FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4020, 664 aa 1>>>pF1KB4020 664 - 664 aa - 664 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6897+/-0.00125; mu= -4.7276+/- 0.074 mean_var=395.8649+/-82.310, 0's: 0 Z-trim(111.1): 166 B-trim: 0 in 0/53 Lambda= 0.064462 statistics sampled from 11961 (12118) to 11961 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.372), width: 16 Scan time: 3.150 The best scores are: opt bits E(32554) CCDS1129.1 LMNA gene_id:4000|Hs108|chr1 ( 664) 4212 406.7 5.4e-113 CCDS72941.1 LMNA gene_id:4000|Hs108|chr1 ( 614) 3837 371.8 1.6e-102 CCDS1131.1 LMNA gene_id:4000|Hs108|chr1 ( 572) 3560 346.0 8.7e-95 CCDS58038.1 LMNA gene_id:4000|Hs108|chr1 ( 574) 3489 339.4 8.4e-93 CCDS72942.1 LMNA gene_id:4000|Hs108|chr1 ( 491) 2843 279.2 9.2e-75 CCDS4140.1 LMNB1 gene_id:4001|Hs108|chr5 ( 586) 2020 202.8 1.1e-51 CCDS12090.2 LMNB2 gene_id:84823|Hs108|chr19 ( 620) 1513 155.7 1.9e-37 >>CCDS1129.1 LMNA gene_id:4000|Hs108|chr1 (664 aa) initn: 4212 init1: 4212 opt: 4212 Z-score: 2142.1 bits: 406.7 E(32554): 5.4e-113 Smith-Waterman score: 4212; 100.0% identity (100.0% similar) in 664 aa overlap (1-664:1-664) 10 20 30 40 50 60 pF1KB4 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN 610 620 630 640 650 660 pF1KB4 CSIM :::: CCDS11 CSIM >>CCDS72941.1 LMNA gene_id:4000|Hs108|chr1 (614 aa) initn: 3837 init1: 3837 opt: 3837 Z-score: 1954.1 bits: 371.8 E(32554): 1.6e-102 Smith-Waterman score: 3837; 100.0% identity (100.0% similar) in 606 aa overlap (1-606:1-606) 10 20 30 40 50 60 pF1KB4 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN :::::: CCDS72 SGSGAQSPQNCSIM 610 >>CCDS1131.1 LMNA gene_id:4000|Hs108|chr1 (572 aa) initn: 3601 init1: 3560 opt: 3560 Z-score: 1815.2 bits: 346.0 E(32554): 8.7e-95 Smith-Waterman score: 3560; 99.8% identity (99.8% similar) in 568 aa overlap (1-568:1-568) 10 20 30 40 50 60 pF1KB4 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA :::::::::::::::::::::::::: : CCDS11 RKLVRSVTVVEDDEDEDGDDLLHHHHVSGSRR 550 560 570 >>CCDS58038.1 LMNA gene_id:4000|Hs108|chr1 (574 aa) initn: 3631 init1: 3489 opt: 3489 Z-score: 1779.5 bits: 339.4 E(32554): 8.4e-93 Smith-Waterman score: 3489; 99.8% identity (100.0% similar) in 545 aa overlap (120-664:8-552) 90 100 110 120 130 140 pF1KB4 KTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALS :::::::::::::::::::::::::::::: CCDS58 MGNSEGCNTKKEGDLIAAQARLKDLEALLNSKEAALS 10 20 30 150 160 170 180 190 200 pF1KB4 TALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKN 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB4 IYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 IYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSA 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB4 KLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 KLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLAR 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB4 ERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRL 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB4 SPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEG 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB4 KFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 KFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPP 340 350 360 370 380 390 510 520 530 540 550 560 pF1KB4 TDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSH 400 410 420 430 440 450 570 580 590 600 610 620 pF1KB4 CSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 CSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSV 460 470 480 490 500 510 630 640 650 660 pF1KB4 GGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM ::::::::::::::::::::::::::::::::::. CCDS58 GGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIIQEMGMRWEVEEGRRKVSLSCLP 520 530 540 550 560 570 >>CCDS72942.1 LMNA gene_id:4000|Hs108|chr1 (491 aa) initn: 2883 init1: 2842 opt: 2843 Z-score: 1455.7 bits: 279.2 E(32554): 9.2e-75 Smith-Waterman score: 2843; 95.6% identity (96.6% similar) in 475 aa overlap (96-568:13-487) 70 80 90 100 110 120 pF1KB4 SEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKV--REEFKELKARNTKK :.::. : . : . : . :::: CCDS72 MQPLLCLGNLEDARERTGTLLAQHPAWGRTRAKPGSPLNTKK 10 20 30 40 130 140 150 160 170 180 pF1KB4 EGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 EGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQL 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB4 QDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 QDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLAD 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB4 ALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 ALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLS 170 180 190 200 210 220 310 320 330 340 350 360 pF1KB4 AQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 AQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELL 230 240 250 260 270 280 370 380 390 400 410 420 pF1KB4 DIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 DIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLES 290 300 310 320 330 340 430 440 450 460 470 480 pF1KB4 TESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 TESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRF 350 360 370 380 390 400 490 500 510 520 530 540 pF1KB4 PPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 PPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKL 410 420 430 440 450 460 550 560 570 580 590 600 pF1KB4 VRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGS ::::::::::::::::::::::: : CCDS72 VRSVTVVEDDEDEDGDDLLHHHHVSGSRR 470 480 490 >>CCDS4140.1 LMNB1 gene_id:4001|Hs108|chr5 (586 aa) initn: 2045 init1: 1813 opt: 2020 Z-score: 1041.1 bits: 202.8 E(32554): 1.1e-51 Smith-Waterman score: 2020; 55.0% identity (82.9% similar) in 580 aa overlap (3-573:5-580) 10 20 30 40 50 pF1KB4 METP-SQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENA :: : ..:.:. .:::::::..::::::.:.:::::::::::.::::::::. CCDS41 MATATPVPPRMGSRAGG--PTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENS 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 GLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELK .:.:..:: ::: .::..:.:: ::.::.:::..::..:.:::.::.::.: . : .: CCDS41 ALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 ARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALG .:::.:: .:: .:.. :: ::::.:::.:::..:..:::.:.::. :.:.:::.:. CCDS41 LNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 EAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREF ::::: :: : .:: ::: :.. :.:.:.:..: ::. ::.:.:::::::.:.:.: :. CCDS41 AAKKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 ESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRI : .::.::.:.: ::. ::. ::.:::.:: :::.::: :.: :.. :..:.:::..::. CCDS41 EYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 RIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLD ::.:::.:::.:::. : ....::: ::.:.:.:::.:..:::::::.: .:::::. CCDS41 RIESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 EYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTK .:..:::.:::::::: :::::::::::::.:::::.:. . .:::: : :. : CCDS41 DYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGK-RK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB4 KRKLESTESRSS--FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGD . .: .:. :: .:. : ..: : .::.: .:::.::.: :..:: ::.:.. :. :: CCDS41 RVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB4 DPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTG . .:.. ...:::::.::::::.::.: ::::::.:: ::.:: :..... : :: : CCDS41 TSV-SYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQG 480 490 500 510 520 530 540 550 560 570 580 pF1KB4 EEVAMRKLVRSVTVVEDDEDED---G---DDLLHHHHGSHCSSSGDPAEYNLRSRTVLCG ::::.:. : ..:. :..:.:. : .. : :..:. .:. CCDS41 EEVAQRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM 540 550 560 570 580 590 600 610 620 630 640 pF1KB4 TCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLG >>CCDS12090.2 LMNB2 gene_id:84823|Hs108|chr19 (620 aa) initn: 2005 init1: 1495 opt: 1513 Z-score: 786.0 bits: 155.7 E(32554): 1.9e-37 Smith-Waterman score: 1996; 53.4% identity (80.5% similar) in 599 aa overlap (1-573:21-614) 10 20 30 40 pF1KB4 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELND : :: :: :. : :::::::..::::::.:.:::: CCDS12 MSPPSPGRRREQRRPRAAATMATPLPGRA---GGPA--TPLSPTRLSRLQEKEELRELND 10 20 30 40 50 50 60 70 80 90 100 pF1KB4 RLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERA ::: ::::::.:: :: : :.:.:.:::..:::::::: ::.::.:::..:: .:.::: CCDS12 RLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB4 RLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG :::.:..:.: :. :.. :.::.: .::.:.::::.:.. .:. :..:::.:: ::. CCDS12 RLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLES 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB4 ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKR .. .::.:.:: : . . :::::. : : ::: ::: :...:::::.:... ::.:::.: CCDS12 DVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB4 RHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAER ::: ::::.:...:.:.. ..:.::.:::.::..::. :: :::.::.::::.:. :... CCDS12 RHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB4 NSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAE :.. ..::.:::...:.:..::: ::: :::: .: : ..:.::...: ::: :..: CCDS12 NDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB4 KEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRG ::.::.::: ::::: :::::::.::::::::.:::::::::::::.:::::.:. . . CCDS12 KEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVS 360 370 380 390 400 410 410 420 430 440 pF1KB4 RASSHSSQT---QGGGSVTKKRKLESTESRSS----------------FSQHARTSGRVA ::.: :: . : . .:...:: : .: ..:.: .:: :. CCDS12 RATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB4 VEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAG .::.: :::::.:.:.:..:::.:::.:::: . ..:.: ::. :.:::.::.:::: CCDS12 IEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAG 480 490 500 510 520 530 510 520 530 540 550 pF1KB4 AGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDED---- ::..::::. ::::.:..:: :.:.::.:.:. ::::::: . .: .. :... :. CCDS12 AGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEE 540 550 560 570 580 590 560 570 580 590 600 610 pF1KB4 ---GDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSG :.. : :..:. ..: CCDS12 AEFGEEDLFHQQGDPRTTSRGCYVM 600 610 620 664 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:14:47 2016 done: Thu Nov 3 14:14:47 2016 Total Scan time: 3.150 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]