FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4308, 183 aa 1>>>pF1KB4308 183 - 183 aa - 183 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1852+/-0.000381; mu= 8.2280+/- 0.023 mean_var=168.3963+/-36.306, 0's: 0 Z-trim(118.2): 681 B-trim: 360 in 1/50 Lambda= 0.098834 statistics sampled from 29982 (30942) to 29982 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.363), width: 16 Scan time: 5.550 The best scores are: opt bits E(85289) NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 332 59.9 1.6e-08 XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 332 59.9 1.7e-08 XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 (1223) 293 54.4 8e-07 XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695) 277 51.8 2.8e-06 XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059) 277 52.0 3.6e-06 XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 277 52.1 3.8e-06 XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 (1301) 274 51.7 5.4e-06 XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 274 51.7 5.5e-06 XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 274 51.7 5.5e-06 NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens (1327) 274 51.7 5.5e-06 XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 258 49.6 3.2e-05 XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 258 49.6 3.2e-05 XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 258 49.6 3.2e-05 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 258 49.6 3.2e-05 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 258 49.6 3.2e-05 XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 258 49.6 3.2e-05 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 258 49.6 3.2e-05 XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 258 49.6 3.2e-05 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 258 49.6 3.3e-05 XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 258 49.6 3.3e-05 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 258 49.6 3.3e-05 XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 258 49.6 3.3e-05 XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 258 49.6 3.3e-05 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 258 49.6 3.3e-05 XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 258 49.6 3.3e-05 NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 258 49.6 3.3e-05 XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977) 254 48.7 3.3e-05 XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 258 49.7 3.3e-05 XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 258 49.7 3.3e-05 NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 258 49.7 3.3e-05 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 258 49.7 3.3e-05 XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 258 49.7 3.3e-05 XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 258 49.7 3.3e-05 XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 258 49.7 3.3e-05 XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 258 49.7 3.3e-05 XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 258 49.7 3.3e-05 XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 258 49.7 3.3e-05 XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 258 49.7 3.3e-05 XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 258 49.7 3.3e-05 XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 258 49.7 3.4e-05 XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 258 49.7 3.4e-05 XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 258 49.7 3.4e-05 XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 258 49.7 3.4e-05 XP_016863569 (OMIM: 106410,600919) PREDICTED: anky (1970) 258 49.7 3.4e-05 XP_016863568 (OMIM: 106410,600919) PREDICTED: anky (2006) 258 49.7 3.4e-05 XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 258 49.7 3.5e-05 XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 254 48.8 3.5e-05 XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 254 48.8 3.5e-05 XP_005270242 (OMIM: 607128) PREDICTED: tankyrase-2 (1190) 254 48.8 3.7e-05 XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 ( 506) 248 47.5 4e-05 >>NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens] (1166 aa) initn: 559 init1: 247 opt: 332 Z-score: 273.8 bits: 59.9 E(85289): 1.6e-08 Smith-Waterman score: 332; 39.3% identity (63.7% similar) in 168 aa overlap (5-170:4-163) 10 20 30 40 50 60 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP : :: : .:. .:. . .:. :: : :::. :::.:. : .. NP_079 MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR 10 20 30 40 50 70 80 90 100 110 pF1KB4 DSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS :.:: : ::.:. :. : ..::..::. .:. :: :: : ::.:.. ::: NP_079 DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 HGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLR ::..: . :. ..: ::.:: .:. :.: .::::. : .::. .: : :: NP_079 HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEPTIRNTDGRTALDLADPSAKAV 120 130 140 150 160 170 180 pF1KB4 DLLSS NP_079 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 180 190 200 210 220 230 >-- initn: 843 init1: 232 opt: 277 Z-score: 231.4 bits: 52.1 E(85289): 3.8e-06 Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:477-643) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG ::: :.: . .: . :: ::. NP_079 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE 450 460 470 480 490 500 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: ... . : : : ::.:. .. .: ..::. :: :. .:: . :: NP_079 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 510 520 530 540 550 560 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::..::. :.: .: ::.:: .:. .::.:::::. : . ..: NP_079 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD 570 580 590 600 610 620 170 180 pF1KB4 ARLACDLLP-CNSDLRDLLSS . ::. ..:..::: NP_079 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 630 640 650 660 670 680 >-- initn: 385 init1: 205 opt: 248 Z-score: 209.0 bits: 48.0 E(85289): 6.6e-05 Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:652-796) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.:::.: .. .. . :. : NP_079 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS 630 640 650 660 670 680 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::. :: .:: .:: :: :. ::...: ::..... . NP_079 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 690 700 710 720 730 740 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ ::. . :. ::.. NP_079 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM 750 760 770 780 790 NP_079 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 800 810 820 830 840 850 >>XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 iso (1169 aa) initn: 559 init1: 247 opt: 332 Z-score: 273.7 bits: 59.9 E(85289): 1.7e-08 Smith-Waterman score: 332; 39.3% identity (63.7% similar) in 168 aa overlap (5-170:4-163) 10 20 30 40 50 60 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP : :: : .:. .:. . .:. :: : :::. :::.:. : .. XP_016 MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR 10 20 30 40 50 70 80 90 100 110 pF1KB4 DSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS :.:: : ::.:. :. : ..::..::. .:. :: :: : ::.:.. ::: XP_016 DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 HGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLR ::..: . :. ..: ::.:: .:. :.: .::::. : .::. .: : :: XP_016 HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEPTIRNTDGRTALDLADPSAKAV 120 130 140 150 160 170 180 pF1KB4 DLLSS XP_016 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 180 190 200 210 220 230 >-- initn: 843 init1: 232 opt: 254 Z-score: 213.6 bits: 48.8 E(85289): 3.7e-05 Smith-Waterman score: 254; 39.3% identity (67.5% similar) in 117 aa overlap (66-181:531-646) 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTH : ::.:. .. .: ..::. :: :. . XP_016 PSIKLGSIFQIEKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 510 520 530 540 550 560 100 110 120 130 140 150 pF1KB4 GGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPA :: . :: : :: :.:.::..::. :.: .: ::.:: .:. .::.:::::. : XP_016 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-A 570 580 590 600 610 160 170 180 pF1KB4 LKAIRDRKARLACDLLP-CNSDLRDLLSS . ..: . ::. ..:..::: XP_016 DPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQ 620 630 640 650 660 670 >-- initn: 385 init1: 205 opt: 248 Z-score: 209.0 bits: 48.0 E(85289): 6.7e-05 Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:655-799) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.:::.: .. .. . :. : XP_016 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS 630 640 650 660 670 680 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::. :: .:: .:: :: :. ::...: ::..... . XP_016 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 690 700 710 720 730 740 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ ::. . :. ::.. XP_016 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM 750 760 770 780 790 800 XP_016 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 810 820 830 840 850 860 >>XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1223 aa) initn: 991 init1: 226 opt: 293 Z-score: 243.5 bits: 54.4 E(85289): 8e-07 Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321) 10 20 30 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI : : :: . : :: :. . : : XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE------- 140 150 160 170 180 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ : :::..:::.:.. : . . : :: . ::.:. :. : . ::. ::. :. XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS :: :: : ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::. XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 250 260 270 280 290 300 160 170 180 pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS : ::. .. : :: XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 310 320 330 340 350 360 >-- initn: 878 init1: 211 opt: 259 Z-score: 217.3 bits: 49.6 E(85289): 2.3e-05 Smith-Waterman score: 259; 35.0% identity (65.0% similar) in 157 aa overlap (30-181:695-848) 10 20 30 40 50 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERG---IWSAALNGDLGRVKHLIQKAED :. :: . .:: .: :.::..: :. XP_011 TVKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-EN 670 680 690 700 710 720 60 70 80 90 100 110 pF1KB4 PSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIAR . :. : : :: :. .. : ..::: :: .:: .:: :: :. ::..:: XP_011 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA 730 740 750 760 770 780 120 130 140 150 160 170 pF1KB4 LLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCN ::..... ..: ..: ::.::..:. ..:.::: :. : ........ :: . XP_011 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD 790 800 810 820 830 840 180 pF1KB4 SDLRDLLSS :.: :: XP_011 -DIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVG 850 860 870 880 890 900 >>XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 iso (695 aa) initn: 605 init1: 232 opt: 277 Z-score: 233.8 bits: 51.8 E(85289): 2.8e-06 Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:6-172) 10 20 30 40 50 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLGRVKHLIQKA ::: :.: . .: . :: ::. ::.: . XP_011 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCT-V 10 20 30 40 60 70 80 90 100 110 pF1KB4 EDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEI .. . : : : ::.:. .. .: ..::. :: :. .:: . :: : :: :. XP_011 QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEV 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 ARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLP :.::..::. :.: .: ::.:: .:. .::.:::::. : . ..: . ::. XP_011 AELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRDGNTPLDLVK 110 120 130 140 150 160 180 pF1KB4 -CNSDLRDLLSS ..:..::: XP_011 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLE 170 180 190 200 210 220 >-- initn: 385 init1: 205 opt: 248 Z-score: 211.5 bits: 47.7 E(85289): 4.8e-05 Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:181-325) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.:::.: .. .. . :. : XP_011 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS 160 170 180 190 200 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::. :: .:: .:: :: :. ::...: ::..... . XP_011 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 210 220 230 240 250 260 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ ::. . :. ::.. XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM 270 280 290 300 310 320 XP_011 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 330 340 350 360 370 380 >>XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 iso (1059 aa) initn: 843 init1: 232 opt: 277 Z-score: 231.8 bits: 52.0 E(85289): 3.6e-06 Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:370-536) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG ::: :.: . .: . :: ::. XP_016 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE 340 350 360 370 380 390 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: ... . : : : ::.:. .. .: ..::. :: :. .:: . :: XP_016 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 400 410 420 430 440 450 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::..::. :.: .: ::.:: .:. .::.:::::. : . ..: XP_016 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD 460 470 480 490 500 510 170 180 pF1KB4 ARLACDLLP-CNSDLRDLLSS . ::. ..:..::: XP_016 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 520 530 540 550 560 570 >-- initn: 385 init1: 205 opt: 248 Z-score: 209.5 bits: 47.9 E(85289): 6.3e-05 Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:545-689) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.:::.: .. .. . :. : XP_016 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS 520 530 540 550 560 570 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::. :: .:: .:: :: :. ::...: ::..... . XP_016 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 580 590 600 610 620 630 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ ::. . :. ::.. XP_016 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM 640 650 660 670 680 690 XP_016 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 700 710 720 730 740 750 >>XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 iso (1187 aa) initn: 544 init1: 232 opt: 277 Z-score: 231.3 bits: 52.1 E(85289): 3.8e-06 Smith-Waterman score: 277; 36.1% identity (61.5% similar) in 169 aa overlap (22-181:498-664) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEE------MDFERGIWSAALNGDLG ::: :.: . .: . :: ::. XP_011 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE 470 480 490 500 510 520 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: ... . : : : ::.:. .. .: ..::. :: :. .:: . :: XP_011 TVKKLCT-VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 530 540 550 560 570 580 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::..::. :.: .: ::.:: .:. .::.:::::. : . ..: XP_011 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG-ADPTKKNRD 590 600 610 620 630 640 170 180 pF1KB4 ARLACDLLP-CNSDLRDLLSS . ::. ..:..::: XP_011 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 650 660 670 680 690 700 >-- initn: 689 init1: 225 opt: 261 Z-score: 219.0 bits: 49.8 E(85289): 1.9e-05 Smith-Waterman score: 291; 35.4% identity (57.1% similar) in 189 aa overlap (5-170:4-184) 10 20 30 40 50 60 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP : :: : .:. .:. . .:. :: : :::. :::.:. : .. XP_011 MSGRRCAGGGAACASAAAEAVEPAAREL-FE-----ACRNGDVERVKRLVTP-EKVNSR 10 20 30 40 50 70 80 90 pF1KB4 DSAGY--TALHYASRN---------------------GHYAVCQFLLESGAKCDAQTHGG :.:: : ::.:. : :. : ..::..::. .:. :: XP_011 DTAGRKSTPLHFAAGNRGQRPLASLQTPPAQPGPTGFGRKDVVEYLLQNGANVQARDDGG 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB4 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK :: : ::.:.. ::: ::..: . :. ..: ::.:: .:. :.: .::::. : XP_011 LIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEP 120 130 140 150 160 170 160 170 180 pF1KB4 AIRDRKARLACDLLPCNSDLRDLLSS .::. .: : :: XP_011 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 180 190 200 210 220 230 >-- initn: 385 init1: 205 opt: 248 Z-score: 208.9 bits: 48.0 E(85289): 6.7e-05 Smith-Waterman score: 248; 33.1% identity (67.6% similar) in 148 aa overlap (38-183:673-817) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.:::.: .. .. . :. : XP_011 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHS 650 660 670 680 690 700 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::. :: .:: .:: :: :. ::...: ::..... . XP_011 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 710 720 730 740 750 760 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ ::. . :. ::.. XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTAAM 770 780 790 800 810 XP_011 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 820 830 840 850 860 870 >>XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1301 aa) initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.4e-06 Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321) 10 20 30 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI : : :: . : :: :. . : : XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE------- 140 150 160 170 180 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ : :::..:::.:.. : . . : :: . ::.:. :. : . ::. ::. :. XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS :: :: : ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::. XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 250 260 270 280 290 300 160 170 180 pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS : ::. .. : :: XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 310 320 330 340 350 360 >-- initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.4e-06 Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG ::: : : : . . :. ::: XP_011 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE 610 620 630 640 650 660 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: . ... . : : : ::.:. .. .: ..::. :: :. .:: . :: XP_011 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 670 680 690 700 710 720 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::. ::.. :.: .: ::.:: .:. .::.:::.:. : . ..: XP_011 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD 730 740 750 760 770 780 170 180 pF1KB4 ARLACDLLPC-NSDLRDLLSS . ::. ..:..::: XP_011 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 790 800 810 820 830 840 >-- initn: 361 init1: 211 opt: 254 Z-score: 213.1 bits: 48.9 E(85289): 3.9e-05 Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.::..: :. . :. : XP_011 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS 780 790 800 810 820 830 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::: :: .:: .:: :: :. ::..:: ::..... . XP_011 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 840 850 860 870 880 890 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ :: . :.: :: XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM 900 910 920 930 940 950 XP_011 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG 960 970 980 990 1000 1010 >>XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1316 aa) initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321) 10 20 30 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI : : :: . : :: :. . : : XP_011 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE------- 140 150 160 170 180 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ : :::..:::.:.. : . . : :: . ::.:. :. : . ::. ::. :. XP_011 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS :: :: : ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::. XP_011 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 250 260 270 280 290 300 160 170 180 pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS : ::. .. : :: XP_011 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 310 320 330 340 350 360 >-- initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG ::: : : : . . :. ::: XP_011 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE 610 620 630 640 650 660 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: . ... . : : : ::.:. .. .: ..::. :: :. .:: . :: XP_011 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 670 680 690 700 710 720 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::. ::.. :.: .: ::.:: .:. .::.:::.:. : . ..: XP_011 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD 730 740 750 760 770 780 170 180 pF1KB4 ARLACDLLPC-NSDLRDLLSS . ::. ..:..::: XP_011 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 790 800 810 820 830 840 >-- initn: 361 init1: 211 opt: 254 Z-score: 213.1 bits: 48.9 E(85289): 4e-05 Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.::..: :. . :. : XP_011 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS 780 790 800 810 820 830 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::: :: .:: .:: :: :. ::..:: ::..... . XP_011 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 840 850 860 870 880 890 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ :: . :.: :: XP_011 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM 900 910 920 930 940 950 XP_011 