FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4017, 464 aa 1>>>pF1KB4017 464 - 464 aa - 464 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5887+/-0.000871; mu= 16.8260+/- 0.052 mean_var=80.2896+/-15.401, 0's: 0 Z-trim(108.1): 23 B-trim: 114 in 1/49 Lambda= 0.143135 statistics sampled from 9953 (9966) to 9953 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.306), width: 16 Scan time: 3.040 The best scores are: opt bits E(32554) CCDS47816.1 GFRA2 gene_id:2675|Hs108|chr8 ( 464) 3198 670.1 1.4e-192 CCDS55208.1 GFRA2 gene_id:2675|Hs108|chr8 ( 359) 2372 499.4 2.4e-141 CCDS55207.1 GFRA2 gene_id:2675|Hs108|chr8 ( 331) 2204 464.7 6.4e-131 CCDS44481.1 GFRA1 gene_id:2674|Hs108|chr10 ( 465) 1443 307.7 1.7e-83 CCDS7593.1 GFRA1 gene_id:2674|Hs108|chr10 ( 460) 1436 306.2 4.6e-83 CCDS13055.1 GFRA4 gene_id:64096|Hs108|chr20 ( 269) 617 136.9 2.4e-32 CCDS4201.1 GFRA3 gene_id:2676|Hs108|chr5 ( 400) 574 128.2 1.6e-29 CCDS13056.1 GFRA4 gene_id:64096|Hs108|chr20 ( 299) 343 80.4 2.8e-15 CCDS4957.1 GFRAL gene_id:389400|Hs108|chr6 ( 394) 283 68.1 1.9e-11 >>CCDS47816.1 GFRA2 gene_id:2675|Hs108|chr8 (464 aa) initn: 3198 init1: 3198 opt: 3198 Z-score: 3571.2 bits: 670.1 E(32554): 1.4e-192 Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464) 10 20 30 40 50 60 pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM 370 380 390 400 410 420 430 440 450 460 pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL :::::::::::::::::::::::::::::::::::::::::::: CCDS47 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL 430 440 450 460 >>CCDS55208.1 GFRA2 gene_id:2675|Hs108|chr8 (359 aa) initn: 2372 init1: 2372 opt: 2372 Z-score: 2650.9 bits: 499.4 E(32554): 2.4e-141 Smith-Waterman score: 2372; 100.0% identity (100.0% similar) in 346 aa overlap (119-464:14-359) 90 100 110 120 130 140 pF1KB4 PLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGT :::::::::::::::::::::::::::::: CCDS55 MILANVFCLFFFLGEEFYEASPYEPVTSRLSDIFRLASIFSGT 10 20 30 40 150 160 170 180 190 200 pF1KB4 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB4 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB4 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB4 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB4 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP 290 300 310 320 330 340 450 460 pF1KB4 SAALTVLSVLMLKLAL :::::::::::::::: CCDS55 SAALTVLSVLMLKLAL 350 >>CCDS55207.1 GFRA2 gene_id:2675|Hs108|chr8 (331 aa) initn: 2198 init1: 2198 opt: 2204 Z-score: 2464.0 bits: 464.7 E(32554): 6.4e-131 Smith-Waterman score: 2204; 97.6% identity (98.8% similar) in 330 aa overlap (135-464:3-331) 110 120 130 140 150 160 pF1KB4 CLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDA :...: : .: :::::::::::::::::: CCDS55 MILANVFCLF-FFLGTGADPVVSAKSNHCLDA 10 20 30 170 180 190 200 210 220 pF1KB4 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB4 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB4 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB4 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB4 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL 280 290 300 310 320 330 >>CCDS44481.1 GFRA1 gene_id:2674|Hs108|chr10 (465 aa) initn: 1379 init1: 612 opt: 1443 Z-score: 1612.6 bits: 307.7 E(32554): 1.7e-83 Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452) 10 20 30 40 50 60 pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR .:::.:.. : :..::..:::::::.::. CCDS44 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF . : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:... CCDS44 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI : ::::::.::::::::.. ..: . . :.:.::::::::::.: ::: ::.:: CCDS44 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS . :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: :: CCDS44 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG ::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.:: CCDS44 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN :::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::. CCDS44 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT 300 310 320 330 340 350 370 380 390 400 410 pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE : .: : . .: : ::.. : : .. . . : :. :...: : ::.: : . CCDS44 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN 360 370 380 390 400 410 420 430 440 450 460 pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL .:... . .. .:. . : ..: :: .:. : ::.. CCDS44 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS 420 430 440 450 460 >>CCDS7593.1 GFRA1 gene_id:2674|Hs108|chr10 (460 aa) initn: 1385 init1: 612 opt: 1436 Z-score: 1604.8 bits: 306.2 E(32554): 4.6e-83 Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (38-460:27-447) 10 20 30 40 50 60 pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR .:::.:.. : :..::..:::::::.::. CCDS75 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF . : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:... CCDS75 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI : ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.:: CCDS75 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS . :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: :: CCDS75 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG ::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.:: CCDS75 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN :::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::. CCDS75 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT 290 300 310 320 330 340 370 380 390 400 410 pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE : .: : . .: : ::.. : : .. . . : :. :...: : ::.: : . CCDS75 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN 350 360 370 380 390 400 420 430 440 450 460 pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL .:... . .. .:. . : ..: :: .:. : ::.. CCDS75 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS 410 420 430 440 450 460 >>CCDS13055.1 GFRA4 gene_id:64096|Hs108|chr20 (269 aa) initn: 505 init1: 249 opt: 617 Z-score: 694.1 bits: 136.9 E(32554): 2.4e-32 Smith-Waterman score: 617; 43.0% identity (69.1% similar) in 207 aa overlap (155-358:20-222) 130 140 150 160 170 180 pF1KB4 ASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISI :. .:.:.:::.::. . :..::: :.. CCDS13 MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQ 10 20 30 40 190 200 210 220 230 240 pF1KB4 C-NREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSY : .: . : : .:..:::.:: : : :. .::: : :::::::::..:::.. CCDS13 CLGRAAQGG--CPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAF 50 60 70 80 90 100 250 260 270 280 290 300 pF1KB4 EDK--EKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMI :.::. . :. ...:: :: :...: . .. .: :. :: .:::.. CCDS13 SGPGPAPPSCLEPLNFCERSRVCRPRLLAFQVSCTPAPSAPDGCLLDQGARCLRAYAGLV 110 120 130 140 150 160 310 320 330 340 350 360 pF1KB4 GFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDV : .::::::. .. :.:::.: .::: .:.:: : ::.: :: .:::::..: CCDS13 GTAVTPNYVDN--VSARVAPWCDCGASGNRREDCEAFRGLFTRNRCLDGAIQAFASGWPP 170 180 190 200 210 220 370 380 390 400 410 420 pF1KB4 NVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMC CCDS13 VLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSILPVLALPALL 230 240 250 260 >>CCDS4201.1 GFRA3 gene_id:2676|Hs108|chr5 (400 aa) initn: 538 init1: 138 opt: 574 Z-score: 643.7 bits: 128.2 E(32554): 1.6e-29 Smith-Waterman score: 733; 34.6% identity (63.2% similar) in 370 aa overlap (40-394:44-393) 10 20 30 40 50 60 pF1KB4 FFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDR :..: . : :. .::. :. : .: .. CCDS42 VLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSI-- 20 30 40 50 60 70 70 80 90 100 110 120 pF1KB4 NTMLANKE------CQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFY .: : ..: : : . :..: : : :.: ::... ::.:::..: . . :. CCDS42 STPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYEL 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB4 EASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYIS ..:::: ... . :... ... :. :: : :.:::.: .::..: CCDS42 DVSPYEDTVTSKPWKMNLSKL-------NMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGE 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC--QDQACAERRRQTILPSC :. .: .:.:. : . : ::... .. .:.: : .:..:.::::.:: :.: CCDS42 