FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4123, 468 aa 1>>>pF1KB4123 468 - 468 aa - 468 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5683+/-0.000554; mu= 11.8820+/- 0.034 mean_var=172.0384+/-40.379, 0's: 0 Z-trim(112.3): 543 B-trim: 2185 in 2/48 Lambda= 0.097783 statistics sampled from 20437 (21143) to 20437 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.248), width: 16 Scan time: 7.730 The best scores are: opt bits E(85289) NP_004058 (OMIM: 602857) beta-chimaerin isoform 2 ( 468) 3145 456.9 5.5e-128 NP_001279998 (OMIM: 602857) beta-chimaerin isoform ( 543) 3074 446.9 6.2e-125 XP_011513409 (OMIM: 602857) PREDICTED: beta-chimae ( 494) 3062 445.2 1.9e-124 XP_011513407 (OMIM: 602857) PREDICTED: beta-chimae ( 569) 3062 445.3 2.1e-124 NP_001280001 (OMIM: 602857) beta-chimaerin isoform ( 453) 3058 444.6 2.6e-124 XP_016867211 (OMIM: 602857) PREDICTED: beta-chimae ( 500) 3058 444.6 2.8e-124 XP_016867210 (OMIM: 602857) PREDICTED: beta-chimae ( 575) 3058 444.7 3.1e-124 NP_001279999 (OMIM: 602857) beta-chimaerin isoform ( 481) 3050 443.5 6e-124 XP_011513408 (OMIM: 602857) PREDICTED: beta-chimae ( 556) 3050 443.6 6.6e-124 NP_001280000 (OMIM: 602857) beta-chimaerin isoform ( 433) 2823 411.4 2.5e-114 NP_001813 (OMIM: 118423,604356) N-chimaerin isofor ( 459) 2319 340.3 6.4e-93 NP_001035025 (OMIM: 602857) beta-chimaerin isoform ( 332) 1885 279.0 1.4e-74 NP_001280002 (OMIM: 602857) beta-chimaerin isoform ( 287) 1715 254.9 2.1e-67 NP_001280010 (OMIM: 602857) beta-chimaerin isoform ( 261) 1708 253.9 4e-67 NP_001193531 (OMIM: 118423,604356) N-chimaerin iso ( 334) 1503 225.1 2.4e-58 NP_001020372 (OMIM: 118423,604356) N-chimaerin iso ( 433) 1409 211.9 2.7e-54 NP_001280005 (OMIM: 602857) beta-chimaerin isoform ( 274) 1065 163.2 8.3e-40 NP_001280009 (OMIM: 602857) beta-chimaerin isoform ( 286) 1007 155.0 2.5e-37 NP_001280008 (OMIM: 602857) beta-chimaerin isoform ( 197) 994 153.0 6.9e-37 NP_001280004 (OMIM: 602857) beta-chimaerin isoform ( 241) 837 130.9 3.7e-30 NP_001280006 (OMIM: 602857) beta-chimaerin isoform ( 260) 824 129.2 1.4e-29 NP_001280007 (OMIM: 602857) beta-chimaerin isoform ( 228) 589 95.9 1.2e-19 NP_001123537 (OMIM: 602129,609753) unconventional (2022) 463 79.3 1.1e-13 NP_004136 (OMIM: 602129,609753) unconventional myo (2157) 463 79.3 1.1e-13 XP_011519925 (OMIM: 604875) PREDICTED: unconventio (1737) 458 78.5 1.6e-13 XP_016877719 (OMIM: 604875) PREDICTED: unconventio (2547) 458 78.7 2.1e-13 NP_008832 (OMIM: 604875) unconventional myosin-IXa (2548) 458 78.7 2.1e-13 XP_011519924 (OMIM: 604875) PREDICTED: unconventio (2566) 458 78.7 2.1e-13 XP_016877718 (OMIM: 604875) PREDICTED: unconventio (2566) 458 78.7 2.1e-13 XP_011519923 (OMIM: 604875) PREDICTED: unconventio (2598) 458 78.7 2.1e-13 XP_011519922 (OMIM: 604875) PREDICTED: unconventio (2618) 458 78.7 2.1e-13 XP_006720602 (OMIM: 604875) PREDICTED: unconventio (2619) 458 78.7 2.1e-13 XP_016877717 (OMIM: 604875) PREDICTED: unconventio (2619) 458 78.7 2.1e-13 XP_011519921 (OMIM: 604875) PREDICTED: unconventio (2619) 458 78.7 2.1e-13 XP_011519920 (OMIM: 604875) PREDICTED: unconventio (2620) 458 78.7 2.1e-13 XP_011519919 (OMIM: 604875) PREDICTED: unconventio (2637) 458 78.7 2.1e-13 XP_011519918 (OMIM: 604875) PREDICTED: unconventio (2638) 458 78.7 2.1e-13 XP_011519915 (OMIM: 604875) PREDICTED: unconventio (2638) 458 78.7 2.1e-13 XP_011519916 (OMIM: 604875) PREDICTED: unconventio (2638) 458 78.7 2.1e-13 XP_011519917 (OMIM: 604875) PREDICTED: unconventio (2638) 458 78.7 2.1e-13 XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 442 75.5 3e-13 XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 442 75.5 3.2e-13 NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 