Result of FASTA (omim) for pF1KB4146
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4146, 619 aa
  1>>>pF1KB4146 619 - 619 aa - 619 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4790+/-0.000438; mu= 18.5009+/- 0.027
 mean_var=71.2600+/-14.505, 0's: 0 Z-trim(110.5): 112  B-trim: 816 in 1/49
 Lambda= 0.151933
 statistics sampled from 18798 (18914) to 18798 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.222), width:  16
 Scan time: 10.200

The best scores are:                                      opt bits E(85289)
NP_000848 (OMIM: 139397) guanylate cyclase soluble ( 619) 4107 910.0       0
NP_001278881 (OMIM: 139397) guanylate cyclase solu ( 599) 3927 870.5       0
XP_016863622 (OMIM: 139397) PREDICTED: guanylate c ( 551) 3671 814.4       0
NP_001278884 (OMIM: 139397) guanylate cyclase solu ( 551) 3671 814.4       0
XP_016863621 (OMIM: 139397) PREDICTED: guanylate c ( 551) 3671 814.4       0
NP_001278880 (OMIM: 139397) guanylate cyclase solu ( 641) 3465 769.3       0
NP_001278883 (OMIM: 139397) guanylate cyclase solu ( 586) 2582 575.7 1.5e-163
XP_011530203 (OMIM: 139397) PREDICTED: guanylate c ( 662) 2582 575.7 1.7e-163
XP_016863619 (OMIM: 139397) PREDICTED: guanylate c ( 594) 2146 480.2  9e-135
NP_001278882 (OMIM: 139397) guanylate cyclase solu ( 594) 2146 480.2  9e-135
XP_016863620 (OMIM: 139397) PREDICTED: guanylate c ( 594) 2146 480.2  9e-135
NP_000846 (OMIM: 601244) guanylate cyclase soluble ( 732)  952 218.5 6.5e-56
XP_011530202 (OMIM: 139396,615750) PREDICTED: guan ( 455)  773 179.1 2.8e-44
NP_001124157 (OMIM: 139396,615750) guanylate cycla ( 455)  773 179.1 2.8e-44
XP_006714261 (OMIM: 139396,615750) PREDICTED: guan ( 455)  773 179.1 2.8e-44
XP_005263013 (OMIM: 139396,615750) PREDICTED: guan ( 455)  773 179.1 2.8e-44
XP_005263014 (OMIM: 139396,615750) PREDICTED: guan ( 455)  773 179.1 2.8e-44
NP_000847 (OMIM: 139396,615750) guanylate cyclase  ( 690)  773 179.2   4e-44
NP_001124154 (OMIM: 139396,615750) guanylate cycla ( 690)  773 179.2   4e-44
NP_001124156 (OMIM: 139396,615750) guanylate cycla ( 690)  773 179.2   4e-44
XP_006714259 (OMIM: 139396,615750) PREDICTED: guan ( 690)  773 179.2   4e-44
XP_006714260 (OMIM: 139396,615750) PREDICTED: guan ( 690)  773 179.2   4e-44
NP_001243378 (OMIM: 139396,615750) guanylate cycla ( 690)  773 179.2   4e-44
XP_005263012 (OMIM: 139396,615750) PREDICTED: guan ( 690)  773 179.2   4e-44
NP_001124155 (OMIM: 139396,615750) guanylate cycla ( 690)  773 179.2   4e-44
NP_001124159 (OMIM: 139396,615750) guanylate cycla ( 624)  770 178.6 5.8e-44
NP_001243353 (OMIM: 601244) guanylate cyclase solu ( 763)  746 173.3 2.6e-42
XP_005245275 (OMIM: 108960) PREDICTED: atrial natr (1035)  573 135.5 8.9e-31
NP_000897 (OMIM: 108960) atrial natriuretic peptid (1061)  573 135.5 9.1e-31
XP_016870237 (OMIM: 108961,602875,615923,616255) P ( 579)  569 134.5   1e-30
XP_016870239 (OMIM: 108961,602875,615923,616255) P ( 579)  569 134.5   1e-30
XP_016870238 (OMIM: 108961,602875,615923,616255) P ( 579)  569 134.5   1e-30
XP_011516197 (OMIM: 108961,602875,615923,616255) P ( 582)  569 134.5   1e-30
XP_016870236 (OMIM: 108961,602875,615923,616255) P ( 718)  569 134.5 1.2e-30
XP_016870235 (OMIM: 108961,602875,615923,616255) P ( 718)  569 134.5 1.2e-30
XP_011516192 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
XP_016870234 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
XP_011516195 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
XP_005251536 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
XP_011516194 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
XP_011516193 (OMIM: 108961,602875,615923,616255) P ( 721)  569 134.5 1.2e-30
NP_003986 (OMIM: 108961,602875,615923,616255) atri (1047)  569 134.6 1.6e-30
XP_005251535 (OMIM: 108961,602875,615923,616255) P (1050)  569 134.6 1.6e-30
NP_000171 (OMIM: 204000,600179,601777) retinal gua (1103)  545 129.4 6.6e-29
XP_011522118 (OMIM: 204000,600179,601777) PREDICTE (1103)  545 129.4 6.6e-29
NP_001513 (OMIM: 300041) retinal guanylyl cyclase  (1108)  537 127.6 2.2e-28
XP_011518933 (OMIM: 601330,614616,614665) PREDICTE ( 991)  514 122.6 6.7e-27
NP_004954 (OMIM: 601330,614616,614665) heat-stable (1073)  514 122.6 7.1e-27
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338)  393 95.8 2.6e-19
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563)  393 95.9   4e-19


