Result of FASTA (omim) for pF1KB4308
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4308, 183 aa
  1>>>pF1KB4308 183 - 183 aa - 183 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1852+/-0.000381; mu= 8.2280+/- 0.023
 mean_var=168.3963+/-36.306, 0's: 0 Z-trim(118.2): 681  B-trim: 360 in 1/50
 Lambda= 0.098834
 statistics sampled from 29982 (30942) to 29982 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.363), width:  16
 Scan time:  5.550

The best scores are:                                      opt bits E(85289)
NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166)  332 59.9 1.6e-08
XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169)  332 59.9 1.7e-08
XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 (1223)  293 54.4   8e-07
XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695)  277 51.8 2.8e-06
XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059)  277 52.0 3.6e-06
XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187)  277 52.1 3.8e-06
XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 (1301)  274 51.7 5.4e-06
XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 (1316)  274 51.7 5.5e-06
XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 (1316)  274 51.7 5.5e-06
NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens (1327)  274 51.7 5.5e-06
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755)  258 49.6 3.2e-05
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763)  258 49.6 3.2e-05
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770)  258 49.6 3.2e-05
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797)  258 49.6 3.2e-05
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806)  258 49.6 3.2e-05
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810)  258 49.6 3.2e-05
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816)  258 49.6 3.2e-05
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818)  258 49.6 3.2e-05
XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838)  258 49.6 3.3e-05
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839)  258 49.6 3.3e-05
XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846)  258 49.6 3.3e-05
XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850)  258 49.6 3.3e-05
XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851)  258 49.6 3.3e-05
XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858)  258 49.6 3.3e-05
XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862)  258 49.6 3.3e-05
NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863)  258 49.6 3.3e-05
XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977)  254 48.7 3.3e-05
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871)  258 49.7 3.3e-05
XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871)  258 49.7 3.3e-05
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform  (1872)  258 49.7 3.3e-05
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879)  258 49.7 3.3e-05
XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881)  258 49.7 3.3e-05
XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882)  258 49.7 3.3e-05
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886)  258 49.7 3.3e-05
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887)  258 49.7 3.3e-05
XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893)  258 49.7 3.3e-05
XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898)  258 49.7 3.3e-05
XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899)  258 49.7 3.3e-05
XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902)  258 49.7 3.3e-05
XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915)  258 49.7 3.4e-05
XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917)  258 49.7 3.4e-05
XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926)  258 49.7 3.4e-05
XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931)  258 49.7 3.4e-05
XP_016863569 (OMIM: 106410,600919) PREDICTED: anky (1970)  258 49.7 3.4e-05
XP_016863568 (OMIM: 106410,600919) PREDICTED: anky (2006)  258 49.7 3.4e-05
XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020)  258 49.7 3.5e-05
XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062)  254 48.8 3.5e-05
XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062)  254 48.8 3.5e-05
XP_005270242 (OMIM: 607128) PREDICTED: tankyrase-2 (1190)  254 48.8 3.7e-05
XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 ( 506)  248 47.5   4e-05


>>NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens]     (1166 aa)
 initn: 559 init1: 247 opt: 332  Z-score: 273.8  bits: 59.9 E(85289): 1.6e-08
Smith-Waterman score: 332; 39.3% identity (63.7% similar) in 168 aa overlap (5-170:4-163)

               10        20        30        40        50        60
pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP
           : :: :      .:. .:. . .:. ::     :  :::. :::.:.   :  .. 
NP_079  MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR
                10        20         30             40         50  

                 70        80        90       100       110        
pF1KB4 DSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS
       :.::   : ::.:.  :.  : ..::..::. .:.  ::   :: :   ::.:.. ::: 
NP_079 DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR
             60        70        80        90       100       110  

      120       130       140       150       160       170        
pF1KB4 HGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLR
       ::..: . :. ..: ::.:: .:. :.: .::::. :  .::.  .: : ::        
NP_079 HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEPTIRNTDGRTALDLADPSAKAV
            120       130       140        150       160       170 

      180                                                          
pF1KB4 DLLSS                                                       
                                                                   
NP_079 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL
             180       190       200       210       220       230 

>--
 initn: 843 init1: 232 opt: 277  Z-score: 231.4  bits: 52.1 E(85289): 3.8e-06
Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:477-643)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG
                                     ::: :.:       . .: .  ::  ::. 
NP_079 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE
        450       460       470       480       490       500      

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.:   ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
NP_079 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN
        510        520       530       540       550       560     

