FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4000, 214 aa 1>>>pF1KB4000 214 - 214 aa - 214 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0362+/-0.000852; mu= 15.0084+/- 0.052 mean_var=72.9970+/-14.841, 0's: 0 Z-trim(108.3): 168 B-trim: 627 in 2/49 Lambda= 0.150114 statistics sampled from 9905 (10094) to 9905 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.31), width: 16 Scan time: 1.860 The best scores are: opt bits E(32554) CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 ( 214) 1472 327.7 3.4e-90 CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 ( 205) 1023 230.4 6.1e-61 CCDS221.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 834 189.5 1.2e-48 CCDS222.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 822 186.9 7.4e-48 CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 ( 192) 802 182.6 1.5e-46 CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 ( 192) 797 181.5 3.2e-46 CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 ( 192) 777 177.1 6.3e-45 CCDS7748.1 RHOG gene_id:391|Hs108|chr11 ( 191) 666 153.1 1.1e-37 CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 ( 258) 660 151.9 3.4e-37 CCDS2795.1 RHOA gene_id:387|Hs108|chr3 ( 193) 632 145.7 1.8e-35 CCDS854.1 RHOC gene_id:389|Hs108|chr1 ( 193) 627 144.7 3.8e-35 CCDS10068.1 RHOV gene_id:171177|Hs108|chr15 ( 236) 619 143.0 1.5e-34 CCDS1699.1 RHOB gene_id:388|Hs108|chr2 ( 196) 613 141.6 3.2e-34 CCDS9222.1 RHOF gene_id:54509|Hs108|chr12 ( 211) 575 133.4 1e-31 CCDS8155.1 RHOD gene_id:29984|Hs108|chr11 ( 210) 537 125.2 3e-29 CCDS82775.1 RHOA gene_id:387|Hs108|chr3 ( 187) 521 121.7 3e-28 CCDS2190.1 RND3 gene_id:390|Hs108|chr2 ( 244) 491 115.3 3.4e-26 CCDS3458.1 RHOH gene_id:399|Hs108|chr4 ( 191) 470 110.6 6.5e-25 CCDS11452.1 RND2 gene_id:8153|Hs108|chr17 ( 227) 464 109.4 1.8e-24 CCDS5349.1 RAC1 gene_id:5879|Hs108|chr7 ( 211) 438 103.8 8.6e-23 CCDS8771.1 RND1 gene_id:27289|Hs108|chr12 ( 232) 425 101.0 6.5e-22 CCDS6034.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 727) 279 69.8 5.1e-12 CCDS55211.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 734) 279 69.8 5.1e-12 CCDS55210.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 749) 279 69.8 5.2e-12 CCDS7261.1 RHOBTB1 gene_id:9886|Hs108|chr10 ( 696) 268 67.4 2.6e-11 CCDS76806.1 RAB26 gene_id:25837|Hs108|chr16 ( 190) 256 64.3 5.8e-11 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 253 63.6 8.4e-11 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 253 63.7 9.1e-11 >>CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 (214 aa) initn: 1472 init1: 1472 opt: 1472 Z-score: 1732.8 bits: 327.7 E(32554): 3.4e-90 Smith-Waterman score: 1472; 99.5% identity (99.5% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: CCDS97 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ 130 140 150 160 170 180 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPKKKKKRCSEGHSCCSII :::::::::::::::::::::::::::::::::: CCDS97 KGLKAVFDEAILTIFHPKKKKKRCSEGHSCCSII 190 200 210 >>CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 (205 aa) initn: 1032 init1: 1004 opt: 1023 Z-score: 1207.5 bits: 230.4 E(32554): 6.1e-61 Smith-Waterman score: 1023; 79.1% identity (89.8% similar) in 196 aa overlap (21-213:9-204) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV ::::::::::::::::::::::::::: :::::::::::: CCDS33 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK .:::::::.:::::::::::::..::::::: :::::::::::::::..::.:::::::: CCDS33 SVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELK 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ . :.::..:::::::::::::::::: :::::. :.: :::: ::: ::.::::::: CCDS33 EYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPKK---KKKRCSEGHSCCSII ::::.::::::..:. ::: ::. :. .:: : CCDS33 KGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT 170 180 190 200 >>CCDS221.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 825 init1: 825 opt: 834 Z-score: 986.7 bits: 189.5 E(32554): 1.2e-48 Smith-Waterman score: 834; 64.2% identity (86.6% similar) in 187 aa overlap (20-204:2-188) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV . .::::::::::::::::.::... ::.::::::::.::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAV 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK :: .::. . :::.::::::::..:::::::.:::::.:::::.:.:..::.:.::::. CCDS22 TVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ :..:..:.::::::::::.:. .: :.::.: : . :::. . : :.::::::: CCDS22 HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPK--KKKKRCSEGHSCCSII :::: :::::::. ..: ::..:: CCDS22 KGLKNVFDEAILAALEPPEPKKSRRCVLL 170 180 190 >>CCDS222.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 844 init1: 811 opt: 822 Z-score: 972.7 bits: 186.9 E(32554): 7.4e-48 Smith-Waterman score: 822; 62.6% identity (86.1% similar) in 187 aa overlap (20-204:2-188) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV . .::::::::::::::::.::... ::.::::::::.::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAV 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK :: .::. . :::.::::::::..:::::::.:::::.:::::.:.:..::.:.::::. CCDS22 TVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ :..:..:.::::::::::.:. .: :.::.: : . :::. . : :.::::::: CCDS22 HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPK--KKKKRCSEGHSCCSII .::: :::::::. ..: . :..: CCDS22 RGLKNVFDEAILAALEPPETQPKRKCCIF 170 180 190 >>CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 (192 