>>NP_000848 (OMIM: 139397) guanylate cyclase soluble sub  (619 aa)
 initn: 4107 init1: 4107 opt: 4107  Z-score: 4863.3  bits: 910.0 E(85289):    0
Smith-Waterman score: 4107; 100.0% identity (100.0% similar) in 619 aa overlap (1-619:1-619)

               10        20        30        40        50        60
pF1KB4 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
              550       560       570       580       590       600

              610         
pF1KB4 VWFLSRKNTGTEETKQDDD
       :::::::::::::::::::
NP_000 VWFLSRKNTGTEETKQDDD
              610         

>>NP_001278881 (OMIM: 139397) guanylate cyclase soluble   (599 aa)
 initn: 3927 init1: 3927 opt: 3927  Z-score: 4650.3  bits: 870.5 E(85289):    0
Smith-Waterman score: 3927; 100.0% identity (100.0% similar) in 593 aa overlap (27-619:7-599)

               10        20        30        40        50        60
pF1KB4 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
                                 ::::::::::::::::::::::::::::::::::
NP_001                     MLMCFIKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
                                   10        20        30        40

               70        80        90       100       110       120
pF1KB4 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
               50        60        70        80        90       100

              130       140       150       160       170       180
pF1KB4 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
              110       120       130       140       150       160

              190       200       210       220       230       240
pF1KB4 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
              170       180       190       200       210       220

              250       260       270       280       290       300
pF1KB4 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
              230       240       250       260       270       280

              310       320       330       340       350       360
pF1KB4 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
              290       300       310       320       330       340

              370       380       390       400       410       420
pF1KB4 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
              350       360       370       380       390       400

              430       440       450       460       470       480
pF1KB4 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
              410       420       430       440       450       460

              490       500       510       520       530       540
pF1KB4 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
              470       480       490       500       510       520

              550       560       570       580       590       600
pF1KB4 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
              530       540       550       560       570       580

              610         
pF1KB4 VWFLSRKNTGTEETKQDDD
       :::::::::::::::::::
NP_001 VWFLSRKNTGTEETKQDDD
              590         

>>XP_016863622 (OMIM: 139397) PREDICTED: guanylate cycla  (551 aa)
 initn: 3671 init1: 3671 opt: 3671  Z-score: 4347.6  bits: 814.4 E(85289):    0
Smith-Waterman score: 3671; 100.0% identity (100.0% similar) in 551 aa overlap (69-619:1-551)

       40        50        60        70        80        90        
pF1KB4 VRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFL
                                     ::::::::::::::::::::::::::::::
XP_016                               MFGKMFFVFCQESGYDTILRVLGSNVREFL
                                             10        20        30

      100       110       120       130       140       150        
pF1KB4 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
              280       290       300       310       320       330

      400       410       420       430       440       450        
pF1KB4 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
              340       350       360       370       380       390

      460       470       480       490       500       510        
pF1KB4 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
              400       410       420       430       440       450

      520       530       540       550       560       570        
pF1KB4 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
              460       470       480       490       500       510

      580       590       600       610         
pF1KB4 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::::::::::::::::::::::::::::::
XP_016 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
              520       530       540       550 

