FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4062, 175 aa 1>>>pF1KB4062 175 - 175 aa - 175 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1321+/-0.000427; mu= 14.0663+/- 0.027 mean_var=90.6191+/-20.288, 0's: 0 Z-trim(112.0): 240 B-trim: 1382 in 2/48 Lambda= 0.134730 statistics sampled from 20432 (20817) to 20432 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.244), width: 16 Scan time: 5.140 The best scores are: opt bits E(85289) NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 1173 237.9 6.4e-63 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 860 177.1 1.4e-44 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 860 177.1 1.4e-44 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 856 176.3 2.3e-44 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 856 176.3 2.3e-44 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 856 176.3 2.3e-44 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 856 176.3 2.3e-44 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 809 167.1 1.3e-41 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 797 164.8 6.5e-41 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 668 139.7 2.3e-33 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 634 133.0 1.9e-31 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 632 133.1 5.1e-31 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 632 133.3 6.6e-31 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 623 131.1 1.1e-30 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 567 120.6 4.2e-27 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 567 120.6 4.2e-27 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 558 118.4 6.6e-27 NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 552 117.2 1.4e-26 NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 550 116.8 1.8e-26 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 540 115.4 1.5e-25 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 528 112.5 3.6e-25 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 527 112.4 4.3e-25 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 527 112.4 4.4e-25 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 514 109.8 2.4e-24 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 514 109.8 2.4e-24 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 504 107.9 9.8e-24 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 504 107.9 9.8e-24 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 504 107.9 9.8e-24 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 504 107.9 9.8e-24 NP_001287997 (OMIM: 603425) ADP-ribosylation facto ( 135) 478 102.7 2.5e-22 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 471 101.5 8.2e-22 XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 471 101.5 8.2e-22 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 452 97.8 1.1e-20 NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 452 97.8 1.1e-20 XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 448 97.0 1.8e-20 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 448 97.0 1.8e-20 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 448 97.0 1.8e-20 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 448 97.0 1.8e-20 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 446 96.6 2.4e-20 NP_001032251 (OMIM: 608960) ADP-ribosylation facto ( 142) 444 96.1 2.5e-20 NP_817114 (OMIM: 608960) ADP-ribosylation factor-l ( 142) 444 96.1 2.5e-20 XP_005252458 (OMIM: 608909) PREDICTED: ADP-ribosyl ( 142) 444 96.1 2.5e-20 NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 418 91.2 1e-18 NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 402 88.0 8.7e-18 XP_016862801 (OMIM: 209900,268000,600151,608845,61 ( 159) 389 85.5 4.5e-17 NP_001310443 (OMIM: 209900,268000,600151,608845,61 ( 159) 389 85.5 4.5e-17 XP_011526784 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 357 79.3 3.9e-15 XP_011526785 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 357 79.3 3.9e-15 NP_001254477 (OMIM: 604699) ADP-ribosylation facto ( 201) 357 79.3 3.9e-15 NP_003215 (OMIM: 604699) ADP-ribosylation factor-r ( 201) 357 79.3 3.9e-15 >>NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 [Ho (175 aa) initn: 1173 init1: 1173 opt: 1173 Z-score: 1250.6 bits: 237.9 E(85289): 6.4e-63 Smith-Waterman score: 1173; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 VWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIF 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 ANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS 130 140 150 160 170 >>XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosylatio (181 aa) initn: 897 init1: 836 opt: 860 Z-score: 921.6 bits: 177.1 E(85289): 1.4e-44 Smith-Waterman score: 860; 69.5% identity (90.2% similar) in 174 aa overlap (2-175:6-179) 10 20 30 40 50 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN :..:....:.:::::::.:::::::::::::::::. ::::::.::::::: ::: XP_005 MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. XP_005 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... :. XP_005 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNK 130 140 150 160 170 180 XP_005 K >>NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 [Ho (181 aa) initn: 897 init1: 836 opt: 860 Z-score: 921.6 bits: 177.1 E(85289): 1.4e-44 Smith-Waterman score: 860; 69.5% identity (90.2% similar) in 174 aa overlap (2-175:6-179) 10 20 30 40 50 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN :..:....:.:::::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... :. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNK 130 140 150 160 170 180 NP_001 K >>NP_001019398 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 876 init1: 851 opt: 856 Z-score: 917.4 bits: 176.3 E(85289): 2.3e-44 Smith-Waterman score: 856; 67.6% identity (88.3% similar) in 179 aa overlap (1-175:1-179) 10 20 30 40 50 pF1KB4 MGKVLSKIF----GNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ::......: :.:::::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... .. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001019397 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 876 init1: 851 opt: 856 Z-score: 917.4 bits: 176.3 E(85289): 2.3e-44 Smith-Waterman score: 856; 67.6% identity (88.3% similar) in 179 aa overlap (1-175:1-179) 10 20 30 40 50 pF1KB4 MGKVLSKIF----GNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ::......: :.:::::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... .. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 [Ho (181 aa) initn: 876 init1: 851 opt: 856 Z-score: 917.4 bits: 176.3 E(85289): 2.3e-44 Smith-Waterman score: 856; 67.6% identity (88.3% similar) in 179 aa overlap (1-175:1-179) 10 20 30 40 50 pF1KB4 MGKVLSKIF----GNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ::......: :.:::::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... .. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001019399 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 876 init1: 851 opt: 856 Z-score: 917.4 bits: 176.3 E(85289): 2.3e-44 Smith-Waterman score: 856; 67.6% identity (88.3% similar) in 179 aa overlap (1-175:1-179) 10 20 30 40 50 pF1KB4 MGKVLSKIF----GNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ::......: :.:::::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI ..:.:::::::::::::::::. .::::::::: ::.:..:::.:: :.. . :.:::. NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.::. :: .:::: .: ::::.: .:::::::::::: ::... .. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 [Ho (180 aa) initn: 840 init1: 799 opt: 809 Z-score: 868.1 bits: 167.1 E(85289): 1.3e-41 Smith-Waterman score: 809; 67.1% identity (90.4% similar) in 167 aa overlap (4-170:8-174) 10 20 30 40 50 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ..:.:::.:.:::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI . :.:::::::::::::::::. .::::::::: ::.:..:. .::...... :.:::. NP_001 ICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::.:.:: :. .:::: ..:.:.:::: .:::.: :::.:: ::. NP_001 LLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR 130 140 150 160 170 180 >>NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 [Ho (180 aa) initn: 825 init1: 783 opt: 797 Z-score: 855.5 bits: 164.8 E(85289): 6.5e-41 Smith-Waterman score: 797; 65.5% identity (88.9% similar) in 171 aa overlap (1-171:5-175) 10 20 30 40 50 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN .....:..::.:.:::::.:::::::::::::::::. ::::::.::::::: ::: NP_001 MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI . :.::::::::.:::::.::. .::::::::: ::.::.:. .::.... :.:::. NP_001 ICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQEVADELQKMLLVDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS .:.::::::::.:: :. .:::: .:.:.:::: .:::.: :::::: ::.. NP_001 LLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR 130 140 150 160 170 180 >>NP_001168 (OMIM: 603425) ADP-ribosylation factor-like (181 aa) initn: 668 init1: 668 opt: 668 Z-score: 719.9 bits: 139.7 E(85289): 2.3e-33 Smith-Waterman score: 668; 55.2% identity (84.3% similar) in 172 aa overlap (4-175:8-179) 10 20 30 40 50 pF1KB4 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN ..:..::..:::::.::::.::::::::.:..:. ::::::.::::::::::: NP_001 MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 VKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAI .::.:::.::: .::: :: ::..:...:.::: ::::: ...:: .....:.: :: NP_001 LKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 ILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS ...::::::. .:: :. ..::: ..::.: . . ::.: :: :.. ::. . :: NP_001 LVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSR 130 140 150 160 170 180 NP_001 Q 175 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:50:26 2016 done: Fri Nov 4 02:50:27 2016 Total Scan time: 5.140 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]