aa) initn: 792 init1: 792 opt: 802 Z-score: 949.3 bits: 182.6 E(32554): 1.5e-46 Smith-Waterman score: 802; 61.2% identity (84.0% similar) in 188 aa overlap (20-204:2-189) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV . .::::::::::::::::.::...::::::.:::::.:.. CCDS53 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSA 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK .: : :: :::.::::::::..:::::::.:::::::::.:.:::..::. .: ::.. CCDS53 NVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ :..: .:.::..::::: :. .: : :.:: .:. .:: ::: ::::::::: CCDS53 HHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHP---KKKKKRCSEGHSCCSII .:::.:::::: ... : ::.:..: CCDS53 RGLKTVFDEAIRAVLCPPPVKKRKRKCLLL 170 180 190 >>CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 (192 aa) initn: 787 init1: 787 opt: 797 Z-score: 943.4 bits: 181.5 E(32554): 3.2e-46 Smith-Waterman score: 797; 60.8% identity (83.1% similar) in 189 aa overlap (20-205:2-190) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV . .::::::::::::::::.::...::::::.:::::.:.. CCDS11 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSA 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK .: : :: :::.::::::::..:::::::.:::::::::.:.:::..::. .: ::.. CCDS11 NVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ ::.: .:.::..::::: :. :: : :.:: .:. .:. ::. ::::::::: CCDS11 HHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHP---KKKKKRCSEGHSCCSII .:::.:::::: ... : :: :.:. CCDS11 RGLKTVFDEAIRAVLCPPPVKKPGKKCTVF 170 180 190 >>CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 (192 aa) initn: 804 init1: 764 opt: 777 Z-score: 920.0 bits: 177.1 E(32554): 6.3e-45 Smith-Waterman score: 777; 59.8% identity (82.5% similar) in 189 aa overlap (20-205:2-190) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV . .::::::::::::::::.::...::::::.:::::.:.. CCDS13 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSA 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK .: : .: :::.::::::::..:::::::.:::::::::.:.::::.::. .: ::.. CCDS13 NVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ : .: .:.::..::::: :. .: : :.:: .:. ::: : . ::::::::: CCDS13 HHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHP---KKKKKRCSEGHSCCSII .:::.:::::: ... : ...:. :: CCDS13 RGLKTVFDEAIRAVLCPQPTRQQKRACSLL 170 180 190 >>CCDS7748.1 RHOG gene_id:391|Hs108|chr11 (191 aa) initn: 667 init1: 652 opt: 666 Z-score: 790.1 bits: 153.1 E(32554): 1.1e-37 Smith-Waterman score: 666; 53.4% identity (76.7% similar) in 189 aa overlap (22-210:4-188) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV .::::::::::::::::. :...::: ::.:::::.:.. CCDS77 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSA 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK .: :. :.:.::::::.:..:: ::::.:.::.::::...: ::.::...: ::. CCDS77 QSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ : :: .:.::. ::: .: :: :: . . :.: ..: ::: : : ::::::: : CCDS77 HHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQ 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPKKKKKRCSEGHSCCSII :.: :: ::. ....: :. :.:: CCDS77 DGVKEVFAEAVRAVLNPTPIKR----GRSCILL 170 180 190 >>CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 (258 aa) initn: 656 init1: 635 opt: 660 Z-score: 781.3 bits: 151.9 E(32554): 3.4e-37 Smith-Waterman score: 660; 50.2% identity (76.1% similar) in 205 aa overlap (6-203:34-238) 10 20 30 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKT : .. : :. : . .:::.::::::::: CCDS15 QQGDPAFPDRCEAPPVPPRRERGGRGGRGPGEPGGRGRAGGAEGRGVKCVLVGDGAVGKT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 CLLMSYANDAFPGEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDV :..::.....: ::.::.::.....:.: :. : : :::::.....:::: : :::. CCDS15 SLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 FLICFSVVNPASYHNVQEEWVPELKDCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPL ::.:::::.:.:..::.:.::::.. :..: .:.::: :::.: :.: .: ::::. CCDS15 FLLCFSVVSPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPV 130 140 150 160 170 180 160 170 180 190 200 pF1KB4 TYEHGVKLAKAIGAQCYLECSALTQKGLKAVFDEAIL-------TIFHPKKKKKRCSEGH : . :. : : :.::::::::.:: ::: ::. : .:::.:.: CCDS15 PEEAAKLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKSRTPDKM 190 200 210 220 230 240 210 pF1KB4 SCCSII CCDS15 KNLSKSWWKKYCCFV 250 >>CCDS2795.1 RHOA gene_id:387|Hs108|chr3 (193 aa) initn: 635 init1: 619 opt: 632 Z-score: 750.3 bits: 145.7 E(32554): 1.8e-35 Smith-Waterman score: 632; 50.3% identity (77.3% similar) in 181 aa overlap (23-203:7-187) 10 20 30 40 50 60 pF1KB4 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPGEYVPTVFDHYAV : :.::::: ::::::. ...: :: ::::::..:.. CCDS27 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA 10 20 30 40 70 80 90 100 110 120 pF1KB4 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK . : ::: :.:.::::::::..:::::::.:::.:.:::. .: : .:. :.:.::.: CCDS27 DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVK 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ :.:: .:.:.. :::.: .: .: ::..:. :.: .:. ::: :.:::: :. CCDS27 HFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTK 110 120 130 140 150 160 190 200 210 pF1KB4 KGLKAVFDEAILTIFHPKKKKKRCSEGHSCCSII :.. ::. : . .. .. ::. CCDS27 DGVREVFEMATRAALQARRGKKKSGCLVL 170 180 190 214 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:48:03 2016 done: Fri Nov 4 02:48:03 2016 Total Scan time: 1.860 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]