443 75.8 3.4e-13 XP_011509781 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 442 75.6 3.4e-13 NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 442 75.6 3.4e-13 XP_016859988 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 442 75.6 3.4e-13 XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 443 75.8 3.5e-13 XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 443 75.9 3.8e-13 XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 443 75.9 3.9e-13 XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 443 75.9 4e-13 >>NP_004058 (OMIM: 602857) beta-chimaerin isoform 2 [Hom (468 aa) initn: 3145 init1: 3145 opt: 3145 Z-score: 2418.8 bits: 456.9 E(85289): 5.5e-128 Smith-Waterman score: 3145; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN 370 380 390 400 410 420 430 440 450 460 pF1KB4 FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF :::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 430 440 450 460 >>NP_001279998 (OMIM: 602857) beta-chimaerin isoform 3 [ (543 aa) initn: 3074 init1: 3074 opt: 3074 Z-score: 2363.9 bits: 446.9 E(85289): 6.2e-125 Smith-Waterman score: 3074; 99.6% identity (99.8% similar) in 457 aa overlap (12-468:87-543) 10 20 30 40 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPK :: .:::::::::::::::::::::::::: NP_001 LASPGFTFGKRVVFDSHCLKRQHTFADGLHSSCTSDAEEYQPPIWKSYLYQLQQEAPRPK 60 70 80 90 100 110 50 60 70 80 90 100 pF1KB4 RIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQ 120 130 140 150 160 170 110 120 130 140 150 160 pF1KB4 TLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATL 180 190 200 210 220 230 170 180 190 200 210 220 pF1KB4 LREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHT 240 250 260 270 280 290 230 240 250 260 270 280 pF1KB4 FRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTT 300 310 320 330 340 350 290 300 310 320 330 340 pF1KB4 LVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANV 360 370 380 390 400 410 350 360 370 380 390 400 pF1KB4 YPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYE 420 430 440 450 460 470 410 420 430 440 450 460 pF1KB4 TLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILI 480 490 500 510 520 530 pF1KB4 ENEDVLF ::::::: NP_001 ENEDVLF 540 >>XP_011513409 (OMIM: 602857) PREDICTED: beta-chimaerin (494 aa) initn: 3060 init1: 3060 opt: 3062 Z-score: 2355.2 bits: 445.2 E(85289): 1.9e-124 Smith-Waterman score: 3083; 94.7% identity (94.7% similar) in 494 aa overlap (1-468:1-494) 10 20 30 pF1KB4 MAASSNSSLSGSSVSS--------------------------DAEEYQPPIWKSYLYQLQ :::::::::::::::: :::::::::::::::::: XP_011 MAASSNSSLSGSSVSSVYSEPRSPRELPKSPDTQASLQFPQTDAEEYQPPIWKSYLYQLQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 QEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 ALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 HIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 YCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 ADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLML 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB4 LPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQK 430 440 450 460 470 480 460 pF1KB4 LIVQILIENEDVLF :::::::::::::: XP_011 LIVQILIENEDVLF 490 >>XP_011513407 (OMIM: 602857) PREDICTED: beta-chimaerin (569 aa) initn: 3060 init1: 3060 opt: 3062 Z-score: 2354.5 bits: 445.3 E(85289): 2.1e-124 Smith-Waterman score: 3062; 97.0% identity (98.5% similar) in 468 aa overlap (1-468:102-569) 10 20 30 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYL . : ... : . ..:::::::::::::: XP_011 SHCLKRQHTFADGLHSSCTSIYSEPRSPRELPKSPDTQASLQFPQTDAEEYQPPIWKSYL 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB4 YQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPG 140 150 160 170 