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::..::.   :.:   .: ::.:: .:. .::.:::::. :  . ..: 
NP_079 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD
         570       580       590       600       610        620    

           170        180                                          
pF1KB4 ARLACDLLP-CNSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
NP_079 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH
          630       640       650       660       670       680    

>--
 initn: 385 init1: 205 opt: 248  Z-score: 209.0  bits: 48.0 E(85289): 6.6e-05
Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:652-796)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.:::.: .. .. .  :. :   
NP_079 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS
             630       640       650       660        670       680

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::. ::  .:: .::   :: :.  ::...: ::.....   .
NP_079 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
              690       700       710       720       730       740

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::.  . :.  ::..  
NP_079 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM
              750       760        770       780        790        

NP_079 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS
      800       810       820       830       840       850        

>>XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 iso  (1169 aa)
 initn: 559 init1: 247 opt: 332  Z-score: 273.7  bits: 59.9 E(85289): 1.7e-08
Smith-Waterman score: 332; 39.3% identity (63.7% similar) in 168 aa overlap (5-170:4-163)

               10        20        30        40        50        60
pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP
           : :: :      .:. .:. . .:. ::     :  :::. :::.:.   :  .. 
XP_016  MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR
                10        20         30             40         50  

                 70        80        90       100       110        
pF1KB4 DSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS
       :.::   : ::.:.  :.  : ..::..::. .:.  ::   :: :   ::.:.. ::: 
XP_016 DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR
             60        70        80        90       100       110  

      120       130       140       150       160       170        
pF1KB4 HGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLR
       ::..: . :. ..: ::.:: .:. :.: .::::. :  .::.  .: : ::        
XP_016 HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEPTIRNTDGRTALDLADPSAKAV
            120       130       140        150       160       170 

      180                                                          
pF1KB4 DLLSS                                                       
                                                                   
XP_016 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL
             180       190       200       210       220       230 

>--
 initn: 843 init1: 232 opt: 254  Z-score: 213.6  bits: 48.8 E(85289): 3.7e-05
Smith-Waterman score: 254; 39.3% identity (67.5% similar) in 117 aa overlap (66-181:531-646)

          40        50        60        70        80        90     
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTH
                                     : ::.:.  .. .: ..::. ::   :. .
XP_016 PSIKLGSIFQIEKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK
              510       520       530       540       550       560

         100       110       120       130       140       150     
pF1KB4 GGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPA
       :: . :: :   :: :.:.::..::.   :.:   .: ::.:: .:. .::.:::::. :
XP_016 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-A
              570       580       590       600       610          

         160       170        180                                  
pF1KB4 LKAIRDRKARLACDLLP-CNSDLRDLLSS                               
         . ..: .    ::.   ..:..:::                                 
XP_016 DPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQ
     620       630       640       650       660       670         

>--
 initn: 385 init1: 205 opt: 248  Z-score: 209.0  bits: 48.0 E(85289): 6.7e-05
Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:655-799)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.:::.: .. .. .  :. :   
XP_016 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS
          630       640       650       660        670       680   

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::. ::  .:: .::   :: :.  ::...: ::.....   .
XP_016 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
           690       700       710       720       730       740   

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::.  . :.  ::..  
XP_016 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM
           750       760       770        780       790        800 

XP_016 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS
             810       820       830       840       850       860 

>>XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 iso  (1223 aa)
 initn: 991 init1: 226 opt: 293  Z-score: 243.5  bits: 54.4 E(85289): 8e-07
Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321)

                                        10        20        30     
pF1KB4                          MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI
                                     : : ::  . : :: :. . : :       
XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE-------
        140       150       160       170        180               

          40        50        60          70        80        90   
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ
         :  :::..:::.:.. : . .  : ::   . ::.:.  :.  : . ::. ::.  :.
XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR
        190       200        210       220       230       240     

           100       110       120       130       140       150   
pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS
         ::   :: :   ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::.
XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG
         250       260       270       280       290       300     

           160       170       180                                 
pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS                              
        :   ::.  .. : ::                                           
XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA
          310       320       330       340       350       360    

>--
 initn: 878 init1: 211 opt: 259  Z-score: 217.3  bits: 49.6 E(85289): 2.3e-05
Smith-Waterman score: 259; 35.0% identity (65.0% similar) in 157 aa overlap (30-181:695-848)

