FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4054, 138 aa 1>>>pF1KB4054 138 - 138 aa - 138 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3554+/-0.00027; mu= 3.9632+/- 0.017 mean_var=134.9604+/-26.616, 0's: 0 Z-trim(123.7): 32 B-trim: 0 in 0/58 Lambda= 0.110400 statistics sampled from 43946 (43978) to 43946 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.831), E-opt: 0.2 (0.516), width: 16 Scan time: 5.360 The best scores are: opt bits E(85289) NP_006529 (OMIM: 603827) bcl-2-like protein 11 iso ( 138) 965 163.3 1.1e-40 XP_005263610 (OMIM: 603827) PREDICTED: bcl-2-like ( 232) 965 163.4 1.7e-40 XP_005263618 (OMIM: 603827) PREDICTED: bcl-2-like ( 146) 757 130.2 1.1e-30 XP_005263609 (OMIM: 603827) PREDICTED: bcl-2-like ( 240) 757 130.3 1.7e-30 NP_619529 (OMIM: 603827) bcl-2-like protein 11 iso ( 109) 748 128.7 2.4e-30 NP_619527 (OMIM: 603827) bcl-2-like protein 11 iso ( 198) 678 117.7 8.7e-27 XP_005263608 (OMIM: 603827) PREDICTED: bcl-2-like ( 292) 678 117.8 1.2e-26 NP_001191042 (OMIM: 603827) bcl-2-like protein 11 ( 98) 519 92.2 2.1e-19 NP_001191041 (OMIM: 603827) bcl-2-like protein 11 ( 80) 509 90.5 5.3e-19 NP_001191040 (OMIM: 603827) bcl-2-like protein 11 ( 75) 508 90.3 5.6e-19 NP_996885 (OMIM: 603827) bcl-2-like protein 11 iso ( 112) 508 90.5 7.8e-19 XP_016858590 (OMIM: 603827) PREDICTED: bcl-2-like ( 169) 508 90.6 1.1e-18 XP_011508766 (OMIM: 603827) PREDICTED: bcl-2-like ( 206) 508 90.6 1.3e-18 XP_005263614 (OMIM: 603827) PREDICTED: bcl-2-like ( 206) 470 84.6 8.4e-17 XP_005263613 (OMIM: 603827) PREDICTED: bcl-2-like ( 206) 470 84.6 8.4e-17 XP_005263607 (OMIM: 603827) PREDICTED: bcl-2-like ( 300) 470 84.7 1.1e-16 NP_001191035 (OMIM: 603827) bcl-2-like protein 11 ( 108) 460 82.8 1.5e-16 NP_001191037 (OMIM: 603827) bcl-2-like protein 11 ( 172) 462 83.2 1.8e-16 NP_619528 (OMIM: 603827) bcl-2-like protein 11 iso ( 169) 461 83.1 1.9e-16 XP_005263616 (OMIM: 603827) PREDICTED: bcl-2-like ( 202) 460 83.0 2.5e-16 NP_619533 (OMIM: 603827) bcl-2-like protein 11 iso ( 45) 287 55.0 1.5e-08 NP_619532 (OMIM: 603827) bcl-2-like protein 11 iso ( 135) 293 56.3 1.8e-08 NP_619530 (OMIM: 603827) bcl-2-like protein 11 iso ( 135) 293 56.3 1.8e-08 NP_001191038 (OMIM: 603827) bcl-2-like protein 11 ( 140) 293 56.3 1.9e-08 NP_619531 (OMIM: 603827) bcl-2-like protein 11 iso ( 75) 287 55.1 2.2e-08 NP_996886 (OMIM: 603827) bcl-2-like protein 11 iso ( 79) 287 55.2 2.3e-08 NP_001191039 (OMIM: 603827) bcl-2-like protein 11 ( 82) 287 55.2 2.4e-08 NP_001191036 (OMIM: 603827) bcl-2-like protein 11 ( 85) 287 55.2 2.4e-08 XP_005263611 (OMIM: 603827) PREDICTED: bcl-2-like ( 229) 293 56.4 2.8e-08 XP_016858591 (OMIM: 603827) PREDICTED: bcl-2-like ( 116) 287 55.3 3.2e-08 XP_011508763 (OMIM: 603827) PREDICTED: bcl-2-like ( 266) 293 56.4 3.2e-08 XP_005263612 (OMIM: 603827) PREDICTED: bcl-2-like ( 210) 287 55.4 5.1e-08 >>NP_006529 (OMIM: 603827) bcl-2-like protein 11 isoform (138 aa) initn: 965 init1: 965 opt: 965 Z-score: 851.2 bits: 163.3 E(85289): 1.1e-40 Smith-Waterman score: 965; 100.0% identity (100.0% similar) in 138 aa overlap (1-138:1-138) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR 70 80 90 100 110 120 130 pF1KB4 MVILRLLRYIVRLVWRMH :::::::::::::::::: NP_006 MVILRLLRYIVRLVWRMH 130 >>XP_005263610 (OMIM: 603827) PREDICTED: bcl-2-like prot (232 aa) initn: 965 init1: 965 opt: 965 Z-score: 847.9 bits: 163.4 E(85289): 1.7e-40 Smith-Waterman score: 965; 100.0% identity (100.0% similar) in 138 aa overlap (1-138:95-232) 10 20 30 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRP :::::::::::::::::::::::::::::: XP_005 RRRARAGRRGAWSLARTLRSEGKARTKKDQMAKQPSDVSSECDREGRQLQPAERPPQLRP 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB4 GAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQ 130 140 150 160 170 180 100 110 120 130 pF1KB4 ELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH 190 200 210 220 230 >>XP_005263618 (OMIM: 603827) PREDICTED: bcl-2-like prot (146 aa) initn: 790 init1: 755 opt: 757 Z-score: 671.8 bits: 130.2 E(85289): 1.1e-30 Smith-Waterman score: 757; 84.7% identity (89.3% similar) in 131 aa overlap (1-131:1-131) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR :::::::::::::::::::::::::::::::::::::::::::::::.. . : : XP_005 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVMMFSLPAFLLTPS 70 80 90 100 110 120 130 pF1KB4 MVILRLLRYIVRLVWRMH : ... : XP_005 PSTLYFFKKTVTSCNYMLILEMITVA 130 140 >>XP_005263609 (OMIM: 603827) PREDICTED: bcl-2-like prot (240 aa) initn: 804 init1: 755 opt: 757 Z-score: 668.7 bits: 130.3 E(85289): 1.7e-30 Smith-Waterman score: 757; 84.7% identity (89.3% similar) in 131 aa overlap (1-131:95-225) 10 20 30 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRP :::::::::::::::::::::::::::::: XP_005 RRRARAGRRGAWSLARTLRSEGKARTKKDQMAKQPSDVSSECDREGRQLQPAERPPQLRP 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB4 GAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQ 130 140 150 160 170 180 100 110 120 130 pF1KB4 ELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH :::::::::::::::::.. . : : : ... : XP_005 ELRRIGDEFNAYYARRVMMFSLPAFLLTPSPSTLYFFKKTVTSCNYMLILEMITVA 190 200 210 220 230 240 >>NP_619529 (OMIM: 603827) bcl-2-like protein 11 isoform (109 aa) initn: 783 init1: 748 opt: 748 Z-score: 665.9 bits: 128.7 E(85289): 2.4e-30 Smith-Waterman score: 748; 99.1% identity (100.0% similar) in 107 aa overlap (1-107:1-107) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR ::::::::::::::::::::::::::::::::::::::::::::::. NP_619 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRLEK 70 80 90 100 130 pF1KB4 MVILRLLRYIVRLVWRMH >>NP_619527 (OMIM: 603827) bcl-2-like protein 11 isoform (198 aa) initn: 951 init1: 678 opt: 678 Z-score: 601.9 bits: 117.7 E(85289): 8.7e-27 Smith-Waterman score: 678; 100.0% identity (100.0% similar) in 97 aa overlap (42-138:102-198) 20 30 40 50 60 70 pF1KB4 CDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM :::::::::::::::::::::::::::::: NP_619 PFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB4 ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_619 ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV 140 150 160 170 180 190 pF1KB4 RLVWRMH ::::::: NP_619 RLVWRMH >-- initn: 299 init1: 287 opt: 293 Z-score: 270.5 