180 190 100 110 120 130 140 150 pF1KB4 CYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTN 200 210 220 230 240 250 160 170 180 190 200 210 pF1KB4 PIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFN 260 270 280 290 300 310 220 230 240 250 260 270 pF1KB4 YEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKR 320 330 340 350 360 370 280 290 300 310 320 330 pF1KB4 IKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDR 380 390 400 410 420 430 340 350 360 370 380 390 pF1KB4 DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 440 450 460 470 480 490 400 410 420 430 440 450 pF1KB4 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDM 500 510 520 530 540 550 460 pF1KB4 RYQKLIVQILIENEDVLF :::::::::::::::::: XP_011 RYQKLIVQILIENEDVLF 560 >>NP_001280001 (OMIM: 602857) beta-chimaerin isoform 6 [ (453 aa) initn: 3058 init1: 3058 opt: 3058 Z-score: 2352.6 bits: 444.6 E(85289): 2.6e-124 Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 452 aa overlap (17-468:2-453) 10 20 30 40 50 60 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF :::::::::::::::::::::::::::::::::::::::::::: NP_001 MDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF 10 20 30 40 70 80 90 100 110 120 pF1KB4 HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN 350 360 370 380 390 400 430 440 450 460 pF1KB4 FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 410 420 430 440 450 >>XP_016867211 (OMIM: 602857) PREDICTED: beta-chimaerin (500 aa) initn: 3131 init1: 3058 opt: 3058 Z-score: 2352.1 bits: 444.6 E(85289): 2.8e-124 Smith-Waterman score: 3071; 93.6% identity (93.6% similar) in 500 aa overlap (1-468:1-500) 10 20 pF1KB4 MAASSNSSLSGSSVSS--------------------------------DAEEYQPPIWKS :::::::::::::::: :::::::::::: XP_016 MAASSNSSLSGSSVSSVYSEPRSPRELPKSPDTQASLQFPQTDYKLLEDAEEYQPPIWKS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB4 YLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQ 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB4 PGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB4 TNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 FNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDL 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB4 KRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAF 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB4 DRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAV 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB4 HEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLH 430 440 450 460 470 480 450 460 pF1KB4 DMRYQKLIVQILIENEDVLF :::::::::::::::::::: XP_016 DMRYQKLIVQILIENEDVLF 490 500 >>XP_016867210 (OMIM: 602857) PREDICTED: beta-chimaerin (575 aa) initn: 3058 init1: 3058 opt: 3058 Z-score: 2351.4 bits: 444.7 E(85289): 3.1e-124 Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 452 aa overlap (17-468:124-575) 10 20 30 40 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICP :::::::::::::::::::::::::::::: XP_016 SEPRSPRELPKSPDTQASLQFPQTDYKLLEDAEEYQPPIWKSYLYQLQQEAPRPKRIICP 100 110 120 130 140 150 50 60 70 80 90 100 pF1KB4 REVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYR 160 170 180 190 200 210 110 120 130 140 150 160 pF1KB4 LFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV 220 230 240 250 260 270 170 180 190 200 210 220 pF1KB4 SRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPH 280 290 300 310 320 330 230 240 250 260 270 280 pF1KB4 WCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAH 340 350 360 370 380 390 290 300 310 320 330 340 pF1KB4 NTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDIN 400 410 420 430 440 450 350 360 370 380 390 400 pF1KB4 IITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYL 460 470 480 490 500 510 