                10        20        30           40        50      
pF1KB4  MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERG---IWSAALNGDLGRVKHLIQKAED
                                     :. ::   . .:: .: :.::..:    :.
XP_011 TVKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-EN
          670       680       690       700       710       720    

         60          70        80        90       100       110    
pF1KB4 PSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIAR
        .  :. :   : :: :.  ..  : ..::: ::  .:: .::   :: :.  ::..:: 
XP_011 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA
           730       740       750       760       770       780   

          120       130       140       150       160       170    
pF1KB4 LLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCN
       ::.....   ..:  ..: ::.::..:. ..:.::: :. :  ........   ::   .
XP_011 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD
           790       800       810       820        830       840  

          180                                                      
pF1KB4 SDLRDLLSS                                                   
        :.: ::                                                     
XP_011 -DIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVG
             850       860       870       880       890       900 

>>XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 iso  (695 aa)
 initn: 605 init1: 232 opt: 277  Z-score: 233.8  bits: 51.8 E(85289): 2.8e-06
Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:6-172)

               10        20              30        40        50    
pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLGRVKHLIQKA
                            ::: :.:       . .: .  ::  ::.  ::.:   .
XP_011                 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCT-V
                               10        20        30        40    

           60          70        80        90       100       110  
pF1KB4 EDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEI
       .. .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: :   :: :.
XP_011 QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEV
            50        60        70        80        90       100   

            120       130       140       150       160       170  
pF1KB4 ARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLP
       :.::..::.   :.:   .: ::.:: .:. .::.:::::. :  . ..: .    ::. 
XP_011 AELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRDGNTPLDLVK
           110       120       130       140        150       160  

             180                                                   
pF1KB4 -CNSDLRDLLSS                                                
         ..:..:::                                                  
XP_011 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLE
            170       180       190       200       210       220  

>--
 initn: 385 init1: 205 opt: 248  Z-score: 211.5  bits: 47.7 E(85289): 4.8e-05
Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:181-325)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.:::.: .. .. .  :. :   
XP_011 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS
              160       170       180       190        200         

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::. ::  .:: .::   :: :.  ::...: ::.....   .
XP_011 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
     210       220       230       240       250       260         

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::.  . :.  ::..  
XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM
     270       280       290        300       310        320       

XP_011 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS
       330       340       350       360       370       380       

>>XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 iso  (1059 aa)
 initn: 843 init1: 232 opt: 277  Z-score: 231.8  bits: 52.0 E(85289): 3.6e-06
Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:370-536)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG
                                     ::: :.:       . .: .  ::  ::. 
XP_016 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE
     340       350       360       370       380       390         

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.:   ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
XP_016 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN
     400        410       420       430       440       450        

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::..::.   :.:   .: ::.:: .:. .::.:::::. :  . ..: 
XP_016 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD
      460       470       480       490       500        510       

           170        180                                          
pF1KB4 ARLACDLLP-CNSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
XP_016 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH
       520       530       540       550       560       570       

>--
 initn: 385 init1: 205 opt: 248  Z-score: 209.5  bits: 47.9 E(85289): 6.3e-05
Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:545-689)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.:::.: .. .. .  :. :   
XP_016 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS
          520       530       540       550        560       570   

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::. ::  .:: .::   :: :.  ::...: ::.....   .
XP_016 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
           580       590       600       610       620       630   

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::.  . :.  ::..  
XP_016 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM
           640       650       660        670       680        690 

XP_016 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS
             700       710       720       730       740       750 

>>XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 iso  (1187 aa)
 initn: 544 init1: 232 opt: 277  Z-score: 231.3  bits: 52.1 E(85289): 3.8e-06
Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:498-664)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG
                                     ::: :.:       . .: .  ::  ::. 
XP_011 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE
       470       480       490       500       510       520       

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.:   ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
XP_011 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN
       530        540       550       560       570       580      

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::..::.   :.:   .: ::.:: .:. .::.:::::. :  . ..: 
XP_011 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD
        590       600       610       620       630        640     

           170        180                                          
pF1KB4 ARLACDLLP-CNSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
XP_011 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH
         650       660       670       680       690       700     

>--
 initn: 689 init1: 225 opt: 261  Z-score: 219.0  bits: 49.8 E(85289): 1.9e-05
Smith-Waterman score: 291; 35.4% identity (57.1% similar) in 189 aa overlap (5-170:4-184)

               10        20        30        40        50        60
pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP
           : :: :      .:. .:. . .:. ::     :  :::. :::.:.   :  .. 
XP_011  MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR
                10        20         30             40         50  

