FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4266, 511 aa 1>>>pF1KB4266 511 - 511 aa - 511 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8940+/-0.000865; mu= 15.4284+/- 0.052 mean_var=85.5550+/-17.398, 0's: 0 Z-trim(108.0): 135 B-trim: 52 in 1/48 Lambda= 0.138660 statistics sampled from 9776 (9931) to 9776 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.305), width: 16 Scan time: 3.030 The best scores are: opt bits E(32554) CCDS7827.1 KCNC1 gene_id:3746|Hs108|chr11 ( 511) 3508 711.9 4.4e-205 CCDS44547.1 KCNC1 gene_id:3746|Hs108|chr11 ( 585) 3444 699.1 3.5e-201 CCDS44193.1 KCNC4 gene_id:3749|Hs108|chr1 ( 626) 2501 510.5 2.3e-144 CCDS821.1 KCNC4 gene_id:3749|Hs108|chr1 ( 635) 2501 510.5 2.3e-144 CCDS58255.1 KCNC2 gene_id:3747|Hs108|chr12 ( 583) 1904 391.0 1.9e-108 CCDS9006.1 KCNC2 gene_id:3747|Hs108|chr12 ( 558) 1889 388.0 1.5e-107 CCDS9005.1 KCNC2 gene_id:3747|Hs108|chr12 ( 613) 1889 388.0 1.6e-107 CCDS58257.1 KCNC2 gene_id:3747|Hs108|chr12 ( 618) 1889 388.0 1.6e-107 CCDS58256.1 KCNC2 gene_id:3747|Hs108|chr12 ( 629) 1889 388.0 1.6e-107 CCDS9007.1 KCNC2 gene_id:3747|Hs108|chr12 ( 638) 1889 388.0 1.6e-107 CCDS12793.1 KCNC3 gene_id:3748|Hs108|chr19 ( 757) 1771 364.5 2.4e-100 CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 ( 511) 639 137.9 2.6e-32 CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 ( 495) 636 137.3 3.8e-32 CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 ( 499) 631 136.3 7.6e-32 CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 ( 575) 628 135.8 1.3e-31 CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 ( 653) 626 135.4 1.9e-31 CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 ( 456) 602 130.5 3.9e-30 CCDS1809.1 KCNG3 gene_id:170850|Hs108|chr2 ( 436) 590 128.1 2e-29 CCDS6209.1 KCNB2 gene_id:9312|Hs108|chr8 ( 911) 547 119.7 1.4e-26 CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 ( 858) 542 118.7 2.7e-26 CCDS12019.1 KCNG2 gene_id:26251|Hs108|chr18 ( 466) 523 114.7 2.3e-25 CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 ( 529) 521 114.3 3.4e-25 CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 ( 613) 505 111.2 3.5e-24 CCDS42674.1 KCNG3 gene_id:170850|Hs108|chr2 ( 425) 497 109.5 7.8e-24 CCDS1676.1 KCNF1 gene_id:3754|Hs108|chr2 ( 494) 451 100.3 5.2e-21 CCDS1692.1 KCNS3 gene_id:3790|Hs108|chr2 ( 491) 405 91.1 3.1e-18 CCDS6447.1 KCNV2 gene_id:169522|Hs108|chr9 ( 545) 392 88.5 2e-17 CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 ( 356) 330 76.0 7.7e-14 CCDS13436.1 KCNG1 gene_id:3755|Hs108|chr20 ( 513) 309 71.9 1.9e-12 CCDS5776.1 KCND2 gene_id:3751|Hs108|chr7 ( 630) 310 72.2 2e-12 CCDS844.1 KCND3 gene_id:3752|Hs108|chr1 ( 636) 303 70.8 5.2e-12 CCDS843.1 KCND3 gene_id:3752|Hs108|chr1 ( 655) 303 70.8 5.4e-12 CCDS14314.1 KCND1 gene_id:3750|Hs108|chrX ( 647) 291 68.4 2.8e-11 CCDS13342.1 KCNS1 gene_id:3787|Hs108|chr20 ( 526) 286 67.3 4.7e-11 CCDS7736.1 KCNQ1 gene_id:3784|Hs108|chr11 ( 676) 285 67.2 6.7e-11 >>CCDS7827.1 KCNC1 gene_id:3746|Hs108|chr11 (511 aa) initn: 3508 init1: 3508 opt: 3508 Z-score: 3795.4 bits: 711.9 E(32554): 4.4e-205 Smith-Waterman score: 3508; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511) 10 20 30 40 50 60 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 430 440 450 460 470 480 490 500 510 pF1KB4 HSTQSDTCPLAQEEILEINRAGRKPLRGMSI ::::::::::::::::::::::::::::::: CCDS78 HSTQSDTCPLAQEEILEINRAGRKPLRGMSI 490 500 510 >>CCDS44547.1 KCNC1 gene_id:3746|Hs108|chr11 (585 aa) initn: 3528 init1: 3444 opt: 3444 Z-score: 3725.4 bits: 699.1 E(32554): 3.5e-201 Smith-Waterman score: 3444; 99.6% identity (99.6% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 430 440 450 460 470 480 490 500 510 pF1KB4 HSTQSDTCPLAQEEILEINRAGRKPLRGMSI ::::::::::::::::::::: : CCDS44 HSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTR 490 500 510 520 530 540 >>CCDS44193.1 KCNC4 gene_id:3749|Hs108|chr1 (626 aa) initn: 2488 init1: 1785 opt: 2501 Z-score: 2705.4 bits: 510.5 E(32554): 2.3e-144 Smith-Waterman score: 2501; 74.6% identity (86.1% similar) in 519 aa overlap (1-504:29-541) 10 20 30 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGT :..:. ::.:.::::::::.:::::::::::: CCDS44 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 40 50 60 70 80 pF1KB4 RLAWLAEPDAHSHFDYDPRAD-----------EFFFDRHPGVFAHILNYYRTGKLHCPAD ::::::.::. .. . : . ::::::::::::..:::::::::::::: CCDS44 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB4 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGD :::::.::::.:::::::::::::::::::::::::::: : .: :.... : ::.: CCDS44 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE-SP-DGGGSGA---GPSD 130 140 150 160 170 150 160 170 180 190 pF1KB4 -SGDGEDELEMTKRLALSDSPDGRPGGFW--RRWQPRIWALFEDPYSSRYARYVAFASLF .:: : :: . .::. .. :. .: : ::::.::::::::::: :: ::::::: CCDS44 EAGDDERELAL-QRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLF 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB4 