FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4185, 385 aa 1>>>pF1KB4185 385 - 385 aa - 385 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9403+/-0.000931; mu= 13.8912+/- 0.056 mean_var=79.2941+/-15.734, 0's: 0 Z-trim(106.5): 126 B-trim: 24 in 1/50 Lambda= 0.144030 statistics sampled from 8862 (8991) to 8862 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.276), width: 16 Scan time: 2.380 The best scores are: opt bits E(32554) CCDS5063.1 NR2E1 gene_id:7101|Hs108|chr6 ( 385) 2557 541.0 6.9e-154 CCDS69165.1 NR2E1 gene_id:7101|Hs108|chr6 ( 422) 2505 530.2 1.3e-150 CCDS73750.1 NR2E3 gene_id:10002|Hs108|chr15 ( 410) 1059 229.7 3.7e-60 CCDS73751.1 NR2E3 gene_id:10002|Hs108|chr15 ( 367) 880 192.5 5.3e-49 CCDS4068.1 NR2F1 gene_id:7025|Hs108|chr5 ( 423) 552 124.4 2e-28 CCDS10375.1 NR2F2 gene_id:7026|Hs108|chr15 ( 414) 541 122.1 9.3e-28 CCDS12352.1 NR2F6 gene_id:2063|Hs108|chr19 ( 404) 540 121.8 1.1e-27 CCDS45359.1 NR2F2 gene_id:7026|Hs108|chr15 ( 261) 532 120.1 2.3e-27 CCDS45358.1 NR2F2 gene_id:7026|Hs108|chr15 ( 281) 532 120.1 2.5e-27 CCDS5234.1 ESR1 gene_id:2099|Hs108|chr6 ( 595) 476 108.6 1.5e-23 CCDS54994.1 PPARD gene_id:5467|Hs108|chr6 ( 402) 431 99.2 6.9e-21 CCDS4803.1 PPARD gene_id:5467|Hs108|chr6 ( 441) 431 99.2 7.5e-21 CCDS33669.1 PPARA gene_id:5465|Hs108|chr22 ( 468) 425 98.0 1.9e-20 CCDS2610.2 PPARG gene_id:5468|Hs108|chr3 ( 477) 393 91.3 1.9e-18 CCDS2609.1 PPARG gene_id:5468|Hs108|chr3 ( 505) 393 91.4 2e-18 CCDS3772.1 NR3C2 gene_id:4306|Hs108|chr4 ( 984) 394 91.7 3.1e-18 CCDS4804.1 PPARD gene_id:5467|Hs108|chr6 ( 361) 384 89.4 5.5e-18 CCDS68131.1 HNF4A gene_id:3172|Hs108|chr20 ( 395) 376 87.8 1.9e-17 CCDS13331.1 HNF4A gene_id:3172|Hs108|chr20 ( 417) 376 87.8 2e-17 CCDS46604.1 HNF4A gene_id:3172|Hs108|chr20 ( 442) 376 87.8 2.1e-17 CCDS74728.1 HNF4A gene_id:3172|Hs108|chr20 ( 449) 376 87.8 2.1e-17 CCDS42876.1 HNF4A gene_id:3172|Hs108|chr20 ( 452) 376 87.8 2.1e-17 CCDS46605.1 HNF4A gene_id:3172|Hs108|chr20 ( 464) 376 87.8 2.2e-17 CCDS13330.1 HNF4A gene_id:3172|Hs108|chr20 ( 474) 376 87.8 2.2e-17 CCDS1004.1 RORC gene_id:6097|Hs108|chr1 ( 518) 375 87.6 2.7e-17 CCDS72970.1 RXRG gene_id:6258|Hs108|chr1 ( 340) 371 86.7 3.4e-17 CCDS35172.1 RXRA gene_id:6256|Hs108|chr9 ( 462) 371 86.8 4.4e-17 CCDS1248.1 RXRG gene_id:6258|Hs108|chr1 ( 463) 371 86.8 4.4e-17 CCDS83303.1 HNF4G gene_id:3174|Hs108|chr8 ( 408) 369 86.3 5.3e-17 CCDS6220.2 HNF4G gene_id:3174|Hs108|chr8 ( 445) 369 86.3 5.7e-17 CCDS30856.1 RORC gene_id:6097|Hs108|chr1 ( 497) 367 85.9 8.4e-17 CCDS74905.1 NR2C2 gene_id:7182|Hs108|chr3 ( 596) 365 85.6 1.3e-16 CCDS2621.1 NR2C2 gene_id:7182|Hs108|chr3 ( 615) 365 85.6 1.3e-16 CCDS10177.1 RORA gene_id:6095|Hs108|chr15 ( 523) 362 84.9 1.8e-16 CCDS4768.1 RXRB gene_id:6257|Hs108|chr6 ( 533) 362 84.9 1.8e-16 CCDS59007.1 RXRB gene_id:6257|Hs108|chr6 ( 537) 362 84.9 1.8e-16 CCDS10178.1 RORA gene_id:6095|Hs108|chr15 ( 548) 362 84.9 1.9e-16 CCDS41821.1 NR2C1 gene_id:7181|Hs108|chr12 ( 467) 355 83.4 4.5e-16 CCDS45271.1 RORA gene_id:6095|Hs108|chr15 ( 468) 355 83.4 4.5e-16 CCDS44953.1 NR2C1 gene_id:7181|Hs108|chr12 ( 483) 355 83.4 4.6e-16 CCDS9051.1 NR2C1 gene_id:7181|Hs108|chr12 ( 603) 355 83.5 5.6e-16 CCDS10179.1 RORA gene_id:6095|Hs108|chr15 ( 556) 353 83.1 6.9e-16 CCDS6646.1 RORB gene_id:6096|Hs108|chr9 ( 459) 343 80.9 2.5e-15 CCDS42316.1 THRA gene_id:7067|Hs108|chr17 ( 410) 341 80.5 3e-15 CCDS58546.1 THRA gene_id:7067|Hs108|chr17 ( 451) 341 80.5 3.3e-15 CCDS58236.1 RARG gene_id:5916|Hs108|chr12 ( 382) 340 80.3 3.3e-15 CCDS11360.1 THRA gene_id:7067|Hs108|chr17 ( 490) 341 80.5 3.5e-15 CCDS41790.1 RARG gene_id:5916|Hs108|chr12 ( 443) 340 80.3 3.7e-15 CCDS8850.1 RARG