FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4066, 424 aa 1>>>pF1KB4066 424 - 424 aa - 424 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2585+/-0.000864; mu= 12.6224+/- 0.052 mean_var=79.3247+/-16.687, 0's: 0 Z-trim(107.6): 54 B-trim: 376 in 1/50 Lambda= 0.144003 statistics sampled from 9661 (9704) to 9661 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.298), width: 16 Scan time: 3.230 The best scores are: opt bits E(32554) CCDS3916.1 SKP2 gene_id:6502|Hs108|chr5 ( 424) 2848 601.2 6e-172 CCDS3915.1 SKP2 gene_id:6502|Hs108|chr5 ( 410) 2375 503.0 2.2e-142 CCDS58944.1 SKP2 gene_id:6502|Hs108|chr5 ( 210) 1329 285.5 3.2e-77 CCDS54560.1 FBXL2 gene_id:25827|Hs108|chr3 ( 355) 293 70.4 3.2e-12 >>CCDS3916.1 SKP2 gene_id:6502|Hs108|chr5 (424 aa) initn: 2848 init1: 2848 opt: 2848 Z-score: 3200.4 bits: 601.2 E(32554): 6e-172 Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 424 aa overlap (1-424:1-424) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK 370 380 390 400 410 420 pF1KB4 PSCL :::: CCDS39 PSCL >>CCDS3915.1 SKP2 gene_id:6502|Hs108|chr5 (410 aa) initn: 2375 init1: 2375 opt: 2375 Z-score: 2669.6 bits: 503.0 E(32554): 2.2e-142 Smith-Waterman score: 2375; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLLVTRAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK CCDS39 VRIRLDSDIGCPQTYRTSKLKSSHKLFCQHVRVICIFVCDFYFYRLVLKQ 370 380 390 400 410 >>CCDS58944.1 SKP2 gene_id:6502|Hs108|chr5 (210 aa) initn: 1329 init1: 1329 opt: 1329 Z-score: 1499.9 bits: 285.5 E(32554): 3.2e-77 Smith-Waterman score: 1329; 99.5% identity (100.0% similar) in 201 aa overlap (224-424:10-210) 200 210 220 230 240 250 pF1KB4 EVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLS .::::::::::::::::::::::::::::: CCDS58 MDQPLAEHFSTLAKNSNLVRLNLSGCSGFSEFALQTLLS 10 20 30 260 270 280 290 300 310 pF1KB4 SCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLV 40 50 60 70 80 90 320 330 340 350 360 370 pF1KB4 HLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 HLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPD 100 110 120 130 140 150 380 390 400 410 420 pF1KB4 GTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 GTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL 160 170 180 190 200 210 >>CCDS54560.1 FBXL2 gene_id:25827|Hs108|chr3 (355 aa) initn: 362 init1: 116 opt: 293 Z-score: 333.0 bits: 70.4 E(32554): 3.2e-12 Smith-Waterman score: 296; 26.6% identity (55.5% similar) in 346 aa overlap (91-421:6-324) 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV : :. .:: :::: ::: : . : . CCDS54 MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRC 10 20 30 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP . . : : :: : : :: .:: :.. :: ::.. . :. :: .:. CCDS54 AQISKAWNILALDGSNWQRIDLF--NFQTDVEGRVVEN--ISKRCG-GFL---------- 40 50 60 70 80 190 200 210 220 pF1KB4 FRVQHMDLSNSV-IEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAK---------- ....: . . . :.:. . ..: ....:.:.: ...: .:.. CCDS54 ---RKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHIQN 90 100 110 120 130 230 240 250 260 270 280 pF1KB4 -NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQ .:: :::..:: ... .. . .: ::. : :: : ..:. ..... .. : CCDS54 YCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTD--ASLTALGLNCPRLQ 140 150 160 170 180 190 290 300 310 320 330 340 pF1KB4 LNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCF-QEFFQLNYLQHLSLSRCY . .. ..: . .. :.: : .: ..:: . ... .. . : .. :: ::::.: CCDS54 ILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCE 200 210 220 230 240 250 350 360 370 380 390 400 pF1KB4 DIIPETLLELGEIPT-LKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKK : . .:.:.. . :.:. . :. : . :: ::. :: . : . . . CCDS54 LITDDGILHLSNSTCGHERLRVLEL--DNCLLITDVALEHLE-NCR---GLERLELYDCQ 260 270 280 290 300 410 420 pF1KB4 NQEIWGIKCRLTLQKPSCL . ::: :. : : CCDS54 QVTRAGIK-RMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL 310 320 330 340 350 424 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:23:26 2016 done: Thu Nov 3 21:23:27 2016 Total Scan time: 3.230 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]