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG 960 970 980 990 1000 1010 >>XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1316 aa) initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321) 10 20 30 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI : : :: . : :: :. . : : XP_006 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE------- 140 150 160 170 180 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ : :::..:::.:.. : . . : :: . ::.:. :. : . ::. ::. :. XP_006 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS :: :: : ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::. XP_006 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 250 260 270 280 290 300 160 170 180 pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS : ::. .. : :: XP_006 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 310 320 330 340 350 360 >-- initn: 546 init1: 228 opt: 274 Z-score: 228.5 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG ::: : : : . . :. ::: XP_006 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE 610 620 630 640 650 660 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: . ... . : : : ::.:. .. .: ..::. :: :. .:: . :: XP_006 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 670 680 690 700 710 720 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::. ::.. :.: .: ::.:: .:. .::.:::.:. : . ..: XP_006 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD 730 740 750 760 770 780 170 180 pF1KB4 ARLACDLLPC-NSDLRDLLSS . ::. ..:..::: XP_006 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 790 800 810 820 830 840 >-- initn: 361 init1: 211 opt: 254 Z-score: 213.1 bits: 48.9 E(85289): 4e-05 Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.::..: :. . :. : XP_006 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS 780 790 800 810 820 830 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::: :: .:: .:: :: :. ::..:: ::..... . XP_006 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 840 850 860 870 880 890 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ :: . :.: :: XP_006 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM 900 910 920 930 940 950 XP_006 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG 960 970 980 990 1000 1010 >>NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens] (1327 aa) initn: 546 init1: 228 opt: 274 Z-score: 228.4 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 298; 38.3% identity (60.5% similar) in 167 aa overlap (6-170:167-321) 10 20 30 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGI : : :: . : :: :. . : : NP_003 SSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVP-AVSGALRELLE------- 140 150 160 170 180 40 50 60 70 80 90 pF1KB4 WSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQ : :::..:::.:.. : . . : :: . ::.:. :. : . ::. ::. :. NP_003 --ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB4 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS :: :: : ::.:.. ::: .:..: . :. ..: ::.:: .:. :.: .::::. NP_003 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 250 260 270 280 290 300 160 170 180 pF1KB4 PALKAIRDRKARLACDLLPCNSDLRDLLSS : ::. .. : :: NP_003 -ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 310 320 330 340 350 360 >-- initn: 546 init1: 228 opt: 274 Z-score: 228.4 bits: 51.7 E(85289): 5.5e-06 Smith-Waterman score: 274; 35.5% identity (60.9% similar) in 169 aa overlap (22-181:635-801) 10 20 30 40 pF1KB4 MATPRPCADGPCCSHPSAVLGVQQTLEEM------DFERGIWSAALNGDLG ::: : : : . . :. ::: NP_003 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE 610 620 630 640 650 660 50 60 70 80 90 100 pF1KB4 RVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR ::.: . ... . : : : ::.:. .. .: ..::. :: :. .:: . :: NP_003 TVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 670 680 690 700 710 720 110 120 130 140 150 160 pF1KB4 ASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRK : :: :.:.::. ::.. :.: .: ::.:: .:. .::.:::.:. : . ..: NP_003 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG-ADPTKKNRD 730 740 750 760 770 780 170 180 pF1KB4 ARLACDLLPC-NSDLRDLLSS . ::. ..:..::: NP_003 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 790 800 810 820 830 840 >-- initn: 361 init1: 211 opt: 254 Z-score: 213.0 bits: 48.9 E(85289): 4e-05 Smith-Waterman score: 254; 35.6% identity (65.8% similar) in 146 aa overlap (38-181:810-952) 10 20 30 40 50 60 pF1KB4 ADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY-- :: .: :.::..: :. . :. : NP_003 NRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS 780 790 800 810 820 830 70 80 90 100 110 120 pF1KB4 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV : :: :. .. : ..::: :: .:: .:: :: :. ::..:: ::..... . NP_003 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 840 850 860 870 880 890 130 140 150 160 170 180 pF1KB4 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS .: ..: ::.::..:. ..:.::: :. : ........ :: . :.: :: NP_003 TDKWAFTPLHEAAQKGRTQLCALLLAHG-ADPTMKNQEGQTPLDLATAD-DIRALLIDAM 900 910 920 930 940 950 NP_003 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG 960 970 980 990 1000 1010 183 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:00:39 2016 done: Sat Nov 5 19:00:40 2016 Total Scan time: 5.550 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]