gene_id:5916|Hs108|chr12 ( 454) 340 80.3 3.8e-15 CCDS2642.1 RARB gene_id:5915|Hs108|chr3 ( 448) 338 79.9 5e-15 >>CCDS5063.1 NR2E1 gene_id:7101|Hs108|chr6 (385 aa) initn: 2557 init1: 2557 opt: 2557 Z-score: 2876.2 bits: 541.0 E(32554): 6.9e-154 Smith-Waterman score: 2557; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385) 10 20 30 40 50 60 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS50 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE 310 320 330 340 350 360 370 380 pF1KB4 VFFKKTIGNVPITRLLSDMYKSSDI ::::::::::::::::::::::::: CCDS50 VFFKKTIGNVPITRLLSDMYKSSDI 370 380 >>CCDS69165.1 NR2E1 gene_id:7101|Hs108|chr6 (422 aa) initn: 2501 init1: 2501 opt: 2505 Z-score: 2817.2 bits: 530.2 E(32554): 1.3e-150 Smith-Waterman score: 2505; 98.2% identity (99.0% similar) in 385 aa overlap (1-385:41-422) 10 20 30 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGV . .:.: ::::::::::::::::::::: CCDS69 KEPSPRPECRADPGPGLGFPLGSGLPWPSLLESPGG---RILDIPCKVCGDRSSGKHYGV 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 YACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 YACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 ERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 PERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH 310 320 330 340 350 360 340 350 360 370 380 pF1KB4 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI 370 380 390 400 410 420 >>CCDS73750.1 NR2E3 gene_id:10002|Hs108|chr15 (410 aa) initn: 1058 init1: 377 opt: 1059 Z-score: 1193.6 bits: 229.7 E(32554): 3.7e-60 Smith-Waterman score: 1059; 44.1% identity (70.7% similar) in 392 aa overlap (4-382:38-410) 10 20 30 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC :.: . .. :.:::: :::::::.::: CCDS73 LMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSP---SLQCRVCGDSSSGKHYGIYAC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG .:::::::::.:: : :. : : :::::.:::::.::::::::...::.::::.:: CCDS73 NGCSGFFKRSVRRRLIYRCQVGA-GMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ 70 80 90 100 110 120 100 110 120 130 140 pF1KB4 PRTSTIRKQVAL-YFRGHKE---ENGAAAHFPSAALP-APAFFTAVTQLEPHGLELAAVS ::... :: : .... : :. .: :.. : .:. ..:. : : . .. CCDS73 PRSTA---QVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB4 TT-----PERQTL-VSLAQPTPKYPHE--VNGTPMYLYEVATESVCESAARLLFMSIKWA : :: ..... :..: ...: : .:. :..::::::..::: CCDS73 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL-----DSIHETSARLLFMAVKWA 190 200 210 220 230 210 220 230 240 250 260 pF1KB4 KSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNK :..:.::.: ..::..:::.:: :::.:: ::..:.:. ::: .. . . .:. CCDS73 KNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 IISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDE : ..:::...::: : .: :::::.: .: :: : : :.... . ::::. CCDS73 ASMETRVLQETISRFRALAVDPTEFACMKALVLFK--P-----ETRGLKDPEHVEALQDQ 300 310 320 330 340 330 340 350 360 370 380 pF1KB4 AQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMY .:. :... ....:.:: ::::::::::.:: :. :: .::.:::::.:. .:: ::. CCDS73 SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMF 350 360 370 380 390 400 pF1KB4 KSSDI :. CCDS73 KN 410 >>CCDS73751.1 NR2E3 gene_id:10002|Hs108|chr15 (367 aa) initn: 874 init1: 377 opt: 880 Z-score: 993.3 bits: 192.5 E(32554): 5.3e-49 Smith-Waterman score: 880; 41.8% identity (69.1% similar) in 349 aa overlap (4-339:38-367) 10 20 30 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC :.: . .. :.:::: :::::::.::: CCDS73 LMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSP---SLQCRVCGDSSSGKHYGIYAC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG .:::::::::.:: : :. : : :::::.:::::.::::::::...::.::::.:: CCDS73 