410 420 430 440 450 460 pF1KB4 MIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV 520 530 540 550 560 570 pF1KB4 LF :: XP_016 LF >>NP_001279999 (OMIM: 602857) beta-chimaerin isoform 4 [ (481 aa) initn: 3050 init1: 3050 opt: 3050 Z-score: 2346.2 bits: 443.5 E(85289): 6e-124 Smith-Waterman score: 3098; 97.1% identity (97.1% similar) in 481 aa overlap (1-468:1-481) 10 20 30 40 pF1KB4 MAASSNSSLSGSSVSS-------------DAEEYQPPIWKSYLYQLQQEAPRPKRIICPR :::::::::::::::: :::::::::::::::::::::::::::::: NP_001 MAASSNSSLSGSSVSSVYSEPRSPRELPKYAEEYQPPIWKSYLYQLQQEAPRPKRIICPR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 EVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 FHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB4 RRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB4 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB4 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB4 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB4 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL 430 440 450 460 470 480 pF1KB4 F : NP_001 F >>XP_011513408 (OMIM: 602857) PREDICTED: beta-chimaerin (556 aa) initn: 3050 init1: 3050 opt: 3050 Z-score: 2345.5 bits: 443.6 E(85289): 6.6e-124 Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 451 aa overlap (18-468:106-556) 10 20 30 40 pF1KB4 MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPR :::::::::::::::::::::::::::::: XP_011 KRQHTFADGLHSSCTSIYSEPRSPRELPKYAEEYQPPIWKSYLYQLQQEAPRPKRIICPR 80 90 100 110 120 130 50 60 70 80 90 100 pF1KB4 EVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRL 140 150 160 170 180 190 110 120 130 140 150 160 pF1KB4 FHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVS 200 210 220 230 240 250 170 180 190 200 210 220 pF1KB4 RRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHW 260 270 280 290 300 310 230 240 250 260 270 280 pF1KB4 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHN 320 330 340 350 360 370 290 300 310 320 330 340 pF1KB4 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINI 380 390 400 410 420 430 350 360 370 380 390 400 pF1KB4 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLM 440 450 460 470 480 490 410 420 430 440 450 460 pF1KB4 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVL 500 510 520 530 540 550 pF1KB4 F : XP_011 F >>NP_001280000 (OMIM: 602857) beta-chimaerin isoform 5 [ (433 aa) initn: 2823 init1: 2823 opt: 2823 Z-score: 2173.7 bits: 411.4 E(85289): 2.5e-114 Smith-Waterman score: 2823; 100.0% identity (100.0% similar) in 420 aa overlap (49-468:14-433) 20 30 40 50 60 70 pF1KB4 EEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEG :::::::::::::::::::::::::::::: NP_001 MLKNTSLLYGNHTVENRPKYYGREFHGIISREQADELLGGVEG 10 20 30 40 80 90 100 110 120 130 pF1KB4 AYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIET 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB4 KAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVR 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB4 RAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSK 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB4 HVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFT 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB4 EHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKI 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB4 SNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRP 350 360 370 380 390 400 440 450 460 pF1KB4 PEDSTLTTLHDMRYQKLIVQILIENEDVLF :::::::::::::::::::::::::::::: NP_001 PEDSTLTTLHDMRYQKLIVQILIENEDVLF 410 420 430 468 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:39:22 2016 done: Sat Nov 5 05:39:23 2016 Total Scan time: 7.730 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]