FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3998, 191 aa 1>>>pF1KB3998 191 - 191 aa - 191 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0346+/-0.000722; mu= 14.8000+/- 0.044 mean_var=69.9309+/-13.973, 0's: 0 Z-trim(110.1): 171 B-trim: 358 in 1/49 Lambda= 0.153370 statistics sampled from 11205 (11388) to 11205 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.35), width: 16 Scan time: 1.620 The best scores are: opt bits E(32554) CCDS222.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 1283 292.3 1.2e-79 CCDS221.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 1224 279.2 1.1e-75 CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 ( 192) 946 217.7 3.5e-57 CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 ( 192) 941 216.6 7.5e-57 CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 ( 192) 925 213.0 8.8e-56 CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 ( 205) 880 203.1 9.2e-53 CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 ( 214) 821 190.1 8.1e-49 CCDS7748.1 RHOG gene_id:391|Hs108|chr11 ( 191) 814 188.5 2.2e-48 CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 ( 258) 769 178.6 2.7e-45 CCDS2795.1 RHOA gene_id:387|Hs108|chr3 ( 193) 696 162.4 1.6e-40 CCDS10068.1 RHOV gene_id:171177|Hs108|chr15 ( 236) 695 162.2 2.1e-40 CCDS854.1 RHOC gene_id:389|Hs108|chr1 ( 193) 684 159.7 9.9e-40 CCDS1699.1 RHOB gene_id:388|Hs108|chr2 ( 196) 660 154.4 4e-38 CCDS8155.1 RHOD gene_id:29984|Hs108|chr11 ( 210) 595 140.1 9e-34 CCDS9222.1 RHOF gene_id:54509|Hs108|chr12 ( 211) 584 137.6 4.9e-33 CCDS82775.1 RHOA gene_id:387|Hs108|chr3 ( 187) 575 135.6 1.8e-32 CCDS3458.1 RHOH gene_id:399|Hs108|chr4 ( 191) 524 124.3 4.5e-29 CCDS5349.1 RAC1 gene_id:5879|Hs108|chr7 ( 211) 523 124.1 5.6e-29 CCDS2190.1 RND3 gene_id:390|Hs108|chr2 ( 244) 513 122.0 2.9e-28 CCDS11452.1 RND2 gene_id:8153|Hs108|chr17 ( 227) 483 115.3 2.7e-26 CCDS8771.1 RND1 gene_id:27289|Hs108|chr12 ( 232) 435 104.7 4.4e-23 CCDS6034.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 727) 327 81.2 1.7e-15 CCDS55211.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 734) 327 81.2 1.7e-15 CCDS55210.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 749) 327 81.2 1.7e-15 CCDS7261.1 RHOBTB1 gene_id:9886|Hs108|chr10 ( 696) 326 80.9 1.9e-15 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 273 68.8 2.3e-12 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 262 66.3 1.3e-11 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 261 66.2 1.6e-11 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 261 66.2 1.7e-11 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 259 65.7 2e-11 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 259 65.7 2.1e-11 CCDS62431.1 RIT2 gene_id:6014|Hs108|chr18 ( 153) 256 64.9 2.7e-11 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 256 65.0 3.1e-11 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 256 65.1 3.5e-11 CCDS41846.1 RAB35 gene_id:11021|Hs108|chr12 ( 201) 250 63.7 8.3e-11 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 250 63.7 8.4e-11 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 249 63.4 8.5e-11 >>CCDS222.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 1283 init1: 1283 opt: 1283 Z-score: 1543.1 bits: 292.3 E(32554): 1.2e-79 Smith-Waterman score: 1283; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB3 ETQPKRKCCIF ::::::::::: CCDS22 ETQPKRKCCIF 190 >>CCDS221.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 1271 init1: 1224 opt: 1224 Z-score: 1472.6 bits: 279.2 E(32554): 1.1e-75 Smith-Waterman score: 1224; 95.3% identity (98.4% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: CCDS22 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB3 ETQPKRKCCIF : . .:.: .. CCDS22 EPKKSRRCVLL 190 >>CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 (192 aa) initn: 994 init1: 917 opt: 946 Z-score: 1140.1 bits: 217.7 E(32554): 3.5e-57 Smith-Waterman score: 946; 70.3% identity (88.0% similar) in 192 aa overlap (1-191:1-192) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: CCDS11 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::.:::::..::: CCDS11 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP :: .:::.: .: ::: . .::.. .:::.:::::::::::.:::::: :.: :: CCDS11 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB3 ETQ-PKRKCCIF .. : .:: .: CCDS11 PVKKPGKKCTVF 190 >>CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 (192 aa) initn: 1011 init1: 941 opt: 941 Z-score: 1134.1 bits: 216.6 E(32554): 7.5e-57 Smith-Waterman score: 941; 69.1% identity (89.