>>NP_001278884 (OMIM: 139397) guanylate cyclase soluble   (551 aa)
 initn: 3671 init1: 3671 opt: 3671  Z-score: 4347.6  bits: 814.4 E(85289):    0
Smith-Waterman score: 3671; 100.0% identity (100.0% similar) in 551 aa overlap (69-619:1-551)

       40        50        60        70        80        90        
pF1KB4 VRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFL
                                     ::::::::::::::::::::::::::::::
NP_001                               MFGKMFFVFCQESGYDTILRVLGSNVREFL
                                             10        20        30

      100       110       120       130       140       150        
pF1KB4 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
              280       290       300       310       320       330

      400       410       420       430       440       450        
pF1KB4 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
              340       350       360       370       380       390

      460       470       480       490       500       510        
pF1KB4 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
              400       410       420       430       440       450

      520       530       540       550       560       570        
pF1KB4 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
              460       470       480       490       500       510

      580       590       600       610         
pF1KB4 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::::::::::::::::::::::::::::::
NP_001 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
              520       530       540       550 

>>XP_016863621 (OMIM: 139397) PREDICTED: guanylate cycla  (551 aa)
 initn: 3671 init1: 3671 opt: 3671  Z-score: 4347.6  bits: 814.4 E(85289):    0
Smith-Waterman score: 3671; 100.0% identity (100.0% similar) in 551 aa overlap (69-619:1-551)

       40        50        60        70        80        90        
pF1KB4 VRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFL
                                     ::::::::::::::::::::::::::::::
XP_016                               MFGKMFFVFCQESGYDTILRVLGSNVREFL
                                             10        20        30

      100       110       120       130       140       150        
pF1KB4 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
              280       290       300       310       320       330

      400       410       420       430       440       450        
pF1KB4 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
              340       350       360       370       380       390

      460       470       480       490       500       510        
pF1KB4 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
              400       410       420       430       440       450

      520       530       540       550       560       570        
pF1KB4 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
              460       470       480       490       500       510

      580       590       600       610         
pF1KB4 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::::::::::::::::::::::::::::::
XP_016 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
              520       530       540       550 

>>NP_001278880 (OMIM: 139397) guanylate cyclase soluble   (641 aa)
 initn: 3461 init1: 3461 opt: 3465  Z-score: 4102.6  bits: 769.3 E(85289):    0
Smith-Waterman score: 4053; 96.6% identity (96.6% similar) in 641 aa overlap (1-619:1-641)

               10        20        30        40        50        60
pF1KB4 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
               10        20        30        40        50        60

               70        80        90                              
pF1KB4 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQ---------------------
       :::::::::::::::::::::::::::::::::::::::                     
NP_001 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQKNESKHISDLHHCFLGIYLCC
               70        80        90       100       110       120

      100       110       120       130       140       150        
pF1KB4 -NLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
              130       140       150       160       170       180

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              190       200       210       220       230       240

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              250       260       270       280       290       300

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              310       320       330       340       350       360

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVL
              370       380       390       400       410       420

      400       410       420       430       440       450        
pF1KB4 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFD
              430       440       450       460       470       480

      460       470       480       490       500       510        
pF1KB4 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQ
              490       500       510       520       530       540

      520       530       540       550       560       570        
pF1KB4 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS
              550       560       570       580       590       600

      580       590       600       610         
pF1KB4 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::::::::::::::::::::::::::::::
NP_001 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
              610       620       630       640 

>>NP_001278883 (OMIM: 139397) guanylate cyclase soluble   (586 aa)
 initn: 2582 init1: 2582 opt: 2582  Z-score: 3057.1  bits: 575.7 E(85289): 1.5e-163
Smith-Waterman score: 3816; 94.7% identity (94.7% similar) in 619 aa overlap (1-619:1-586)

               10        20        30        40        50        60
pF1KB4 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
       ::::::::::::::::::::::::::::::::                            
NP_001 EEYKLTQELEILTDRLQLTLRALEDEKKKTDT----------------------------
              370       380       390                              

              430       440       450       460       470       480
pF1KB4 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----GIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
                 400       410       420       430       440       

              490       500       510       520       530       540
pF1KB4 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
       450       460       470       480       490       500       

              550       560       570       580       590       600
pF1KB4 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
       510       520       530       540       550       560       

