XP_011514379 (OMIM: 606868) PREDICTED: homeodomain (1377) 729 64.2 3.5e-09 XP_016872566 (OMIM: 604424) PREDICTED: homeodomain (1194) 713 63.1 6.6e-09 NP_001265092 (OMIM: 604424) homeodomain-interactin (1194) 713 63.1 6.6e-09 NP_001041665 (OMIM: 604424) homeodomain-interactin (1194) 713 63.1 6.6e-09 >>XP_005259455 (OMIM: 604556,615812) PREDICTED: dual spe (629 aa) initn: 4331 init1: 4331 opt: 4331 Z-score: 1580.6 bits: 302.6 E(85289): 2.7e-81 Smith-Waterman score: 4331; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 550 560 570 580 590 600 610 620 pF1KB3 PPLPPPDDPATLGPHLGLRGVPQSTAASS ::::::::::::::::::::::::::::: XP_005 PPLPPPDDPATLGPHLGLRGVPQSTAASS 610 620 >>NP_004705 (OMIM: 604556,615812) dual specificity tyros (629 aa) initn: 4331 init1: 4331 opt: 4331 Z-score: 1580.6 bits: 302.6 E(85289): 2.7e-81 Smith-Waterman score: 4331; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 550 560 570 580 590 600 610 620 pF1KB3 PPLPPPDDPATLGPHLGLRGVPQSTAASS ::::::::::::::::::::::::::::: NP_004 PPLPPPDDPATLGPHLGLRGVPQSTAASS 610 620 >>NP_006475 (OMIM: 604556,615812) dual specificity tyros (601 aa) initn: 2624 init1: 2546 opt: 2596 Z-score: 959.1 bits: 187.6 E(85289): 1.1e-46 Smith-Waterman score: 4064; 95.5% identity (95.5% similar) in 629 aa overlap (1-629:1-601) 10 20 30 40 50 60 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI ::::::::::::::::: ::::::::::::::: NP_006 KELRKDYQGPGTRRLQE----------------------------DLVLRMLEYEPAARI 370 380 390 430 440 450 460 470 480 pF1KB3 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR 520 530 540 550 560 570 610 620 pF1KB3 PPLPPPDDPATLGPHLGLRGVPQSTAASS ::::::::::::::::::::::::::::: NP_006 PPLPPPDDPATLGPHLGLRGVPQSTAASS 580 590 600 >>XP_016883775 (OMIM: 600855,614104) PREDICTED: dual spe (734 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.3 bits: 183.8 E(85289): 1.8e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:40-569) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_016 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_016 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_016 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_016 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_016 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_016 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_016 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 430 440 450 460 470 480 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_016 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_016 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 550 560 570 580 590 600 >>XP_006724041 (OMIM: 600855,614104) PREDICTED: dual spe (763 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.8 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:69-598) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_006 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_006 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_006 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_006 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_006 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_006 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_006 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_006 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 460 470 480 490 500 510 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_006 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 520 530 540 550 560 570 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_006 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 580 590 600 610 620 630 >>XP_006724039 (OMIM: 600855,614104) PREDICTED: dual spe (763 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.8 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:69-598) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_006 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_006 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_006 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_006 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_006 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_006 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_006 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_006 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 460 470 480 490 500 510 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_006 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 520 530 540 550 560 570 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_006 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 580 590 600 610 620 630 >>XP_006724040 (OMIM: 600855,614104) PREDICTED: dual spe (763 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.8 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:69-598) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_006 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_006 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_006 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_006 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_006 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_006 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_006 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_006 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 460 470 480 490 500 510 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_006 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 520 530 540 550 560 570 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_006 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 580 590 600 610 620 630 >>XP_011527785 (OMIM: 600855,614104) PREDICTED: dual spe (763 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.8 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:69-598) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_011 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_011 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_011 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_011 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_011 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_011 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_011 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 460 470 480 490 500 510 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_011 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 520 530 540 550 560 570 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_011 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 580 590 600 610 620 630 >>NP_001387 (OMIM: 600855,614104) dual specificity tyros (763 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.8 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:69-598) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: NP_001 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: NP_001 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: NP_001 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: NP_001 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: NP_001 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: NP_001 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: NP_001 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 460 470 480 490 500 510 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: NP_001 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 520 530 540 550 560 570 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : NP_001 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 580 590 600 610 620 630 >>XP_011527784 (OMIM: 600855,614104) PREDICTED: dual spe (770 aa) initn: 2472 init1: 2446 opt: 2538 Z-score: 937.1 bits: 183.9 E(85289): 1.9e-45 Smith-Waterman score: 2538; 71.3% identity (87.0% similar) in 537 aa overlap (21-549:76-605) 10 20 30 40 50 pF1KB3 MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSV ::.::. .: ::.: .::: ..:::::::: XP_011 QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSV 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB3 DLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLER :::::::::::::::::::: ::. .:::.:::.:: : ::::::.::::..::.:..: XP_011 DLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB3 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK ::::::::::::::::::::. :: :::::::::::::::::::.:::::::.:::::: XP_011 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB3 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT :::::::::::::::::::::.::::::::::::.:::::::::::.:::.::::::::: XP_011 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB3 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPY 290 300 310 320 330 340 300 310 320 330 340 350 pF1KB3 DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL :::::::::::::::::::::::::.:::::::.:::::::::: .:::::::::.::.: XP_011 DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKL 350 360 370 380 390 400 360 370 380 390 400 410 pF1KB3 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR : : :.:..::. ...:. ::::.:...:::.::::::::::: ::. ::::.:.::.:: XP_011 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 410 420 430 440 450 460 420 430 440 450 460 470 pF1KB3 MLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSS ::.:.: .::.: ::::.::..::::.::: ..:.::::: .. :..:.:. ::: XP_011 MLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVSTSPAMEQSQSSGTTSSTSSSS 470 480 490 500 510 520 480 490 500 510 520 pF1KB3 GGSSGSSSDNRTYR---YSNRYCGG---PGPPITDCEMNSPQVPPSQPLRP--WAGGDVP :::::.:...:. ...:. :: . ::: .:::: . : : :.: ..: XP_011 GGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPA-PLGWSGTEAP 530 540 550 560 570 580 530 540 550 560 570 580 pF1KB3 HKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAP :. . . . : .. :: : XP_011 T---QVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPR 590 600 610 620 630 629 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:12:03 2016 done: Thu Nov 3 14:12:05 2016 Total Scan time: 14.200 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]