                 70                             80        90       
pF1KB4 DSAGY--TALHYASRN---------------------GHYAVCQFLLESGAKCDAQTHGG
       :.::   : ::.:. :                     :.  : ..::..::. .:.  ::
XP_011 DTAGRKSTPLHFAAGNRGQRPLASLQTPPAQPGPTGFGRKDVVEYLLQNGANVQARDDGG
             60        70        80        90       100       110  

       100       110       120       130       140       150       
pF1KB4 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK
          :: :   ::.:.. ::: ::..: . :. ..: ::.:: .:. :.: .::::. :  
XP_011 LIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEP
            120       130       140       150       160        170 

       160       170       180                                     
pF1KB4 AIRDRKARLACDLLPCNSDLRDLLSS                                  
       .::.  .: : ::                                               
XP_011 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR
             180       190       200       210       220       230 

>--
 initn: 385 init1: 205 opt: 248  Z-score: 208.9  bits: 48.0 E(85289): 6.7e-05
Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:673-817)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.:::.: .. .. .  :. :   
XP_011 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS
            650       660       670       680        690       700 

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::. ::  .:: .::   :: :.  ::...: ::.....   .
XP_011 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
             710       720       730       740       750       760 

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::.  . :.  ::..  
XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM
             770       780        790       800        810         

XP_011 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS
     820       830       840       850       860       870         

>>XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 iso  (1301 aa)
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.4e-06
Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321)

                                        10        20        30     
pF1KB4                          MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI
                                     : : ::  . : :: :. . : :       
XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE-------
        140       150       160       170        180               

          40        50        60          70        80        90   
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ
         :  :::..:::.:.. : . .  : ::   . ::.:.  :.  : . ::. ::.  :.
XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR
        190       200        210       220       230       240     

           100       110       120       130       140       150   
pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS
         ::   :: :   ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::.
XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG
         250       260       270       280       290       300     

           160       170       180                                 
pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS                              
        :   ::.  .. : ::                                           
XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA
          310       320       330       340       350       360    

>--
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.4e-06
Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG
                                     ::: : :       : .  .  :.  ::: 
XP_011 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE
          610       620       630       640       650       660    

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.: . ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
XP_011 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN
          670        680       690       700       710       720   

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::. ::..  :.:   .: ::.:: .:. .::.:::.:. :  . ..: 
XP_011 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD
           730       740       750       760       770        780  

           170        180                                          
pF1KB4 ARLACDLLPC-NSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
XP_011 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH
            790       800       810       820       830       840  

>--
 initn: 361 init1: 211 opt: 254  Z-score: 213.1  bits: 48.9 E(85289): 3.9e-05
Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.::..:    :. .  :. :   
XP_011 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS
     780       790       800       810       820        830        

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::: ::  .:: .::   :: :.  ::..:: ::.....   .
XP_011 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA
      840       850       860       870       880       890        

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::   . :.: ::    
XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM
      900       910       920        930       940        950      

XP_011 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG
        960       970       980       990      1000      1010      

>>XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 iso  (1316 aa)
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321)

                                        10        20        30     
pF1KB4                          MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI
                                     : : ::  . : :: :. . : :       
XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE-------
        140       150       160       170        180               

          40        50        60          70        80        90   
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ
         :  :::..:::.:.. : . .  : ::   . ::.:.  :.  : . ::. ::.  :.
XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR
        190       200        210       220       230       240     

           100       110       120       130       140       150   
pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS
         ::   :: :   ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::.
XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG
         250       260       270       280       290       300     

           160       170       180                                 
pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS                              
        :   ::.  .. : ::                                           
XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA
          310       320       330       340       350       360    

>--
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG
                                     ::: : :       : .  .  :.  ::: 
XP_011 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE
          610       620       630       640       650       660    

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.: . ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
XP_011 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN
          670        680       690       700       710       720   

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::. ::..  :.:   .: ::.:: .:. .::.:::.:. :  . ..: 
XP_011 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD
           730       740       750       760       770        780  

           170        180                                          
pF1KB4 ARLACDLLPC-NSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
XP_011 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH
            790       800       810       820       830       840  

>--
 initn: 361 init1: 211 opt: 254  Z-score: 213.1  bits: 48.9 E(85289): 4e-05
Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.::..:    :. .  :. :   
XP_011 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS
     780       790       800       810       820        830        

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::: ::  .:: .::   :: :.  ::..:: ::.....   .
XP_011 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA
      840       850       860       870       880       890        