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTF ::::::::::::::: :: : ::: : : :.:.. ::.::: .:::::::::.:::. CCDS44 FILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTL 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB4 EFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRI :::.:.. ::. ..:.:: ::::::::::::::::::::::::::.:::::::::::::: CCDS44 EFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRI 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB4 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:: . CCDS44 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB4 SEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNN ..:: :::::::::::::::::::::::::.::::::::::::::::::::::::::::: CCDS44 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN 420 430 440 450 460 470 440 450 460 470 480 490 pF1KB4 FGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILE :::::::::::::::::.:::.::: :: :: :::: .::. :: ::: : :.:: ..: CCDS44 FGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIE 480 490 500 510 520 530 500 510 pF1KB4 INRAGRKPLRGMSI .:: : CCDS44 RKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLST 540 550 560 570 580 590 >>CCDS821.1 KCNC4 gene_id:3749|Hs108|chr1 (635 aa) initn: 2488 init1: 1785 opt: 2501 Z-score: 2705.4 bits: 510.5 E(32554): 2.3e-144 Smith-Waterman score: 2501; 74.6% identity (86.1% similar) in 519 aa overlap (1-504:29-541) 10 20 30 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGT :..:. ::.:.::::::::.:::::::::::: CCDS82 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 40 50 60 70 80 pF1KB4 RLAWLAEPDAHSHFDYDPRAD-----------EFFFDRHPGVFAHILNYYRTGKLHCPAD ::::::.::. .. . : . ::::::::::::..:::::::::::::: CCDS82 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB4 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGD :::::.::::.:::::::::::::::::::::::::::: : .: :.... : ::.: CCDS82 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE-SP-DGGGSGA---GPSD 130 140 150 160 170 150 160 170 180 190 pF1KB4 -SGDGEDELEMTKRLALSDSPDGRPGGFW--RRWQPRIWALFEDPYSSRYARYVAFASLF .:: : :: . .::. .. :. .: : ::::.::::::::::: :: ::::::: CCDS82 EAGDDERELAL-QRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLF 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB4 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTF ::::::::::::::: :: : ::: : : :.:.. ::.::: .:::::::::.:::. CCDS82 FILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTL 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB4 EFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRI :::.:.. ::. ..:.:: ::::::::::::::::::::::::::.:::::::::::::: CCDS82 EFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRI 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB4 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:: . CCDS82 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB4 SEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNN ..:: :::::::::::::::::::::::::.::::::::::::::::::::::::::::: CCDS82 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN 420 430 440 450 460 470 440 450 460 470 480 490 pF1KB4 FGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILE :::::::::::::::::.:::.::: :: :: :::: .::. :: ::: : :.:: ..: CCDS82 FGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIE 480 490 500 510 520 530 500 510 pF1KB4 INRAGRKPLRGMSI .:: : CCDS82 RKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLST 540 550 560 570 580 590 >>CCDS58255.1 KCNC2 gene_id:3747|Hs108|chr12 (583 aa) initn: 2558 init1: 1555 opt: 1904 Z-score: 2060.5 bits: 391.0 E(32554): 1.9e-108 Smith-Waterman score: 2450; 70.3% identity (79.1% similar) in 556 aa overlap (7-510:7-547) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS58 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS58 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS58 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS58 PDLIG-GDPGDDED--LAAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . ::: : : :::.: : ::. :::. CCDS58 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKT--EPVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS58 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS58 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::.: . :... CCDS58 LGKDNRLLEHNRSGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL 530 540 550 560 570 580 >>CCDS9006.1 KCNC2 gene_id:3747|Hs108|chr12 (558 aa) initn: 2585 init1: 1540 opt: 1889 Z-score: 2044.5 bits: 388.0 E(32554): 1.5e-107 Smith-Waterman score: 2435; 71.1% identity (79.3% similar) in 547 aa overlap (7-501:7-538) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS90 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS90 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS90 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS90 PDLIG-GDPGDDEDL--AAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . :::: : :::.: : ::. :::. CCDS90 