FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4066, 424 aa 1>>>pF1KB4066 424 - 424 aa - 424 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3317+/-0.000375; mu= 12.3436+/- 0.023 mean_var=95.2915+/-19.473, 0's: 0 Z-trim(114.7): 88 B-trim: 0 in 0/52 Lambda= 0.131385 statistics sampled from 24657 (24747) to 24657 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.29), width: 16 Scan time: 9.670 The best scores are: opt bits E(85289) NP_005974 (OMIM: 601436) S-phase kinase-associated ( 424) 2848 550.3 3.4e-156 XP_011512384 (OMIM: 601436) PREDICTED: S-phase kin ( 358) 2375 460.6 2.8e-129 XP_011512383 (OMIM: 601436) PREDICTED: S-phase kin ( 379) 2375 460.6 3e-129 NP_116026 (OMIM: 601436) S-phase kinase-associated ( 410) 2375 460.6 3.2e-129 XP_011512385 (OMIM: 601436) PREDICTED: S-phase kin ( 255) 1688 330.3 3.4e-90 NP_001230049 (OMIM: 601436) S-phase kinase-associa ( 210) 1329 262.2 8.8e-70 XP_016865242 (OMIM: 601436) PREDICTED: S-phase kin ( 241) 1215 240.6 3.2e-63 NP_001165184 (OMIM: 605652) F-box/LRR-repeat prote ( 355) 293 66.0 1.8e-10 NP_001171835 (OMIM: 609086) F-box/LRR-repeat prote ( 404) 264 60.5 8.9e-09 XP_005257804 (OMIM: 609086) PREDICTED: F-box/LRR-r ( 441) 264 60.5 9.6e-09 XP_011512300 (OMIM: 605656) PREDICTED: F-box/LRR-r ( 444) 216 51.4 5.3e-06 NP_001265246 (OMIM: 605656) F-box/LRR-repeat prote ( 444) 216 51.4 5.3e-06 XP_016864751 (OMIM: 605656) PREDICTED: F-box/LRR-r ( 486) 216 51.4 5.7e-06 NP_036436 (OMIM: 605656) F-box/LRR-repeat protein ( 491) 216 51.5 5.8e-06 XP_016866217 (OMIM: 605654,615471) PREDICTED: F-bo ( 379) 203 48.9 2.6e-05 XP_005270207 (OMIM: 610287) PREDICTED: F-box/LRR-r ( 300) 200 48.3 3.1e-05 NP_077302 (OMIM: 610287) F-box/LRR-repeat protein ( 300) 200 48.3 3.1e-05 XP_016872120 (OMIM: 610287) PREDICTED: F-box/LRR-r ( 300) 200 48.3 3.1e-05 XP_005270208 (OMIM: 610287) PREDICTED: F-box/LRR-r ( 300) 200 48.3 3.1e-05 NP_001265645 (OMIM: 605654,615471) F-box/LRR-repea ( 621) 203 49.0 3.9e-05 XP_016866215 (OMIM: 605654,615471) PREDICTED: F-bo ( 621) 203 49.0 3.9e-05 NP_036292 (OMIM: 605654,615471) F-box/LRR-repeat p ( 621) 203 49.0 3.9e-05 XP_005270206 (OMIM: 610287) PREDICTED: F-box/LRR-r ( 387) 200 48.4 3.9e-05 NP_036294 (OMIM: 609076) F-box/LRR-repeat protein ( 539) 181 44.8 0.00062 XP_016861583 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 318) 167 42.1 0.0025 XP_005265074 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 318) 167 42.1 0.0025 XP_016861581 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 349) 167 42.1 0.0027 XP_011531861 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 349) 167 42.1 0.0027 XP_005265072 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 349) 167 42.1 0.0027 XP_016861582 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 349) 167 42.1 0.0027 XP_005265073 (OMIM: 605652) PREDICTED: F-box/LRR-r ( 349) 167 42.1 0.0027 NP_060173 (OMIM: 609079) F-box/LRR-repeat protein ( 326) 163 41.3 0.0043 >>NP_005974 (OMIM: 601436) S-phase kinase-associated pro (424 aa) initn: 2848 init1: 2848 opt: 2848 Z-score: 2925.3 bits: 550.3 E(85289): 3.4e-156 Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 424 aa overlap (1-424:1-424) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK 370 380 390 400 410 420 pF1KB4 PSCL :::: NP_005 PSCL >>XP_011512384 (OMIM: 601436) PREDICTED: S-phase kinase- (358 aa) initn: 2375 init1: 2375 opt: 2375 Z-score: 2441.8 bits: 460.6 E(85289): 2.8e-129 Smith-Waterman score: 2375; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLIQNS 310 320 330 340 350 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK >>XP_011512383 (OMIM: 601436) PREDICTED: S-phase kinase- (379 aa) initn: 2375 init1: 2375 opt: 2375 Z-score: 2441.5 bits: 460.6 E(85289): 3e-129 Smith-Waterman score: 2375; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLGHECKC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK XP_011 TRSIKNIKSKLSEEPTLTR 370 >>NP_116026 (OMIM: 601436) S-phase kinase-associated pro (410 aa) initn: 2375 init1: 2375 opt: 2375 Z-score: 2440.9 bits: 460.6 E(85289): 3.2e-129 