FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3988, 173 aa 1>>>pF1KB3988 173 - 173 aa - 173 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5843+/-0.000371; mu= 10.3037+/- 0.023 mean_var=84.9976+/-17.434, 0's: 0 Z-trim(115.1): 251 B-trim: 283 in 1/49 Lambda= 0.139114 statistics sampled from 24943 (25281) to 24943 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.296), width: 16 Scan time: 5.390 The best scores are: opt bits E(85289) NP_003454 (OMIM: 601585) protein tyrosine phosphat ( 173) 1181 246.6 1.5e-65 XP_016866760 (OMIM: 601585) PREDICTED: protein tyr ( 173) 1181 246.6 1.5e-65 XP_011534414 (OMIM: 601585) PREDICTED: protein tyr ( 173) 1181 246.6 1.5e-65 XP_016866759 (OMIM: 601585) PREDICTED: protein tyr ( 173) 1181 246.6 1.5e-65 XP_011534413 (OMIM: 601585) PREDICTED: protein tyr ( 173) 1181 246.6 1.5e-65 NP_536316 (OMIM: 601584) protein tyrosine phosphat ( 167) 1044 219.1 2.7e-57 XP_011515107 (OMIM: 606449) PREDICTED: protein tyr ( 173) 962 202.7 2.5e-52 NP_116000 (OMIM: 606449) protein tyrosine phosphat ( 173) 962 202.7 2.5e-52 XP_005250821 (OMIM: 606449) PREDICTED: protein tyr ( 173) 962 202.7 2.5e-52 XP_011515105 (OMIM: 606449) PREDICTED: protein tyr ( 173) 962 202.7 2.5e-52 XP_016866761 (OMIM: 601585) PREDICTED: protein tyr ( 135) 912 192.6 2.1e-49 XP_006716563 (OMIM: 606449) PREDICTED: protein tyr ( 149) 764 162.9 2e-40 XP_005271289 (OMIM: 601584) PREDICTED: protein tyr ( 136) 683 146.6 1.5e-35 NP_001182030 (OMIM: 601584) protein tyrosine phosp ( 136) 683 146.6 1.5e-35 XP_016857890 (OMIM: 601584) PREDICTED: protein tyr ( 136) 683 146.6 1.5e-35 XP_005271288 (OMIM: 601584) PREDICTED: protein tyr ( 142) 674 144.8 5.3e-35 NP_001182029 (OMIM: 601584) protein tyrosine phosp ( 142) 674 144.8 5.3e-35 XP_016868487 (OMIM: 606449) PREDICTED: protein tyr ( 148) 616 133.2 1.8e-31 NP_009010 (OMIM: 606449) protein tyrosine phosphat ( 148) 616 133.2 1.8e-31 XP_016868488 (OMIM: 606449) PREDICTED: protein tyr ( 124) 418 93.4 1.4e-19 XP_016870738 (OMIM: 603505) PREDICTED: dual specif ( 296) 188 47.5 2.2e-05 XP_011517461 (OMIM: 603505) PREDICTED: dual specif ( 331) 188 47.6 2.4e-05 XP_016870737 (OMIM: 603505) PREDICTED: dual specif ( 390) 188 47.6 2.7e-05 XP_016870736 (OMIM: 603505) PREDICTED: dual specif ( 422) 188 47.6 2.9e-05 XP_016870735 (OMIM: 603505) PREDICTED: dual specif ( 448) 188 47.7 3e-05 XP_005252345 (OMIM: 603505) PREDICTED: dual specif ( 448) 188 47.7 3e-05 NP_003662 (OMIM: 603505) dual specificity protein ( 459) 188 47.7 3e-05 NP_001070649 (OMIM: 603505) dual specificity prote ( 461) 188 47.7 3.1e-05 XP_011517460 (OMIM: 603505) PREDICTED: dual specif ( 471) 188 47.7 3.1e-05 XP_016870734 (OMIM: 603505) PREDICTED: dual specif ( 479) 188 47.7 3.2e-05 XP_016870733 (OMIM: 603505) PREDICTED: dual specif ( 483) 188 47.7 3.2e-05 XP_016870732 (OMIM: 603505) PREDICTED: dual specif ( 485) 188 47.7 3.2e-05 NP_201588 (OMIM: 603505) dual specificity protein ( 498) 188 47.7 3.2e-05 XP_011517458 (OMIM: 603505) PREDICTED: dual specif ( 514) 188 47.7 3.3e-05 XP_016870731 (OMIM: 603505) PREDICTED: dual specif ( 520) 188 47.7 3.4e-05 XP_016870730 (OMIM: 603505) PREDICTED: dual specif ( 544) 188 47.7 3.5e-05 XP_011517455 (OMIM: 603505) PREDICTED: dual specif ( 552) 188 47.7 3.5e-05 XP_011517454 (OMIM: 603505) PREDICTED: dual specif ( 564) 188 47.7 3.6e-05 XP_011517453 (OMIM: 603505) PREDICTED: dual specif ( 578) 188 47.7 3.6e-05 XP_011517452 (OMIM: 603505) PREDICTED: dual specif ( 578) 188 47.7 3.6e-05 XP_011517451 (OMIM: 603505) PREDICTED: dual specif ( 585) 188 47.7 3.7e-05 XP_011517450 (OMIM: 603505) PREDICTED: dual specif ( 591) 188 47.7 3.7e-05 XP_011517449 (OMIM: 603505) PREDICTED: dual specif ( 603) 188 47.7 3.8e-05 XP_016870729 (OMIM: 603505) PREDICTED: dual specif ( 613) 188 47.8 3.8e-05 NP_201570 (OMIM: 603504,616958) dual specificity p ( 383) 179 45.8 9.3e-05 XP_011540648 (OMIM: 603504,616958) PREDICTED: dual ( 392) 179 45.8 9.4e-05 XP_016858136 (OMIM: 603504,616958) PREDICTED: dual ( 489) 179 45.9 0.00011 XP_016858135 (OMIM: 603504,616958) PREDICTED: dual ( 490) 179 45.9 0.00011 XP_011540647 (OMIM: 603504,616958) PREDICTED: dual ( 495) 179 45.9 0.00011 NP_001306140 (OMIM: 603504,616958) dual specificit ( 565) 179 45.9 0.00013 >>NP_003454 (OMIM: 601585) protein tyrosine phosphatase (173 aa) initn: 1181 init1: 1181 opt: 1181 Z-score: 1298.1 bits: 246.6 E(85289): 1.5e-65 Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ 130 140 150 160 170 >>XP_016866760 (OMIM: 601585) PREDICTED: protein tyrosin (173 aa) initn: 1181 init1: 1181 opt: 1181 Z-score: 1298.1 bits: 246.6 E(85289): 1.5e-65 Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ 130 140 150 160 170 >>XP_011534414 (OMIM: 601585) PREDICTED: protein tyrosin (173 aa) initn: 1181 init1: 1181 opt: 1181 Z-score: 1298.1 bits: 246.6 E(85289): 1.5e-65 Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ 130 140 150 160 170 >>XP_016866759 (OMIM: 601585) PREDICTED: protein tyrosin (173 aa) initn: 1181 init1: 1181 opt: 1181 Z-score: 1298.1 bits: 246.6 E(85289): 1.5e-65 Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ 130 140 150 160 170 >>XP_011534413 (OMIM: 601585) PREDICTED: protein tyrosin (173 aa) initn: 1181 init1: 1181 opt: 1181 Z-score: 1298.1 bits: 246.6 E(85289): 1.5e-65 Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ 130 140 150 160 170 >>NP_536316 (OMIM: 601584) protein tyrosine phosphatase (167 aa) initn: 1046 init1: 1023 opt: 1044 Z-score: 1149.7 bits: 219.1 E(85289): 2.7e-57 Smith-Waterman score: 1044; 87.6% identity (94.7% similar) in 170 aa overlap (4-173:1-167) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK ::::::::..:.:::::::::::::::::: ::::::::::.::::.:::: . ::: NP_536 MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEK 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI :::::::::::::::: ::::::::.:.: :::::::::.:::::::::::::::::::: NP_536 EGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALI 60 70 80 90 100 110 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ : ::::::::::::::::::::::::::::::::::::::.:.::: ::.: NP_536 ECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGH---CCVQ 120 130 140 150 160 >>XP_011515107 (OMIM: 606449) PREDICTED: protein tyrosin (173 aa) initn: 962 init1: 962 opt: 962 Z-score: 1060.5 bits: 202.7 E(85289): 2.5e-52 Smith-Waterman score: 962; 79.1% identity (92.4% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK ::::::::::::.::.::::::::::::::. :::.:::::.::.:::::.::: : .:: XP_011 MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI .:: :.:::::::::: ...:.::::::: :: : :: :.:::::::::::::::::::: XP_011 DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ :.:::::::.::::::::::.::::: ::::::::.:::::: . :.. ::. XP_011 ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM 130 140 150 160 170 >>NP_116000 (OMIM: 606449) protein tyrosine phosphatase (173 aa) initn: 962 init1: 962 opt: 962 Z-score: 1060.5 bits: 202.7 E(85289): 2.5e-52 Smith-Waterman score: 962; 79.1% identity (92.4% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK ::::::::::::.::.::::::::::::::. :::.:::::.::.:::::.::: : .:: NP_116 MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI .:: :.:::::::::: ...:.::::::: :: : :: :.:::::::::::::::::::: NP_116 DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ :.:::::::.::::::::::.::::: ::::::::.:::::: . :.. ::. NP_116 ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM 130 140 150 160 170 >>XP_005250821 (OMIM: 606449) PREDICTED: protein tyrosin (173 aa) initn: 962 init1: 962 opt: 962 Z-score: 1060.5 bits: 202.7 E(85289): 2.5e-52 Smith-Waterman score: 962; 79.1% identity (92.4% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK ::::::::::::.::.::::::::::::::. :::.:::::.::.:::::.::: : .:: XP_005 MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI .:: :.:::::::::: ...:.::::::: :: : :: :.:::::::::::::::::::: XP_005 DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ :.:::::::.::::::::::.::::: ::::::::.:::::: . :.. ::. XP_005 ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM 130 140 150 160 170 >>XP_011515105 (OMIM: 606449) PREDICTED: protein tyrosin (173 aa) initn: 962 init1: 962 opt: 962 Z-score: 1060.5 bits: 202.7 E(85289): 2.5e-52 Smith-Waterman score: 962; 79.1% identity (92.4% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KB3 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK ::::::::::::.::.::::::::::::::. :::.:::::.::.:::::.::: : .:: XP_011 MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI .:: :.:::::::::: ...:.::::::: :: : :: :.:::::::::::::::::::: XP_011 DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ :.:::::::.::::::::::.::::: ::::::::.:::::: . :.. ::. XP_011 ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM 130 140 150 160 170 173 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:20:15 2016 done: Thu Nov 3 21:20:16 2016 Total Scan time: 5.390 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]