ACS---GP--HCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNC 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 SYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMI . ::::.:: .: .: ::::::.::...:. .. . .: : . . :: .: :.: CCDS42 ALPPVA-PNCLELRRLCFSDPLCRSRLVDFQTHCHP-MDILGTC-ATEQSRCLRAYLGLI 240 250 260 270 280 290 310 320 330 340 350 pF1KB4 GFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQA---FGNG : ::::.:.. :....: :.::::::..:::: . :..:::: .:: : : . CCDS42 GTAMTPNFVSNVNTSVALS--CTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 TDVNVSPKGPSF----QATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANN . :. :.: . .. : :. : .:. .: . : CCDS42 LFSQDWPH-PTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW 360 370 380 390 400 420 430 440 450 460 pF1KB4 SKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL >>CCDS13056.1 GFRA4 gene_id:64096|Hs108|chr20 (299 aa) initn: 537 init1: 216 opt: 343 Z-score: 387.7 bits: 80.4 E(32554): 2.8e-15 Smith-Waterman score: 465; 36.7% identity (58.6% similar) in 237 aa overlap (155-358:20-252) 130 140 150 160 170 180 pF1KB4 ASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISI :. .:.:.:::.::. . :..::: :.. CCDS13 MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQ 10 20 30 40 190 200 210 220 230 240 pF1KB4 C-NREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSY : .: . : : .:..:::.:: : : :. .::: : :::::::::..:::.. CCDS13 CLGRAAQGG--CPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAF 50 60 70 80 90 100 250 260 270 280 pF1KB4 EDK--EKPNCLDLRGVCRTDHLCR-SR------------LADFH--ANCRASYQTVTSC- :.::. . :. ...:: .: :. : .:: ... CCDS13 SGPGPAPPSCLEPLNFCERSRVCRCARAAAGPWRGWGRGLSPAHRPPAAQASPPGLSGLV 110 120 130 140 150 160 290 300 310 320 330 pF1KB4 -------------PADNYQACLGSYAGM-IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNM :. : : . :. : .::::::. .. :.:::.: .::: CCDS13 HPSAQRPRRLPAGPGRPLPARLRGPRGVPAGTAVTPNYVDN--VSARVAPWCDCGASGNR 170 180 190 200 210 220 340 350 360 370 380 390 pF1KB4 EEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDS .:.:: : ::.: :: .:::::..: CCDS13 REDCEAFRGLFTRNRCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRS 230 240 250 260 270 280 >>CCDS4957.1 GFRAL gene_id:389400|Hs108|chr6 (394 aa) initn: 121 init1: 68 opt: 283 Z-score: 319.0 bits: 68.1 E(32554): 1.9e-11 Smith-Waterman score: 292; 24.5% identity (52.3% similar) in 331 aa overlap (44-348:15-317) 20 30 40 50 60 70 pF1KB4 DETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLR-QCLAGRDRNTM :: . .::. : :: ::: :: : CCDS49 MIVFIFLAMGLSLENEYTSQTNNCT--Y--LREQCL--RDANG- 10 20 30 80 90 100 110 120 pF1KB4 LANKECQAALEVLQES-----PLYDCRCKRGMKKELQC-LQIYWSIHLGLTEGEEFYEAS :. : .:.... : :. :.. : :.: . .. .. : . . CCDS49 -----CKHAWRVMEDACNDSDPGDPCK----MRNSSYCNLSIQYLVESNFQFKECLCTDD 40 50 60 70 80 130 140 150 160 170 pF1KB4 PYEPVTSRLSDIFRLASIFSGTGADPV---VSAKSNH-------CLDAAKACNLNDNCKK : :.. :. . . ... : ....:.: ::..:.:: . :. CCDS49 FYCTVNKLLGK--KCINKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNA 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB4 LRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC--QDQACAERRR .::.. :. . .: :. ..:. :.: :.. .: . . . ::.: .: : . .. CCDS49 QLASYLKACSANGNP---CDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKE 150 160 170 180 190 200 240 250 260 270 280 290 pF1KB4 QTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVT-SCPADNYQAC .:. . :.::.. :..:.::: . :...: .: :: .: : . : CCDS49 ALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTFQSKC---WQRVTRKCHED--ENC 210 220 230 240 250 300 310 320 330 340 pF1KB4 LGSYAGM----IGFD-MTPNYVDSSPTGIVVSPWCSCRGSGNMEEE-CEKFLRDFTENPC ... . . : : :.: : :.. :.:: . :: :. : . . .. : CCDS49 ISTLSKQDLTCSGSDDCKAAYID--ILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSC 260 270 280 290 300 310 350 360 370 380 390 400 pF1KB4 LRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQE . CCDS49 FNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMTVTCGILLLVMVKLRTS 320 330 340 350 360 370 464 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:32:39 2016 done: Sat Nov 5 05:32:39 2016 Total Scan time: 3.040 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]