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: CCDS53 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::..::::..::: CCDS53 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP :: .::::: ..: ::: . .:... ::::.:::::::::::.:::::: :.: :: CCDS53 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB3 ETQPKRKCCIF .. ... :.. CCDS53 PVKKRKRKCLLL 190 >>CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 (192 aa) initn: 954 init1: 919 opt: 925 Z-score: 1115.0 bits: 213.0 E(32554): 8.8e-56 Smith-Waterman score: 925; 69.3% identity (87.5% similar) in 192 aa overlap (1-191:1-192) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: CCDS13 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: CCDS13 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEP- :: .::::: ..: ::: . ::... .:::.:::::::::::.:::::: :.: : CCDS13 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 180 190 pF1KB3 PETQPKRKCCIF : : :: : .. CCDS13 PTRQQKRACSLL 190 >>CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 (205 aa) initn: 888 init1: 868 opt: 880 Z-score: 1060.8 bits: 203.1 E(32554): 9.2e-53 Smith-Waterman score: 880; 64.9% identity (84.5% similar) in 194 aa overlap (4-190:10-203) 10 20 30 40 50 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: CCDS33 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: CCDS33 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAIL :::::::::.:. .: :.::: : ..:::... : :::::::::.:::.::::::. CCDS33 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII 130 140 150 160 170 180 180 190 pF1KB3 AALEPPETQPKRK-------CCIF : : : . :.. ::. CCDS33 AILTPKKHTVKKRIGSRCINCCLIT 190 200 >>CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 (214 aa) initn: 843 init1: 810 opt: 821 Z-score: 990.0 bits: 190.1 E(32554): 8.1e-49 Smith-Waterman score: 821; 62.6% identity (85.6% similar) in 187 aa overlap (2-188:20-204) 10 20 30 40 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAV . .::::::::::::::::.::... :: ::::::::.::: CCDS97 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT :: .::. . :::.::::::::..:::::::.:::::.:::::.:.:..::.:.::::. CCDS97 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQ :..:..:.::::::::::.:. .: :.::.: : . :::. . : :.::::::: CCDS97 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ 130 140 150 160 170 180 170 180 190 pF1KB3 RGLKNVFDEAILAALEPPETQPKRKCCIF .::: :::::::. ..: . :..: CCDS97 KGLKAVFDEAILTIFHPK--KKKKRCSEGHSCCSII 190 200 210 >>CCDS7748.1 RHOG gene_id:391|Hs108|chr11 (191 aa) initn: 814 init1: 799 opt: 814 Z-score: 982.3 bits: 188.5 E(32554): 2.2e-48 Smith-Waterman score: 814; 59.2% identity (84.3% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG ::.:::::::::::::::::: :::: ::.::.:::::::.. . :. .:.:.:::: CCDS77 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR ::.::::: ::::::.::..:::..:: :.:::..:: ::. :::: .:.:::::. ::: CCDS77 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP .:.:...: .. : ::::. .. ::....::.:.::::: : :.:.:: ::. :.:.: CCDS77 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB3 ETQPKRKCCIF . :.: .. CCDS77 PIKRGRSCILL 190 >>CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 (258 aa) initn: 805 init1: 763 opt: 769 Z-score: 926.6 bits: 178.6 E(32554): 2.7e-45 Smith-Waterman score: 769; 60.2% identity (86.0% similar) in 186 aa overlap (4-186:50-234) 10 20 30 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYV .:::.::::::::: :..::::: .:.::. CCDS15 PPRRERGGRGGRGPGEPGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB3 PTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENV ::.:::....: . :.: : : :::::...:.:::: : .::.::.::::::::::.:: CCDS15 PTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB3 KEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKL-ARDLKAV .::::::: ::::.:..::::: :::.: ... .: : :.::. :: : :: :...::. CCDS15 SEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPV-PEEAAKLCAEEIKAA 140 150 160 170 180 190 160 170 180 190 pF1KB3 KYVECSALTQRGLKNVFDEAILAALEPPETQ--PKRKCCIF .:.:::::::..::.::: ::.:... .:: ::. CCDS15 SYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKSRTPDKMKNLSKSWWKKYCCFV 200 210 220 230 240 250 >>CCDS2795.1 RHOA gene_id:387|Hs108|chr3 (193 aa) initn: 688 init1: 669 opt: 696 Z-score: 841.1 bits: 162.4 E(32554): 1.6e-40 Smith-Waterman score: 696; 52.4% identity (78.1% similar) in 187 aa overlap (5-191:7-193) 10 20 30 40 50 pF1KB3 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDT : :.::::: ::::::: .. ..:: ::::::.::.. . . :. :.:.:: CCDS27 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 AGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQID :::::::::::::::.:::.:.:::. ::.:.::. :::.::. : ::..:..:::.. : CCDS27 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 LRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALE ::.: : ..::: ::.:. :: .. .: . : :.:::: :. :...::. : :::. CCDS27 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 130 140 150 160 170 180 180 190 pF1KB3 PPETQPKRKCCIF . . : : .. CCDS27 ARRGKKKSGCLVL 190 191 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:31:20 2016 done: Sat Nov 5 05:31:21 2016 Total Scan time: 1.620 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]