FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4203, 318 aa 1>>>pF1KB4203 318 - 318 aa - 318 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2114+/-0.00052; mu= -1.6258+/- 0.031 mean_var=695.6068+/-159.097, 0's: 0 Z-trim(117.1): 1403 B-trim: 0 in 0/58 Lambda= 0.048629 statistics sampled from 26798 (28792) to 26798 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.338), width: 16 Scan time: 7.260 The best scores are: opt bits E(85289) XP_005256780 (OMIM: 602315) PREDICTED: dual specif ( 318) 2123 164.4 2.9e-40 XP_016880347 (OMIM: 602315) PREDICTED: dual specif ( 318) 2123 164.4 2.9e-40 NP_002747 (OMIM: 602315) dual specificity mitogen- ( 318) 2123 164.4 2.9e-40 NP_001303261 (OMIM: 602315) dual specificity mitog ( 318) 2123 164.4 2.9e-40 XP_016880348 (OMIM: 602315) PREDICTED: dual specif ( 318) 2123 164.4 2.9e-40 XP_011522261 (OMIM: 602315) PREDICTED: dual specif ( 318) 2123 164.4 2.9e-40 XP_016880346 (OMIM: 602315) PREDICTED: dual specif ( 343) 2123 164.4 3e-40 NP_659731 (OMIM: 602315) dual specificity mitogen- ( 347) 2123 164.4 3e-40 NP_002749 (OMIM: 601254) dual specificity mitogen- ( 334) 1759 138.9 1.4e-32 XP_011523328 (OMIM: 601254) PREDICTED: dual specif ( 337) 1759 138.9 1.4e-32 XP_011523327 (OMIM: 601254) PREDICTED: dual specif ( 345) 1759 138.9 1.5e-32 XP_006722038 (OMIM: 601254) PREDICTED: dual specif ( 278) 1623 129.2 9.8e-30 XP_011523329 (OMIM: 601254) PREDICTED: dual specif ( 278) 1623 129.2 9.8e-30 XP_005257573 (OMIM: 601254) PREDICTED: dual specif ( 278) 1623 129.2 9.8e-30 NP_001317379 (OMIM: 601254) dual specificity mitog ( 278) 1623 129.2 9.8e-30 XP_011522260 (OMIM: 602315) PREDICTED: dual specif ( 298) 1533 122.9 8.1e-28 NP_003001 (OMIM: 601335) dual specificity mitogen- ( 399) 1147 96.1 1.3e-19 NP_001268364 (OMIM: 601335) dual specificity mitog ( 410) 1147 96.1 1.3e-19 XP_005256810 (OMIM: 601335) PREDICTED: dual specif ( 281) 1065 90.0 6e-18 XP_005256812 (OMIM: 601335) PREDICTED: dual specif ( 253) 954 82.2 1.3e-15 XP_011522279 (OMIM: 601335) PREDICTED: dual specif ( 253) 954 82.2 1.3e-15 XP_011522278 (OMIM: 601335) PREDICTED: dual specif ( 319) 909 79.2 1.3e-14 NP_660186 (OMIM: 603014) dual specificity mitogen- ( 419) 874 77.0 7.8e-14 NP_001284484 (OMIM: 603014) dual specificity mitog ( 435) 874 77.0 7.9e-14 NP_001284485 (OMIM: 603014) dual specificity mitog ( 426) 742 67.7 4.8e-11 XP_006722863 (OMIM: 603014) PREDICTED: dual specif ( 442) 742 67.7 4.9e-11 NP_001193733 (OMIM: 602520) dual specificity mitog ( 412) 638 60.4 7.4e-09 NP_660143 (OMIM: 602520) dual specificity mitogen- ( 448) 638 60.4 7.7e-09 NP_109587 (OMIM: 601263,615280) dual specificity m ( 400) 620 59.1 1.8e-08 XP_016882478 (OMIM: 601263,615280) PREDICTED: dual ( 512) 620 59.3 2e-08 XP_011520085 (OMIM: 163950,176872,615279) PREDICTE ( 371) 608 58.2 3.1e-08 NP_002746 (OMIM: 163950,176872,615279) dual specif ( 393) 608 58.2 3.1e-08 XP_006722862 (OMIM: 601263,615280) PREDICTED: dual ( 307) 504 50.7 4.4e-06 XP_016882479 (OMIM: 601263,615280) PREDICTED: dual ( 419) 504 51.0 5.1e-06 XP_016882480 (OMIM: 601263,615280) PREDICTED: dual ( 252) 494 49.9 6.6e-06 XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 496 50.5 7.8e-06 NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 496 50.6 8e-06 NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 496 50.6 8.2e-06 XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 496 50.6 8.3e-06 XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 496 50.6 8.3e-06 XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 496 50.7 8.6e-06 XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580) 496 50.7 8.6e-06 XP_011527322 (OMIM: 604965,614868) PREDICTED: seri ( 404) 492 50.1 8.9e-06 XP_005260588 (OMIM: 604965,614868) PREDICTED: seri ( 478) 492 50.3 9.6e-06 XP_016883522 (OMIM: 604965,614868) PREDICTED: seri ( 388) 490 50.0 9.7e-06 XP_005260587 (OMIM: 604965,614868) PREDICTED: seri ( 503) 492 50.3 9.9e-06 XP_005260590 (OMIM: 604965,614868) PREDICTED: seri ( 462) 490 50.1 1e-05 NP_006273 (OMIM: 604965,614868) serine/threonine-p ( 487) 490 50.1 1.1e-05 NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 495 51.0 1.1e-05 XP_016883521 (OMIM: 604965,614868) PREDICTED: seri ( 458) 480 49.4 1.7e-05 >>XP_005256780 (OMIM: 602315) PREDICTED: dual specificit (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: XP_005 TKKTDIAAFVKEILGEDS 310 >>XP_016880347 (OMIM: 602315) PREDICTED: dual specificit (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: XP_016 TKKTDIAAFVKEILGEDS 310 >>NP_002747 (OMIM: 602315) dual specificity mitogen-acti (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: NP_002 TKKTDIAAFVKEILGEDS 310 >>NP_001303261 (OMIM: 602315) dual specificity mitogen-a (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: NP_001 TKKTDIAAFVKEILGEDS 