NGCSGFFKRSVRRRLIYRCQVGA-GMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ 70 80 90 100 110 120 100 110 120 130 140 pF1KB4 PRTSTIRKQVAL-YFRGHKE---ENGAAAHFPSAALP-APAFFTAVTQLEPHGLELAAVS ::... :: : .... : :. .: :.. : .:. ..:. : : . .. CCDS73 PRSTA---QVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB4 TT-----PERQTL-VSLAQPTPKYPHE--VNGTPMYLYEVATESVCESAARLLFMSIKWA : :: ..... :..: ...: : .:. :..::::::..::: CCDS73 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL-----DSIHETSARLLFMAVKWA 190 200 210 220 230 210 220 230 240 250 260 pF1KB4 KSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNK :..:.::.: ..::..:::.:: :::.:: ::..:.:. ::: .. . . .:. CCDS73 KNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 IISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDE : ..:::...::: : .: :::::.: .: :: : : :.... . ::::. CCDS73 ASMETRVLQETISRFRALAVDPTEFACMKALVLFK--P-----ETRGLKDPEHVEALQDQ 300 310 320 330 340 330 340 350 360 370 380 pF1KB4 AQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMY .:. :... ....:.:: : CCDS73 SQVMLSQHSKAHHPSQPVR 350 360 >>CCDS4068.1 NR2F1 gene_id:7025|Hs108|chr5 (423 aa) initn: 951 init1: 302 opt: 552 Z-score: 624.0 bits: 124.4 E(32554): 2e-28 Smith-Waterman score: 880; 38.1% identity (65.5% similar) in 383 aa overlap (4-382:74-409) 10 20 30 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC : :: . : : ::::.::::::: ..: CCDS40 AGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTC 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG .::..:::::.::: ::.:... .::.:. :::::. :::::::.:.: ..:::. : CCDS40 EGCKSFFKRSVRRNLTYTCRANR--NCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRM 110 120 130 140 150 160 100 110 120 130 140 pF1KB4 PRTSTIRKQVALY----FRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVST : :. : :: . :: .: ... . . ::. CCDS40 PPTQPNPGQYALTNGDPLNGHCYLSG--------------YISLLLRAEPY--------- 170 180 190 150 160 170 180 190 200 pF1KB4 TPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTL :: .: . : .. . :..:: :::::: ...::...: : : CCDS40 ------------PTSRYGSQCM-QPNNIMGI--ENICELAARLLFSAVEWARNIPFFPDL 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 SLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQ .. ::. ::. .: :::::. :: ..:. . :::..:.... ..... ....:. .: CCDS40 QITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQ 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB4 EVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYI : : ... :..:..:..::: :: : :. .. .:: : .::...: .:. :. CCDS40 EQVEKLKALHVDSAEYSCLKAIVLFT-------SDACGLSDAAHIESLQEKSQCALEEYV 310 320 330 340 350 330 340 350 360 370 380 pF1KB4 HTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI ...::.:: ::::::: ::.::..: :.::..:: . .:..:: :. :: : CCDS40 RSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWP 360 370 380 390 400 410 CCDS40 YMSIQCS 420 >>CCDS10375.1 NR2F2 gene_id:7026|Hs108|chr15 (414 aa) initn: 924 init1: 312 opt: 541 Z-score: 611.8 bits: 122.1 E(32554): 9.3e-28 Smith-Waterman score: 863; 37.7% identity (67.2% similar) in 369 aa overlap (14-382:77-402) 10 20 30 40 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRS : : ::::.::::::: ..:.::..::::: CCDS10 GPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRS 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB4 IRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQV .::: .:.:... . ::.:. :::::. :::::::.:.: ..:::. : : :. . : CCDS10 VRRNLSYTCRANRN--CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQF 110 120 130 140 150 160 110 120 130 140 150 160 pF1KB4 ALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPT :: :: . : .... . . ::. : . . :: CCDS10 AL-------TNGDPLNCHSYL---SGYISLLLRAEPY----------PTSRFGSQCMQP- 