FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4102, 715 aa 1>>>pF1KB4102 715 - 715 aa - 715 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9866+/-0.000402; mu= -4.7055+/- 0.025 mean_var=316.1945+/-66.382, 0's: 0 Z-trim(121.8): 9 B-trim: 2179 in 1/59 Lambda= 0.072127 statistics sampled from 38856 (38877) to 38856 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.754), E-opt: 0.2 (0.456), width: 16 Scan time: 14.720 The best scores are: opt bits E(85289) NP_909119 (OMIM: 606671) NCK-interacting protein w ( 715) 4706 503.6 1.1e-141 NP_057537 (OMIM: 606671) NCK-interacting protein w ( 722) 4682 501.1 6.3e-141 XP_016862084 (OMIM: 606671) PREDICTED: NCK-interac ( 755) 4273 458.6 4.2e-128 XP_016862083 (OMIM: 606671) PREDICTED: NCK-interac ( 762) 4249 456.1 2.4e-127 XP_016862089 (OMIM: 606671) PREDICTED: NCK-interac ( 637) 4198 450.7 8.2e-126 XP_016862088 (OMIM: 606671) PREDICTED: NCK-interac ( 644) 4174 448.2 4.7e-125 XP_016862087 (OMIM: 606671) PREDICTED: NCK-interac ( 677) 3765 405.7 3.2e-112 XP_016862086 (OMIM: 606671) PREDICTED: NCK-interac ( 684) 3741 403.2 1.8e-111 XP_016862085 (OMIM: 606671) PREDICTED: NCK-interac ( 684) 3741 403.2 1.8e-111 >>NP_909119 (OMIM: 606671) NCK-interacting protein with (715 aa) initn: 4706 init1: 4706 opt: 4706 Z-score: 2664.7 bits: 503.6 E(85289): 1.1e-141 Smith-Waterman score: 4706; 100.0% identity (100.0% similar) in 715 aa overlap (1-715:1-715) 10 20 30 40 50 60 pF1KB4 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPPPPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPPPPVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 RRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 RRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 RRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 RRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 MALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 MALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 VCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 VCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVEL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 ARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 ARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 EQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 EQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 PQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 PQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAI 610 620 630 640 650 660 670 680 690 700 710 pF1KB4 VRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_909 VRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS 670 680 690 700 710 >>NP_057537 (OMIM: 606671) NCK-interacting protein with (722 aa) initn: 3645 init1: 3645 opt: 4682 Z-score: 2651.1 bits: 501.1 E(85289): 6.3e-141 Smith-Waterman score: 4682; 99.0% identity (99.0% similar) in 722 aa overlap (1-715:1-722) 10 20 30 40 50 60 pF1KB4 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIP-------PQPRRAAPT :::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_057 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 TPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 PTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 KAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 VEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 LTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 SVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 GLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 VRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEY 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 LSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEA 670 680 690 700 710 720 pF1KB4 PS :: NP_057 PS >>XP_016862084 (OMIM: 606671) PREDICTED: NCK-interacting (755 aa) initn: 4366 init1: 4270 opt: 4273 Z-score: 2420.8 bits: 458.6 E(85289): 4.2e-128 Smith-Waterman score: 4273; 98.5% identity (99.4% similar) in 662 aa overlap (1-662:1-661) 10 20 30 40 50 60 pF1KB4 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPPPPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPPPPVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 RRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 RRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 MALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 VCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVEL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 ARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 EQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 PQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAI ::::::::::::::::::::::::::::::::::::::::::::::::.:. :. .:. XP_016 PQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKMRISPWSF-KAL 610 620 630 640 650 670 680 690 700 710 pF1KB4 VRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS .: XP_016 LRHLMQEGVPGCEGDSDASFGTPTPFPGRAPACLPPWCQVLCPLLTRLWTQKALVLSKPL 660 670 680 690 700 710 >>XP_016862083 (OMIM: 606671) PREDICTED: NCK-interacting (762 aa) initn: 4314 init1: 3209 opt: 4249 Z-score: 2407.3 bits: 456.1 E(85289): 2.4e-127 Smith-Waterman score: 4249; 97.5% identity (98.4% similar) in 669 aa overlap (1-662:1-668) 10 20 30 40 50 60 pF1KB4 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIP-------PQPRRAAPT :::::::::::::::::::::::::::::::::::::::::::: ::::::::: XP_016 TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 TPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 PTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 KAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 VEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 LTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 SVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 GLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 VRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:. XP_016 VRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKMRISP 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 LSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEA :. .:..: XP_016 WSF-KALLRHLMQEGVPGCEGDSDASFGTPTPFPGRAPACLPPWCQVLCPLLTRLWTQKA 670 680 690 700 710 >>XP_016862089 (OMIM: 606671) PREDICTED: NCK-interacting (637 aa) initn: 4198 init1: 4198 opt: 4198 Z-score: 2379.7 bits: 450.7 E(85289): 8.2e-126 Smith-Waterman score: 4198; 100.0% identity (100.0% similar) in 637 aa overlap (79-715:1-637) 50 60 70 80 90 100 pF1KB4 PPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRG :::::::::::::::::::::::::::::: XP_016 MRDGGKYSLEQRGVLQKLIHHRKETLSRRG 10 20 30 110 120 130 140 150 160 pF1KB4 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPR 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB4 RAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB4 GSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSL 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB4 GTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQ 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB4 VLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLE 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB4 ELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAII 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB4 STLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLL 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB4 NIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLN 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB4 RGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDK 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB4 LRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFL 580 590 600 610 620 630 710 pF1KB4 VLGEAPS ::::::: XP_016 VLGEAPS >>XP_016862088 (OMIM: 606671) PREDICTED: NCK-interacting (644 aa) initn: 3645 init1: 3645 opt: 4174 Z-score: 2366.1 bits: 448.2 E(85289): 4.7e-125 Smith-Waterman score: 4174; 98.9% identity (98.9% similar) in 644 aa overlap (79-715:1-644) 50 60 70 80 90 100 pF1KB4 PPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRG :::::::::::::::::::::::::::::: XP_016 MRDGGKYSLEQRGVLQKLIHHRKETLSRRG 10 20 30 110 120 130 140 150 160 pF1KB4 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIP---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSS 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB4 ---PQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB4 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB4 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB4 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB4 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB4 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB4 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB4 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB4 DLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVR 580 590 600 610 620 630 710 pF1KB4 EMCKEFLVLGEAPS :::::::::::::: XP_016 EMCKEFLVLGEAPS 640 >>XP_016862087 (OMIM: 606671) PREDICTED: NCK-interacting (677 aa) initn: 3858 init1: 3762 opt: 3765 Z-score: 2135.8 bits: 405.7 E(85289): 3.2e-112 Smith-Waterman score: 3765; 98.3% identity (99.3% similar) in 584 aa overlap (79-662:1-583) 50 60 70 80 90 100 pF1KB4 PPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRG :::::::::::::::::::::::::::::: XP_016 MRDGGKYSLEQRGVLQKLIHHRKETLSRRG 10 20 30 110 120 130 140 150 160 pF1KB4 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPR 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB4 RAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB4 GSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSL 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB4 GTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQ 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB4 VLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLE 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB4 ELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAII 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB4 STLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLL 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB4 NIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLN 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB4 RGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDK 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB4 LRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFL .:. :. .:..: XP_016 MRISPWSF-KALLRHLMQEGVPGCEGDSDASFGTPTPFPGRAPACLPPWCQVLCPLLTRL 580 590 600 610 620 >>XP_016862086 (OMIM: 606671) PREDICTED: NCK-interacting (684 aa) initn: 3806 init1: 3209 opt: 3741 Z-score: 2122.3 bits: 403.2 E(85289): 1.8e-111 Smith-Waterman score: 3741; 97.1% identity (98.1% similar) in 591 aa overlap (79-662:1-590) 50 60 70 80 90 100 pF1KB4 PPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRG :::::::::::::::::::::::::::::: XP_016 MRDGGKYSLEQRGVLQKLIHHRKETLSRRG 10 20 30 110 120 130 140 150 160 pF1KB4 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIP---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSS 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB4 ---PQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB4 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB4 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB4 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB4 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB4 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB4 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB4 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB4 DLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVR :::::::.:. :. .:..: XP_016 DLSPGDKMRISPWSF-KALLRHLMQEGVPGCEGDSDASFGTPTPFPGRAPACLPPWCQVL 580 590 600 610 620 >>XP_016862085 (OMIM: 606671) PREDICTED: NCK-interacting (684 aa) initn: 3806 init1: 3209 opt: 3741 Z-score: 2122.3 bits: 403.2 E(85289): 1.8e-111 Smith-Waterman score: 3741; 97.1% identity (98.1% similar) in 591 aa overlap (79-662:1-590) 50 60 70 80 90 100 pF1KB4 PPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRG :::::::::::::::::::::::::::::: XP_016 MRDGGKYSLEQRGVLQKLIHHRKETLSRRG 10 20 30 110 120 130 140 150 160 pF1KB4 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIP---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSS 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB4 ---PQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB4 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB4 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPA 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB4 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEG 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB4 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMC 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB4 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGT 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB4 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSE 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB4 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIA 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB4 DLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVR :::::::.:. :. .:..: XP_016 DLSPGDKMRISPWSF-KALLRHLMQEGVPGCEGDSDASFGTPTPFPGRAPACLPPWCQVL 580 590 600 610 620 715 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:25:30 2016 done: Thu Nov 3 21:25:32 2016 Total Scan time: 14.720 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]