Smith-Waterman score: 2375; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB4 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLLVTRAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK NP_116 VRIRLDSDIGCPQTYRTSKLKSSHKLFCQHVRVICIFVCDFYFYRLVLKQ 370 380 390 400 410 >>XP_011512385 (OMIM: 601436) PREDICTED: S-phase kinase- (255 aa) initn: 1688 init1: 1688 opt: 1688 Z-score: 1740.3 bits: 330.3 E(85289): 3.4e-90 Smith-Waterman score: 1688; 100.0% identity (100.0% similar) in 255 aa overlap (170-424:1-255) 140 150 160 170 180 190 pF1KB4 LDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLH :::::::::::::::::::::::::::::: XP_011 MDQPLAEHFSPFRVQHMDLSNSVIEVSTLH 10 20 30 200 210 220 230 240 250 pF1KB4 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB4 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB4 SVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLL 160 170 180 190 200 210 380 390 400 410 420 pF1KB4 KEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL ::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL 220 230 240 250 >>NP_001230049 (OMIM: 601436) S-phase kinase-associated (210 aa) initn: 1329 init1: 1329 opt: 1329 Z-score: 1373.8 bits: 262.2 E(85289): 8.8e-70 Smith-Waterman score: 1329; 99.5% identity (100.0% similar) in 201 aa overlap (224-424:10-210) 200 210 220 230 240 250 pF1KB4 EVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLS .::::::::::::::::::::::::::::: NP_001 MDQPLAEHFSTLAKNSNLVRLNLSGCSGFSEFALQTLLS 10 20 30 260 270 280 290 300 310 pF1KB4 SCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLV 40 50 60 70 80 90 320 330 340 350 360 370 pF1KB4 HLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPD 100 110 120 130 140 150 380 390 400 410 420 pF1KB4 GTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL 160 170 180 190 200 210 >>XP_016865242 (OMIM: 601436) PREDICTED: S-phase kinase- (241 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1256.1 bits: 240.6 E(85289): 3.2e-63 Smith-Waterman score: 1215; 100.0% identity (100.0% similar) in 185 aa overlap (170-354:1-185) 140 150 160 170 180 190 pF1KB4 LDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLH :::::::::::::::::::::::::::::: XP_016 MDQPLAEHFSPFRVQHMDLSNSVIEVSTLH 10 20 30 200 210 220 230 240 250 pF1KB4 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB4 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB4 SVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLL ::::::::::::::::::::::::::::::::::: XP_016 SVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLLVTRAGVRIRLDSDIGCPQTYRTSK 160 170 180 190 200 210 380 390 400 410 420 pF1KB4 KEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL XP_016 LKSSHKLFCQHVRVICIFVCDFYFYRLVLKQ 220 230 240 >>NP_001165184 (OMIM: 605652) F-box/LRR-repeat protein 2 (355 aa) initn: 362 init1: 116 opt: 293 Z-score: 309.1 bits: 66.0 E(85289): 1.8e-10 Smith-Waterman score: 296; 26.6% identity (55.5% similar) in 346 aa overlap (91-421:6-324) 70 80 90 100 110 120 pF1KB4 HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV : :. .:: :::: ::: : . : . NP_001 MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRC 10 20 30 130 140 150 160 170 180 pF1KB4 SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP . . : : :: : : :: .:: :.. :: ::.. . :. :: .:. NP_001 AQISKAWNILALDGSNWQRIDLF--NFQTDVEGRVVEN--ISKRCG-GFL---------- 40 50 60 70 80 190 200 210 220 pF1KB4 FRVQHMDLSNSV-IEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAK---------- ....: . . . :.:. . ..: ....:.:.: ...: .:.. NP_001 ---RKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHIQN 90 100 110 120 130 230 240 250 260 270 280 pF1KB4 -NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQ .:: :::..:: ... .. . .: ::. : :: : ..:. ..... .. : NP_001 YCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTD--ASLTALGLNCPRLQ 140 150 160 170 180 190 290 300 310 320 330 340 pF1KB4 LNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCF-QEFFQLNYLQHLSLSRCY . .. ..: . .. :.: : .: ..:: . ... .. . : .. :: ::::.: NP_001 ILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCE 200 