FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4033, 1262 aa 1>>>pF1KB4033 1262 - 1262 aa - 1262 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4423+/-0.00123; mu= 21.6383+/- 0.074 mean_var=62.6507+/-12.486, 0's: 0 Z-trim(99.6): 36 B-trim: 18 in 1/49 Lambda= 0.162036 statistics sampled from 5770 (5788) to 5770 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.528), E-opt: 0.2 (0.178), width: 16 Scan time: 4.890 The best scores are: opt bits E(32554) CCDS6694.1 IARS gene_id:3376|Hs108|chr9 (1262) 8407 1975.1 0 CCDS1523.1 IARS2 gene_id:55699|Hs108|chr1 (1012) 1050 255.2 6.2e-67 >>CCDS6694.1 IARS gene_id:3376|Hs108|chr9 (1262 aa) initn: 8407 init1: 8407 opt: 8407 Z-score: 10608.3 bits: 1975.1 E(32554): 0 Smith-Waterman score: 8407; 100.0% identity (100.0% similar) in 1262 aa overlap (1-1262:1-1262) 10 20 30 40 50 60 pF1KB4 MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 AGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 AGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 RAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 FSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 EMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 ENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 ENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 EVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 EVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 NMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 NMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 IGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 IGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 PFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 PFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 MSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 MSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 RFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 PRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 PRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 YQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 YQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 IPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 IPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMV 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 LGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 LGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 FEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 FEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 YLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 YLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPAC 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 AYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 AYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQN 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB4 QTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 QTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB4 GQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 GQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTA 1210 1220 1230 1240 1250 1260 pF1KB4 DF :: CCDS66 DF >>CCDS1523.1 IARS2 gene_id:55699|Hs108|chr1 (1012 aa) initn: 764 init1: 235 opt: 1050 Z-score: 1315.1 bits: 255.2 E(32554): 6.2e-67 Smith-Waterman score: 1052; 29.1% identity (54.7% similar) in 919 aa overlap (1-858:65-923) 10 20 pF1KB4 MLQQVPENINFPAEEEKILEFWTEFNC-FQ .: :. ... .... :. . .: :. CCDS15 GATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFS 40 50 60 70 80 90 30 40 50 60 70 80 pF1KB4 ECL---KQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWD : .. : : .: ..::::.:.: :: :: : .:::..:. ..: .. ::: CCDS15 ELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWD 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB4 CHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDN :::::.: .. . :: : .... : : .. :... . ::. : : :..: CCDS15 CHGLPIEIKVLSELG-REAQNLSAM---EIRKKARSFAKAAIEKQKSAFIRWGIMADWNN 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB4 DYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSV : :. .. . .: :.::::::::. : . .: . : :.. : . : . :. :. CCDS15 CYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSR-SI 220 230 240 250 260 210 220 230 240 250 pF1KB4 FVTFPL-----------EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRL .: ::: . . ::...::: :::.:.: ::: :: .:. .: : : CCDS15 YVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDL 270 280 290 300 310 320 260 270 280 290 300 310 pF1KB4 LILMEARLSALYK-LESDYEILERFPGAYLK-GKKYRPLFDYFLKCKENGAFTVLVDNYV .: ..... . ::. .: . . :. :. : .::. . : .: :.: CCDS15 YVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIP-------DKASPLLPANHV 330 340 350 360 370 380 320 330 340 350 360 370 pF1KB4 KEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPV-CPVDASGCFTTEVTDFAGQYVKD .:::.:: :: : ::: : . : ::. : :: .: :: : :: ... CCDS15 TMAKGTGLVHTAPAHGMEDYGVASQHN------LPMDCLVDEDGVFT----DVAGPELQN 390 400 410 420 430 380 390 400 410 420 pF1KB4 ------ADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQL . .:. :. :: ..::::. ::. :.. .: .::. . CCDS15 KAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINI------- 440 450 460 470 480 430 440 450 460 470 pF1KB4 LRNNDLCYWVPELVREKRF--GNWLK------DARD-WTISRNRYWGTPIPLWVSDDFEE .:. . ::... .: :. :. : : : :::.: ::.:::.. .: CCDS15 ---TDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDE 490 500 510 520 530 540 480 490 500 510 520 pF1KB4 VVCIGS-----VAELEELSGAKIS-DLHRESVDHLTIPSRCG-KGSLHRI--SEVFDCWF . :.: ...: : :. : : :.. . :. : .:. . ....: :: CCDS15 YL-INSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWF 550 560 570 580 590 600 530 540 550 560 570 580 pF1KB4 ESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVI .::. .. : : ..: ::. :: :: ::: . :. ..: . :.:.:: CCDS15 DSGT-SWSYV-LPGPDQR-------ADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVI 610 620 630 640 650 590 600 610 620 630 pF1KB4 VNGLVLASDGQKMSKRKKN--YPDPV-------SIIQKYGADALRLYLINSPVVRAENLR :.:..:. :.:::: : .:: : : ::::.:: .. .: : . CCDS15 VHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIG 660 670 680 690 700 710 640 650 660 670 680 690 pF1KB4 FKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSF .: .. .: . :. :::. :: .. : ... .. . :...: . CCDS15 ---PSVLNAARDDISKLRNTLRFLLGNVADFNPE-------TDSIPVNDMYVIDQYMLHL 720 730 740 750 760 700 710 720 730 740 750 pF1KB4 MQSLIGFFETEMAAYRLYTVVPRLVK--FVDILTNWYVRMNRRRL--KGENGME--DCVM .:.: . . ::. . : ::.. .. :.:.: . . :: . :: . .: CCDS15 LQDLANKI-TELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQT 770 780 790 800 810 820 760 770 780 790 800 810 pF1KB4 ALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREEL :: ...:.. : .:: : :.: ..:.. . .: :: .: . .. CCDS15 ALVEILDVIV---RSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIW----KKPG 830 840 850 860 870 820 830 840 850 860 pF1KB4 IDKKTESAVSQMQSVIEL--GRVIRDRKTIPIKYP--LKEIVVIHQDPEALKDIKSLEKY ... .::: .. .: . :. . :.: . : : ::. . :. : CCDS15 LEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELM 880 890 900 910 920 930 870 880 890 900 910 920 pF1KB4 IIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQK CCDS15 MASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYT 940 950 960 970 980 990 1262 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:03:26 2016 done: Fri Nov 4 23:03:27 2016 Total Scan time: 4.890 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]