              610         
pF1KB4 VWFLSRKNTGTEETKQDDD
       :::::::::::::::::::
NP_001 VWFLSRKNTGTEETKQDDD
       570       580      

>>XP_011530203 (OMIM: 139397) PREDICTED: guanylate cycla  (662 aa)
 initn: 2582 init1: 2582 opt: 2582  Z-score: 3056.3  bits: 575.7 E(85289): 1.7e-163
Smith-Waterman score: 3939; 93.4% identity (93.4% similar) in 651 aa overlap (1-608:1-651)

               10        20        30        40        50        60
pF1KB4 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
              310       320       330       340       350       360

              370       380       390                              
pF1KB4 EEYKLTQELEILTDRLQLTLRALEDEKKKTDT----------------------------
       ::::::::::::::::::::::::::::::::                            
XP_011 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGF
              370       380       390       400       410       420

                           400       410       420       430       
pF1KB4 ---------------LLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKH
                      :::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKH
              430       440       450       460       470       480

       440       450       460       470       480       490       
pF1KB4 ASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSIC
              490       500       510       520       530       540

       500       510       520       530       540       550       
pF1KB4 HLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTG
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KB4 EKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQD
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_011 EKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQD
              610       620       630       640       650       660

         
pF1KB4 DD
         
XP_011 DD
         

>>XP_016863619 (OMIM: 139397) PREDICTED: guanylate cycla  (594 aa)
 initn: 2146 init1: 2146 opt: 2146  Z-score: 2540.6  bits: 480.2 E(85289): 9e-135
Smith-Waterman score: 3503; 92.6% identity (92.6% similar) in 583 aa overlap (69-608:1-583)

       40        50        60        70        80        90        
pF1KB4 VRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFL
                                     ::::::::::::::::::::::::::::::
XP_016                               MFGKMFFVFCQESGYDTILRVLGSNVREFL
                                             10        20        30

      100       110       120       130       140       150        
pF1KB4 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDT------
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
XP_016 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARI
              280       290       300       310       320       330

                                                 400       410     
pF1KB4 -------------------------------------LLYSVLPPSVANELRHKRPVPAK
                                            :::::::::::::::::::::::
XP_016 QAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAK
              340       350       360       370       380       390

         420       430       440       450       460       470     
pF1KB4 RYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETV
              400       410       420       430       440       450

         480       490       500       510       520       530     
pF1KB4 GDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQ
              460       470       480       490       500       510

         540       550       560       570       580       590     
pF1KB4 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK
              520       530       540       550       560       570

         600       610         
pF1KB4 KEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::           
XP_016 KEPMQVWFLSRKNTGTEETKQDDD
              580       590    

>>NP_001278882 (OMIM: 139397) guanylate cyclase soluble   (594 aa)
 initn: 2146 init1: 2146 opt: 2146  Z-score: 2540.6  bits: 480.2 E(85289): 9e-135
Smith-Waterman score: 3503; 92.6% identity (92.6% similar) in 583 aa overlap (69-608:1-583)

       40        50        60        70        80        90        
pF1KB4 VRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFL
                                     ::::::::::::::::::::::::::::::
NP_001                               MFGKMFFVFCQESGYDTILRVLGSNVREFL
                                             10        20        30

      100       110       120       130       140       150        
pF1KB4 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIH
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KB4 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KB4 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVL
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KB4 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGL
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KB4 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDT------
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
NP_001 YLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARI
              280       290       300       310       320       330

                                                 400       410     
pF1KB4 -------------------------------------LLYSVLPPSVANELRHKRPVPAK
                                            :::::::::::::::::::::::
NP_001 QAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAK
              340       350       360       370       380       390

         420       430       440       450       460       470     
pF1KB4 RYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETV
              400       410       420       430       440       450

         480       490       500       510       520       530     
pF1KB4 GDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQ
              460       470       480       490       500       510

         540       550       560       570       580       590     
pF1KB4 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGK
              520       530       540       550       560       570

         600       610         
pF1KB4 KEPMQVWFLSRKNTGTEETKQDDD
       :::::::::::::           
NP_001 KEPMQVWFLSRKNTGTEETKQDDD
              580       590    




619 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 07:12:00 2016 done: Sat Nov  5 07:12:02 2016
 Total Scan time: 10.200 Total Display time:  0.180

Function used was FASTA [36.3.4 Apr, 2011]
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