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::   . :.: ::    
XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM
      900       910       920        930       940        950      

XP_011 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG
        960       970       980       990      1000      1010      

>>XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 iso  (1316 aa)
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321)

                                        10        20        30     
pF1KB4                          MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI
                                     : : ::  . : :: :. . : :       
XP_006 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE-------
        140       150       160       170        180               

          40        50        60          70        80        90   
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ
         :  :::..:::.:.. : . .  : ::   . ::.:.  :.  : . ::. ::.  :.
XP_006 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR
        190       200        210       220       230       240     

           100       110       120       130       140       150   
pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS
         ::   :: :   ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::.
XP_006 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG
         250       260       270       280       290       300     

           160       170       180                                 
pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS                              
        :   ::.  .. : ::                                           
XP_006 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA
          310       320       330       340       350       360    

>--
 initn: 546 init1: 228 opt: 274  Z-score: 228.5  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG
                                     ::: : :       : .  .  :.  ::: 
XP_006 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE
          610       620       630       640       650       660    

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.: . ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
XP_006 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN
          670        680       690       700       710       720   

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::. ::..  :.:   .: ::.:: .:. .::.:::.:. :  . ..: 
XP_006 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD
           730       740       750       760       770        780  

           170        180                                          
pF1KB4 ARLACDLLPC-NSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
XP_006 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH
            790       800       810       820       830       840  

>--
 initn: 361 init1: 211 opt: 254  Z-score: 213.1  bits: 48.9 E(85289): 4e-05
Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.::..:    :. .  :. :   
XP_006 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS
     780       790       800       810       820        830        

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::: ::  .:: .::   :: :.  ::..:: ::.....   .
XP_006 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA
      840       850       860       870       880       890        

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::   . :.: ::    
XP_006 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM
      900       910       920        930       940        950      

XP_006 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG
        960       970       980       990      1000      1010      

>>NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens]     (1327 aa)
 initn: 546 init1: 228 opt: 274  Z-score: 228.4  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321)

                                        10        20        30     
pF1KB4                          MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI
                                     : : ::  . : :: :. . : :       
NP_003 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE-------
        140       150       160       170        180               

          40        50        60          70        80        90   
pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ
         :  :::..:::.:.. : . .  : ::   . ::.:.  :.  : . ::. ::.  :.
NP_003 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR
        190       200        210       220       230       240     

           100       110       120       130       140       150   
pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS
         ::   :: :   ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::.
NP_003 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG
         250       260       270       280       290       300     

           160       170       180                                 
pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS                              
        :   ::.  .. : ::                                           
NP_003 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA
          310       320       330       340       350       360    

>--
 initn: 546 init1: 228 opt: 274  Z-score: 228.4  bits: 51.7 E(85289): 5.5e-06
Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801)

                        10        20              30        40     
pF1KB4          MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG
                                     ::: : :       : .  .  :.  ::: 
NP_003 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE
          610       620       630       640       650       660    

          50        60          70        80        90       100   
pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR
        ::.: . ... .  :  :   : ::.:.  .. .: ..::. ::   :. .:: . :: 
NP_003 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN
          670        680       690       700       710       720   

           110       120       130       140       150       160   
pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK
       :   :: :.:.::. ::..  :.:   .: ::.:: .:. .::.:::.:. :  . ..: 
NP_003 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD
           730       740       750       760       770        780  

           170        180                                          
pF1KB4 ARLACDLLPC-NSDLRDLLSS                                       
       .    ::.   ..:..:::                                         
NP_003 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH
            790       800       810       820       830       840  

>--
 initn: 361 init1: 211 opt: 254  Z-score: 213.0  bits: 48.9 E(85289): 4e-05
Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952)

        10        20        30        40        50        60       
pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--
                                     :: .: :.::..:    :. .  :. :   
NP_003 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS
     780       790       800       810       820        830        

          70        80        90       100       110       120     
pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV
       : :: :.  ..  : ..::: ::  .:: .::   :: :.  ::..:: ::.....   .
NP_003 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA
      840       850       860       870       880       890        

         130       140       150       160       170       180     
pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS  
       .:  ..: ::.::..:. ..:.::: :. :  ........   ::   . :.: ::    
NP_003 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM
      900       910       920        930       940        950      

NP_003 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG
        960       970       980       990      1000      1010      




183 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 19:00:39 2016 done: Sat Nov  5 19:00:40 2016
 Total Scan time:  5.550 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
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