210 220 230 240 250 350 360 370 380 390 400 pF1KB4 DIIPETLLELGEIPT-LKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKK : . .:.:.. . :.:. . :. : . :: ::. :: . : . . . NP_001 LITDDGILHLSNSTCGHERLRVLEL--DNCLLITDVALEHLE-NCR---GLERLELYDCQ 260 270 280 290 300 410 420 pF1KB4 NQEIWGIKCRLTLQKPSCL . ::: :. : : NP_001 QVTRAGIK-RMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL 310 320 330 340 350 >>NP_001171835 (OMIM: 609086) F-box/LRR-repeat protein 2 (404 aa) initn: 290 init1: 114 opt: 264 Z-score: 278.5 bits: 60.5 E(85289): 8.9e-09 Smith-Waterman score: 264; 28.1% identity (57.1% similar) in 310 aa overlap (100-388:28-324) 70 80 90 100 110 120 pF1KB4 LKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYR :: :::: ::: : . : . . : . : NP_001 MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNV 10 20 30 40 50 130 140 150 160 170 180 pF1KB4 LASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQP-----LAEHFSPFRVQ :: : : :: .:: ... :. ::.. . :. :: .:. . :. . .:. NP_001 LALDGSNWQRIDLF--DFQRDIEGRVVEN--ISKRCG-GFLRKLSLRGCLGVGDNALRTF 60 70 80 90 100 110 190 200 210 220 230 pF1KB4 HMDLSNSVIEVSTLHGILSQCSKLQNLS----LEGLRLS--DPI----VNTLAKN-SNLV .. : ::: .:.: :.: . :: : .: : . ...:... ..: NP_001 AQNCRN--IEVLNLNG----CTKTTDAEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLK 120 130 140 150 160 240 250 260 270 280 290 pF1KB4 RLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGY : :.::. . . ::. . . : .: :::. :...:.. . ... . . . .: :: NP_001 ALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGL-ITICRGCHKLQSLCASGC 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB4 RKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDIIPET .:. . :..: . :: : :... .: . : . . . :....: .: .: : NP_001 -SNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST 230 240 250 260 270 280 360 370 380 390 400 pF1KB4 LLELG-EIPTLKTLQVFG---IVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQE :..:. . : :..:.. :. :: .: . : : :. NP_001 LIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLK 290 300 310 320 330 340 410 420 pF1KB4 IWGIKCRLTLQKPSCL NP_001 SCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL 350 360 370 380 390 400 >>XP_005257804 (OMIM: 609086) PREDICTED: F-box/LRR-repea (441 aa) initn: 323 init1: 114 opt: 264 Z-score: 278.0 bits: 60.5 E(85289): 9.6e-09 Smith-Waterman score: 264; 28.1% identity (57.1% similar) in 310 aa overlap (100-388:65-361) 70 80 90 100 110 120 pF1KB4 LKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYR :: :::: ::: : . : . . : . : XP_005 KMAPSRDRLLHFGFKATMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 LASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQP-----LAEHFSPFRVQ :: : : :: .:: ... :. ::.. . :. :: .:. . :. . .:. XP_005 LALDGSNWQRIDLF--DFQRDIEGRVVEN--ISKRCG-GFLRKLSLRGCLGVGDNALRTF 100 110 120 130 140 190 200 210 220 230 pF1KB4 HMDLSNSVIEVSTLHGILSQCSKLQNLS----LEGLRLS--DPI----VNTLAKN-SNLV .. : ::: .:.: :.: . :: : .: : . ...:... ..: XP_005 AQNCRN--IEVLNLNG----CTKTTDAEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLK 150 160 170 180 190 200 240 250 260 270 280 290 pF1KB4 RLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGY : :.::. . . ::. . . : .: :::. :...:.. . ... . . . .: :: XP_005 ALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGL-ITICRGCHKLQSLCASGC 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB4 RKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDIIPET .:. . :..: . :: : :... .: . : . . . :....: .: .: : XP_005 -SNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST 270 280 290 300 310 320 360 370 380 390 400 pF1KB4 LLELG-EIPTLKTLQVFG---IVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQE :..:. . : :..:.. :. :: .: . : : :. XP_005 LIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLK 330 340 350 360 370 380 410 420 pF1KB4 IWGIKCRLTLQKPSCL XP_005 SCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL 390 400 410 420 430 440 424 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:23:27 2016 done: Thu Nov 3 21:23:28 2016 Total Scan time: 9.670 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]