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS90 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS90 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS90 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::. CCDS90 LGKDNRLLEHNRSDNCKEVVITGYTQAEARSLT 530 540 550 >>CCDS9005.1 KCNC2 gene_id:3747|Hs108|chr12 (613 aa) initn: 2585 init1: 1540 opt: 1889 Z-score: 2043.9 bits: 388.0 E(32554): 1.6e-107 Smith-Waterman score: 2435; 71.1% identity (79.3% similar) in 547 aa overlap (7-501:7-538) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS90 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS90 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS90 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS90 PDLIG-GDPGDDEDL--AAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . :::: : :::.: : ::. :::. CCDS90 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS90 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS90 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS90 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::. CCDS90 LGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTC 530 540 550 560 570 580 >>CCDS58257.1 KCNC2 gene_id:3747|Hs108|chr12 (618 aa) initn: 2585 init1: 1540 opt: 1889 Z-score: 2043.9 bits: 388.0 E(32554): 1.6e-107 Smith-Waterman score: 2435; 71.1% identity (79.3% similar) in 547 aa overlap (7-501:7-538) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS58 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS58 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS58 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS58 PDLIG-GDPGDDEDL--AAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . :::: : :::.: : ::. :::. CCDS58 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS58 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS58 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::. CCDS58 LGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTC 530 540 550 560 570 580 >>CCDS58256.1 KCNC2 gene_id:3747|Hs108|chr12 (629 aa) initn: 2585 init1: 1540 opt: 1889 Z-score: 2043.8 bits: 388.0 E(32554): 1.6e-107 Smith-Waterman score: 2435; 71.1% identity (79.3% similar) in 547 aa overlap (7-501:7-538) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS58 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS58 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS58 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS58 PDLIG-GDPGDDEDL--AAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . :::: : :::.: : ::. :::. CCDS58 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS58 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS58 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::. CCDS58 LGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTC 530 540 550 560 570 580 >>CCDS9007.1 KCNC2 gene_id:3747|Hs108|chr12 (638 aa) initn: 2512 init1: 1540 opt: 1889 Z-score: 2043.7 bits: 388.0 E(32554): 1.6e-107 Smith-Waterman score: 2435; 71.1% identity (79.3% similar) in 547 aa overlap (7-501:7-538) 10 20 30 40 pF1KB4 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHS-------------H .::...:::::::.::::::.:::::::: :: :: . CCDS90 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 10 20 30 40 50 60 50 60 70 pF1KB4 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT .. ::: ::::::::::::..:::::: CCDS90 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD :::::::::::::.::::::::::::::::::::::::::::::::: : . CCDS90 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 130 140 150 160 170 140 150 160 170 180 pF1KB4 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY : : :: :: :: .:::.. :. :::. .: ::: :::.::::::::::: CCDS90 PDLIG-GDPGDDEDL--AAKRLGIEDAAGLGGPDGK-SGRWRRLQPRMWALFEDPYSSRA 180 190 200 210 220 190 200 210 220 230 240 pF1KB4 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI ::..::::::::::::::::::::: :: . :::: : :::.: : ::. :::. CCDS90 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB4 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG :::::::::::::.:..: :::.::::: ::::::::::::::::::::::::::::::: CCDS90 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS90 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB4 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI .:::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: CCDS90 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB4 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC :::::::::::::::::::::::::.:.::::: :: .::..::. .: .::::::: CCDS90 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 470 480 490 500 510 520 490 500 510 pF1KB4 PLAQEEILEINRAGRKPLRGMSI ....:: ::. CCDS90 LGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTC 530 540 550 560 570 580 511 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:45:23 2016 done: Sat Nov 5 05:45:23 2016 Total Scan time: 3.030 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]