310 >>XP_016880348 (OMIM: 602315) PREDICTED: dual specificit (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: XP_016 TKKTDIAAFVKEILGEDS 310 >>XP_011522261 (OMIM: 602315) PREDICTED: dual specificit (318 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.9 bits: 164.4 E(85289): 2.9e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 250 260 270 280 290 300 310 pF1KB4 TKKTDIAAFVKEILGEDS :::::::::::::::::: XP_011 TKKTDIAAFVKEILGEDS 310 >>XP_016880346 (OMIM: 602315) PREDICTED: dual specificit (343 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.6 bits: 164.4 E(85289): 3e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:26-343) 10 20 30 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDL ::::::::::::::::::::::::::::::::::: XP_016 MNSPSLLPQRDPGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 VTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 TFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 SVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ 250 260 270 280 290 300 280 290 300 310 pF1KB4 CLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS ::::::::::::::::::::::::::::::::::::::::::: XP_016 CLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS 310 320 330 340 >>NP_659731 (OMIM: 602315) dual specificity mitogen-acti (347 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 843.6 bits: 164.4 E(85289): 3e-40 Smith-Waterman score: 2123; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:30-347) 10 20 30 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVE ::::::::::::::::::::::::::::::: NP_659 MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD 250 260 270 280 290 300 280 290 300 310 pF1KB4 FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS ::::::::::::::::::::::::::::::::::::::::::::::: NP_659 FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS 310 320 330 340 >>NP_002749 (OMIM: 601254) dual specificity mitogen-acti (334 aa) initn: 1751 init1: 1751 opt: 1759 Z-score: 705.7 bits: 138.9 E(85289): 1.4e-32 Smith-Waterman score: 1759; 82.7% identity (93.9% similar) in 312 aa overlap (5-316:23-334) 10 20 30 40 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELG : . ::::.:::.. :.::..::::.:::: : ::: NP_002 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 RGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALF :::::::::.::. :: :::::::::::::::::::::::::.:::::: .::::::::: NP_002 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 REGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDV ::::::::::::::::::::..:.::..::::::::.::::::.:::::::::::::::: NP_002 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB4 KPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDV :::::::: :.:::::::::::::::::::.::::::::::::::::::::::.::::. NP_002 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB4 WSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPA :::::::::.:::::::.:::::::::::::::::::::::.:: ::::::.:::.:: NP_002 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 250 260 270 280 290 300 290 300 310 pF1KB4 ERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS :: .: :::.:::::::..: ::.:.::: :::. NP_002 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 310 320 330 >>XP_011523328 (OMIM: 601254) PREDICTED: dual specificit (337 aa) initn: 1751 init1: 1751 opt: 1759 Z-score: 705.7 bits: 138.9 E(85289): 1.4e-32 Smith-Waterman score: 1759; 82.7% identity (93.9% similar) in 312 aa overlap (5-316:26-337) 10 20 30 pF1KB4 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTIS : . ::::.:::.. :.::..::::.:::: : XP_011 MSHRAWAEGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIM 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 ELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYG ::::::::::::.::. :: :::::::::::::::::::::::::.:::::: .:::::: XP_011 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 ALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIH :::::::::::::::::::::::..:.::..::::::::.::::::.::::::::::::: XP_011 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 RDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVK ::::::::::: :.:::::::::::::::::::.::::::::::::::::::::::.:: XP_011 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 SDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRK ::.:::::::::.:::::::.:::::::::::::::::::::::.:: ::::::.:::.: XP_011 SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKK 250 260 270 280 290 300 280 290 300 310 pF1KB4 NPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS : :: .: :::.:::::::..: ::.:.::: :::. XP_011 NSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 310 320 330 318 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:43:25 2016 done: Fri Nov 4 20:43:26 2016 Total Scan time: 7.260 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]