bits: 56.4 E(85289): 2.5e-08 Smith-Waterman score: 293; 71.6% identity (76.1% similar) in 67 aa overlap (1-60:1-67) 10 20 30 40 50 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPM-----SCDK-ST ::::::::::::::::::::::::::::::::::::::::: . :: . : NP_619 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 QTP-SPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQ : : .:: NP_619 QGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPP 70 80 90 100 110 120 >>XP_005263608 (OMIM: 603827) PREDICTED: bcl-2-like prot (292 aa) initn: 951 init1: 678 opt: 678 Z-score: 599.4 bits: 117.8 E(85289): 1.2e-26 Smith-Waterman score: 678; 100.0% identity (100.0% similar) in 97 aa overlap (42-138:196-292) 20 30 40 50 60 70 pF1KB4 CDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM :::::::::::::::::::::::::::::: XP_005 PFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM 170 180 190 200 210 220 80 90 100 110 120 130 pF1KB4 ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV 230 240 250 260 270 280 pF1KB4 RLVWRMH ::::::: XP_005 RLVWRMH 290 >-- initn: 295 init1: 287 opt: 293 Z-score: 268.0 bits: 56.5 E(85289): 3.4e-08 Smith-Waterman score: 293; 71.6% identity (76.1% similar) in 67 aa overlap (1-60:95-161) 10 20 30 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRP :::::::::::::::::::::::::::::: XP_005 RRRARAGRRGAWSLARTLRSEGKARTKKDQMAKQPSDVSSECDREGRQLQPAERPPQLRP 70 80 90 100 110 120 40 50 60 70 80 pF1KB4 GAPTSLQTEPQDRSPAPM-----SCDK-STQTP-SPPCQAFNHYLSAMASMRQAEPADMR ::::::::::: . :: . : : : .:: XP_005 GAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLS 130 140 150 160 170 180 90 100 110 120 130 pF1KB4 PEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH XP_005 RSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQ 190 200 210 220 230 240 >>NP_001191042 (OMIM: 603827) bcl-2-like protein 11 isof (98 aa) initn: 508 init1: 508 opt: 519 Z-score: 469.5 bits: 92.2 E(85289): 2.1e-19 Smith-Waterman score: 519; 80.2% identity (87.5% similar) in 96 aa overlap (1-90:1-96) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 CQAFNHYLSAM-----ASMRQAEPADMR-PEIWIAQELRRIGDEFNAYYARRVFLNNYQA ::::::::::: .:.: : ... : :.:. NP_001 CQAFNHYLSAMDDSAGSSLRIALHREVQWPLKWLAKSS 70 80 90 120 130 pF1KB4 AEDHPRMVILRLLRYIVRLVWRMH >>NP_001191041 (OMIM: 603827) bcl-2-like protein 11 isof (80 aa) initn: 508 init1: 508 opt: 509 Z-score: 462.1 bits: 90.5 E(85289): 5.3e-19 Smith-Waterman score: 509; 93.6% identity (96.2% similar) in 78 aa overlap (1-78:1-76) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR ::::::::::: .:. : NP_001 CQAFNHYLSAM--VREIEEVVV 70 80 >>NP_001191040 (OMIM: 603827) bcl-2-like protein 11 isof (75 aa) initn: 508 init1: 508 opt: 508 Z-score: 461.7 bits: 90.3 E(85289): 5.6e-19 Smith-Waterman score: 508; 100.0% identity (100.0% similar) in 71 aa overlap (1-71:1-71) 10 20 30 40 50 60 pF1KB4 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR ::::::::::: NP_001 CQAFNHYLSAMGIFE 70 138 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:49:51 2016 done: Fri Nov 4 02:49:52 2016 Total Scan time: 5.360 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]