170 180 190 200 170 180 190 200 210 220 pF1KB4 PKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWR ... : :..:: :::.:: ...::...: : :.. ::. ::. .: CCDS10 ----NNIMGI---------ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS 210 220 230 240 250 230 240 250 260 270 280 pF1KB4 ELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDAT :::::. :: ..:. . :::..:.... ..... ....:. .:: : ... :..:.. CCDS10 ELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSA 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB4 EFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKL :..::: :: : :. .. ..: . .::...: .:. :....::.:: ::::: CCDS10 EYSCLKAIVLFT-------SDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKL 320 330 340 350 360 350 360 370 380 pF1KB4 LLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI :: ::.::..: :.::..:: . .:..:: :. :: : CCDS10 LLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 370 380 390 400 410 >>CCDS12352.1 NR2F6 gene_id:2063|Hs108|chr19 (404 aa) initn: 846 init1: 300 opt: 540 Z-score: 610.8 bits: 121.8 E(32554): 1.1e-27 Smith-Waterman score: 858; 37.7% identity (66.5% similar) in 382 aa overlap (2-382:42-392) 10 20 30 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVY ..:. :.. : ::::.::::::::. CCDS12 GGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB4 ACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHE .:.::..::::::::: .:.:.:. . : .:. :::::. ::::::..:.: :.:::. CCDS12 TCEGCKSFFKRSIRRNLSYTCRSNRD--CQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRG 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 RGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTP : : :. ...:: :.. : . ..::.. : .: . . CCDS12 RIP---------------HSLPGAVAA---SSGSPPGSALAAVAS----GGDLFPGQPVS 130 140 150 160 160 170 180 190 200 210 pF1KB4 ERQTLVSLAQPTPKYPHEVN-GTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS : . . :.: : . . : .. ..::: :::::: ...::. .: : : CCDS12 ELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELP 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB4 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE . ::. ::. .: :::::. :: :.:. . :::..:... ... ......:.:: CCDS12 VADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQE 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB4 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH : .. .:..:..:..::: :. : .: : . . : . .::..::..:. :.. CCDS12 QVDKLGRLQVDSAEYGCLKAIALF--TPDACG-----LSDPAHVESLQEKAQVALTEYVR 290 300 310 320 330 340 340 350 360 370 380 pF1KB4 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI ..::.:: :::.::: :::::.. : : ..:: . .:..:: :. :: : CCDS12 AQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY 350 360 370 380 390 400 CCDS12 GSGQ >>CCDS45359.1 NR2F2 gene_id:7026|Hs108|chr15 (261 aa) initn: 553 init1: 312 opt: 532 Z-score: 604.7 bits: 120.1 E(32554): 2.3e-27 Smith-Waterman score: 532; 36.4% identity (71.5% similar) in 228 aa overlap (157-382:29-249) 130 140 150 160 170 180 pF1KB4 APAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYE--VATES .:: . :: :. . . .. :. CCDS45 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIEN 10 20 30 40 50 190 200 210 220 230 240 pF1KB4 VCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLA .:: :::.:: ...::...: : :.. ::. ::. .: :::::. :: ..:. . ::: CCDS45 ICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLA 60 70 80 90 100 110 250 260 270 280 290 300 pF1KB4 VSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSE ..:.... ..... ....:. .:: : ... :..:..:..::: :: : :. CCDS45 AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SD 120 130 140 150 160 170 310 320 330 340 350 360 pF1KB4 LRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFK .. ..: . .::...: .:. :....::.:: ::::::: ::.::..: :.::..:: CCDS45 ACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFV 180 190 200 210 220 230 370 380 pF1KB4 KTIGNVPITRLLSDMYKSSDI . .:..:: :. :: : CCDS45 RLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 240 250 260 >>CCDS45358.1 NR2F2 gene_id:7026|Hs108|chr15 (281 aa) initn: 581 init1: 312 opt: 532 Z-score: 604.3 bits: 120.1 E(32554): 2.5e-27 Smith-Waterman score: 532; 36.4% identity (71.5% similar) in 228 aa overlap (157-382:49-269) 130 140 150 160 170 180 pF1KB4 APAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYE--VATES .:: . :: :. . . .. :. CCDS45 GRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIEN 20 30 40 50 60 70 190 200 210 220 230 240 pF1KB4 VCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLA .:: :::.:: ...::...: : :.. ::. ::. .: :::::. :: ..:. . ::: CCDS45 ICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLA 80 90 100 110 120 130 250 260 270 280 290 300 pF1KB4 VSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSE ..:.... ..... ....:. .:: : ... :..:..:..::: :: : :. CCDS45 AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SD 140 150 160 170 180 190 310 320 330 340 350 360 pF1KB4 LRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFK .. ..: . .::...: .:. :....::.:: ::::::: ::.::..: :.::..:: CCDS45 ACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFV 200 210 220 230 240 250 370 380 pF1KB4 KTIGNVPITRLLSDMYKSSDI . .:..:: :. :: : CCDS45 RLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 260 270 280 >>CCDS5234.1 ESR1 gene_id:2099|Hs108|chr6 (595 aa) initn: 483 init1: 189 opt: 476 Z-score: 536.4 bits: 108.6 E(32554): 1.5e-23 Smith-Waterman score: 574; 32.1% identity (60.9% similar) in 371 aa overlap (16-379:185-543) 10 20 30 40 pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIR : ::.: .:: ::::..:.::..::::::. CCDS52 DNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQ 160 170 180 190 200 210 50 60 70 80 90 100 pF1KB4 RNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHER-GPRTSTIRKQVA . :.: . :: : .::..:..:.::::.:: ::.: : .....: : : ..: CCDS52 GHNDYMCPATNQ--CTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRD 220 230 240 250 260 270 110 120 130 140 150 160 pF1KB4 LYFRGH-KEENGAAAHFPSAAL-PAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQP :. . : :.:. . .: : :.: . . . . ..: :.: : .... . : CCDS52 ---DGEGRGEVGSAGDMRAANLWPSPLM---IKRSKKNSL---ALSLTADQMVSALLDAE 280 290 300 310 320 170 180 190 200 210 220 pF1KB4 TPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAW : : . : . . . : : : :.::: ::.: :.:.::. ::: :: CCDS52 PPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAW 330 340 350 360 370 380 230 240 250 260 270 280 pF1KB4 RELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDA :....:.. : . :: . .. : .... .. .. .. : . .:::.. :.. CCDS52 LEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQG 390 400 410 420 430 440 290 300 310 320 330 pF1KB4 TEFACLKCIVTFKA-VPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPT---QPC ::.::: :. ... : : .: :.:... : . :. :: . : : CCDS52 EEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQ 450 460 470 480 490 500 340 350 360 370 380 pF1KB4 RFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI :...:::.: .: .: . .:... : . ::. :: .: CCDS52 RLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEE 510 520 530 540 550 560 CCDS52 TDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 570 580 590 385 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:57:09 2016 done: Fri Nov 4 22:57:09 2016 Total Scan time: 2.380 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]